Relativistic Heavy Ion Collider and the Large Hadron Collider for Heavy Ion Fusion

Heavy Ion Fusion makes use of the Relativistic Heavy Ion Collider at Brookhaven National Lab and the Large Hadron Collider in Geneva, Switzerland for Inertial Confinement Fusion. Two Storage Rings, which may or may not initially be needed, added to each of the Colliders increases the intensity of the Heavy Ion Beams making it comparable to the Total Energy delivered to the DT target by the National Ignition Facility at the Lawrence Livermore Lab. The basic Physics involved gives Heavy Ion Fusion an advantage over Laser Fusion because heavy ions have greater penetration power than photons. The Relativistic Heavy Ion Collider can be used as a Prototype Heavy Ion Fusion Reactor for the Large Hadron Collider.

创伤性脊髓损伤急性期前列腺素E1对血管相关因子的调节和微循环功能的保护

背景:前列腺素E1被证明在血管扩张、炎症、白细胞迁移和黏附中发挥调节作用,但其对创伤性脊髓损伤后脊髓微循环的作用尚缺乏深入的研究。目的:探讨在大鼠创伤性脊髓损伤急性期给予前列腺素E1对血管相关因子的调节和微循环功能的保护作用机制。方法:将72只雌性SD大鼠随机分为3组(n=24),即假手术组、脊髓损伤组、前列腺素E1组。后两组用Allen’s打击法建立脊髓损伤的体内模型,前列腺素E1组大鼠在脊髓损伤后15 min内立即尾静脉注射脂质前列腺素E110μg/kg。分别在损伤后2,24 h测定脊髓微循环血流量和血氧饱和度、脊髓微血管直径和面积、脊髓含水量、血管功能调节因子(血浆血管性血友病因子、血栓素A2、前列环素、内皮素1)和炎症因子(肿瘤坏死因子α、白细胞介素1β)的表达。结果与结论:①脊髓损伤后2 h,前列腺素E1组大鼠的脊髓微血管直径及面积、脊髓微循环血流量和血氧饱和度均高于脊髓损伤组(P<0.05),脊髓含水量低于脊髓损伤组(P<0.05),血浆血管性血友病因子、脊髓组织血栓素A2/前列环素及内皮素1质量浓度均低于脊髓损伤组(P<0.05);②脊髓损伤后24 h,前列腺素E1组大鼠的脊髓微血管面积、血流量和血氧饱和度均高于脊髓损伤组(P<0.05),脊髓含水量低于脊髓损伤组(P<0.05),血浆血管性血友病因子、脊髓组织血栓素A2/前列环素及内皮素1、肿瘤坏死因子α、白细胞介素1β的质量浓度均低于脊髓损伤组(P<0.05);③脊髓损伤组大鼠损伤后24 h的脊髓微血管直径及面积、脊髓微循环血流量和血氧饱和度均高于损伤后2 h(P<0.05),血浆血管性血友病因子、脊髓组织血栓素A2/前列环素、肿瘤坏死因子α、白细胞介素1β的质量浓度均高于损伤后2 h(P<0.05),但是脊髓组织内皮素1质量浓度低于损伤后2 h(P<0.05);④前列腺素E1组大鼠损伤后24 h的脊髓微循环血流量和血氧饱和度低于损伤后2 h(P<0.05),脊髓微血管直径及面积、脊髓含水量高于损伤后2 h(P<0.05);⑤以上结果表明,脊髓损伤大鼠伤后即刻静脉给予前列腺素E1,可调节血管功能调节因子、炎症因子并改善脊髓损伤后脊髓微循环,这为寻找治疗急性脊髓损伤的药物提供了潜在的基础。

Single Charged Top-Pion Production at the Next Generation e^＋e^- Colliders

The single charged top-pion production processes e~+ e~- → tbΠ_t~- and e~+e~- → W~+Π_t~- are studied in the framework of top-color-assisted technicolor (TC2) model. Ourstudies show that the cross section σ(e~+ e~- → tbΠ_t~-) Teaches the level of tens of fb andσ(e~+ e~- → W~+Π_t~-) reaches the level of a few fb. With the yearly integrated luminosity of ￡～ 500 fb~(-1) expected at the planned colliders, one could collect thousands of charged top-pion ofevents via the process e~+ e~- → tbΠ_t~- and hundreds of events via the process e~+ e~- →W~+Π_t~-. The flavor changing decay mode Π_t~- → bc is the best channel to detect chargedtop-pion due to the clean SM background. With a large number of events and the clean background, thecharged top-pion should be observable at the planned colliders. Therefore, our studies in thispaper can help us to search for charged top-pion, and furthermore, to test the TC2 model.

Lambda polarization at the Electron-ion collider in China

Lambda polarization can be measured through its self-analyzing weak decay, making it an ideal candidate for studying spin effects in high-energy scattering. In lepton-nucleon deep inelastic scattering(DIS), Lambda polarization measurements can probe polarized parton distribution functions(PDFs) and polarized fragmentation functions(FFs). One of the most promising facilities for high-energy nuclear physics research is the proposed Electron-ion collider in China(EicC). As a next-generation facility, EicC is set to advance our understanding of nuclear physics to new heights. In this article, we study the Lambda production in electron-proton collisions at the EicC energy, in particular the reconstruction of Lambda based on the performance of the designed EicC detector. In addition, taking spontaneous transverse polarization as an example, we provide a theoretical prediction with a statistical projection based on one month of EicC data, offering valuable insights into future research prospects.

Unparticle Effects on Top Quark Pair Production at Photon Collider

The unparticle effects on tt^- production at the future photon collider are investigated. Distributions of tt^- invariant mass and that for transverse momentum of top quark with respect to Standard Model and unparticle production are predicted. An odd valley with scalar unparticle contribution appears for some values of du, which is due to the big cancellation between the contribution from SM and that from unparticle. This character may be used to study the properties of scalar unparticle. Our investigations also show that scalar unparticle may play a significant role in tt^- production at the photon collider if it exists.

An SLC-Type e<sup>+</sup/>e<sup>&minus;</sup/>/γγ Facility at a Future Circular Collider

It is proposed to place the arcs of an SLC-type facility inside the tunnel of a Future Circular Collider (FCC). Accelerated by a linear accelerator (linac), electron and positron beams would traverse the bending arcs in opposite directions and collide at centre-of-mass energies considerably exceeding those attainable at circular e+e&minus;colliders. The proposed SLC-type facility would have the same luminosity as a conventional two-linace e+e&minus;collider. Using an optical free-electron laser, the facility could be converted into a γγ collider. A superconducting L-band linac at the proposed facility may form a part of the injector chain for a 100-TeV proton collider in the FCC tunnel. The whole accelerator complex would serve as a source of e+e&minus;, γγ, pp and ep interactions. The L-band linac could also be used to produce high-intensity neutrino, kaon and muon beams for fixed-target experiments, as well as X-ray free-electron laser (XFEL) photons for applications in material science and medicine.

An <i>e</i>⁺<i>e</i>^-/<i>γγ</i>/<i>ep</i>Accelerator Complex at a Future Circular Collider

This is the second paper by the author describing versatile accelerator complexes that could be built at a Future Circular Collider (FCC) in order to produce e+e-, γγ and ep collisions. The facility described here features an ILC-based e+e- collider placed tangentially to the FCC tunnel. If the collider is positioned asymmetrically with respect to the FCC tunnel, electron (or positron) bunches could be accelerated by both linacs before they are brought into collision with the 50-TeV beams from the FCC proton storage ring (FCC-pp). The two linacs may also form a part of the injector chain for FCC-pp. The facility could be converted into a γγ collider or a source of multi-MW beams for fixed-target experiments.

Measuring Mass and Spin of Dark Matter Particles with the Aid Energy Spectra of Single Lepton and Dijet at the e⁺e^-Linear Collider

In many models stability of Dark Matter particles D is ensured by conservation of a new quantum number referred to as D -parity. Our models also contain charged D -odd particles D± with the same spin as D. (For more information,please refer to the PDF.)

Production of Top-Pions Associated with W Boson at Next Generation γγ Colliders

In the context of topcolor-assisted technicolor （TC2） model, we study the charged and neutral top-pions production process γγ →W＋ ∏t-∏t^0. We find that the production cross section is larger than that of the process γγ→ W＋ H-H in the minimal supersymmetric standard model. With reasonable values of the parameters in the TC2 model, the cross section can reach the level of a few fb. Furthermore, the flavor-changing （FC） decay mode ∏t^0 → te^- is the best channel to detect the neutral top-pion due to the clean SM background. With a large number of events and the clean background, the neutral top-pion should be observable at future linear colliders operating in γγ mode at the TeV energy scale.

Beam-beam effects and mitigation in a future proton-proton collider

The beam-beam effects in a hadron collider with an unprecedented energy scale were studied.These effects are strongly related to the attainable luminosity of the collider.Long-range interactions were identified as the major factor limiting the dynamic aperture,which is strongly dependent on the crossing angle,β*,and bunch population.Different mitigation methods of the beam-beam effects were addressed,with a focus on the compensation of long-range interactions by electric curren wires.The CEPC-SPPC project is a two-stage large circular collider,with a first-stage circular electron-positron collider(CEPC)and a second-stage super proton-proton collider(SPPC).The design of the SPPC aims to achieve a center-of-mass energy of 75 TeV and peak luminosity of approximately 1×10^(35) cm^(-2)s^(-1).We studied the beam-beam effects in the SPPC and tested the effectiveness of the mitigation methods.We found that with compensation using electric current wires,the dynamic aperture is at an acceptable level.Moreover,considering the significant emittance damping in this future proton-proton collider the beam-beam effects and compensation are more complicated and are studied using long-term tracking.It was found that with a smaller emittance,the head-on interactions with a crossing angle become more prominent in reducing the beam stability,and combined head-on and long-range compensation is needed to improve the beam quality.When the reduction in population owing to burnoff was included,it was found that the coupling between the transverse and longitudinal planes at smaller emittance is the main driving source of the instabilities.Thus,crab cavities and emittance control are also necessary than just the compensation of the long-range interactions to improve the beam stability.This study serves as an example for studying the beam-beam effects in future proton-proton colliders.

Charged Top-Pion Production at Hadron Colliders

We studied the charged top-pion in the topcolor assisted technicolor model(TC2).If the charged top-pionsare heavy,m_(πt)>m_t+m_b,they will decay mainly via the channel π_t^+→tb^-.We also calculated the production of chargedtop-pion at the Tevatron and LHC.The cross section can reach to 100 fb at the Tevatron and dozens of pb at the LHCdepending on the mass of the top-pion.

Effects of R-Parity Violating Supersymmetry in Top Pair Production at Linear Colliders with Polarized Beams

In the minimal supersymmetric standard model with R-parity violation, the lepton number violating top quark interactions can contribute to the top pair production at a linear collider via tree-level u-channel squark exchange diagrams. We calculate such contributions and find that in the allowed range of these R-violating couplings, the top pair production rate as well as the top quark polarization and the forward-backward asymmetry can be significantly altered. By comparing the unpolarized beams with the polarized beams, we find that the polarized beams are more powerful in probing such new physics.

SUSY QCD Impact on Top-Pair Production Associated with a Z^0-Boson at a Photon-Photon Collider

The top-pair production in association with a Z^0-boson at a photon-photon collider is an important process in probing the coupling between top-quarks and vector boson and discovering the signature of possible new physics. We describe the impact of the complete supersymmetric QCD （SQCD） next-to-leading order （NLO） radiative corrections on this process at a polarized or unpolarized photon collider, and make a comparison between the effects of the SQCD and the standard model （SM） QCD. We investigate the dependence of the lowest-order （LO） and QCD NLO corrected cross sections in both the SM and minimal supersymmetric standard model （MSSM） on colliding energy √s in different polarized photon collision modes. The LO, SM NLO, and SQCD NLO corrected distributions of the invariant mass of tt^--pair and the transverse momenta of final Z^0-boson are presented. Our numerical results show that the pure SQCD effects in γγ →tt^- Z^0 process can be more significant in the ＋＋ polarized photon collision mode than in other collision modes, and the relative SQCD radiative correction in unpolarized photon collision mode varies from 32.09% to -1.89% when √s goes up from 500 GeV to 1.5 TeV.

Single t-Quark Productions via Flavor-Changing Processes in Topcolor-Assisted Technicolor Model at Hadron Colliders

In the framework of topcolor-assisted technicolor （TC2） model, there exist tree-level flavor-changing （FC） couplings, which can result in the loop-level FC coupling tcg. Such tcg coupling can contribute significant clues at the forthcoming Large Hadron Collider （LHC） experiments. In this paper, based on the TC2 model, we study some single t-quark production processes involving tcg coupling at the Tevatron and LHC： pp（pp） → tq （q = u, d, s）, tg. We calculate the cross sections of these processes. The results show that the cross sections at the Tevatron are too small to observe the signal, but at the LHC it can reach a few pb. With the high luminosity, the LHC has considerable capability to find the single t-quark signal produced via some FC processes involving coupling tcg. On the other hand, these processes can also provide some valuable information of the coupling tcg with detailed study of the processes and furthermore provide the reliable evidence to test the TC2 model

Associated Productions of HZZ and HHZ at Linear Colliders in Large Extra Dimension Model

In this paper we investigate the effects of the large extra dimensions on the two processes e＋ e-→＋ H^0 Z^0 Z^0 and e^＋e^-→ H^0H^0 Z^0 at linear colliders in both unpolarized and polarized collision modes. We find that the virtual Kaluza-Klein graviton exchange can significantly enhance the cross section from their standard model expectations for these two processes. The results show that the LED effect on the process e＋ e-→＋ H^0 Z^0 Z^0 allows the observation limits on the effective scale Ms to be probed up to 9. 75 TeV and 10.1 TeV in the unpolarized and ＋-（λe＋ =1/2, λe-= -1/2） polarized beam collision modes （with Pe＋ = 0.6, Pe-=0.8）, respectively. For the process e＋ e-→＋ H^0 H^0 Z^0, these limits on Ms can be probed up to 6.06 TeV and 6.38 TeV in the unpolarized and polarized collision modes separately. We find that the λe＋ = 1/2, λe-= -1/2 polarization collision mode in both processe＋ e-→＋ H^0 Z^0 Z^0 and e＋ e-→＋ H^0 H^0 Z^0 may provide a possibility to improve the sensitivity in probing the LED effects.

Wireless Network Requirements and Solutions for the Future Circular Collider:A Hostile Indoor Environment

The European organization for nuclear research(CERN)is planning a high performance particle collider by 2050,which will update the currently used Large Hadron Collider(LHC).The design of the new experiment facility includes the definition of a suitable communication infrastructure to support the future needs of scientists.The huge amount of data collected by the measurement devices call for a data rate of at least 1 Gb/s per node,while the need of timely control of instruments requires a low latency of the order of 0.01μs.Moreover,the main tunnel will be 100 km long,and will need appropriate coverage for voice and data traffic,in a special underground environment subject also to strong radiations.Reliable voice,data and video transmission in a tunnel of this length is necessary to ensure timely and localized intervention,reducing access time.In addition,using wireless communication for voice,control and data acquisition of accelerator technical systems could lead to a significant reduction in cabling costs,installation times and maintenance efforts.The communication infrastructure of the Future Circular Collider(FCC)tunnel must be able to circumvent the problems of radioactivity,omnipresent in the tunnel.Current technologies transceivers cannot transmit in such a severely radioactive environment.This is due to the immediate destruction of any active or passive equipment by radioactivity.The scope of this paper is to determine the feasibility of robust wireless transmission in an underground radioactive tunnel environment.The network infrastructure design to meet the demand will be introduced,and the performance of different wireless technologies will be evaluated.

Correlations of the expression of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ubiquitination.Conversely,reduced expression results in a loss of this capacity to facilitate cyclin E degradation.The ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical residues.AIM To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon cancer.METHODS Expression levels of Cx43,SCFFBXW7,p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their correlations.RESULTS Positive rate of Cx43,SCFFBXW7,p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%respectively.Positive expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node metastasis.Cx43 and SCFFBXW7(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCFFBXW7 and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(P<0.05),and expressions of the above proteins were positively correlated in colon cancer.CONCLUSION Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCFFBXW7,thereby influencing the ubiquitination and degradation of cyclin E1.

The B - L ＋ xY Model and the Higgs-strahlung Processes at a Collider

The gauge extension of the standard model with the U（1）B-L＋xy symmetry predicts the existence of a lightgauge boson Z′ with small couplings to ordinary fermions. We discuss its contributions to the muon anomalous magnetic moment αμ. Taking account of the constraints on the relevant free parameters, we further calculate the contributions of the light gauge boson Z′ to the Higgs-strahlung processes e＋ e-→ZH and e＋ e- →Z′H.

Clinical,laboratory,and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children

BACKGROUND Although breast milk is ideal for newborns,in some cases,it is replaced with cow’s milk,which contains proteins that increase the risk of cow’s milk protein allergy(CMPA).AIM To evaluate CMPA prevalence in Bahrain and compare clinical characteristics of children with immunoglobulin E(IgE)-and non-IgE-mediated CMPA.METHODS This retrospective cohort study examined children with CMPA diagnosed at the pediatric gastroenterology outpatient clinic of the Salmaniya Medical Complex,Bahrain,between 2014 and 2022,and assessed CMPA prevalence.Clinical presentations,laboratory findings,dietary modifications,and outcomes were compared between children with IgE-mediated and non-IgE-mediated CMPA.Categorical variables were compared using Fisher’s exact test or Pearson’sχ2 test,whereas continuous variables were compared using Student’s t-test or the Mann-Whitney U test.RESULTS Of 8332 patients,6022(72.3%)adhered to their appointment.Of them,618(10.3%)were suggested of having CMPA and 595(96.3%)were included;CMPA prevalence was 2%.Most patients were Bahraini(93.8%)and males(55.3%).Non-IgE-mediated type accounted for 77.3%cases and IgE-mediated type,22.7%.IgE-mediated CMPA presented more in boys(P=0.030),and later in life(5.1 months±4.5 months vs 4.2 months±4.2 months,P=0.016,95%CI:0.08-1.73),had more associated diseases(P<0.001);and presented with more cutaneous(P=0.024)and respiratory(P=0.003)manifestations,severe symptoms[rash/dry skin(P=0.031),facial swelling/angioedema(P=0.003),failure to thrive(P=0.013),apparent life-threatening event(P<0.001)],and positive physical findings(P=0.002)than non-IgE-mediated CMPA.Most patients were exclusively fed cow milk formula(50.3%).The amino acid-based formula(AAF)was most prescribed(60.5%)with no difference between the two types(P=0.173).Although breastfeeding was recommended to 49.6%,only 8.2%were exclusively breastfed.IgE-mediated CMPA was associated with a longer follow-up duration than non-IgE-mediated CMPA(17.3 months±14.0 months vs 13.5 months±13.4 months,P=0.005,95%CI:1.1-6.3).CONCLUSION This study revealed a high CMPA prevalence with clinical differences between both types that can influence treatment.AAF was most prescribed,while breastfeeding with dietary modification is rarely applied.

Q550E高强钢及焊接接头的疲劳裂纹扩展研究

焊接构造是钢桥的薄弱部位,在反复车辆荷载作用下,疲劳损伤正逐步成为影响桥梁服役安全的关键问题之一。以Q550E高强钢为研究对象,开展母材和对接焊缝接头的静力拉伸和疲劳裂纹扩展试验,建立母材及焊接连接件的疲劳裂纹增长模型,揭示了应力比对高强钢焊接节点疲劳裂纹扩展速率的影响规律;开展基于FRANC3D和ABAQUS的联合仿真模拟分析,通过敏感性分析明确关键影响参数。结果表明:随着应力比的增大,疲劳裂纹扩展速率参数m增大、lg C减小,应力强度因子门槛值减小;对接焊缝m值约为母材的2倍,对接焊缝裂纹门槛值大于母材,且对应力比更敏感;联合仿真方法可准确预测高强钢焊接接头疲劳寿命,高应力比下试件厚度和初始裂纹深度对疲劳扩展影响显著。