Assessment of early factors for identification or prediction severe acute pancreatitis in pregnancy

BACKGROUND Acute pancreatitis in pregnancy(APIP)is a rare and serious condition,and severe APIP(SAPIP)can lead to pancreatic necrosis,abscess,multiple organ dysfunction,and other adverse maternal and infant outcomes.Therefore,early identification or prediction of SAPIP is important.AIM To assess factors for early identification or prediction of SAPIP.METHODS The clinical data of patients with APIP were retrospectively analyzed.Patients were classified with mild acute pancreatitis or severe acute pancreatitis,and the clinical characteristics and laboratory biochemical indexes were compared between the two groups.Logical regression and receiver operating characteristic curve analyses were performed to assess the efficacy of the factors for identification or prediction of SAPIP.RESULTS A total of 45 APIP patients were enrolled.Compared with the mild acute pancreatitis group,the severe acute pancreatitis group had significantly increased(P<0.01)heart rate(HR),hemoglobin,neutrophil ratio(NEUT%),and neutrophil–lymphocyte ratio(NLR),while lymphocytes were significantly decreased(P<0.01).Logical regression analysis showed that HR,NEUT%,NLR,and lymphocyte count differed significantly(P<0.01)between the groups.These may be factors for early identification or prediction of SAPIP.The area under the curve of HR,NEUT%,NLR,and lymphocyte count in the receiver operating characteristic curve analysis was 0.748,0.732,0.821,and 0.774,respectively.The combined analysis showed that the area under the curve,sensitivity,and specificity were 0.869,90.5%,and 70.8%,respectively.CONCLUSION HR,NEUT%,NLR,and lymphocyte count can be used for early identification or prediction of SAPIP,and the combination of the four factors is expected to improve identification or prediction of SAPIP.

Factors Associated with Early Pregnancy among Adolescent Girls in Schools in Bohicon, Benin in 2022

Introduction: The growing phenomenon of early pregnancies in Benin has adverse consequences on the lives of adolescent girls, impacting various social, health, economic, and educational aspects. This study aims to identify the factors associated with early pregnancies in the municipality of Bohicon in 2022. Materials and Methods: This is a case-control study conducted in Bohicon, involving 47 cases and 94 controls from 16 secondary and technical schools. Cases were selected exhaustively, while controls were randomly drawn from girls aged 10 to 19 in the same class who had never been pregnant. Matching was based on the type of institution and class. Data were collected through a questionnaire and analyzed using Epi info 7.2.1.0 and STATA 15 software, employing multiple conditional logistic regression (5% significance threshold) to identify factors related to early pregnancies. Results: The average age of adolescents was 17.63 years ± 0.09 for cases and 17.12 years ± 0.13 for controls. Associated factors included age over 16 years (p = 0.049), the marital status of the adolescent (single) (p = 0.001), and the monthly pocket money of the adolescent less than 10,000 FCFA (p = 0.031). Conclusion: Three factors related to early pregnancies were identified. To counteract this phenomenon and promote responsible sexuality among adolescents, it is essential to strengthen communication efforts aimed at modifying behaviors.

Research Progress about Nature of Early Pregnancy Factor

Platelet-activating factor (PAF) exhibits a variety of biological activities and it be thought to involved in various pathophysiological process. In this paper, some studies were summarized about those roles of PAF in a variety productive processes of female of mammalian that include fertilization, implantation and parturition, and that was involved in the concentration, degradation and some assay methods of PAF. The relationship between PAF and early pregnancy factor(EPF was reviewed.

ISOLATION AND CHARACTERIZATION OF EARLY PREGNANCY FACTOR

Early pregnancy factor (EPF) was purified from the pooled sera of 21 0 pregnant women at 3- 8 weeks of gestation. Sera from healthy nonpregnant women were used as control. The samples (G-Ⅱ . G-Ⅲ and G-Ⅳ) obtained from pregnant women had EPF activity but no HCG activity. Polyacrylamide gel electrophoresis showed that the major bands in pregnant G-Ⅲ and G-Ⅳ were at similar positions in tube gels. The results of SDS-PAGE showed 3 bands in pregnant G-Ⅳ: 57. 0 kD. 38. 0 kD and 19. 0 kD. The basic active form of EPF may be a small peptide of 1 9. 0 kD. The isoelectric points of pregnant G-Ⅳ were 6. 45 and 8. 20.

Detection and significance of reproductive hormones, prethrombotic state markers and coagulation related factors in threatened abortion in early pregnancy

Objective:To investigate the changes and significance of reproductive hormones, prethrombotic state markers and coagulation related factors in threatened abortion in early pregnancy.Methods:Review the clinical data of threatened abortion in early pregnancy (include continuing pregnancy and miscarriages) and healthy pregnant women in the early pregnancy in our hospital, and the levels of reproductive hormones, prethrombotic state markers and coagulation related factors were compared between the three groups.Results: The results of single factor variance showed that the levels ofβ-HCG, progesterone, E2, PC, PLG, D-D, TAT, F1+2 and PAI-1 level were all statistically significant. Compared with the control group, the average levels ofβ-HCG, progesterone, E2 and PLG in the pregnancy maintenance group and the interrupted pregnancy group were significantly decreased, and the level of the interrupted pregnancy group was significantly lower than that of the pregnancy maintenance group. The levels of PC, D-D, TAT, F1+2 and PAI-1 in the pregnancy maintenance group and the interrupted pregnancy group were significantly higher than those in the control group, and the level of the interrupted pregnancy group was significantly higher than that of the pregnancy maintenance group. There was no significant difference in the level of AT III between the groups.Conclusion: There are significant abnormal levels of reproductive hormones, prethrombotic state markers and coagulation related factors in patients with threatened abortion in early pregnancy, the detection of its index level is of great value in predicting threatened abortion in the early stage.

Prediction of Gestational Diabetes Mellitus in Early Pregnancy: Is Abdominal Skin Fold Thickness 20 mm or More an Independent Risk Predictor?

Background: Gestational Diabetes Mellitus (GDM) is associated with several maternal and perinatal complications. Early detection and treatment can improve pregnancy outcomes. Objectives: To determine the prevalence, risk factors and predictors of GDM in early pregnancy at the University of Port Harcourt Teaching Hospital, (UPTH), Port Harcourt Nigeria. Methods: A cohort of 235 mothers who registered for antenatal care between 15 - 18 weeks of gestation at UPTH was prospectively studied. Their socio-demographic data, examination findings, anthropometric measurements, fasting blood sugar at booking and OGTT results at 28 weeks gestation were collated and entered into PC with SPSS for windows version 21.0 which was also used for the analysis. Variables were expressed as absolute numbers, percentages or means with standard deviations and significant differences determined using chi square test or the student “t” test as appropriate. The level of significance was set at P < 0.05. Results: Of the 235 participants, 35 (14.9%) developed GDM. Women who had GDM were significantly older (P = 0.001), had higher weight (t = 2.95, P = 0.01), BMI (t = 2.29, P = 0.02), abdominal skin fold thickness (t = 4.15, P = 0.001), blood pressure (t = 3.38, P = 0.001) compared to women who did not. Previous history of GDM was significantly different between two groups as χ2 = 93.56 and P = 0.001. Abdominal skin fold thickness and prior GDM history were found to be independent predictors of GDM on application of multiple logistic regression analysis. Conclusion: The prevalence of GDM in Port Harcourt is 14.9% and major risk factors are obesity, previous GDM history, advanced age and hypertension. Abdominal skin fold thickness ≥ 20 mm is an independent predictor. The risk of developing GDM can be predicted in early second trimester using algorithm incorporating risk factor screening and anterior abdominal wall skin fold thickness estimation.

The actions,detection and synthesis of platelet-activating factor (PAF) in mammalian pregnancy

Platelet-activating factor (PAF) exhibits a variety of biological activities and it be thought to involved in various pathophysiological process. In this paper, some studies were summarized about those roles ofPAF in a variety productive processes of female of mammalian that inctude fertilization, implantation and parturition, and that was involved in the concentration, synthesis, deiradation and some assay methods of PAF. Therelationship between PAF and early pregnancy factor (EPF) was reviewed.

早孕期血压高值对妊娠期高血压疾病的影响及相关危险因素分析

目的:早孕期血压高值对妊娠期高血压疾病的影响及相关危险因素分析。方法:以2020年1月至2020年12月期间在我院就诊的早孕期血压高值孕妇120例作为观察组。并选取同期在我院接受常规孕检的血压正常孕妇120例作为对照组,记录所有参与研究者的基本资料以及相关指标值,并对其进行跟踪随访,记录其妊娠期高血压疾病发生情况。对其开展单因素与Logistic多因素分析,分析影响早孕期血压高值发生的因素。结果:单因素分析得出,两组孕妇的年龄、最高学历、HDL、UA以及FPG对比,无显著差异(P>0.05);观察组初产率、孕前BMI≥25kg/m^(2)率、LDL、TG与TC值显著高于对照组(P<0.05);产次、孕前BMI、LDL、TG与TC均为影响早孕期血压高值发生的危险因素(P<0.05);经Logistic多因素分析后结果表明,孕前BMI、初产与TG均是诱发早孕期血压高值发生的危险因素(P<0.05)。结论:早孕期血压高值后期发展为妊娠期高血压疾病风险更高,其中孕早期TG水平、初产、孕前BMI≥25kg/m^(2)为诱发早孕期血压高发生的主要因素。

玫瑰花环抑制实验检测肉牛早孕因子(EPF)活性

[目的]为了根据早孕因子活性的检测作为依据来判断肉牛妊娠状态。[方法]本实验采集不同孕期的肉牛的血样,同时进行了妊娠诊断,通过玫瑰花环抑制实验检测活性。[结果]实验表明,未怀孕牛和怀孕牛花环抑制滴度差异显著(P<0.05),不同孕期的早孕因子活性差异不显著。[结论]玫瑰花环抑制滴度高于8可以确认牛怀孕,低于4为未怀孕。

EPF单克隆抗体杂交瘤细胞株的建立

本文用纯化的早孕因子（ＥＰＦ）免疫ＢＡＬＢ／ｃ小鼠，通过鼠－鼠杂交瘤技术，成功地建立了２株（１Ｂ＿６、２Ｆ＿（１０））分泌ＥＰＦ单克隆抗体（ＭｃＡｂ）的杂交瘤细胞系。经检测，它们所分泌的抗体亚类均为ＩｇＧ＿１，杂交瘤染色体数目１００～１０６条，ＥＬＩＳＡ检测诱生腹水抗体效价为１：１．２８×１０￣５，连续培养生物学性状稳定。抗ＥＰＦ抗原的单克隆抗体的建立，为深入研究ＥＰＦ的生物学性质、特征提供了有力的工具。

妊娠早期孕妇25(OH)D水平及其与妊娠期糖尿病的相关性研究

目的探讨南充地区妊娠早期孕妇血清25-羟基维生素D[25(OH)D]水平及其与发生妊娠期糖尿病(GDM)的关联。方法回顾性选取2019年1月至2022年12月在川北医学院附属医院早孕建册正规产检且资料完整的3491例孕妇为研究对象,收集孕妇的年龄、孕前及建册时体质量指数(BMI)、既往妊娠及分娩等一般资料,以及孕妇妊娠11~13+6周的血清25(OH)D水平和妊娠24~28周的75g口服葡萄糖耐量试验(OGTT)检测值。以OGTT结果将孕妇分为正常组(2916例)与GDM组(575例)。再以OGTT结果进行分层分组:①以OGTT空腹血糖水平为依据,将孕妇分为OGTT空腹血糖正常组(3201例)与OGTT空腹血糖异常组(290例);②以OGTT 1小时血糖水平为依据,将孕妇分为OGTT 1小时血糖正常组(3254例)与OGTT 1小时血糖异常组(237例);③以OGTT 2小时血糖水平为依据,将孕妇分为OGTT 2小时血糖正常组(3296例)与OGTT 2小时血糖异常组(195例);④在575例GDM孕妇中,将患者分为单指标组(符合OGTT的三项检测值中一项诊断标准的孕妇,450例)与多指标组(符合OGTT的二项及以上诊断标准的孕妇,125例)。比较各组间血清25(OH)D水平等检测指标;采用Spearman相关性分析妊娠早期血清25(OH)D水平与妊娠中期OGTT 1小时及OGTT 2小时血糖的相关性,通过Logistic回归分析妊娠早期血清25(OH)D水平与GDM发生的关系。结果研究共纳入3491份孕妇资料,其中正常组2916例(83.5%),GDM组575例(16.5%),GDM的发生率为16.5%。血清25(OH)D的严重缺乏者有1569例(44.9%),轻度缺乏者有1192例(34.2%),正常者有730例(20.9%)。正常组孕妇的血清25(OH)D水平中位数为32.3(22.3,46.4)nmol/L,GDM组为30.5(19.8,43.0)nmol/L,经比较差异具有统计学意义(Z=-3.713,P<0.001)。对OGTT结果进行分层分析,OGTT空腹血糖正常组孕妇血清25(OH)D水平与OGTT空腹血糖异常组比较,差异无统计学意义(Z=0.746,P=0.387);OGTT 1小时血糖正常组孕妇血清25(OH)D水平与OGTT 1小时血糖异常组比较,差异有统计学意义(Z=21.509,P<0.001);OGTT 2小时血糖正常组孕妇血清25(OH)D水平与OGTT 2小时血糖异常组比较,差异有统计学意义(Z=44.924,P<0.001);在575例GDM孕妇中,符合OGTT的三项检测值中一项诊断标准(单指标组)的孕妇血清25(OH)D水平与符合二项及以上诊断标准(多指标组)者比较,差异有统计学意义(Z=58.717,P<0.001)。血清25(OH)D与OGTT空腹血糖无明显相关性(r=0.009,P>0.05),而与OGTT 1小时和OGTT 2小时血糖均呈明显负相关(r值分别为-0.070、-0.085,P<0.05)。妊娠早期严重缺乏25(OH)D的孕妇患GDM的风险是正常者的1.299倍(OR=1.299,95%CI:1.018~1.657,P=0.036)。结论南充地区孕妇妊娠早期血清25(OH)D水平普遍偏低,且严重缺乏25(OH)D的妊娠早期孕妇患GDM的风险显著增加。

肉牛早孕因子(EPF)的活性检测及分离纯化

【目的】检测怀孕肉牛早孕因子（Early pregnancy factor,EPF）的活性,并对其进行分离纯化,以期为EPF快速检测方法的建立提供依据。【方法】采集妊娠1~9个月的肉牛血样,并进行妊娠诊断,通过玫瑰花环抑制试验（Rosette inhibition test,RIT）检测其早孕因子的活性。对有活性的血样依次进行DEAE-52离子交换层析、ConASepharose 4B亲和层析和Heparin Sepharose Cl 6B亲和层析,分离纯化EPF,对纯化产物进行SDS-PAGE检测,并测定其等电点。【结果】怀孕牛和未怀孕牛血清的玫瑰花环抑制滴度差异显著（P〈0.05）。玫瑰花环抑制试验显示,纯化出的EPF具有活性,其分子质量为53.6 ku,等电点为6.8。【结论】利用玫瑰花环抑制试验检测早孕因子活性,可以鉴定肉牛的妊娠状态;利用层析的方法可以分离出早孕因子的活性蛋白。

血清miR-182-5p、CFB和ADAM12在孕早期产前筛查唐氏综合征中的应用价值

目的探讨孕早期血清微小核糖核酸(miR)-182-5p、补体因子B(CFB)和解整合素金属蛋白酶12(ADAM12)水平在产前唐氏综合征(DS)筛查中的应用价值。方法选取2015年1月至2022年1月雅安市人民医院收治的150例DS胎儿孕妇为DS组,另选取同期87名健康胎儿孕妇为对照组。采用实时荧光定量聚合酶链式反应检测孕早期血清miR-182-5p水平,酶联免疫吸附法检测CFB、ADAM12水平。通过多因素Logistic回归分析DS的影响因素,受试者工作特征(ROC)曲线分析孕早期血清miR-182-5p、CFB和ADAM12水平对DS的预测价值。结果DS组年龄大于对照组,吸烟比例和CFB水平高于对照组,miR-182-5p、ADAM12水平低于对照组,差异均有统计学意义(χ^(2)/t/Z值介于3.141~8.793之间,P<0.05);多因素Logistic回归分析显示,年龄增加、吸烟、CFB升高为DS的独立危险因素,miR-182-5p、ADAM12升高为独立保护因素,其OR值及95%CI分别为1.122(1.012~1.243)、4.290(1.216~15.131)、1.460(1.268~1.681)、0.656(0.563~0.765)、0.996(0.994~0.998),P<0.05;ROC曲线分析显示,孕早期血清miR-182-5p、CFB和ADAM12水平联合预测DS的曲线下面积(AUC)为0.913,大于各指标单独预测(Z值分别为5.233、4.414、4.809,P<0.05)。结论孕妇血清miR-182-5p、CFB和ADAM12在孕早期产前筛查唐氏综合征中具有潜在应用价值,三者联合有利于在孕早期筛查唐氏综合征。

夫精人工授精早期妊娠丢失的影响因素分析

目的探讨夫精宫腔内人工授精(IUI)早期妊娠丢失发生的影响因素。方法回顾性分析2015年1月至2023年12月于我中心接受IUI助孕后HCG阳性的405对夫妇共426个周期的临床资料。根据妊娠情况分为早期妊娠丢失组(n=85)和继续妊娠组(n=341)。比较两组患者的基本情况、HCG日内膜厚度、男方精液情况等,并对早期妊娠丢失的相关因素进行单因素和多因素分析。结果本研究中所回顾周期的早期妊娠丢失率19.95%(85/426)。单因素分析发现,女方年龄、BMI、基础FSH、不孕年限、处理后精子总数、治疗方案、周期数、男方抽烟情况、精子正常形态率、禁欲天数、男方因素、PCOS和盆腔输卵管因素等没有统计学差异(P>0.05);两组之间FSH/LH比值、不孕类型、HCG日子宫内膜厚度的差异有统计学意义(P<0.05)。多因素回归显示,FSH/LH比值(P<0.05)、不孕类型(P<0.05)、PCOS(P<0.05)是IUI早期妊娠丢失的独立影响因素。结论FSH/LH≥2,不孕类型和PCOS是宫腔内人工授精发生早期妊娠丢失的显著影响因素。

体外受精-胚胎移植患者早期流产的影响因素分析

目的探讨体外受精/卵胞质内单精子注射-胚胎移植(IVF/ICSI-ET)后早期流产的相关影响因素。方法选取2018年1月至12月中信湘雅生殖与遗传专科医院的6107例经IVF/ICSI-ET治疗后成功妊娠患者作为研究对象,依据妊娠结局将患者分为早期流产组(n=987)和继续妊娠组(n=5120),对比两组基线资料及临床指标,并采用二元Logistic回归分析探究早期流产的影响因素。结果所有患者早期流产率为16.16%。单因素分析结果表明,两组年龄、窦卵泡数、移植后14 d人绒毛膜促性腺激素(β-hCG)水平、基础抗米勒管激素水平、基础睾酮水平、不孕年限、助孕方式、不孕类型、有无染色体病及男方因素比较,差异具有统计学意义(P<0.05)。二元Logistic回归分析结果显示,年龄、移植后14 dβ-hCG水平及助孕方式是IVF/ICSI-ET患者早期流产的影响因素。结论高龄、移植后14 dβ-hCG水平低和冻胚移植的IVF/ICSI-ET患者会增加早期流产风险。

双单抗夹心ELISA方法检测EPF活性

目的建立双单抗夹心酶联免疫吸附试验法用于测定早孕因子(EPF)。方法筛选可稳定分泌抗EPF单克隆抗体的细胞株,制备腹水型单抗(McAb)并分离纯化,用改良碘化钠法进行辣根过氧化物酶(HRP)标记单抗,分析McAb的结合位点,通过抗体配对试验选择合适的捕获和检测McAb,建立双McAb-ELISA检测方法。结果筛选出二株稳定分泌抗EPF抗体的单克隆细胞株;两株单抗识别不同的抗原表位;双McAb夹心ELISA法测EPF活性灵敏度可达0.01ug/ml,线性测定范围在0.01～10ug/ml,2份同批血清标本分别重复8次测定,平均批内变异系数为7.7%,2份不同批血清分别重复6次测定,平均批间变异系数为5.8%。建立的双McAb-ELISA法灵敏度90.2%和特异度为92.8%。结论建立的双McAb夹心ELISA法,有优异的灵敏度和特异度,稳定性强,而且简便、快速,适用于血清EPF检测,并有一定的临床应用前景。

孕早期孕妇抑郁的影响因素

目的:分析孕早期孕妇抑郁的影响因素。方法:选取2019年3月至2021年10月于空军特色医学中心临床心理科建档的567名孕早期孕妇进行前瞻性研究,采用抑郁自评量表(SDS)评估孕妇抑郁状况,根据结果将其分为抑郁组和未抑郁组,统计两组基线资料,分析孕早期孕妇抑郁的影响因素。结果:567名孕早期孕妇中,59名SDS得分≥53分,孕早期抑郁发生率为10.41%(59/567);两组年龄、体质量指数、居住面积、孕周、职业、配偶年龄、配偶职业、父母同住、妊娠次数、分娩次数、不良孕产史、计划受孕、双方父母对怀孕态度、影响夫妻生活、分娩方式的选择比较,差异均无统计学意义(P>0.05);两组学历、吸烟史、饮酒史、抑郁病史、家庭月收入、居住地、围生儿死亡经历、妊娠期合并症、被家人照顾情况、恐惧怀孕过程、对孩子性别有期待、父母对孩子性别有期待、生活事件量表(LES)评分比较,差异均有统计学意义(P<0.05);Logistic回归分析结果显示,有饮酒史、有抑郁病史、对孩子性别有期待、父母对孩子性别有期待、LES评分≥20分均为孕早期孕妇抑郁的危险因素(OR>1,P<0.05)。结论:有饮酒史、有抑郁病史、对孩子性别有期待、父母对孩子性别有期待、LES评分≥20分均为孕早期孕妇抑郁的危险因素。

CNV结合STR分型技术检测孕早期流产组织潜在葡萄胎效果及风险因素分析

目的:评估基因组拷贝数变异测序(CNV-seq)结合短串联重复序列(STR)多态性分析技术在检测孕早期(≤9周)流产物组织中潜在葡萄胎病例的应用效果.方法:收集2021年1月-2022年12月行孕早期流产组织CNV-seq结合STR多态性检测病例114例,其中部分新鲜绒毛组织进行CNV-seq结合STR多态性检测,部分组织行病理学检测.比较两种检测方法结果,并分析潜在葡萄胎病例的临床特征和影响因素.结果:CNV-seq结合STR多态性检测共检出染色体异常病例28例,阳性率为24.6%,其中单亲二倍体(UPD)8例,占阳性病例28.6%;病理学检出葡萄胎病例12例,阳性率为10.5%,其中完全性葡萄胎(CHM)10例,占阳性病例的83.3%.两种检测方法的结果一致率为89.5%,Kappa值为0.75,两种方法具较好一致性.潜在葡萄胎病例与非葡萄胎病例在年龄、孕次、流产次、β-hCG水平、超声表现等方面有差异,其中年龄、β-hCG水平和超声表现是潜在葡萄胎危险因素(均P<0.05).结论:CNV-seq结合STR多态性分析技术能有效检测孕早期流产物组织中潜在葡萄胎病例,有助于指导临床治疗和避免再次流产.

妊娠期糖尿病的影响因素及其与妊娠早期膳食铁摄入量的相关性

目的探究妊娠期糖尿病(GDM)发生的影响因素,并分析其与妊娠早期膳食铁摄入量相关性。方法选取1094例定期产检的孕妇作为研究对象,应用多因素Logistic回归模型分析GDM发生的影响因素,应用Pearson相关性分析研究GDM发生与妊娠早期膳食铁摄入量的相关性。结果1094例孕妇中,189例(17.28%)诊断为GDM。多因素Logistic回归模型分析结果显示,年龄≥35岁、孕前月经周期紊乱、膳食结构不均衡、妊娠早期膳食铁摄入量高和甘油三酯水平高均是孕妇发生GDM的危险因素(均P<0.05)。GDM的发生风险与妊娠早期膳食铁摄入呈正相关(r=0.537,P<0.001)。结论年龄≥35岁、孕前月经周期紊乱、膳食结构不均衡、妊娠早期膳食铁摄入量高和甘油三酯水平高均是孕妇发生GDM的危险因素,且GDM发生风险与妊娠早期妇女膳食铁摄入量呈正相关。

孕早期甲状腺功能异常与妊娠期糖尿病的关系研究

目的 探讨孕早期甲状腺功能异常与妊娠期糖尿病(GDM)的关系。方法 100例孕早期孕妇,根据是否发生GDM分成GDM组(n=24)与非GDM组(n=76),对所有孕妇进行甲状腺功能检测,并收集所有孕妇一般资料调查问卷,包括年龄、体质量指数(BMI)、孕次、产次、甲状腺功能指标[甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、FT_(3)/FT_(4)]。比较两组孕妇一般资料,分析GDM发生的影响因素以及甲状腺功能对GDM的预测价值。结果 与非GDM组的(21.84±2.15)kg/m^(2)、43.42%、(3.24±0.62)IU/ml、(2.18±0.59)mU/L、(4.57±0.69)pmol/L、(0.28±0.05)比较,GDM组的BMI(22.94±2.37)kg/m^(2)、TgAb阳性率66.67%、TPOAb(4.39±0.75)IU/ml、TSH(3.36±0.71)mU/L、FT_(3)(5.19±0.76)pmol/L、FT_(3)/FT_(4)(0.33±0.07)水平更高(P<0.05)。以单因素分析差异有统计学意义的因素作为自变量,以GDM作为因变量,分别进行0与1赋值。建立多因素Logistic回归模型,发现TPOAb(OR=3.725)、TSH(OR=2.965)、FT_(3)/FT_(4)(OR=4.137)是GDM发生的独立影响因素(P<0.05)。绘制受试者工作特征曲线(ROC曲线)显示,TPOAb、TSH、FT_(3)/FT_(4)的曲线下面积分别为0.698、0.709、0.759。结论 GDM的发生受到孕早期甲状腺功能异常的影响,TPOAb、TSH、FT_(3)/FT_(4)是其独立影响因素,对GDM有较高的预测价值。