BACKGROUND： Heart rate variability refers to the beat-to-beat alteration in heart rate. It is usually a slight periodic variation of R-R intervals. Much information of autonomic nerve system balance can be obtained b...BACKGROUND： Heart rate variability refers to the beat-to-beat alteration in heart rate. It is usually a slight periodic variation of R-R intervals. Much information of autonomic nerve system balance can be obtained by measuring the heart rate variability of patients. It remains to be shown whether heart rate variability can be used as an index for determining the severity of insomnia and cerebral infarction. OBJECTIVE： This study aimed to analyze the correlation for each frequency spectrum parameter of heart rate variability with an insomnia index, as well as the degree of neurological defects in patients with simple cerebral infarction and cerebral infarction complicated by insomnia. The goal was to verify the feasibility of frequency spectrum parameters for heart rate variability as a marker for insomnia and cerebral infarction. DESIGN： A case-control observation. SETTING： Department of Neurology, First Hospital Affiliated to China Medical University. PARTICIPANTS： Sixty inpatients, and/or outpatients, with cerebral infarction were admitted to the 202 Hospital of Chinese PLA between December 2005 and October 2006, confirmed by CT, and recruited to the study. According to the insomnia condition （insomnia is defined by a Pittsburgh Sleep Quality Index score 〉 7）, the patients were assigned to a simple cerebral infarction group and a cerebral infarction complicated by insomnia group, with 30 subjects in each group. Thirty additional subjects, who concurrently received examinations and were confirmed to not suffer from cerebral infarction and insomnia, were recruited into the control group. Written informed consent was obtained from each subject for laboratory specimens. The protocol was approved by the Hospital＇s Ethics Committee. METHODS： Following admission, each subject＇s neurological impairment was assessed with the National Institutes of Health Stroke Scale and Pittsburgh Sleep Quality Index. Heart rate variability of each subject was measured with an autonomic nerve analyzer （Weijin Science and Technology Co., Ltd., Taiwan）. Each frequency spectrum parameter of heart rate variability was obtained, including very low frequency, low frequency, high frequency, total power, R-R interval, and its mean square. In addition, percentage of low frequency, high frequency, and ratio of low frequency to high frequency were calculated. For each heart rate frequency spectrum parameter, the difference between groups was analyzed. Moreover, correlations of each frequency spectrum parameter with insomnia and disease condition were analyzed. Data from each index, which were not normally distributed, were processed by logarithmic transformation. The t-test was used for the comparison of intergroup differences. Single-factor linear regression analysis and t-test were used for the analysis of factor-factor correlation and coefficient of correlation, respectively. MAIN OUTCOME MEASURES： （1） Differences of scores in the National Institutes of Health Stroke Scale and Pittsburgh Sleep Quality Index between the simple cerebral infarction group and the cerebral infarction complicated by insomnia group. （2） Differences of heart rate variability parameters between the simple cerebral infarction group and the control group. （3） Correlation of heart rate variability parameters, the Pittsburgh Sleep Quality Index score, and the neurological impairment score. RESULTS： Sixty patients and thirty healthy controls were included in the final analysis. （1） The scores of the Pittsburgh Sleep Quality Index and the neurological impairment were significantly higher in the cerebral infarction complicated by insomnia group compared to the simple cerebral infarction group （P 〈 0.05-0.01）. （2） R-R interval was significantly longer in the simple cerebral infarction group than in the control group, while R-R interval variance and high-frequency band were significantly lower in the simple cerebral infarction group compared to the control group （P 〈 0.05）. （3） For cerebral infarction patients with insomnia, the Pittsburgh Sleep Quality Index score was significantly positively correlated with neurological impairment （r = 0.54, P 〈 0.01）. The low-frequency band, very low-frequency band, high-frequency band, R-R interval variance, total power, R-R interval, and the percentage of high-frequency were significantly negatively correlated with the National Institutes of Health Stroke Scale score （r =4）.45 to 4）.90, P 〈 0.054）.01） and with the Pittsburgh Sleep Quality Index scores （r = 4）.56 to 4）.36, P 〈 0.054）.01）. CONCLUSION： Each heart rate variability parameter can be used as an index for assessing dyssomnia and neurologic impairment （r =4）.56 to 4）.36, P 〈 0.054）.01）.展开更多
In order to study the therapeutic effects of the TCM drugs on senile dyssomnia, 121 such patients were randomly divided into a treatment group of 63 cases (given the TCM drugs) and a control group of 58 cases (given e...In order to study the therapeutic effects of the TCM drugs on senile dyssomnia, 121 such patients were randomly divided into a treatment group of 63 cases (given the TCM drugs) and a control group of 58 cases (given estazolam). The changes shown in the SDRS and HAMA scores and the other indexes were observed in both of the two groups to evaluate the therapeutic effects. The results showed that the effective rate was 76.3% in the treatment group, and it was 69.1% in the control group; and that the TCM drugs had better effects in improving such symptoms as lethargy, dry mouth, and rebound of insomnia. Therefore, it can be concluded that the effect of the TCM drugs is better for senile dyssomnia than that of the Western drug estazolam.展开更多
Objective:To observe the curative effect of TCM massage on difficulty in falling asleep, waking during night and other sleep disorder of infants. Methods: The 51 outpatients were treated by basic recipe for massage tr...Objective:To observe the curative effect of TCM massage on difficulty in falling asleep, waking during night and other sleep disorder of infants. Methods: The 51 outpatients were treated by basic recipe for massage treatment and modified recipe according to syndromes. Results: The total Athens Insomnia Scale (AIS) score 3.2800±1.5784 after treatment is lower than 9.2400±1.4286 before treatment (P<0.01), there is statistical difference in AIS scores before and after treatment. Conclusion: TCM massage can remarkably improve sleep condition of infants with dyssomnia.展开更多
文摘BACKGROUND： Heart rate variability refers to the beat-to-beat alteration in heart rate. It is usually a slight periodic variation of R-R intervals. Much information of autonomic nerve system balance can be obtained by measuring the heart rate variability of patients. It remains to be shown whether heart rate variability can be used as an index for determining the severity of insomnia and cerebral infarction. OBJECTIVE： This study aimed to analyze the correlation for each frequency spectrum parameter of heart rate variability with an insomnia index, as well as the degree of neurological defects in patients with simple cerebral infarction and cerebral infarction complicated by insomnia. The goal was to verify the feasibility of frequency spectrum parameters for heart rate variability as a marker for insomnia and cerebral infarction. DESIGN： A case-control observation. SETTING： Department of Neurology, First Hospital Affiliated to China Medical University. PARTICIPANTS： Sixty inpatients, and/or outpatients, with cerebral infarction were admitted to the 202 Hospital of Chinese PLA between December 2005 and October 2006, confirmed by CT, and recruited to the study. According to the insomnia condition （insomnia is defined by a Pittsburgh Sleep Quality Index score 〉 7）, the patients were assigned to a simple cerebral infarction group and a cerebral infarction complicated by insomnia group, with 30 subjects in each group. Thirty additional subjects, who concurrently received examinations and were confirmed to not suffer from cerebral infarction and insomnia, were recruited into the control group. Written informed consent was obtained from each subject for laboratory specimens. The protocol was approved by the Hospital＇s Ethics Committee. METHODS： Following admission, each subject＇s neurological impairment was assessed with the National Institutes of Health Stroke Scale and Pittsburgh Sleep Quality Index. Heart rate variability of each subject was measured with an autonomic nerve analyzer （Weijin Science and Technology Co., Ltd., Taiwan）. Each frequency spectrum parameter of heart rate variability was obtained, including very low frequency, low frequency, high frequency, total power, R-R interval, and its mean square. In addition, percentage of low frequency, high frequency, and ratio of low frequency to high frequency were calculated. For each heart rate frequency spectrum parameter, the difference between groups was analyzed. Moreover, correlations of each frequency spectrum parameter with insomnia and disease condition were analyzed. Data from each index, which were not normally distributed, were processed by logarithmic transformation. The t-test was used for the comparison of intergroup differences. Single-factor linear regression analysis and t-test were used for the analysis of factor-factor correlation and coefficient of correlation, respectively. MAIN OUTCOME MEASURES： （1） Differences of scores in the National Institutes of Health Stroke Scale and Pittsburgh Sleep Quality Index between the simple cerebral infarction group and the cerebral infarction complicated by insomnia group. （2） Differences of heart rate variability parameters between the simple cerebral infarction group and the control group. （3） Correlation of heart rate variability parameters, the Pittsburgh Sleep Quality Index score, and the neurological impairment score. RESULTS： Sixty patients and thirty healthy controls were included in the final analysis. （1） The scores of the Pittsburgh Sleep Quality Index and the neurological impairment were significantly higher in the cerebral infarction complicated by insomnia group compared to the simple cerebral infarction group （P 〈 0.05-0.01）. （2） R-R interval was significantly longer in the simple cerebral infarction group than in the control group, while R-R interval variance and high-frequency band were significantly lower in the simple cerebral infarction group compared to the control group （P 〈 0.05）. （3） For cerebral infarction patients with insomnia, the Pittsburgh Sleep Quality Index score was significantly positively correlated with neurological impairment （r = 0.54, P 〈 0.01）. The low-frequency band, very low-frequency band, high-frequency band, R-R interval variance, total power, R-R interval, and the percentage of high-frequency were significantly negatively correlated with the National Institutes of Health Stroke Scale score （r =4）.45 to 4）.90, P 〈 0.054）.01） and with the Pittsburgh Sleep Quality Index scores （r = 4）.56 to 4）.36, P 〈 0.054）.01）. CONCLUSION： Each heart rate variability parameter can be used as an index for assessing dyssomnia and neurologic impairment （r =4）.56 to 4）.36, P 〈 0.054）.01）.
文摘In order to study the therapeutic effects of the TCM drugs on senile dyssomnia, 121 such patients were randomly divided into a treatment group of 63 cases (given the TCM drugs) and a control group of 58 cases (given estazolam). The changes shown in the SDRS and HAMA scores and the other indexes were observed in both of the two groups to evaluate the therapeutic effects. The results showed that the effective rate was 76.3% in the treatment group, and it was 69.1% in the control group; and that the TCM drugs had better effects in improving such symptoms as lethargy, dry mouth, and rebound of insomnia. Therefore, it can be concluded that the effect of the TCM drugs is better for senile dyssomnia than that of the Western drug estazolam.
文摘Objective:To observe the curative effect of TCM massage on difficulty in falling asleep, waking during night and other sleep disorder of infants. Methods: The 51 outpatients were treated by basic recipe for massage treatment and modified recipe according to syndromes. Results: The total Athens Insomnia Scale (AIS) score 3.2800±1.5784 after treatment is lower than 9.2400±1.4286 before treatment (P<0.01), there is statistical difference in AIS scores before and after treatment. Conclusion: TCM massage can remarkably improve sleep condition of infants with dyssomnia.
