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Impacts of agri-food e-commerce on traditional wholesale industry:Evidence from China
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作者 Ruyi Yang Jifang Liu +2 位作者 Shanshan Cao Wei Sun Fantao Kong 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第4期1409-1428,共20页
Rapidly expanding studies investigate the effects of e-commerce on company operations in the retail market.However,the interaction between agri-food e-commerce(AEC)and the traditional agri-food wholesale industry(AWI)... Rapidly expanding studies investigate the effects of e-commerce on company operations in the retail market.However,the interaction between agri-food e-commerce(AEC)and the traditional agri-food wholesale industry(AWI)has not received enough attention in the existing literature.Based on the provincial panel data from 2013 to 2020 in China,this paper examines the effect of AEC on AWI,comprising three dimensions:digitalization(DIGITAL),agrifood e-commerce infrastructure and supporting services(AECI),and agri-food e-commerce economy(AECE).First,AWI and AEC are measured using an entropy-based combination of indicators.The results indicate that for China as a whole,AWI has remained practically unchanged,whereas AEC exhibits a significant rising trend.Second,the findings of the fixed-effect regression reveal that DIGITAL and AECE tend to raise AWI,whereas AECI negatively affects AWI.Third,threshold regression results indicate that AECI tends to diminish AWI with three-stage inhibitory intensity,which manifests as a first increase and then a drop in the inhibition degree.These results suggest that with the introduction of e-commerce for agricultural product circulation,digital development will have catfish effects that tend to stimulate the vitality of the conventional wholesale industry and promote technical progress.Furthermore,the traditional wholesale industry benefits financially from e-commerce even while it diverts part of the traditional wholesale circulation for agricultural products. 展开更多
关键词 agri-food e-commerce traditional wholesale industry panel threshold model dual-channel circulation
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Impact of BRICS Trade Facilitation on China's Exports Using Cross-Border E-Commerce
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作者 Longling LI Kaimei CHEN Zijian LONG 《Asian Agricultural Research》 2024年第5期1-7,共7页
With the rapid growth of the global digital economy, cross-border e-commerce, as an emerging form of trade, has gradually become a powerful engine to promote the development of global trade. BRICS is an important forc... With the rapid growth of the global digital economy, cross-border e-commerce, as an emerging form of trade, has gradually become a powerful engine to promote the development of global trade. BRICS is an important force in the global economy, and the progress of the BRICS countries' trade facilitation level has an important impact on the global trade environment. This paper conducts an in-depth study of the dynamic changes in BRICS trade facilitation from 2013 to 2022, and uses an extended gravity model to analyze the specific impact of this change on China's exports using cross-border e-commerce. The results show that although the BRICS countries have made some progress in trade facilitation, the overall level still needs to be improved, and there are obvious differences among member countries. However, the improvement of trade facilitation among BRICS countries has undoubtedly brought significant positive effects to China's exports using cross-border e-commerce. 展开更多
关键词 Trade facilitation BRICS Cross-border e-commerce Export trade
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Predicting Purchasing Behavior on E-Commerce Platforms: A Regression Model Approach for Understanding User Features that Lead to Purchasing
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作者 Abraham Jallah Balyemah Sonkarlay J. Y. Weamie +2 位作者 Jiang Bin Karmue Vasco Jarnda Felix Jwakdak Joshua 《International Journal of Communications, Network and System Sciences》 2024年第6期81-103,共23页
This research introduces a novel approach to improve and optimize the predictive capacity of consumer purchase behaviors on e-commerce platforms. This study presented an introduction to the fundamental concepts of the... This research introduces a novel approach to improve and optimize the predictive capacity of consumer purchase behaviors on e-commerce platforms. This study presented an introduction to the fundamental concepts of the logistic regression algorithm. In addition, it analyzed user data obtained from an e-commerce platform. The original data were preprocessed, and a consumer purchase prediction model was developed for the e-commerce platform using the logistic regression method. The comparison study used the classic random forest approach, further enhanced by including the K-fold cross-validation method. Evaluation of the accuracy of the model’s classification was conducted using performance indicators that included the accuracy rate, the precision rate, the recall rate, and the F1 score. A visual examination determined the significance of the findings. The findings suggest that employing the logistic regression algorithm to forecast customer purchase behaviors on e-commerce platforms can improve the efficacy of the approach and yield more accurate predictions. This study serves as a valuable resource for improving the precision of forecasting customers’ purchase behaviors on e-commerce platforms. It has significant practical implications for optimizing the operational efficiency of e-commerce platforms. 展开更多
关键词 e-commerce Platform Purchasing Behavior Prediction Logistic Regression Algorithm
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Research on Current Situation and Legal Regulation of Cosmetics Live Streaming E-commerce in China
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作者 Jiang Ying 《China Detergent & Cosmetics》 CAS 2024年第1期63-70,共8页
Analyze the compatibility between cosmetics and live streaming e-commerce from its own nature,marketing means and supply chain characteristics.According to the prominent problems,sort out the relationship between all ... Analyze the compatibility between cosmetics and live streaming e-commerce from its own nature,marketing means and supply chain characteristics.According to the prominent problems,sort out the relationship between all parties in the cosmetics live e-commerce industry chain.Combined with the latest regulatory policies of live streaming e-commerce and cosmetics,the responsibilities of different subjects in cosmetics live streaming e-commerce are summarized,and relevant suggestions and countermeasures are put forward for the standardization and development of live streaming e-commerce.Cosmetics brand owners are the first responsible persons for product quality.Anchors,as a mixed identity between intermediary,advertising spokesperson and operator,should bear stricter joint and several liability when recommending products related to consumers’health.If anchors fail to clearly identify themselves in the recommendation process,thus causing consumers to mistake them for the operator of the cosmetics,they should assume the obligations of the operator. 展开更多
关键词 COSMETICS live streaming e-commerce legal relationship responsibilities of parties
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How Does E-Commerce Policy Affect Consumption Disparities of Rural Households?-Evidence from China
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作者 Zhang Cheng Weng Xiyan 《China Economist》 2024年第4期107-128,共22页
In the context of China’s ongoing efforts to promote countryside revitalization and facilitate domestic economic circulation,it is of great significance to reduce the consumption disparity among rural households and ... In the context of China’s ongoing efforts to promote countryside revitalization and facilitate domestic economic circulation,it is of great significance to reduce the consumption disparity among rural households and unleash the consumption potential in the countryside.Based on data from China Family Panel Studies,this paper adopts a staggered difference-in-differences method to assess the impact of the e-commerce to enter rural areas on the consumption disparity among rural households.Findings:the comprehensive demonstration work of promoting e-commerce to enter rural areas has reduced the consumption disparity among rural households through the following mechanisms.Firstly,this policy initiative has mitigated the consumption-inhibiting effect on rural household consumption due to the local market size and external market accessibility by promoting the distribution of consumer goods to villages.Secondly,this policy initiative has also increased the agricultural income of rural households and reduced their consumption disparity by distributing farm produce to cities and enhancing the agricultural income of rural households.Moreover,the work is characterized by inclusive growth and is not susceptible to the“elite capture”phenomenon. 展开更多
关键词 e-commerce to enter rural areas consumption disparity among rural household market accessibility market size income of rural households
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The Impact of E-Commerce Live Broadcasts on Consumers’Purchase Intention
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作者 Xingchao Bian Thanakon Ratchatakulpat Rattanavalee Maisak 《Proceedings of Business and Economic Studies》 2024年第4期263-268,共6页
E-commerce live broadcast has an important influence on consumers’purchase intention.The three dimensions of live broadcast content in the broadcast room are the number of comments,product quality,and live content as... E-commerce live broadcast has an important influence on consumers’purchase intention.The three dimensions of live broadcast content in the broadcast room are the number of comments,product quality,and live content as independent variables.A theoretical model is constructed with perceived value and risk as intermediaries and the consumers’purchase intention as the dependent variable,and corresponding hypotheses are put forward.We designed the scale,collected relevant data,and tested the model hypothesis using Statistical Package for Social Sciences(SPSS)and Analysis of Moment Structure(AMOS)software.The study found that the number of comments and product quality had a significant impact on perceived value,perceived risk,and consumers’purchase intention.From this conclusion,it is suggested that businesses should control the number of comments,strengthen the product quality of comments,and distinguish the repetition degree of the content of live broadcasts. 展开更多
关键词 Livestreaming e-commerce Perceived value Perceived risk Purchase intention
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Analysis of the Current Situation, Influential Factors, and Countermeasures of Rural E-commerce Development
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作者 Yi Wei Guizhen He 《Journal of Electronic Research and Application》 2024年第2期140-145,共6页
The development of rural e-commerce is becoming an important driver for the transformation of China’s rural economy,and with the rapid development of information technology and the upgrading of the agricultural indus... The development of rural e-commerce is becoming an important driver for the transformation of China’s rural economy,and with the rapid development of information technology and the upgrading of the agricultural industry,rural e-commerce is showing a vigorous momentum of development.Traditionally,agricultural products are mainly sold through traditional farmers’markets,which are subjected to geography and channel limitations,resulting in inefficient circulation of agricultural products.This paper analyzes the definition,the status quo,as well as the influencing factors of rural e-commerce development.On this basis,countermeasures for the advancement of rural e-commerce development are put forward. 展开更多
关键词 Rural e-commerce Influencing factors Industrial clusters RESPONSE
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Research on Professional Teaching Reform of the E-Commerce Major in Vocational Colleges Under the Internet Era
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作者 Yong Liang 《Journal of Contemporary Educational Research》 2024年第5期21-26,共6页
With the rapid development of science and technology,the face of human society has undergone great changes;with the emergence of the Internet era,all kinds of educational technology,equipment,and software in vocationa... With the rapid development of science and technology,the face of human society has undergone great changes;with the emergence of the Internet era,all kinds of educational technology,equipment,and software in vocational colleges have been widely used to carry out education and teaching,and has achieved remarkable results.Based on this,colleges and universities’electronic commerce(e-commerce)professional teachers should try to rely on the Internet to build information teaching classrooms,introduce advanced methods to build efficient classrooms by integrating teaching resources,and optimize the top-level design,so as to activate the classroom atmosphere,mobilize students’emotions,make them immersed in the teaching of electronic commerce courses.In view of this,this paper combines the existing theory and experience,first analyzes the dilemma faced by the current teaching of e-commerce in vocational colleges,then discusses the practical significance of teaching reform based on the Internet era,and lastly puts forward the specific practice path. 展开更多
关键词 INTERNET Vocational colleges e-commerce major Teaching reform
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Optimization and Innovation of the Operation Model of Mobile Social E-commerce under AI Empowerment:Taking the Female Community Platform“Little Red Book”as an Example
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作者 Mi Liu Jia Yu +1 位作者 Yan Li Jun Zheng 《Proceedings of Business and Economic Studies》 2024年第4期269-274,共6页
This article takes the female community platform“Little Red Book”as an example to explore the optimization and innovation of mobile community e-commerce operation mode under Artificial Intelligence(AI)empowerment.Fi... This article takes the female community platform“Little Red Book”as an example to explore the optimization and innovation of mobile community e-commerce operation mode under Artificial Intelligence(AI)empowerment.Firstly,the relevant concepts were defined,and then the unique attributes of mobile community e-commerce were analyzed.As a typical representative of mobile community e-commerce,Little Red Book introduces the background and characteristics of its platform,analyzes its mobile community operation mode,and focuses on exploring how to establish a mobile community e-commerce platform and effective operation mode under the empowerment of AI technology,to provide some reference and inspiration for the development and operation of Little Red Book and other e-commerce platform enterprises. 展开更多
关键词 Mobile social e-commerce Little Red Book Female community platform AI User experience UGC
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Spatial Structure of China's E-commerce Express Logistics Network Based on Space of Flows 被引量:3
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作者 LI Yuanjun WU Qitao +2 位作者 ZHANG Yuling HUANG Guangqing ZHANG Hongou 《Chinese Geographical Science》 SCIE CSCD 2023年第1期36-50,共15页
The intermediate link compression characteristics of e-commerce express logistics ne tworks influence the tradition al mode of circulation of goods and economic organization,and alter the city spatial pattern.Based on... The intermediate link compression characteristics of e-commerce express logistics ne tworks influence the tradition al mode of circulation of goods and economic organization,and alter the city spatial pattern.Based on the theory of space of flows,this study adopts China Smart Logistics Network relational data to build China's e-commerce express logistics network and explore its spatial structure characteristics through social network analysis(SNA),the PageRank technique,and geospatial methods.The results are as follows:the network density is 0.9270,which is close to 1;hence,indicating that e-commerce express logistics lines between Chinese cities are nearly complete and they form a typical network structure,thereby eliminating fragmented spaces.Moreover,the average minimum number of edges is 1.1375,which indicates that the network has a small world effect and thus has a high flow efficiency of logistics elements.A significant hierarchical diffusion effect was observed in dominant flows with the highest edge weights.A diamond-structured network was formed with Shanghai,Guangzhou,Chongqing,and Beijing as the four core nodes.Other node cities with a large logistics scale and importance in the network are mainly located in the 19 city agglomerations of China,revealing the fact that the development of city agglomerations is essential for promoting the separation of experience space and changing the urban spatial pattern.This study enriches the theory of urban networks,reveals the flow laws of modern logistics elements,and encourages coordinated development of urban logistics. 展开更多
关键词 space of flows e-commerce express logistics urban logistics network logistics big data
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Transaction Frequency Based Trust for E-Commerce
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作者 Dong Huang Sean Xu 《Computers, Materials & Continua》 SCIE EI 2023年第3期5319-5329,共11页
Most traditional trust computing models in E-commerce do not take the transaction frequency among participating entities into consideration,which makes it easy for one party of the transaction to obtain a high trust v... Most traditional trust computing models in E-commerce do not take the transaction frequency among participating entities into consideration,which makes it easy for one party of the transaction to obtain a high trust value in a short time,and brings many disadvantages,uncertainties and even attacks.To solve this problem,a transaction frequency based trust is proposed in this study.The proposed method is composed of two parts.The first part is built on the classic Bayes analysis based trust modelswhich are ease of computing for the E-commerce system.The second part is the transaction frequency module which can mitigate the potential insecurity caused by one participating entity gaining trust in a short time.Simulations show that the proposed method can effectively mitigate the self-promoting attacks so as to maintain the function of E-commerce system. 展开更多
关键词 Transaction frequency TRUST Bayes analysis e-commerce
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Enhanced E-commerce Fraud Prediction Based on a Convolutional Neural Network Model
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作者 Sumin Xie Ling Liu +3 位作者 Guang Sun Bin Pan Lin Lang Peng Guo 《Computers, Materials & Continua》 SCIE EI 2023年第4期1107-1117,共11页
The rapidly escalating sophistication of e-commerce fraud in recent years has led to an increasing reliance on fraud detection methods based on machine learning.However,fraud detection methods based on conventional ma... The rapidly escalating sophistication of e-commerce fraud in recent years has led to an increasing reliance on fraud detection methods based on machine learning.However,fraud detection methods based on conventional machine learning approaches suffer from several problems,including an excessively high number of network parameters,which decreases the efficiency and increases the difficulty of training the network,while simultaneously leading to network overfitting.In addition,the sparsity of positive fraud incidents relative to the overwhelming proportion of negative incidents leads to detection failures in trained networks.The present work addresses these issues by proposing a convolutional neural network(CNN)framework for detecting ecommerce fraud,where network training is conducted using historical market transaction data.The number of network parameters reduces via the local perception field and weight sharing inherent in the CNN framework.In addition,this deep learning framework enables the use of an algorithmiclevel approach to address dataset imbalance by focusing the CNN model on minority data classes.The proposed CNN model is trained and tested using a large public e-commerce service dataset from 2018,and the test results demonstrate that the model provides higher fraud prediction accuracy than existing state-of-the-art methods. 展开更多
关键词 CNN model detection e-commerce FRAUD
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An Enhanced Intelligent Intrusion Detection System to Secure E-Commerce Communication Systems
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作者 Adil Hussain Kashif Naseer Qureshi +1 位作者 Khalid Javeed Musaed Alhussein 《Computer Systems Science & Engineering》 SCIE EI 2023年第11期2513-2528,共16页
Information and communication technologies are spreading rapidly due to their fast proliferation in many fields.The number of Internet users has led to a spike in cyber-attack incidents.E-commerce applications,such as... Information and communication technologies are spreading rapidly due to their fast proliferation in many fields.The number of Internet users has led to a spike in cyber-attack incidents.E-commerce applications,such as online banking,marketing,trading,and other online businesses,play an integral role in our lives.Network Intrusion Detection System(NIDS)is essential to protect the network from unauthorized access and against other cyber-attacks.The existing NIDS systems are based on the Backward Oracle Matching(BOM)algorithm,which minimizes the false alarm rate and causes of high packet drop ratio.This paper discussed the existing NIDS systems and different used pattern-matching techniques regarding their weaknesses and limitations.To address the existing system issues,this paper proposes an enhanced version of the BOM algorithm by using multiple pattern-matching methods for the NIDS system to improve the network performance.The proposed solution is tested in simulation with existing solutions using the Snort and NSL-KDD datasets.The experimental results indicated that the proposed solution performed better than the existing solutions and achieved a 5.17%detection rate and a 0.22%lower false alarm rate than the existing solution. 展开更多
关键词 e-commerce NIDS security algorithm network applications CIA detection
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Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable hepatocellular carcinoma 被引量:3
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作者 Kun-Peng Ma Jin-Xin Fu +1 位作者 Feng Duan Mao-Qiang Wang 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第4期1236-1247,共12页
BACKGROUND The efficacy and safety of transarterial chemoembolization(TACE)combined with lenvatinib plus programmed cell death protein-1(PD-1)for unresectable hepato-cellular carcinoma(HCC)have rarely been evaluated a... BACKGROUND The efficacy and safety of transarterial chemoembolization(TACE)combined with lenvatinib plus programmed cell death protein-1(PD-1)for unresectable hepato-cellular carcinoma(HCC)have rarely been evaluated and it is unknown which factors are related to efficacy.AIM To evaluate the efficacy and independent predictive factors of TACE combined with lenvatinib plus PD-1 inhibitors for unresectable HCC.METHODS This study retrospectively enrolled patients with unresectable HCC who received TACE/lenvatinib/PD-1 treatment between March 2019 and April 2022.Overall survival(OS)and progression-free survival(PFS)were determined.The objective response rate(ORR)and disease control rate(DCR)were evaluated in accordance with the modified Response Evaluation Criteria in Solid Tumors.Additionally,the prognostic factors affecting the clinical outcome were assessed.RESULTS One hundred and two patients were enrolled with a median follow-up duration of 12.63 months.The median OS was 26.43 months(95%CI:17.00-35.87),and the median PFS was 10.07 months(95%CI:8.50-11.65).The ORR and DCR were 61.76%and 81.37%,respectively.The patients with Barcelona Clinic Liver Cancer Classification(BCLC)B stage,early neutrophil-to-lymphocyte ratio(NLR)response(decrease),or early alpha-fetoprotein(AFP)response(decrease>20%)had superior OS and PFS than their counterparts.CONCLUSION This study showed that TACE/lenvatinib/PD-1 treatment was well tolerated with encouraging efficacy in patients with unresectable HCC.The patients with BCLC B-stage disease with early NLR response(decrease)and early AFP response(decrease>20%)may achieve better clinical outcomes with this triple therapy. 展开更多
关键词 Transarterial chemoembolization EFFICACY Lenvatinib programmed cell death protein-1 inhibitors Unresectable hepatocellular carcinoma
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Recent Progress in Reinforcement Learning and Adaptive Dynamic Programming for Advanced Control Applications 被引量:4
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作者 Ding Wang Ning Gao +2 位作者 Derong Liu Jinna Li Frank L.Lewis 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第1期18-36,共19页
Reinforcement learning(RL) has roots in dynamic programming and it is called adaptive/approximate dynamic programming(ADP) within the control community. This paper reviews recent developments in ADP along with RL and ... Reinforcement learning(RL) has roots in dynamic programming and it is called adaptive/approximate dynamic programming(ADP) within the control community. This paper reviews recent developments in ADP along with RL and its applications to various advanced control fields. First, the background of the development of ADP is described, emphasizing the significance of regulation and tracking control problems. Some effective offline and online algorithms for ADP/adaptive critic control are displayed, where the main results towards discrete-time systems and continuous-time systems are surveyed, respectively.Then, the research progress on adaptive critic control based on the event-triggered framework and under uncertain environment is discussed, respectively, where event-based design, robust stabilization, and game design are reviewed. Moreover, the extensions of ADP for addressing control problems under complex environment attract enormous attention. The ADP architecture is revisited under the perspective of data-driven and RL frameworks,showing how they promote ADP formulation significantly.Finally, several typical control applications with respect to RL and ADP are summarized, particularly in the fields of wastewater treatment processes and power systems, followed by some general prospects for future research. Overall, the comprehensive survey on ADP and RL for advanced control applications has d emonstrated its remarkable potential within the artificial intelligence era. In addition, it also plays a vital role in promoting environmental protection and industrial intelligence. 展开更多
关键词 Adaptive dynamic programming(ADP) advanced control complex environment data-driven control event-triggered design intelligent control neural networks nonlinear systems optimal control reinforcement learning(RL)
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Cytokine release syndrome triggered by programmed death 1 blockade(sintilimab)therapy in a psoriasis patient:A case report 被引量:1
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作者 Ming-Hui Zhou Min-Feng Ye +2 位作者 Zhen-Xing Zhang Feng Tao Yu Zhang 《World Journal of Clinical Cases》 SCIE 2024年第18期3555-3560,共6页
BACKGROUND In recent years,immune checkpoint inhibitors(ICIs)have demonstrated remarkable efficacy across diverse malignancies.Notably,in patients with advanced gastric cancer,the use of programmed death 1(PD-1)blocka... BACKGROUND In recent years,immune checkpoint inhibitors(ICIs)have demonstrated remarkable efficacy across diverse malignancies.Notably,in patients with advanced gastric cancer,the use of programmed death 1(PD-1)blockade has significantly prolonged overall survival,marking a pivotal advancement comparable to the impact of Herceptin over the past two decades.While the therapeutic benefits of ICIs are evident,the increasing use of immunotherapy has led to an increase in immune-related adverse events.CASE SUMMARY This article presents the case of a patient with advanced gastric cancer and chronic plaque psoriasis.Following sintilimab therapy,the patient developed severe rashes accompanied by cytokine release syndrome(CRS).Fortunately,effective management was achieved through the administration of glucocorticoid,tocilizumab,and acitretin,which resulted in favorable outcomes.CONCLUSION Glucocorticoid and tocilizumab therapy was effective in managing CRS after PD-1 blockade therapy for gastric cancer in a patient with chronic plaque psoriasis. 展开更多
关键词 Cytokine release syndrome programmed death 1 blockade Sintilimab PSORIASIS Gastric cancer Case report
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Adaptive Optimal Discrete-Time Output-Feedback Using an Internal Model Principle and Adaptive Dynamic Programming 被引量:1
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作者 Zhongyang Wang Youqing Wang Zdzisław Kowalczuk 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第1期131-140,共10页
In order to address the output feedback issue for linear discrete-time systems, this work suggests a brand-new adaptive dynamic programming(ADP) technique based on the internal model principle(IMP). The proposed metho... In order to address the output feedback issue for linear discrete-time systems, this work suggests a brand-new adaptive dynamic programming(ADP) technique based on the internal model principle(IMP). The proposed method, termed as IMP-ADP, does not require complete state feedback-merely the measurement of input and output data. More specifically, based on the IMP, the output control problem can first be converted into a stabilization problem. We then design an observer to reproduce the full state of the system by measuring the inputs and outputs. Moreover, this technique includes both a policy iteration algorithm and a value iteration algorithm to determine the optimal feedback gain without using a dynamic system model. It is important that with this concept one does not need to solve the regulator equation. Finally, this control method was tested on an inverter system of grid-connected LCLs to demonstrate that the proposed method provides the desired performance in terms of both tracking and disturbance rejection. 展开更多
关键词 Adaptive dynamic programming(ADP) internal model principle(IMP) output feedback problem policy iteration(PI) value iteration(VI)
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Recovery after ischemic stroke:Effects of FuekFone home-based program on upper limb and cognitive function
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作者 Yaowalak Kumkwan Ketsarin Utriyaprasit +2 位作者 Thitipong Tankumpuan Zeng Lertmanorat Boonyanit Mathayomchan 《International Journal of Nursing Sciences》 CSCD 2024年第4期414-420,I0001,共8页
Objectives:This study aimed to explore the effects of the“FuekFone(F.F.)home-based program”on the upper limb and cognitive function of ischemic stroke patients after discharge.Methods:A single group pre-and post-tes... Objectives:This study aimed to explore the effects of the“FuekFone(F.F.)home-based program”on the upper limb and cognitive function of ischemic stroke patients after discharge.Methods:A single group pre-and post-test design was conducted.A total of 40 patients with recovery after ischemic stroke were recruited from two university hospitals in Thailand.The study was conducted between June 2022 and January 2023.Participants underwent a six-week“F.F.home-based program,”which combined an upper limb and cognitive function rehabilitation device with Android games,including stationary barrel,adventure walk,adventure stroll,sliding barrel,sauce squeeze,and cut objects.Each game has different difficulty levels.Patients can perform corresponding exercises through the games according to their conditions under the guidance of medical staff.The patients played for 24 min per time,4 min each game,three days a week.The second week,let the patients play games for 30 min per time,5 min each game,3 days a week.Then,in the 3e6 weeks,let the patients play games for 1 h per time,10 min each game,5 days a week.At the pre-and post-intervention,the Thai version of the National Institutes of Health Stroke Scale(NIHSS),the Motor Assessment Scale,and the Montreal Cognitive Assessment(MoCA score)were administered to patients at discharge and at 2,4,and 6 weeksafter discharge,and the results were compared.Results:All participants completed this program.Participants had statistically improved upper limb function(upper arm function score,hand movements score,advanced hand activities score,total Motor Assessment Scale score)and MoCA score at 2,4,and 6 weeks after discharge(P<0.001).In the comparison of upper limb function and cognitive function at each of the study times,we found statistically improved upper limb function(upper arm function score,hand movements score,advanced hand activities score,total Motor Assessment Scale score)and MoCA score at 4,and 6 weeks after discharge when compared to after discharge and 2 weeks after discharge,respectively(P<0.05).Conclusions:Continuing care of patients post-stroke after discharge from hospital,such as F.F.homebased program should be applied at home to enhance upper limb and cognitive function. 展开更多
关键词 Application program COGNITIVE Home-based program Ischemic stroke Patients Upper extremity
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In vivo astrocyte reprogramming following spinal cord injury
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作者 Yannick N.Gerber Florence E.Perrin 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期487-488,共2页
Harmful and helpful roles of astrocytes in spinal cord injury(SCI):SCI induce gradable sensory,motor and autonomic impairments that correlate with the lesion severity and the rostro-caudal location of the injury site.... Harmful and helpful roles of astrocytes in spinal cord injury(SCI):SCI induce gradable sensory,motor and autonomic impairments that correlate with the lesion severity and the rostro-caudal location of the injury site.The absence of spontaneous axonal regeneration after injury results from neuron-intrinsic and neuron-extrinsic parameters.Indeed,not only adult neurons display limited capability to regrow axons but also the injury environment contains inhibitors to axonal regeneration and a lack of growth-promoting factors.Amongst other cell populations that respond to the lesion,reactive astrocytes were first considered as only detrimental to spontaneous axonal regeneration.Indeed,astrocytes. 展开更多
关键词 INJURY IMPAIRMENT programMING
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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
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作者 Morten S.Hansen Kaja Madsen +6 位作者 Maria Price Kent Søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten Frost Alexander Rauch 《Bone Research》 SCIE CAS CSCD 2024年第1期180-198,共19页
Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone formation.As novel antiosteoporotic therapeutic... Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone formation.As novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment targets.This study aimed to provide an overview of transcriptional reprogramming during human osteoclast differentiation.Osteoclasts were differentiated from CD14+monocytes from eight female donors.RNA sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across donors.These patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density SNPs.Network analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional networks.The donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature osteoclasts.The expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and activity.The regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature osteoclasts.In conclusion,we report the occurrence of transcriptional reprogramming during human osteoclast differentiation and identified SSTR2 and FFAR4 as antiresorptive G-protein coupled receptors and FLNB and LOX-1 as potential molecular markers of osteoclast activity.These data can help future investigations identify molecular regulators of osteoclast differentiation and activity and provide the basis for novel antiosteoporotic targets. 展开更多
关键词 OSTEOCLAST programMING identif
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