Heterosis is an important biological phenomenon, and it has been used to increase grain yield, quality and resistance to abiotic and biotic stresses in many crops. However, the genetic mechanism of heterosis remains u...Heterosis is an important biological phenomenon, and it has been used to increase grain yield, quality and resistance to abiotic and biotic stresses in many crops. However, the genetic mechanism of heterosis remains unclear up to now. In this study, a set of 184 chromosome segment substitution lines （CSSLs） population, which derived from two inbred lines Ix9801 （the recurrent parent） and Chang 72 （the donor parent）, were used as basal material to construct two test populations with the inbred lines Zheng 58 and Xun 9058. The two test populations were evaluated in two locations over two years, and the heterotic loci for plant height and ear height were identified by comparing the performance of each test hybrid with the corresponding CK at P〈0.05 significant level using one-way ANOVA analysis and Duncan＇s multiple comparisons. There were 24 and 29 different heterotic loci （HL） identified for plant height and ear height in the two populations at two locations over two years. Three HL （hlPH4a, hlPH7c, hlPHlb） for plant height and three （hlEHld, hlEH6b, hlEHlb） for ear height were identified in the CSSLs×Zheng 58 and CSSLs×Xun 9058 populations as contributing highly to heterosis performance of plant height and ear height across four environments. Among the 29 HL identified for ear height, 12 HL （41.4%） shared the same chromosomal region associated with the HL （50.0%） identified for plant height in the same test population and environment.展开更多
目的分析3岁听障儿童与同龄健听儿童语言细节句子测试结果,为提高康复教学效果提供参考依据。方法在康复机构和普通幼儿园选取听障儿童与健听儿童各30例,采用言语听觉反应评估(evaluation of auditory resporse to speech,EARS)中的语...目的分析3岁听障儿童与同龄健听儿童语言细节句子测试结果,为提高康复教学效果提供参考依据。方法在康复机构和普通幼儿园选取听障儿童与健听儿童各30例,采用言语听觉反应评估(evaluation of auditory resporse to speech,EARS)中的语言细节句子测试表进行测试,比较两组儿童的句子和词汇水平得分。结果儿童的听力状况对语言细节句子测试得分影响显著(T句子(1,58)=3.36,P<0.01;T词语(1,58)=2.89,P<0.01),健听儿童句子和词汇水平得分(M句子=8.47,M词语=58.23)均显著高于听障儿童(M句子=7.03,M词语=56.63)(P<0.05)。结论与健听儿童相比,语言年龄达到3岁水平的听障儿童句法语法能力滞后,这可能与听障儿童输入性语言信息不足及输入环境有关。康复训练中应加强相应训练,拓展应用到生活场景中。展开更多
Autoimmune inner ear disease(AIED) represents a very fertile research field and the advancements in the understanding of this disease have a direct application not only in patients affected with this condition but als...Autoimmune inner ear disease(AIED) represents a very fertile research field and the advancements in the understanding of this disease have a direct application not only in patients affected with this condition but also in other inner ear disorders that share the same injury mechanism, damage to the inner ear hair cells. AIED also presents many challenges that have still to be overcome. Firstly, access to the inner ear is limited, as many interventions such as biopsies can result in great irreversible damage. Secondly, there are no completely specific markers for AIED. Lack of a definitive diagnosis can result in the treatment of patients not affected with the disease and, therefore, no response. Finally, some patients become refractory to glucocorticoids and new therapies are needed. This review offers an overview of the animal models that have contributed to the understanding of AIED pathophysiology, the value of currently available diagnostic tests, and therapeutic options, with a special focus on new therapies for non responders or patients refractory to glucocorticoids. Among these new options for therapy, biological agents have been tested recently, whereas gene and stem celltherapy may have a role in the future. The intratympanic route of administration avoids the systemic side effects associated with currently used drugs, and may become a more frequent approach in the future.展开更多
Infants with congenital deafness caused by severe bilateral inner ear malformations frequently suffer from severe hearing loss and poor balance. Unfortunately, the use of hearing aids is usually ineffective in recover...Infants with congenital deafness caused by severe bilateral inner ear malformations frequently suffer from severe hearing loss and poor balance. Unfortunately, the use of hearing aids is usually ineffective in recovering hearing, necessitating cochlear implants. We report a case of a 6-year-old boy with congenital deafness and bilateral inner ear malformations(right side, incomplete partition type I [IP-I]; left side, common cavity deformity). Hearing aids had a remarkable effect in this patient, enabling sufficient and favorable hearing recovery such as to allow the patient to engage in daily conversations. Per-rotatory nystagmus was recorded on an electronystagmogram for both right and left rotations in a damped rotational chair test. It is rare for deaf children with severe bilateral inner ear malformation to demonstrate favorable development in hearing and good equilibrium function. Our findings suggest that auditoryevestibular hair cells in this patient may have been partially preserved despite IP-I in the right ear and common cavity deformity of the left ear.展开更多
基金supported by the National Basic Research Program of China (2014CB138203)the National Natural Science Foundation of China (31271732)
文摘Heterosis is an important biological phenomenon, and it has been used to increase grain yield, quality and resistance to abiotic and biotic stresses in many crops. However, the genetic mechanism of heterosis remains unclear up to now. In this study, a set of 184 chromosome segment substitution lines （CSSLs） population, which derived from two inbred lines Ix9801 （the recurrent parent） and Chang 72 （the donor parent）, were used as basal material to construct two test populations with the inbred lines Zheng 58 and Xun 9058. The two test populations were evaluated in two locations over two years, and the heterotic loci for plant height and ear height were identified by comparing the performance of each test hybrid with the corresponding CK at P〈0.05 significant level using one-way ANOVA analysis and Duncan＇s multiple comparisons. There were 24 and 29 different heterotic loci （HL） identified for plant height and ear height in the two populations at two locations over two years. Three HL （hlPH4a, hlPH7c, hlPHlb） for plant height and three （hlEHld, hlEH6b, hlEHlb） for ear height were identified in the CSSLs×Zheng 58 and CSSLs×Xun 9058 populations as contributing highly to heterosis performance of plant height and ear height across four environments. Among the 29 HL identified for ear height, 12 HL （41.4%） shared the same chromosomal region associated with the HL （50.0%） identified for plant height in the same test population and environment.
文摘目的分析3岁听障儿童与同龄健听儿童语言细节句子测试结果,为提高康复教学效果提供参考依据。方法在康复机构和普通幼儿园选取听障儿童与健听儿童各30例,采用言语听觉反应评估(evaluation of auditory resporse to speech,EARS)中的语言细节句子测试表进行测试,比较两组儿童的句子和词汇水平得分。结果儿童的听力状况对语言细节句子测试得分影响显著(T句子(1,58)=3.36,P<0.01;T词语(1,58)=2.89,P<0.01),健听儿童句子和词汇水平得分(M句子=8.47,M词语=58.23)均显著高于听障儿童(M句子=7.03,M词语=56.63)(P<0.05)。结论与健听儿童相比,语言年龄达到3岁水平的听障儿童句法语法能力滞后,这可能与听障儿童输入性语言信息不足及输入环境有关。康复训练中应加强相应训练,拓展应用到生活场景中。
文摘Autoimmune inner ear disease(AIED) represents a very fertile research field and the advancements in the understanding of this disease have a direct application not only in patients affected with this condition but also in other inner ear disorders that share the same injury mechanism, damage to the inner ear hair cells. AIED also presents many challenges that have still to be overcome. Firstly, access to the inner ear is limited, as many interventions such as biopsies can result in great irreversible damage. Secondly, there are no completely specific markers for AIED. Lack of a definitive diagnosis can result in the treatment of patients not affected with the disease and, therefore, no response. Finally, some patients become refractory to glucocorticoids and new therapies are needed. This review offers an overview of the animal models that have contributed to the understanding of AIED pathophysiology, the value of currently available diagnostic tests, and therapeutic options, with a special focus on new therapies for non responders or patients refractory to glucocorticoids. Among these new options for therapy, biological agents have been tested recently, whereas gene and stem celltherapy may have a role in the future. The intratympanic route of administration avoids the systemic side effects associated with currently used drugs, and may become a more frequent approach in the future.
文摘Infants with congenital deafness caused by severe bilateral inner ear malformations frequently suffer from severe hearing loss and poor balance. Unfortunately, the use of hearing aids is usually ineffective in recovering hearing, necessitating cochlear implants. We report a case of a 6-year-old boy with congenital deafness and bilateral inner ear malformations(right side, incomplete partition type I [IP-I]; left side, common cavity deformity). Hearing aids had a remarkable effect in this patient, enabling sufficient and favorable hearing recovery such as to allow the patient to engage in daily conversations. Per-rotatory nystagmus was recorded on an electronystagmogram for both right and left rotations in a damped rotational chair test. It is rare for deaf children with severe bilateral inner ear malformation to demonstrate favorable development in hearing and good equilibrium function. Our findings suggest that auditoryevestibular hair cells in this patient may have been partially preserved despite IP-I in the right ear and common cavity deformity of the left ear.
