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Comparison on serum biomarkers for anovulatory and ovulatory dysfunctional uterine bleeding in Lizu females 被引量:11
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作者 Shan Bao Shu-Ying Yang +1 位作者 Zhuo-Ri Li Ge-Bo Wen 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2014年第2期149-152,共4页
Objective:To screen,identify,and compare the serum biomarkers between anovulatory dysfunctional uterine bleeding(ADUB)and ovulatory dysfunctional uterine bleeding(ODUB)in Lizu females.Methods:The subjects included 128... Objective:To screen,identify,and compare the serum biomarkers between anovulatory dysfunctional uterine bleeding(ADUB)and ovulatory dysfunctional uterine bleeding(ODUB)in Lizu females.Methods:The subjects included 128 ADLB patients,63 ODUB patients,and 93controls.The serum and supernate of the subjects'mense were collected and stored at-80°C until use.Differential proteins in the sera of three groups were screened using surface-enhaneed laser desorption ionization time-of-flight mass spectrometry.The screened proteins were then identified by tricine-SDS-PAGE gel and spectrometry.Protein expression levels in the menses of ADUB,ODUB,and control subjects were determined using ELISA,RT-PCR,and Western blotting.SPSS 14.1 was used for statistical analysis and chart drawing(a=0.05),Results:Three differentia)protein peaks with peak values of 11.80,13.59,and 14.68 km/z were,screened and identified as serum amyploid protein A(SAA),vascular endothelial growth factor,and vitamin K epoxide reductase,respectively.The SAA was highly expressed in the menses of ADUB and ODUB patients but poorly expressed in the controls.The vascular endothelial growth factor was highly expressed in the menses of ODUB and controls but poorly expressed in ADUB patients.Meanwhile,the vitamin K epoxide reductase was highly expressed in the menses of ADUB and control subjects but poorly expressed in ODUB patients.Conclusions:The SAA is the common serum biomarker of ADUB and ODUB.ADUB may be related to angiogenesis impairment,whereas ODUB may be associated with blood coagulation disruption. 展开更多
关键词 Anovulatory dysfunctional uterine bleeding Biomarker Serum amyploid protein A Vascular ENDOTHELIA growth factor VITAMIN K EPOXIDE REDUCTASE
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The Mechanisms of Abnormal Bleeding in Patients with Anovulatory Dysfunctional Uterine Bleeding 被引量:3
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作者 Lu LUO Feng-chuan ZHU Yao-ying ZENG 《Journal of Reproduction and Contraception》 CAS 2002年第4期222-230,共9页
Objective To investigate the mechanisms of abnormal bleeding in patients with anovulatory dysfunctional uterine bleeding (DUB) and to analyze the correlation between vascular endothelial growth factor (VEGF) and micro... Objective To investigate the mechanisms of abnormal bleeding in patients with anovulatory dysfunctional uterine bleeding (DUB) and to analyze the correlation between vascular endothelial growth factor (VEGF) and microvessel density in the endometrium Materials & Methods Immunohistochemistry was used to study the expression of VEGF protein in the proliferative and hyperplastic endometrium. CD34 ,a marker of microvessel, was selected to measure microvessel density (MVD) in the endometrium.Fifteen women who were found to have no condition with normal menstrual cycles were set as control group.Results VEGF immunoreactivity in glandular epithelia cells was significantly lower in the hyperplastic endometrium than that of controls(P < 0. 05). There was no significant difference in VEGF protein level between proliferative DUB endometrium and that of controls. A positive correlation was found between glandular VEGF and MVD in the endometrium(r=0. 666, P<0.05). Conclusion The anovulatory DUB is associated with down-regulation of VEGF in the endometrium, and decreased secretion of VEGF will result in the disruption of angiogenesis, as a clinical manifestation of irregular bleeding. 展开更多
关键词 dysfunctional uterine bleeding anovulatory ENDOMETRIAL hyperplasia endothelial growth factors angiogenesis
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Adolescence dysfunctional uterine bleeding:perspectives from the combination of traditional Chinese medicine and modern medicine 被引量:1
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作者 Can Liu Jun-Ze Geng Shu-Ping Hu 《TMR Integrative Medicine》 2022年第17期1-5,共5页
Because their endocrine system is not yet developmentally mature,adolescent girls are prone to dysfunctional uterine bleeding caused by insufficiency of the hypothalamic-pituitary-gonadal axis.The view of modern medic... Because their endocrine system is not yet developmentally mature,adolescent girls are prone to dysfunctional uterine bleeding caused by insufficiency of the hypothalamic-pituitary-gonadal axis.The view of modern medicine is mainly aimed at the secretory function of sex hormones,such as estrogen and progesterone.However,it causes distress to patients because of the susceptibility of their treatment to endocrine system disorders.Traditional Chinese medicine considers the damage to the function of the Conception Vessel and Thoroughfare Vessel as the key to the disease.In this way,we guide the use of traditional Chinese medicine and acupuncture and achieve good results.The pathogenesis and management of functional uterine bleeding in adolescence are discussed from two medical perspectives in this article. 展开更多
关键词 ADOLESCENCE dysfunctional uterine bleeding GYNAECOLOGY views of traditional Chinese medicine and modern medicine
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OBSERVATION ON THE THERAPEUTIC EFFECT OF COMBINED AURICULAR-PLASTER AND MOXIBUSTION THERAPIES FOR TREATMENT OF 500 CASES OF DYSFUNCTIONAL UTERINE BLEEDING
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作者 刘世忠 朱志萍 朱秀云 《World Journal of Acupuncture-Moxibustion》 1999年第3期37-39,共3页
The present study reports results of 500 cases of dysfunctional uterine bleeding treatedwith combined auricular-plaster and moxibustion therapies. After treatment, 480 cases were cured,constituting 96. 0 %; 16 cases w... The present study reports results of 500 cases of dysfunctional uterine bleeding treatedwith combined auricular-plaster and moxibustion therapies. After treatment, 480 cases were cured,constituting 96. 0 %; 16 cases were improved, constituting 3. 2% and 4 had no any effect, constituting 0. 8 %. The total effective rate was 99. 2 %. 展开更多
关键词 dysfunctional uterine bleeding COMBINED auricular-plaster and MOXIBUSTION therapy
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A retrospective study on estrogen or contraceptives in the treatment of dysfunctional uterine bleeding in adolescent patients
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作者 刘颖 徐苓 《生殖医学杂志》 CAS 2006年第B10期28-33,共6页
Objective: To investigate the clinical efficacy of estrogen or contraceptives in the treatment of acute bleeding of dysfunctional uterine bleeding (DUB) in adolescent patients and the optimal starting dosage of drugs.... Objective: To investigate the clinical efficacy of estrogen or contraceptives in the treatment of acute bleeding of dysfunctional uterine bleeding (DUB) in adolescent patients and the optimal starting dosage of drugs.Methods: The clinical records of 106 girls who with DUB and moderate or severe anemia from February 1990 to July 2005 were analyzed retrospectively.Results: All 106 patients received hormonal therapy. 56 patients were treated with estradiol benzoate(E2), 30 patients with conjugated equine estrogen(CEE) and 20 patients with combined oral contraceptives (COCs). The rates for rapidly controlling bleeding and for rapidly stopping bleeding in E2 group were higher than those in CEE group ,but similar to those in COCs group. The days for controlling and completely stopping bleeding were not significantly different between the starting dosages (≤8 mg/d and >8 mg/d) of E2 groups, and also there were no statistical difference between the starting dosages (<7.5 mg/d and ≥7.5 mg/d) of CEE groups, but during the treatment the rate of increasing the dosage in <7.5 mg/d group was higher than that of ≥7.5 mg/d group(40% vs. 5%),while there were no statistical difference between the starting dosages (≤3 pills/d and >3 pills/d) of COCs groups. Conclusions: The clinical efficiency of E2 treatment on DUB in adolescent patients is similar to that of COCs. And the efficacies of treatment of DUB with E2, CEE and COCs in the different dosages are similar. 展开更多
关键词 雌激素 避孕工具 子宫 患者
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The therapeutic efficacy and safety of Gongxuening capsule in dysfunctional uterine bleeding:a systematic review and meta-analysis
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作者 Xue Bai Yan-Ru Zhang +1 位作者 Feng-Qin Zhang Hai-Zhu Zhang 《Medical Data Mining》 2020年第4期152-165,共14页
Background:Gongxuening capsule is a Chinese patent medicine for treating the dysfunctional uterine bleeding.We report a meta-analysis of the combination efficacy between conventional medicines with Chinese patent drug... Background:Gongxuening capsule is a Chinese patent medicine for treating the dysfunctional uterine bleeding.We report a meta-analysis of the combination efficacy between conventional medicines with Chinese patent drug Gongxuening in the treatment of dysfunctional uterine bleeding.Materials and methods:Seven databases were used to retrieve the relevant research of Chinese patent drug Gongxuening treatment for dysfunctional uterine bleeding from the databases establishment to 2020.The data were extracted independently by 2 researchers according to the described selection research.The meta-analysis was performed using RevMan5.3 software.Results:This study included 23 randomized trials,with a total of 1,836 dysfunctional uterine bleeding patients.Chinese patent drug Gongxuening could significantly improve the effective rate,and reduce endometrial thickness,control bleeding time,complete hemostasis time and sex hormone level,and no serious adverse events.Based on sensitivity analysis and subgroup analysis,the heterogeneity sources of endometrial thickness,complete hemostasis time and sex hormone level were found.In follicle stimulating hormone and luteinizing hormone,there was no significant difference between the two groups when Chinese patent drug Gongxuening combined with desogestrel ethinylestradiol.Conclusion:Conventional medicines combined with Chinese patent drug Gongxuening can make patients with dysfunctional uterine bleeding achieve better effective rate,and no serious adverse events occurred. 展开更多
关键词 Gongxuening capsule Conventional medicines dysfunctional uterine bleeding META-ANALYSIS Systematic review
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滇桂艾纳香提取物促进DUB大鼠子宫收缩机制分析
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作者 陈秀婷 韦玥吟 +2 位作者 覃田田 吴超权 李宇清 《药学研究》 CAS 2024年第1期1-5,14,共6页
目的探讨滇桂艾纳香提取物通过促进子宫平滑肌收缩治疗功能失调性子宫出血(DUB)的作用机制。方法利用米非司酮联合米索前列醇建立DUB大鼠模型,成模的雌性大鼠40只,随机分5组:正常妊娠组、DUB模型组、益母草颗粒3.125 g·kg^(-1)组... 目的探讨滇桂艾纳香提取物通过促进子宫平滑肌收缩治疗功能失调性子宫出血(DUB)的作用机制。方法利用米非司酮联合米索前列醇建立DUB大鼠模型,成模的雌性大鼠40只,随机分5组:正常妊娠组、DUB模型组、益母草颗粒3.125 g·kg^(-1)组、滇桂艾纳香提取物0.4 g·kg^(-1)组以及0.2 g·kg^(-1)组,另取8只未受孕性成熟雌性大鼠作空白对照组,观察滇桂艾纳香提取物对DUB模型大鼠子宫平滑肌收缩的影响,Western blotting法测定大鼠子宫平滑肌中β_(2)肾上腺素受体(β_(2)AR)、环磷腺苷效应元件结合蛋白(CREB)及p-CREB蛋白表达水平,并检测大鼠子宫平滑肌中蛋白激酶A(PKA)活性和Ca^(2+)离子浓度。结果与DUB模型组相比,滇桂艾纳香提取物可提高大鼠子宫收缩频率(P<0.05),增加子宫平滑肌Ca^(2+)离子浓度,并且增加p-CREB/CREB蛋白表达(P<0.05);滇桂艾纳香提取物还可降低子宫平滑肌PKA活力(P<0.01),但对β_(2)受体表达没有明显影响。结论滇桂艾纳香提取物可能是通过抑制β_(2)受体的活化,间接增强转录调节因子CREB对与子宫平滑肌收缩相关的转录调控,从而促使子宫肌层收缩,产生治疗DUB的作用。 展开更多
关键词 滇桂艾纳香 子宫收缩 功能失调性子宫出血 β_(2)肾上腺素受体
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Identification and verification of effective components of Huanghuai for dysfunctional uterine bleeding based on network pharmacology and molecular docking 被引量:6
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作者 Yun-xiu Yao Yu-ling Xu +4 位作者 Bo-wen Liu Hui Yang Song-yang Li Ling-li Zhazo Tao Liu 《Chinese Herbal Medicines》 CAS 2021年第2期177-188,共12页
Objective:The Huanghuai(HH),which is made from the dried roots of Scutellaria baicalensis(Huangqin in Chinese) and the dried flowers and buds of Sophora japonica(Huaihua in Chinese),is a traditional Chinese formula us... Objective:The Huanghuai(HH),which is made from the dried roots of Scutellaria baicalensis(Huangqin in Chinese) and the dried flowers and buds of Sophora japonica(Huaihua in Chinese),is a traditional Chinese formula used to treat dysfunctional uterine bleeding(DUB)(Benglou in Chinese) and proven to treat hemostasis effectively in our previous study.Network pharmacology and molecule docking were performed to study the underlying mechanism of Huanghuai(HH),and pharmacodynamic experiments were conducted to verify its curative effect.Methods:TCMSP,UniProt,GeneCards,STRING,DAVID databases,and Cytoscape 3.7.2 were utilized for the construction of a compound-target-pathway network.Docking the potential effective components with potential targets.The HPLC analysis of the potential effective components was performed.In vivo,the hot plate test model was used to study the analgesic activity,the egg white was used to study the swollen reaction in the sole in mice,and the hemostasis effect was studied by the capillary method,tail-breaking method and abortion uterus test.Results:The results showed that six compounds(acacetin,beta-sitosterol,wogonin,baicalein,kaempferol and quercetin) and four potential targets(PTGS2,AKT1,TP53 and TNF) in the compound-targetpathway network were the potential material basis for HH to treat DUB.It can be seen that the binding energy of the acacetin,wogonin,baicalein,beta-sitosterol,kaempferol and quercetin in HH docked with the receptor proteins PTGS2,AKT1,TP53,and TNF were far less than-5.0 kJ/mol,which means the molecules have low conformational energy,stable structure and high binding activity.And the result of HPLC analysis showed that acacetin,wogonin,baicalein,kaempferol and quercetin were the potential effective components of the hemostasis mechanism of HH,beta-sitosterol was removed due to low content.In vivo testing of the potential effective components,it revealed that the group of potential effective components identified by HPLC could increase the pain threshold,inhibit the swelling hind paws of mice induced by egg white,reduce the bleeding time and clotting time,reduce uterine bleeding,decrease the uterine weight,increase the content of Ca and ET-1,and reduce the content of NO in uterine homogenate tissue,and decrease of E_(2) and P content in uterine serum in aborted rats,whose efficacy was equal to HH.Conclusion:The results indicated that HH and potential active ingredient groups obtained from network pharmacology can treat DUB and play a hemostatic effect.The results obtained by network pharmacology have certain reliability.This study provides new indications for further mechanism research of HH on DUB and the development of HH or its components as an alternative therapy for patients with DUB.At the same time,the application of network pharmacology strategy may provide a powerful tool for exploring the mechanism of traditional Chinese medicine and discovering new biologically active ingredients. 展开更多
关键词 Huanghuai dysfunctional uterine bleeding network pharmacology molecular docking pharmacological study
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止血组方加减治疗功能失调性子宫出血患者的效果及对性激素水平的影响
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作者 吴雅楠 辛兴涛 《四川中医》 2024年第2期175-178,共4页
目的:探讨止血组方加减治疗功能失调性子宫出血(DUB)患者的效果及对性激素水平的影响。方法:选择2021年9月~2022年9月来本院就诊的DUB患者150例进行研究,用随机数表法将患者分两组各75例。对照组给予妈富隆治疗,观察组给予止血组方加减... 目的:探讨止血组方加减治疗功能失调性子宫出血(DUB)患者的效果及对性激素水平的影响。方法:选择2021年9月~2022年9月来本院就诊的DUB患者150例进行研究,用随机数表法将患者分两组各75例。对照组给予妈富隆治疗,观察组给予止血组方加减治疗。治疗3个月经周期,比较两组疗效,记录治疗前后月经量、子宫内膜厚度、血红蛋白及性激素[(雌二醇(E_(2))、孕酮(P)、促卵泡生产数(FSH)、促黄体生成素(LH)]水平变化,并统计患者不良反应。结果:观察组的总有效率(93.33%)高于对照组(77.33,P<0.05);治疗后,两组的月经量、子宫内膜厚度均降低,且观察组低于对照组,而血红蛋白升高,观察组高于对照组(P<0.05);治疗后,两组的E2、P水平升高,观察组高于对照组,而FSH、LH将治疗前降低,观察组低于对照组(P<0.05);观察组不良反应发生率为4.00%,明显低于对照组(17.33%,P<0.05)。结论:止血组方加减治疗DUB效果理想,可有效调节性激素水平,加速病情优化,具有较高的用药安全性,可在临床推广运用。 展开更多
关键词 功能失调性子宫出血 止血组方加减 妈富隆 性激素 疗效 不良反应
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MMP-9和TIMP-1在育龄期DUB患者子宫内膜组织中的表达及意义 被引量:2
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作者 康燕华 张彦芳 +3 位作者 任雁林 舒丽莎 李建平 常丽锦 《河北医药》 CAS 2009年第6期647-648,共2页
目的研究育龄期功能失调性子宫出血(DUB)患者子宫内膜局部基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶抑制剂(TIMP-1)的表达变化。方法采用免疫组化S-P法检测35例育龄期DUB患者(病例组)及20例正常月经健康女性排卵后期(对照组)子宫内膜MM... 目的研究育龄期功能失调性子宫出血(DUB)患者子宫内膜局部基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶抑制剂(TIMP-1)的表达变化。方法采用免疫组化S-P法检测35例育龄期DUB患者(病例组)及20例正常月经健康女性排卵后期(对照组)子宫内膜MMP-9、TIMP-1的表达情况。同时用TUNEL原位标记技术精确测定子宫内膜功能层的细胞凋亡指数。结果育龄期DUB女性以排卵型为主(30/35),其子宫内膜组织中MMP-9在出血部位的表达显著高于正常部位及对照组(P<0.05),TIMP-1在出血部位的表达显著低于正常部位及对照组(P<0.05),且出血部位细胞凋亡指数较正常部位及对照组显著增高(P<0.01),差异均有统计学意义。结论子宫内膜局部MMP-9与TIMP-1失衡与育龄期DUB的发生有关,细胞凋亡也参与了DUB的发生。 展开更多
关键词 功能失调性子宫出血(dub) MMP-9 TIMP-1 细胞凋亡
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宫腔镜与B超诊断功能失调性子宫出血(DUB)和黏膜下子宫肌瘤(SMU)的结果与技术要点 被引量:1
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作者 罗劲 葛华 许耀辉 《中国医药导报》 CAS 2009年第12期155-156,共2页
目的:探讨宫腔镜与B超诊断功能失调性子宫出血(DUB)和黏膜下子宫肌瘤(SMU)的结果与技术要点。方法:将2003年8月~2008年8月我科收治的2864例子宫疾病患者,以B超和宫腔镜联合检查,逐一登记并进行统计学处理。结果:患者中确诊为DUB者828例... 目的:探讨宫腔镜与B超诊断功能失调性子宫出血(DUB)和黏膜下子宫肌瘤(SMU)的结果与技术要点。方法:将2003年8月~2008年8月我科收治的2864例子宫疾病患者,以B超和宫腔镜联合检查,逐一登记并进行统计学处理。结果:患者中确诊为DUB者828例,占28.9%;确诊为SMU者742例,占25.9%;两者共占受检患者的54.8%。结论:应用宫腔镜配合B超检查是目前诊断DUB和SMU的最佳选择,其确诊率高,漏诊、误诊率低。 展开更多
关键词 宫腔镜 B超 功能失调性子宫出血 黏膜下子宫肌瘤
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3种方法治疗围绝经期DUB的疗效与安全性评价 被引量:1
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作者 陈甦 金松 郑小妹 《西南国防医药》 CAS 2015年第12期1319-1322,共4页
目的 比较米非司酮和左炔诺孕酮宫内缓释系统(LNG-IUS)治疗围绝经期功能失调性子宫出血(DUB)的疗效和安全性。方法 将141例围绝经期DUB患者随机分入LNG-IUS组(宫内放置LNG-IUS)、米非司酮间断组(米非司酮10 mg/晚,连续给药5 d,后... 目的 比较米非司酮和左炔诺孕酮宫内缓释系统(LNG-IUS)治疗围绝经期功能失调性子宫出血(DUB)的疗效和安全性。方法 将141例围绝经期DUB患者随机分入LNG-IUS组(宫内放置LNG-IUS)、米非司酮间断组(米非司酮10 mg/晚,连续给药5 d,后5个月月经来潮第1~5 d继续服用米非司酮)、米非司酮连续组(米非司酮10 mg/晚,连续服用6个月),每组47例,比较3组治疗后的月经量、子宫内膜厚度、血红蛋白浓度、疗效和不良反应。结果 LNG-IUS组有效率为95.74%,米非司酮间断组有效率为68.09%,米非司酮连续组有效率为72.34%,LNG-IUS组有效率显著高于其他两组(P〈0.05);LNG-IUS组不良反应率为8.51%,明显低于米非司酮间断组(23.40%)和连续组(29.79%)(P〈0.05)。与其他两组相比,治疗3、6个月时,LNG-IUS组的月经量和子宫内膜厚度均显著减少(P〈0.05),而血红蛋白浓度则显著升高(P〈0.05)。结论 与米非司酮相比,LNG-IUS治疗围绝经期DUB疗效更好,安全性更高。 展开更多
关键词 米非司酮 左炔诺孕酮 宫内缓释 围绝经期 功能失调性子宫出血
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炔雌醇环丙孕酮片联合二味妙方治疗功能失调性子宫出血临床观察
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作者 边庆华 张一沛 +2 位作者 周月娟 朱赛英 黄津伶 《中国中医药现代远程教育》 2024年第20期161-163,共3页
目的探讨炔雌醇环丙孕酮片联合二味妙方治疗功能失调性子宫出血的临床效果。方法选择2023年1月—2023年12月于南昌市洪都中医院就诊并经过检查明确诊断为功能失调性子宫出血的患者40例作为观察对象,采用随机数字表法将其纳入对照组、治... 目的探讨炔雌醇环丙孕酮片联合二味妙方治疗功能失调性子宫出血的临床效果。方法选择2023年1月—2023年12月于南昌市洪都中医院就诊并经过检查明确诊断为功能失调性子宫出血的患者40例作为观察对象,采用随机数字表法将其纳入对照组、治疗组,各20例。对照组给予炔雌醇环丙孕酮片,治疗组给予炔雌醇环丙孕酮片联合二味妙方。连续服药3个月经周期后,对比两组患者临床治疗效果、出血控制时间、完全止血时间及治疗前后的子宫内膜厚度、月经周期与经期天数。结果治疗组临床总有效率为95.00%(19/20),高于对照组的70.00%(14/20),差异有统计学意义(P<0.05)。治疗组出血控制时间、完全止血时间均短于对照组,差异有统计学意义(P<0.05)。治疗组治疗后的子宫内膜厚度小于对照组,月经周期长于对照组,经期天数短于对照组,差异有统计学意义(P<0.05)。结论炔雌醇环丙孕酮片与二味妙方联合治疗功能失调性子宫出血的效果确切,此方案可以缩短出血控制时间及止血时间,还可以降低患者子宫内膜厚度,促使月经周期规律,缩短经期天数。 展开更多
关键词 崩漏 功能失调性子宫出血 二味妙方 中西医结合疗法
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戊酸雌二醇片联合米非司酮治疗围绝经期功能失调性子宫出血患者的效果 被引量:2
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作者 田会勤 《中国民康医学》 2024年第1期69-71,75,共4页
目的:观察戊酸雌二醇片联合米非司酮治疗围绝经期功能失调性子宫出血患者的效果。方法:回顾性分析2020年9月至2022年9月该院收治的128例围绝经期功能失调性子宫出血患者的临床资料,根据治疗方案不同将其分为研究组与对照组各64例。对照... 目的:观察戊酸雌二醇片联合米非司酮治疗围绝经期功能失调性子宫出血患者的效果。方法:回顾性分析2020年9月至2022年9月该院收治的128例围绝经期功能失调性子宫出血患者的临床资料,根据治疗方案不同将其分为研究组与对照组各64例。对照组采用米非司酮片治疗,研究组在对照组基础上联合戊酸雌二醇片治疗,比较两组临床疗效、治疗前后子宫内膜厚度、血红蛋白水平、月经量、性激素指标[孕酮、卵泡刺激素(FSH)、雌二醇(E_(2))、黄体生成素(LH)]水平和不良反应发生率。结果:研究组治疗总有效率为95.31%(61/64),高于对照组的79.69%(51/54),差异有统计学意义(P<0.05);治疗后,两组月经量、子宫内膜厚度均低于治疗前,且研究组低于对照组,两组血红蛋白水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组孕酮、FSH、E_(2)、LH水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:戊酸雌二醇联合米非司酮治疗围绝经期功能失调性子宫出血患者可提高治疗总有效率和血红蛋白水平,降低月经量、子宫内膜厚度和性激素指标水平,其效果优于单纯米非司酮片治疗。 展开更多
关键词 功能失调性子宫出血 围绝经期 戊酸雌二醇片 米非司酮 子宫内膜 性激素 不良反应
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雌激素联合地屈孕酮治疗孕龄期排卵障碍性异常子宫出血的效果和安全性
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作者 鲍明珠 董艳 +1 位作者 赵丹玲 张松英 《中国医药导报》 CAS 2024年第3期122-126,共5页
目的 研究雌激素联合地屈孕酮治疗孕龄期排卵障碍性异常子宫出血的效果和安全性。方法 选取2020年2月至2021年2月徐州医科大学附属沭阳医院妇产科孕龄期排卵障碍性异常子宫出血患者192例,按照随机数字表法分为单药组、联合组,各96例。... 目的 研究雌激素联合地屈孕酮治疗孕龄期排卵障碍性异常子宫出血的效果和安全性。方法 选取2020年2月至2021年2月徐州医科大学附属沭阳医院妇产科孕龄期排卵障碍性异常子宫出血患者192例,按照随机数字表法分为单药组、联合组,各96例。单药组采用地屈孕酮治疗,联合组采用雌激素联合地屈孕酮治疗,两组均治疗3个月。比较两组临床疗效、止血情况;比较两组治疗前后月经周期、月经持续时间、子宫内膜厚度及性激素水平[卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_(2))];记录不良反应发生情况。结果 联合组临床疗效优于单药组(P<0.05)。联合组出血控制时间、完全止血时间短于单药组(P<0.05)。治疗后,两组月经周期、月经持续时间短于治疗前,且联合组短于单药组(P<0.05);两组子宫内膜厚度、FSH、LH、E_(2)水平低于治疗前,且联合组低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 雌激素联合地屈孕酮治疗孕龄期排卵障碍性异常子宫出血效果明显,能缓解止血情况,调节月经周期、月经持续时间及子宫内膜厚度,降低性激素水平,安全性高。 展开更多
关键词 孕龄期 排卵障碍性异常子宫出血 雌激素 地屈孕酮 疗效
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地屈孕酮联合戊酸雌二醇治疗围绝经期功能失调性子宫出血患者的效果
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作者 占娟 李勇 《中国民康医学》 2024年第9期85-87,91,共4页
目的:观察地屈孕酮联合戊酸雌二醇治疗围绝经期功能失调性子宫出血(DUB)患者的效果。方法:回顾性分析2021年3月至2023年1月该院收治的80例围绝经期DUB患者的临床资料,根据治疗方案不同将其分为对照组和研究组各40例。对照组采用戊酸雌... 目的:观察地屈孕酮联合戊酸雌二醇治疗围绝经期功能失调性子宫出血(DUB)患者的效果。方法:回顾性分析2021年3月至2023年1月该院收治的80例围绝经期DUB患者的临床资料,根据治疗方案不同将其分为对照组和研究组各40例。对照组采用戊酸雌二醇片治疗,研究组在对照组基础上联合地屈孕酮片治疗。比较两组临床疗效,治疗前后子宫内膜厚度,止血效果,治疗前后血红蛋白(Hb)、性激素[孕激素(P)、雌二醇(E_(2))、黄体生成素(LH)、卵泡刺激素(FSH)]水平,以及不良反应发生率。结果:研究组治疗总有效率为92.50%(37/40),高于对照组的75.00%(30/40),差异有统计学意义(P<0.05);治疗后,两组子宫内膜厚度均小于治疗前,且研究组小于对照组,差异有统计学意义(P<0.05);治疗后,两组Hb水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);研究组出血控制时间、完全止血时间均短于对照组,差异有统计学意义(P<0.05);两组E_(2)、FSH、LH、P水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:地屈孕酮联合戊酸雌二醇治疗围绝经期DUB患者可提高治疗总有效率和Hb水平,缩短出血控制时间、完全止血时间,减小子宫内膜厚度,降低性激素水平,其效果优于单纯戊酸雌二醇治疗。 展开更多
关键词 地屈孕酮 戊酸雌二醇 围绝经期 功能失调性子宫出血 性激素 止血 子宫内膜厚度
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米非司酮连续给药与改良短周期疗法治疗围绝经期功能障碍性子宫出血的效果
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作者 郑冬梅 孙超佳 《临床研究》 2024年第8期79-81,共3页
目的探索米非司酮连续给药与改良短周期疗法对围绝经期功能障碍性子宫出血患者的效果。方法将平舆县东和店镇中心卫生院2021年8月至2023年8月收治的76例围绝经期功能障碍性子宫出血患者以系统随机化法均分为两组,各38例。两组均采用米... 目的探索米非司酮连续给药与改良短周期疗法对围绝经期功能障碍性子宫出血患者的效果。方法将平舆县东和店镇中心卫生院2021年8月至2023年8月收治的76例围绝经期功能障碍性子宫出血患者以系统随机化法均分为两组,各38例。两组均采用米非司酮治疗,其中对照组为连续给药,观察组则运用改良短周期疗法。比较两组的子宫超声指标水平、性激素水平、不良反应发生情况、复发情况与闭经发生情况。结果治疗前两组子宫体积及子宫内膜厚度比较,差异无统计学意义(P>0.05)。治疗后,两组子宫体积及子宫内膜厚度较治疗前均缩小,观察组较对照组缩小更明显,差异具有统计学意义(P<0.05)。治疗后,观察组雌二醇、孕酮、卵泡刺激素水平均低于对照组,差异有统计学意义(P<0.05)。观察组的不良反应发生率(2.63%)低于对照组(18.42%),差异存在统计学意义(P<0.05)。由随访情况可得观察组复发率与闭经发生率低于对照组,组间差异有统计学意义(P<0.05)。结论运用米非司酮短周期疗法相较于米非司酮连续给药疗法,可有效保障患者的子宫健康,缓解子宫出血情况,有效降低复发率与闭经发生率。 展开更多
关键词 米非司酮 功能障碍性出血 子宫内膜厚度
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醋酸甲羟孕酮联合戊酸雌二醇治疗功能失调性子宫出血患者的临床疗效评价
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作者 陈桂芳 《实用妇科内分泌电子杂志》 2024年第1期88-90,共3页
目的探讨醋酸甲羟孕酮联合戊酸雌二醇治疗功能失调性子宫出血患者的临床疗效。方法选取58例功能失调性子宫出血患者,利用随机数字表法分为对照组与研究组,每组29例。对照组患者给予醋酸甲羟孕酮片治疗,研究组患者给予醋酸甲羟孕酮片联... 目的探讨醋酸甲羟孕酮联合戊酸雌二醇治疗功能失调性子宫出血患者的临床疗效。方法选取58例功能失调性子宫出血患者,利用随机数字表法分为对照组与研究组,每组29例。对照组患者给予醋酸甲羟孕酮片治疗,研究组患者给予醋酸甲羟孕酮片联合戊酸雌二醇片治疗。比较两组患者的临床疗效。结果研究组患者的治疗总有效率为93.10%(27/29),对照组患者的治疗总有效率为72.41%(21/29),研究组患者的治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。研究组患者控制出血时间、完全止血时间均明显短于对照组,差异有统计学意义(P<0.05)。研究组的不良反应发生率为13.79%,对照组的不良反应发生率为37.93%,研究组患者的不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论醋酸甲羟孕酮联合戊酸雌二醇治疗功能失调性子宫出血患者疗效确切,缩短控制出血时间、完全止血时间,具有安全性,值得临床推广。 展开更多
关键词 醋酸甲羟孕酮 戊酸雌二醇 功能失调性子宫出血 临床疗效
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芬吗通联合坤泰胶囊对围绝经期功能失调性子宫出血临床疗效和激素水平的影响
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作者 曹玉芹 《实用妇科内分泌电子杂志》 2024年第1期94-96,共3页
目的分析芬吗通联合坤泰胶囊对围绝经期功能失调性子宫出血(DUB)患者临床疗效和激素水平的影响。方法选取76例DUB患者,依据随机数字表法分为两组,各38例。对照组予以芬吗通治疗,观察组予以芬吗通联合坤泰胶囊治疗。比较两组患者的临床... 目的分析芬吗通联合坤泰胶囊对围绝经期功能失调性子宫出血(DUB)患者临床疗效和激素水平的影响。方法选取76例DUB患者,依据随机数字表法分为两组,各38例。对照组予以芬吗通治疗,观察组予以芬吗通联合坤泰胶囊治疗。比较两组患者的临床疗效、治疗前后性激素水平。结果观察组的总有效率94.74%高于对照组的78.95%,差异具有统计学意义(P<0.05)。治疗后观察组患者卵泡刺激素(FSH)、促黄体生成素(LH)水平均低于对照组,雌二醇(E_(2))水平高于对照组(P<0.05)。结论芬吗通联合坤泰胶囊治疗DUB患者的临床效果确切,可调节激素水平,值得临床推广。 展开更多
关键词 芬吗通 坤泰胶囊 围绝经期功能失调性子宫出血 激素水平
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妇科断红饮胶囊治疗围绝经期功能失调性子宫出血的疗效观察
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作者 张凡凡 苗晶 +2 位作者 段春梅 支雄莉 黄志敏 《实用妇科内分泌电子杂志》 2024年第16期55-58,共4页
目的观察妇科断红饮胶囊和去氧孕烯炔雌醇片治疗围绝经期功能失调性子宫出血的疗效。方法选取本院确诊并接受治疗的150例围绝经期功能失调性子宫出血患者为研究对象,根据给予药物的不同分为两组,各75例。观察组给予妇科断红饮胶囊治疗,... 目的观察妇科断红饮胶囊和去氧孕烯炔雌醇片治疗围绝经期功能失调性子宫出血的疗效。方法选取本院确诊并接受治疗的150例围绝经期功能失调性子宫出血患者为研究对象,根据给予药物的不同分为两组,各75例。观察组给予妇科断红饮胶囊治疗,对照组给予去氧孕烯炔雌醇片治疗,比较两组的疗效和不良反应。结果观察组的总有效率为94.67%,对照组的总有效率为90.67%,两组比较差异无统计学意义(P>0.05)。两组治疗3个疗程后的子宫内膜厚度较治疗前均有显著改善,且观察组子宫内膜厚度改善情况优于对照组(P<0.05)。观察组治疗3个疗程后孕酮、促卵泡生成素、促黄体生成素水平均优于对照组(P<0.05)。观察组完全止血时间和出血控制时间均明显短于对照组(P<0.05)。结论妇科断红饮胶囊治疗围绝经期功能失调性子宫出血疗效确切,且止血效果更为快速,安全有效,不良反应与西药相比较少,值得临床推广与应用。 展开更多
关键词 妇科断红饮胶囊 功能失调性子宫出血 止血 去氧孕烯炔雌醇片
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