Effect of repetitive transcranial magnetic stimulation combined with swallowing training on the nutritional status and neurological function of patients with dysphigin after stroke

Objective: To study the effect of repetitive transcranial magnetic stimulation combined with swallowing training on the nutritional status and neurological function of patients with dysphigin after stroke. Methods: Patients with dysphagia after stroke who received rehabilitation in Nanjing Brain Hospital between June 2014 and September 2016 were selected and randomly divided into magnetic stimulation + training group and training group who received repetitive transcranial magnetic stimulation combined with swallowing training and swallowing training alone respectively. The nutritional status indexes, nerve injury indexes and neurotrophy indexes in serum were determined before treatment and 28 d after treatment. Results: 28 d after treatment, serum ALB, Hb, PAB, TRF, IGF-1, BDNF, NGF and VEGF contents of both groups of patients were higher than those before treatment while VILIP-1, NSE, Fibulin-5, NPY and Nogo-A contents were lower than those before treatment, and serum ALB, Hb, PAB, TRF, IGF-1, BDNF, NGF and VEGF contents of magnetic stimulation+ training group were higher than those of training group while VILIP-1, NSE, Fibulin-5, NPY and Nogo-A contents were lower than those of training group. Conclusion: Repetitive transcranial magnetic stimulation combined with swallowing training for dysphigin after stroke can improve the nutritional status and improve the neurological function.

重复经颅磁刺激联合吞咽训练对脑卒中后吞咽障碍患者营养状态、神经功能的影响

目的:研究重复经颅磁刺激联合吞咽训练对脑卒中后吞咽障碍患者营养状态、神经功能的影响。方法:选择2014年6月~2016年9月期间在南京脑科医院接受康复治疗的脑卒中后吞咽困难患者并随机分为磁刺激+训练组和单纯训练组,分别接受重复经颅磁刺激联合吞咽训练以及单纯吞咽训练。治疗前及治疗后28d,分别测定血清中营养状态指标、神经损伤指标、神经营养指标。结果:治疗后28d,两组患者血清中ALB、Hb、PAB、TRF、IGF-1、BDNF、NGF、VEGF的含量均较治疗前升高,VILIP-1、NSE、Fibulin-5、NPY、Nogo-A的含量较治疗前降低且磁刺激+训练组患者血清中ALB、Hb、PAB、TRF、IGF-1、BDNF、NGF、VEGF的含量高于单纯训练组,VILIP-1、NSE、Fibulin-5、NPY、Nogo-A的含量低于单纯训练组。结论:重复经颅磁刺激联合吞咽训练用于脑卒中后吞咽障碍能够改善营养状态、改善神经功能。