Stathmin destabilizing microtubule dynamics promotes malignant potential in cancer cells by epithelial-mesenchymal transition

BACKGROUND： Stathmin is a ubiquitous cytosolic regulatory phosphoprotein and is overexpressed in different human malignancies. The main physiological function of stathmin is to interfere with microtubule dynamics by promoting depolymerization of microtubules or by preventing polymerization of tubulin heterodimers. Stathmin plays important roles in regulating many cellular functions as a result of its microtubuledestabilizing activity. Currently, the critical roles of stathmin in cancer cells, as well as in lymphocytes have been valued. This review discusses stathmin and microtubule dynamics in cancer development, and hypothesizes their possible relationship with epithelial-mesenchymal transition（EMT）.DATA SOURCES： A PubMed search using such terms as ＂stathmin＂, ＂microtubule dynamics＂, ＂epithelial-mesenchymal transition＂, ＂EMT＂, ＂malignant potential＂ and ＂cancer＂ was performed to identify relevant studies published in English.More than 100 related articles were reviewed.RESULTS： The literature clearly documented the relationship between stathmin and its microtubule-destabilizing activity of cancer development. However, the particular mechanism is poorly understood. Microtubule disruption is essential for EMT, which is a crucial process during cancer development. As a microtubule-destabilizing protein, stathmin may promote malignant potential in cancer cells by initiating EMT.CONCLUSIONS： We propose that there is a stathminmicrotubule dynamics-EMT（S-M-E） axis during cancer development. By this axis, stathmin together with itsmicrotubule-destabilizing activity contributes to EMT, which stimulates the malignant potential in cancer cells.

Photoluminescence and Optical Transition Dynamics of Er^(3+) Ions in Porous Si

Er was doped into porous Si by immersing the porous Si sample in a saturated ErCl3,ethanol solution. Sharp and intense 1.54 μm photoluminescence caused by intra-4f-shefl transitions in Er3+ ions was observed up to room temperature. It is shown that the immersing process is valid to dope Er in high concentration in porous Si. Time resolved study of the Er-doped porous Si revealed that the doped Er3+ ions are excited by energy transfer from photo-generated electron-hole pairs in the host. The energy back transfer process from the excited 4f electrons in the Er3+ion to the host is not a dominant factor to quench the Er-related emission in porous Si. Ourresults are well explained by a proposed model in which an intermediate state was introduced.

Phase transition in a two-dimensional Ising ferromagnet based on the generalized zero-temperature Glauber dynamics

At zero temperature, based on the Ising model, the phase transition in a two-dimensional square lattice is studied using the generalized zero-temperature Glauber dynamics. Using Monte Carlo （MC） renormalization group methods, the static critical exponents and the dynamic exponent are studied; the type of phase transition is found to be of the first order.

Frequency Switches at Transition Temperature in Voltage-Gated Ion Channel Dynamics of Neural Oscillators

Understanding of the mechanisms of neural phase transitions is crucial for clarifying cognitive processes in the brain. We investigate a neural oscillator that undergoes different bifurcation transitions from the big saddle homoclinic orbit type to the saddle node on an invariant circle type, and the saddle node on an invariant circle type to the small saddle homoclinic orbit type. The bifurcation transitions are accompanied by an increase in thermodynamic temperature that affects the voltage-gated ion channel in the neural oscillator. We show that nonlinear and thermodynamical mechanisms are responsible for different switches of the frequency in the neural oscillator. We report a dynamical role of the phase response curve in switches of the frequency, in terms of slopes of frequency-temperature curve at each bifurcation transition. Adopting the transition state theory of voltagegated ion channel dynamics, we confirm that switches of the frequency occur in the first-order phase transition temperature states and exhibit different features of their potential energy derivatives in the ion channel. Each bifurcation transition also creates a discontinuity in the Arrhenius plot used to compute the time constant of the ion channel.

Floquet dynamical quantum phase transitions in transverse XY spin chains under periodic kickings

Floquet dynamical quantum phase transitions(DQPTs),which are nonanalytic phenomena recuring periodically in time-periodic driven quantum many-body systems,have been widely studied in recent years.In this article,the Floquet DQPTs in transverse XY spin chains under the modulation ofδ-function periodic kickings are investigated.We analytically solve the system,and by considering the eigenstate as well as the ground state as the initial state of the Floquet dynamics,we study the corresponding multiple Floquet DQPTs emerged in the micromotion with different kicking moments.The rate function of return amplitude,the Pancharatnam geometric phase and the dynamical topological order parameter are calculated,which consistently verify the emergence of Floquet DQPTs in the system.

Metallogenic Effect of Transition of Tectonic Dynamic System

Tectonic dynamic system transition, one of the main factors in metallogenesis, controls metallogenic fluid movement and ore body location in orefields and on an ore deposit scale (mainly in the continental tectonic setting), and even the formation and distribution of large-scale deposit clusters. Tectonic dynamic system transition can be classified as the spacious difference of the tectonic dynamic system in various geological units and the temporal alteration of different tectonic dynamic systems. The former results in outburst of mineralization, while the latter leads to the metallogenic diversity. Both of them are the main contents of metallogenic effect of tectonic dynamic system transition, that is, the alteration of dynamic system, the occurrence of mineralization, and the difference of regional tectonic dynamic system and metallogenic diversity. Generally speaking, the coupling of spatial difference of tectonic dynamic system and its successive alternation controlled the tempo-spatial evolution regularity of mineralization on a larger scale. In addition, the analysis of mineralization factors and processes of typical ore deposits proved that the changes of tectonic stress field, the direct appearance of tectonic dynamic system transition, may lead to the accident of mineralization physical-chemical field and the corresponding accidental interfaces were always located at ore bodies.

Demage Spreading in the Ising Model with a special Metropolis Dynamics Approach

The time evolution of the Hamming distance (damage spreading) for the and Ising models on the square lattice is performed with a special metropolis dynamics algorithm. Two distinct regimes are observed according to the temperature range for both models: a low-temperature one where the distance in the long-time limit is finite and seems not to depend on the initial distance and the system size; a high-temperature one where the distance vanishes in the long-time limit. Using the finite size scaling method, the dynamical phase transition (damage spreading transition) temperature is obtained as for the Ising model.

Dynamic phase transition of ferroelectric nanotube described by a spin-1/2 transverse Ising model

The dynamic phase transition properties for ferroelectric nanotube under a spin-1/2 transverse Ising model are studied under the effective field theory(EFT)with correlations.The temperature effects on the pseudo-spin systems are unveiled in three-dimensional(3-D)and two-dimensional(2-D)phase diagrams.Moreover,the dynamic behaviors of exchange interactions on the 3-D and 2-D phase transitions under high temperature are exhibited.The results present that it is hard to obtain pure ferroelectric phase under high temperature;that is,the vibration of orderly pseudo-spins cannot be eliminated completely.

Numerical method for simulating rarefaction shocks in the approximation of phase-flip hydrodynamics

A finite-difference algorithm is proposed for numerical modeling of hydrodynamic flows with rarefaction shocks, in which the fluid undergoes a jump-like liquid-gas phase transition. This new type of flow discontinuity, unexplored so far in computational fluid dynamics, arises in the approximation of phase-flip(PF) hydrodynamics, where a highly dynamic fluid is allowed to reach the innermost limit of metastability at the spinodal, upon which an instantaneous relaxation to the full phase equilibrium(EQ) is assumed. A new element in the proposed method is artificial kinetics of the phase transition, represented by an artificial relaxation term in the energy equation for a "hidden"component of the internal energy, temporarily withdrawn from the fluid at the moment of the PF transition. When combined with an appropriate variant of artificial viscosity in the Lagrangian framework, the latter ensures convergence to exact discontinuous solutions, which is demonstrated with several test cases.

Stochastic resonance and nonequilibrium dynamic phase transition of Ising spin system driven by a joint external field

The dynamic response and stochastic resonance of a kinetic Ising spin system （ISS） subject to the joint action of an external field of weak sinusoidal modulation and stochastic white-nolse are studied by solving the mean-field equation of motion based on Glauber dynamics. The periodically driven stochastic ISS shows that the characteristic stochastic resonance as well as nonequilibrium dynamic phase transition （NDPT） occurs when the frequency ω and amplitude h0 of driving field, the temperature t of the system and noise intensity D are all specifically in accordance with each other in quantity. There exist in the system two typical dynamic phases, referred to as dynamic disordered paramagnetic and ordered ferromagnetic phases respectively, corresponding to a zero- and a unit-dynamic order parameter. The NDPT boundary surface of the system which separates the dynamic paramagnetic phase from the dynamic ferromagnetic phase in the 3D parameter space of ho-t-D is also investigated. An interesting dynamical ferromagnetic phase with an intermediate order parameter of 0.66 is revealed for the first time in the ISS subject to the perturbation of a joint determinant and stochastic field. The intermediate order dynamical ferromagnetic phase is dynamically metastable in nature and owns a peculiar characteristic in its stability as well as the response to external driving field as compared with a fully order dynamic ferromagnetic phase.

Dynamical quantum phase transition in XY chains with the Dzyaloshinskii-Moriya and XZY-YZX three-site interactions

We study the dynamical quantum phase transitions(DQPTs)in the XY chains with the Dzyaloshinskii-Moriya interaction and the XZY-YZX type of three-site interaction after a sudden quench.Both the models can be mapped to the spinless free fermion models by the Jordan-Wigner and Bogoliubov transformations with the form■where the quasiparticle excitation spectraεkmay be smaller than 0 for some k and are asymmetrical■It is found that the factors of Loschmidt echo equal 1 for some k corresponding to the quasiparticle excitation spectra of the pre-quench Hamiltonian satisfyingε_(k)·ε_(-k)<0,when the quench is from the gapless phase.By considering the quench from different ground states,we obtain the conditions for the occurrence of DQPTs for the general XY chains with gapless phase,and find that the DQPTs may not occur in the quench across the quantum phase transitions regardless of whether the quench is from the gapless phase to gapped phase or from the gapped phase to gapless phase.This is different from the DQPTs in the case of quench from the gapped phase to gapped phase,in which the DQPTs will always appear.Moreover,we analyze the different reasons for the absence of DQPTs in the quench from the gapless phase and the gapped phase.The conclusion can also be extended to the general quantum spin chains.

Change of State of a Dynamical Unit in the Transition of Coherence

The change of state of one map in the network of nonlocal coupled logistic maps at the transition of coherence is studied. With the increase of coupling strength, the network dynamics transits from the incoherent state into the coherent state. In the process, the iteration of the map first changes from chaos to period state, then from periodic to chaotic state again. For the periodic doubling bifurcations, similar to an isolated map, the largest Lyapunov exponent tends to zero from a negative value. However, the states of coupled maps exhibit complex behavior rather than converge to a few fixed values. The behavior brings a new chimera state of coupled logistic maps. The bifurcation diagram is identical to the phase order of maps iterations. For the bifurcation between 1-band and multi-band chaos, the symmetry of chaotic bands emerges and the transition of the order of iteration direction occurs.

Dynamic Investigations of Pressure-Induced Abnormal Phase Transitions in PbTiO3

The effects of pressure on phonon modes of ferroeleetrie tetragonal P4mm and paraelectric cubic Pm3m PbTiOa are systematically investigated by using first-principles simulations. The pressure-induced tetragonal-to-cubie and subsequent cubic-to-tetragonal phase transitions are the second-order transitions, which are different from the phase transitions induced by temperature [Phys. Rev. Lett. 25 （1970） 167]. As pressure increases, the lowest A1 and E modes of the tetragonal phase become softer and converge to the F1u mode of the cubic phase. As pressure further increases, the lowest Flu mode first hardens and then softens again, and finally diverges into A1 and E modes. The behaviors of optical phonon modes confirm the ferroelectric-to-paraelectric-to-ferroeleetric phase transitions.

Control of epileptic activities in a cortex network of multiple coupled neural populations under electromagnetic induction

Epilepsy is believed to be associated with the abnormal synchronous neuronal activity in the brain,which results from large groups or circuits of neurons.In this paper,we choose to focus on the temporal lobe epilepsy,and establish a cortex network of multiple coupled neural populations to explore the epileptic activities under electromagnetic induction.We demonstrate that the epileptic activities can be controlled and modulated by electromagnetic induction and coupling among regions.In certain regions,these two types of control are observed to show exactly reverse effects.The results show that the strong electromagnetic induction is conducive to eliminating the epileptic seizures.The coupling among regions has a conduction effect that the previous normal background activity of the region gives way to the epileptic discharge,owing to coupling with spike wave discharge regions.Overall,these results highlight the role of electromagnetic induction and coupling among the regions in controlling and modulating epileptic activities,and might provide novel insights into the treatments of epilepsy.

Critical Spreading of Active Region in a Ladder Model Possessing Infinite AbsorbingStates

The spreading of active region of the ladder model is simulated. Finite-time scaling behaviors are observedin the vicinity of the critical point.

El Nino Southern Oscillation as Sporadic Oscillations between Metastable States

The main objective of this article is to establish a new mechanism of ENSO,as a self-organizing and self-excitation system,with two highly coupled processes.The first is the oscillation between the two metastable warm(El Ni(?)o phase) and cold events(La Ni(?)a phase),and the second is the spatiotemporal oscillation of the sea surface temperature(SST) field.The symbiotic interplay between these two processes gives rises the climate variability associated with the ENSO,leads to both the random and deterministic features of the ENSO,and defines a new natural feedback mechanism,which drives the sporadic oscillation of the ENSO.The new mechanism is rigorously derived using a dynamic transition theory developed recently by the authors,which has also been successfully applied to a wide range of problems in nonlinear sciences.

Nonequilibrium behavior of the kinetic metamagnetic spin-5/2 Blume–Capel model

The dynamic magnetic behavior of the kinetic metamagnetic spin-5/2 Blume-Capel model is examined, within a mean-field approach, under a time-dependent oscillating magnetic field. To describe the kinetics of the system, Glauber- type stochastic dynamics has been utilized. The mean-field dynamic equations of the model are obtained from the Master equation. Firstly, these dynamic equations are solved to find the phases in the system. Then, the dynamic phase transition temperatures are obtained by investigating the thermal behavior of dynamic sublattice magnetizations. Moreover, from this investigation, the nature of the phase transitions （first- or second-order） is characterized. Finally, the dynamic phase diagrams are plotted in five different planes. It is found that the dynamic phase diagrams contain the paramagnetic （P）, antiferromagnetic （AF5/2, AF3/2, AF1/2） phases and five different mixed phases. The phase diagrams also display many dynamic critical points, such as tricritical point, triple point, quadruple point, double critical end point and separating point.

Magnetic Properties of Transverse Ising Model under a Time Oscillating Longitudinal Field

A transverse Ising spin system, in the presence of time-dependent longitudinal field, is studied by the effective-field theory （EFT）. The effective-field equations of motion of the average magnetization are given for the simple cubic lattice （Z ---- 6） and the honeycomb lattice （Z = 3）. The Liapunov exponent A is calculated for discussing the stability of the magnetization and it is used to determine the phase boundary. The dynamic phase transition diagrams in ho/ZJ - F/ZJ plane and in ho/ZJ - T/ZJ plane have been drawn, and there is no dynamical tricritical point on the dynamic phase transition boundary. The effect of the thermal fluctuations upon the dynamic phase boundary has been discussed.

The dynamic compensation temperature in a kinetic spin-5/2 Ising model on a hexagonal lattice

We present a study of the dynamic behavior of a two-sublattice spin-5/2 Ising model with bilinear and crystal-field interactions in the presence of a time-dependent oscillating external magnetic field on alternating layers of a hexagonal lattice by using the Glauber-type stochastic dynamics.The lattice is formed by alternate layers of spins σ=5/2 and S=5/2.We employ the Glauber transition rates to construct the mean-field dynamic equations.First,we investigate the time variations of the average sublattice magnetizations to find the phases in the system and then the thermal behavior of the dynamic sublattice magnetizations to characterize the nature（first-or second-order） of the phase transitions and to obtain the dynamic phase transition（DPT） points.We also study the thermal behavior of the dynamic total magnetization to find the dynamic compensation temperature and to determine the type of the dynamic compensation behavior.We present the dynamic phase diagrams,including the dynamic compensation temperatures,in nine different planes.The phase diagrams contain seven different fundamental phases,thirteen different mixed phases,in which the binary and ternary combination of fundamental phases and the compensation temperature or the L-type behavior strongly depend on the interaction parameters.

Dynamic transition mechanism analysis of the impact of energy development on urbanization in Central Asia

Energy development has a significant impact on urbanization. This study employs the entropy method to evaluate the level of urbanization in Central Asia and further analyzes the possible dynamic transition mechanisms of the impact of energy development (characterized by energy development scale, energy trade, energy consumption, and energy endowment) on urbanization using the Panel Smooth Transition Regression model (PSTR). The results demonstrate that energy development in this region is characterized by “three highs and one low”, namely, high production volume, high export volume, high endowment, and low self-consumption, and plays a crucial role in the progress of urbanization. A nonlinear relationship is found to exist between energy development and comprehensive urbanization in the transition economies of Central Asia. Generally speaking, as energy development continues to expand, its impact on urbanization in this region has shifted from constraint to promotion, with the latter gradually tending to flatten out. Energy development characterized by energy development scale, energy consumption, and energy trade can prove the point, whose threshold is 1.47 million tons oil equivalent (Mtoe), 0.29 tons oil equivalent (toe) per capita, and 20.95 Mtoe, respectively. However, not all energy development models exhibit this behavior. Energy development characterized by energy endowment is such a case where the positive effect of it on comprehensive urbanization will be restrained when it exceeds 3.18. These findings can aid decision makers in seeking a better energy development model to promote the sustainable development of urbanization in Central Asia, avoiding energy resources waste and disorderly development.