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基于Google earth engine渭-库绿洲果园遥感提取 被引量:1
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作者 盛艳芳 买买提·沙吾提 +1 位作者 何旭刚 李荣鹏 《江苏农业学报》 CSCD 北大核心 2024年第1期103-111,共9页
针对干旱区果园大面积遥感提取困难、识别精度低等问题,本研究基于GEE(Google earth engine)平台,综合应用Sentinel-1/Sentinel-2影像构建特征集。通过对比原始特征组合、Jeffries-Matusita(J-M)距离、属性重要度3种优化方式,结合随机森... 针对干旱区果园大面积遥感提取困难、识别精度低等问题,本研究基于GEE(Google earth engine)平台,综合应用Sentinel-1/Sentinel-2影像构建特征集。通过对比原始特征组合、Jeffries-Matusita(J-M)距离、属性重要度3种优化方式,结合随机森林(Random forest,RF)分类方法,对比得到最佳优化方式,探索果园最优分类特征集。结果表明:识别效果最好的方案为G17 JM,总体精度为91.25%,kappa系数为0.89,面积精度为82.55%。最优特征集为B8_asm、B8_ent、B8_idm、NDVI re3、B6、B7、a、e、b、EVI、B11、B8A、B8、VV。使用J-M距离进行特征集优化,有效降低数据量、提高计算效率,更有利于精确遥感识别果园种植面积。表明GEE快速、准确获取果园种植面积的可行性,为获取果园动态变化提供强有力的基础。 展开更多
关键词 Google earth engine(GEE) 特征优化 J-M距离 特征集
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基于GEOVIS Earth Studio的高中地理教学案例开发——以“河流地貌”为例 被引量:1
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作者 陈奕文 吕红梅 +1 位作者 杨广斌 李亦秋 《地理教学》 北大核心 2024年第2期42-46,共5页
信息技术与教学的融合发展是教育改革发展的方向,地理信息技术在教育信息化2.0时代给地理教育提供了丰富的教学资源,可有效提高教学效果。本文通过挖掘GEOVIS Earth Studio平台在地理教学中的功能优势,构建其教学应用模式,以人教版必修... 信息技术与教学的融合发展是教育改革发展的方向,地理信息技术在教育信息化2.0时代给地理教育提供了丰富的教学资源,可有效提高教学效果。本文通过挖掘GEOVIS Earth Studio平台在地理教学中的功能优势,构建其教学应用模式,以人教版必修《地理1》“河流地貌”为例阐明平台操作过程并进行案例教学设计,创新地理教学技术手段,促进中学地理教学的信息化进程。 展开更多
关键词 GEOVIS earth Studio 高中地理 虚拟动画 河流地貌
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基于GoogleEarthEngine的黄土高原植被覆盖度时空变化特征分析 被引量:3
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作者 姚楠 董国涛 薛华柱 《水土保持研究》 CSCD 北大核心 2024年第1期260-268,共9页
[目的]探究黄土高原植被覆盖度变化的时空特征,揭示植被对气候因子变化的时滞效应,进而为地区生态保护与高质量发展提供数据支撑。[方法]基于2001年至2020年的黄土高原地区NDVI数据、气温和降水数据,利用像元二分法、一元线性回归和时... [目的]探究黄土高原植被覆盖度变化的时空特征,揭示植被对气候因子变化的时滞效应,进而为地区生态保护与高质量发展提供数据支撑。[方法]基于2001年至2020年的黄土高原地区NDVI数据、气温和降水数据,利用像元二分法、一元线性回归和时滞偏相关分析等方法,开展地区植被与气候因子变化关系的研究。[结果]过去20年间,黄土高原植被覆盖度以0.076/10 a的速率增加,在空间上主要呈现极显著增加,但占总面积38.29%的区域植被覆盖变化波动较大。黄土高原月植被覆盖度与气温和降水呈现显著正相关关系,其中降水是影响植被变化的主要因素。植被对降水的响应滞后时间主要集中在3个月,而气温的滞后时间在空间上存在较大差异,东南部植被主要滞后0至1个月,而西北部植被主要滞后2至3个月。[结论]黄土高原植被变化主要受降水影响,20年间植被恢复情况良好,但变化波动较大,未来应继续生态保护工作进行巩固。 展开更多
关键词 植被覆盖度 GEE 时滞相关 气候变化 黄土高原
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基于Google Earth Engine的八门湾红树林年际变化监测
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作者 薛志泳 田震 +1 位作者 朱建华 赵阳 《自然资源遥感》 CSCD 北大核心 2024年第2期279-286,共8页
该文基于Google Earth Engine(GEE)云平台,选择Landsat系列卫星数据,采用支持向量机(support vector machines,SVM)分类方法对八门湾地区进行地物类型分类,并基于分类结果监测该地区红树林年际变化。结果表明:红树林与陆地树木之间除红... 该文基于Google Earth Engine(GEE)云平台,选择Landsat系列卫星数据,采用支持向量机(support vector machines,SVM)分类方法对八门湾地区进行地物类型分类,并基于分类结果监测该地区红树林年际变化。结果表明:红树林与陆地树木之间除红外波段外反射光谱曲线极其相似,利用红外波段特征指数并结合地形数据可进行有效区分,分类结果总体精度达到0.91;研究区红树林存在先减少后增加的变化趋势,在2009—2013年减少,2014—2016年基本保持不变,2017—2021年缓慢增加,红树林增加和坑塘减少时期是在“南红北柳”政策颁布之后,说明退塘还林政策成效显著;红树林主要是和坑塘相互变化转移,说明毁林造塘和退塘还林是影响该地区红树林变化的重要因素。红树林年际变化监测结果可以精细化分析红树林演变过程,并能精确量化红树林与其他土地类型的转化过程,从而在经济、政策上分析红树林演变因素,更有效地保护红树林。 展开更多
关键词 红树林 Google earth Engine 年际变化监测 八门湾
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The future of artificial hibernation medicine:protection of nerves and organs after spinal cord injury 被引量:1
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作者 Caiyun Liu Haixin Yu +4 位作者 Zhengchao Li Shulian Chen Xiaoyin Li Xuyi Chen Bo Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第1期22-28,共7页
Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries.At present,no effective clinical treatment exists.As one of the artificial hi... Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries.At present,no effective clinical treatment exists.As one of the artificial hibernation techniques,mild hypothermia has preliminarily confirmed its clinical effect on spinal cord injury.However,its technical defects and barriers,along with serious clinical side effects,restrict its clinical application for spinal cord injury.Artificial hibernation is a futureoriented disruptive technology for human life support.It involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons,reduce the central constant temperature setting point,disrupt the normal constant body temperature,make the body adapt"to the external cold environment,and reduce the physiological resistance to cold stimulation.Thus,studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia technology.This review introduces artificial hibernation technologies,including mild hypothermia technology,hibernation inducers,and hibernation-related central neuromodulation technology.It summarizes the relevant research on hypothermia and hibernation for organ and nerve protection.These studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal co rd injury through inflammatory inhibition,immunosuppression,oxidative defense,and possible central protection.It also promotes the repair and protection of res pirato ry and digestive,cardiovascular,locomoto r,urinary,and endocrine systems.This review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial hibernation.At present,artificial hibernation technology is not mature,and research fa ces various challenges.Neve rtheless,the effort is wo rthwhile for the future development of medicine. 展开更多
关键词 artificial hibernation central thermostatic-resista nt regulation hypothermia multi-system protection neuroprotection organ protection spinal cord injury synthetic torpor
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基于Google Earth Engine遥感大数据云平台的盐城盐沼植被精细分类研究 被引量:1
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作者 吕林 易文彬 +3 位作者 崔丹丹 王楠 张东 谢正磊 《海洋通报》 CAS CSCD 北大核心 2024年第1期114-126,共13页
江苏省自1982年开始引种互花米草以来,滨海盐沼植被景观格局发生了巨大变化,芦苇和互花米草面积不断增长,挤占了碱蓬生态位,破坏了生态系统平衡。滨海盐沼湿地是三大蓝碳生态系统之一,具有高固碳和缓解温室效应的生态功能。利用遥感云... 江苏省自1982年开始引种互花米草以来,滨海盐沼植被景观格局发生了巨大变化,芦苇和互花米草面积不断增长,挤占了碱蓬生态位,破坏了生态系统平衡。滨海盐沼湿地是三大蓝碳生态系统之一,具有高固碳和缓解温室效应的生态功能。利用遥感云平台手段监测滨海盐沼植被时空动态变化规律,可为滨海盐沼湿地生态系统保护以及修复提供科学支撑。本文选取植被类型丰富的江苏沿海地区为研究区,基于Google Earth Engine(GEE)平台,选取2000-2020年的Landsat 5、Landsat 7、Landsat 8以及Sentinel-2影像,提出了一种湿地植被提取方法。首先,构建盐城盐沼湿地地表覆盖分类体系,选取样本点,计算特征指数,进行地物分类;然后,利用时间谐波分析法对盐沼植被归一化植被指数(NDVI)变化特征进行分析,确定三类盐沼植被的物候差异;最后,基于物候特征,利用随机森林(Random Forest,RF)分类法提取盐城滨海湿地盐沼植被地表覆盖信息。结果表明:(1)相较传统监测方法,本文所构建的滨海盐沼植被精细化提取方法能够对滨海盐沼植被进行有效细分和监测;(2)2000-2020年,芦苇和互花米草面积呈扩张趋势,碱蓬面积不断缩减;(3)盐城三种典型盐沼植被NDVI值呈现不同变化特征;(4)降水对盐沼植被生长的影响较为显著,气温对盐沼植被生长的直接影响较小。研究结果可为盐城盐沼湿地自然遗产保护以及湿地生态可持续发展提供科学支撑。 展开更多
关键词 Google earth Engine 盐沼植被 特征提取 随机森林分类法 时间谐波分析
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基于Google Earth Engine的前郭县春季农田覆膜提取
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作者 邓韵谣 李晓洁 任建华 《地理科学》 CSCD 北大核心 2024年第8期1417-1425,共9页
本文基于Google Earth Engine(GEE)云平台,综合考虑光学影像的波段反射率、光谱指数特征和雷达影像的极化、纹理特征,分别构建仅使用光学特征、仅使用雷达特征以及光学和雷达特征组合3种特征输入组合;根据精度确定最佳输入特征后,分别... 本文基于Google Earth Engine(GEE)云平台,综合考虑光学影像的波段反射率、光谱指数特征和雷达影像的极化、纹理特征,分别构建仅使用光学特征、仅使用雷达特征以及光学和雷达特征组合3种特征输入组合;根据精度确定最佳输入特征后,分别结合机器学习中的分类与回归树、支持向量机、最小距离分类法、梯度提升树和随机森林5种方法建立覆膜提取模型,依据结果精度评估不同方法的性能,并基于最优化模型提取出最终的覆膜农田面积。结果表明:①最佳输入特征为波段反射率特征+光谱指数特征+极化特征+纹理特征;②采用随机森林方法建立的模型精度最高,研究区I的总体精度达到了95.84%,Kappa系数为0.95,地物错分率为1.2%,明显优于其他4种方法(地物错分率较分类与回归树、支持向量机、最小距离和梯度提升树法降低0.8%、7.3%、38.0%和0.3%),研究区II的验证精度达到了87.84%,证明该模型在覆膜提取中可以取得更加准确的结果;③使用本文方法得到2022年研究区I覆膜农田面积为1302.48 km2,估算地膜使用量约为7585.62 t。本文综合考虑光学和雷达影像在地物识别中的特点建立模型,可以准确、高效的识别农田地膜,掌握地膜面积,对环境治理与防治具有重要意义。 展开更多
关键词 覆膜 Google earth Engine 特征提取 随机森林 支持向量机 分类与回归树 最小距离 梯度提升树
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基于Google Earth Engine的洱海流域建成区范围及生态质量变化分析
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作者 郑舒元 陈星宇 +1 位作者 海燕 王建雄 《湖北农业科学》 2024年第2期199-204,共6页
以洱海流域为研究区,借助Google Earth Engine云平台,利用Landsat 8 OLI系列影像,合成研究区域的增强的指数型建筑指数(EIBI)并对洱海流域建成区进行提取,再对研究区域遥感生态指数进行合成,通过对建成区范围与流域范围内遥感生态指数... 以洱海流域为研究区,借助Google Earth Engine云平台,利用Landsat 8 OLI系列影像,合成研究区域的增强的指数型建筑指数(EIBI)并对洱海流域建成区进行提取,再对研究区域遥感生态指数进行合成,通过对建成区范围与流域范围内遥感生态指数进行空间相关分析,从而对2014—2021年洱海流域及其建成区进行生态评估。结果表明,EIBI可有效增强建筑信息,使用EIBI可有效、准确地提取研究区域建成区,经过EIBI提取,洱海流域2014—2021年建成区扩张面积共14.712 km2;2014—2021年洱海流域生态明显改善,遥感生态指数增加0.008,其上升速率为0.001/年,流域内超过65%的区域生态得到改善;洱海流域建成区与生态未得到改善区域大致匹配,建成区经过生态修复后生态质量未见显著提升,且建成区生态质量呈逐年下降趋势,说明建成区对环境改善具有阻力。 展开更多
关键词 洱海流域 增强的指数型建筑指数 遥感生态指数 Google earth Engine 流域环境
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Biomedical rare-earth magnesium alloy:Current status and future prospects 被引量:1
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作者 Mingli Yang Cheng Chen +5 位作者 Dongsheng Wang Yinjin Shao Wenhao Zhou Cijun Shuai Youwen Yang Xinghai Ning 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第4期1260-1282,共23页
Biomedical magnesium(Mg)alloys have garnered significant attention because of their unique biodegradability,favorable biocompatibility,and suitable mechanical properties.The incorporation of rare earth(RE)elements,wit... Biomedical magnesium(Mg)alloys have garnered significant attention because of their unique biodegradability,favorable biocompatibility,and suitable mechanical properties.The incorporation of rare earth(RE)elements,with their distinct physical and chemical properties,has greatly contributed to enhancing the mechanical performance,degradation behavior,and biological performance of biomedical Mg alloys.Currently,a series of RE-Mg alloys are being designed and investigated for orthopedic implants and cardiovascular stents,achieving substantial and encouraging research progress.In this work,a comprehensive summary of the state-of-the-art in biomedical RE-Mg alloys is provided.The physiological effects and design standards of RE elements in biomedical Mg alloys are discussed.Particularly,the degradation behavior and mechanical properties,including their underlying action are studied in-depth.Furthermore,the preparation techniques and current application status of RE-Mg alloys are reviewed.Finally,we address the ongoing challenges and propose future prospects to guide the development of high-performance biomedical Mg-RE alloys. 展开更多
关键词 Magnesium alloy Rare earth elements Biodegradation behavior Mechanical performance Biological properties
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Efficient unequal error protection for online fountain codes 被引量:1
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作者 SHI Pengcheng WANG Zhenyong +1 位作者 LI Dezhi LYU Haibo 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第2期286-293,共8页
In this paper,an efficient unequal error protection(UEP)scheme for online fountain codes is proposed.In the buildup phase,the traversing-selection strategy is proposed to select the most important symbols(MIS).Then,in... In this paper,an efficient unequal error protection(UEP)scheme for online fountain codes is proposed.In the buildup phase,the traversing-selection strategy is proposed to select the most important symbols(MIS).Then,in the completion phase,the weighted-selection strategy is applied to provide low overhead.The performance of the proposed scheme is analyzed and compared with the existing UEP online fountain scheme.Simulation results show that in terms of MIS and the least important symbols(LIS),when the bit error ratio is 10-4,the proposed scheme can achieve 85%and 31.58%overhead reduction,respectively. 展开更多
关键词 online fountain code random graph unequal error protection(UEP) rateless code
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Network pharmacology and subsequent experimental validation reveal the synergistic myocardial protection mechanism of Salvia miltiorrhiza Bge.and Carthamus tinctorius L. 被引量:1
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作者 Linying Zhong Ling Dong +7 位作者 Jing Sun Jie Yang Zhiying Yu Ping He Bo Zhu Yuxin Zhu Siyuan Li Wenjuan Xu 《Journal of Traditional Chinese Medical Sciences》 CAS 2024年第1期44-54,共11页
Objective:To reveal the molecular mechanism underlying the compatibility of Salvia miltiorrhiza Bge(S.miltiorrhiza,Dan Shen)and C.tinctorius L.(C.tinctorius,Hong Hua)as an herb pair through network pharmacology and su... Objective:To reveal the molecular mechanism underlying the compatibility of Salvia miltiorrhiza Bge(S.miltiorrhiza,Dan Shen)and C.tinctorius L.(C.tinctorius,Hong Hua)as an herb pair through network pharmacology and subsequent experimental validation.Methods:Network pharmacology was applied to construct an active ingredient-efficacy target-disease protein network to reveal the unique regulation pattern of s.miltiorrhiza and C.tinctorius as herb pair.Molecular docking was used to verify the binding of the components of these herbs and their potential targets.An H9c2 glucose hypoxia model was used to evaluate the efficacy of the components and their synergistic effects,which were evaluated using the combination index.Western blot was performed to detect the protein expression of these targets.Results:Network pharmacology analysis revealed 5 pathways and 8 core targets of s.miltiorrhiza and C.tinctorius in myocardial protection.Five of the core targets were enriched in the hypoxia-inducible factor-1(HIF-1)signaling pathway.S.miltiorrhiza-C.tinctorius achieved vascular tone mainly by regulating the target genes of the HIF-1 pathway.As an upstream gene of the HIF-1 pathway,STAT3 can be activated by the active ingredients cryptotanshinone(Ctan),salvianolic acid B(Sal.B),and myricetin(Myric).Cell experiments revealed that Myric,Sal.B,and Ctan also exhibited synergistic myocardial protective activity.Molecular docking verified the strong binding of Myric,Sal.B,and Ctan to STAT3.Western blot further showed that the active ingredients synergistically upregulated the protein expressionof STAT3.Conclusion:The pharmacodynamic transmission analysis revealed that the active ingredients of S.miltiorrhiza and C.tinctorius can synergistically resist ischemia through various targets and pathways.This study provides a methodological reference for interpreting traditional Chinese medicine compatibility. 展开更多
关键词 S.miltiorrhiza-C.tinctorius herb pair Compatibilitymechanism Networkpharmacology Multipletargeteffect Myocardial protection
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Lateral earth pressure of granular backfills on retaining walls with expanded polystyrene geofoam inclusions under limited surcharge loading 被引量:1
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作者 Kewei Fan Guangqing Yang +2 位作者 Weilie Zou Zhong Han Yang Shen 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第4期1388-1397,共10页
Existing studies have focused on the behavior of the retaining wall equipped with expanded polystyrene(EPS)geofoam inclusions under semi-infinite surcharge loading rather than limited surcharge loading.In this paper,t... Existing studies have focused on the behavior of the retaining wall equipped with expanded polystyrene(EPS)geofoam inclusions under semi-infinite surcharge loading rather than limited surcharge loading.In this paper,the failure mode and the earth pressure acting on the rigid retaining wall with EPS geofoam inclusions and granular backfills(henceforth referred to as EPS-wall),under limited surcharge loading are investigated through two-and three-dimensional model tests.The testing results show that different from the sliding of almost all the backfill in the EPS-wall under semi-infinite surcharge loading,only an approximately triangular backfill slides in the wall under limited surcharge loading.The distribution of the lateral earth pressure on the EPS-wall under limited surcharge loading is non-linear,and the distribution changes from the increase of the wall depth to the decrease with the increase of the limited surcharge loading.An approach based on the force equilibrium of a differential element is developed to predict the lateral earth pressure behind the EPS-wall subjected to limited surcharge loading,and its performance was fully validated by the three-dimensional model tests. 展开更多
关键词 Retaining wall Expanded polystyrene(EPS)geofoam Limited surcharge loading Lateral earth pressure Model test Prediction
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Self-actuating protection mechanisms for safer lithium-ion batteries
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作者 Yang Luo Chunchun Sang +3 位作者 Kehan Le Hao Chen Hui Li Xinping Ai 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第7期181-198,共18页
Safety issue is still a problem nowadays for the large-scale application of lithium-ion batteries(LIBs)in electric vehicles and energy storage stations.The unsafe behaviors of LIBs arise from the thermal run-away,whic... Safety issue is still a problem nowadays for the large-scale application of lithium-ion batteries(LIBs)in electric vehicles and energy storage stations.The unsafe behaviors of LIBs arise from the thermal run-away,which is intrinsically triggered by the overcharging and overheating.To improve the safety of LIBs,various protection strategies based on self-actuating reaction control mechanisms(SRCMs)have been proposed,including redox shuttle,polymerizable monomer additive,potential-sensitive separator,thermal shutdown separator,positive-temperature-coefficient electrode,thermally polymerizable addi-tive,and reversible thermal phase transition electrolyte.As build-in protection mechanisms,these meth-ods can sensitively detect either the temperature change inside battery or the potential change of the electrode,and spontaneously shut down the electrode reaction at risky conditions,thus preventing the battery from going into thermal runaway.Given their advantages in enhancing the intrinsic safety of LIBs,this paper overviews the research progresses of SRCMs after a brief introduction of thermal runaway mechanism and limitations of conventional thermal runaway mitigating measures.More importantly,the current states and issues,key challenges,and future developing trends of SRCTs are also discussed and outlined from the viewpoint of practical application,aiming at providing insights and guidance for developing more effective SRCMs for LIBs. 展开更多
关键词 Li-ion battery SAFETY Thermal runaway Thermal protection Overcharge protection
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Hydroxytyrosol and Parkinson's disease:protective actions against alpha-synuclein toxicity
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作者 Ruth Hornedo-Ortega Ana M.Espinosa-Oliva 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1427-1428,共2页
Parkinson’s disease:Parkinson’s disease(PD) is the second most prevalent neurodegenerative disease,after Alzheimer’s disease,affecting 1%of the general population over the age of 65years.According to data from the ... Parkinson’s disease:Parkinson’s disease(PD) is the second most prevalent neurodegenerative disease,after Alzheimer’s disease,affecting 1%of the general population over the age of 65years.According to data from the World Health Organization(WHO),its prevalence has doubled in the past 25 years.In 2019,global estimates indicated over 8.5 million individuals with PD and it is suggested that PD caused 329000 deaths,an increase of over 100% since 2000(WHO,2022). 展开更多
关键词 protective ALZHEIMER PREVALENCE
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Corrigendum to“Targeted metabolomics reveals the aberrant energy status in diabetic peripheral neuropathy and the neuroprotective mechanism of traditional Chinese medicine JinMaiTong”[J.Pharm.Anal.14(2024)225e243]
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作者 Bingjia Zhao Qian Zhang +3 位作者 Yiqian He Weifang Cao Wei Song Xiaochun Liang 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第4期622-622,共1页
Original statement in the caption of Fig.5:Fig.5.JinMaiTong(JMT)treatment restored the perturbed central carbohydrate metabolism in the circulation and sciatic nerve of diabetic peripheral neuropathy(DPN)rats.Dash lin... Original statement in the caption of Fig.5:Fig.5.JinMaiTong(JMT)treatment restored the perturbed central carbohydrate metabolism in the circulation and sciatic nerve of diabetic peripheral neuropathy(DPN)rats.Dash line arrows indicate the direct metabolic reactions,and solid line arrows indicate the indirect reactions.*P<0.05 and**P<0.01.ns:no significant difference.CON:control;TCA:tricarboxylic acid cycle;ADP:adenosine diphosphate:ATP:adenosine triphosphate;GDP:guanosine diphosphate;GTP:guanosine triphosphate. 展开更多
关键词 protective NEUROPATHY metabolism
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Ambroxol,the cough expectorant with neuroprotective effects
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作者 Kristin Patzwaldt Salvador Castaneda-Vega 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第11期2345-2346,共2页
Ambroxol hydrochloride(2-amino-3,5-dibromo-N-methylbenzylamine hydrochloride)has been used as a mucolytic agent in the treatment of respiratory diseases since the late 1970s.Its effects on mucus membranes such as mucu... Ambroxol hydrochloride(2-amino-3,5-dibromo-N-methylbenzylamine hydrochloride)has been used as a mucolytic agent in the treatment of respiratory diseases since the late 1970s.Its effects on mucus membranes such as mucus disruption,increased mucus production,and low toxicity profile were addressed in its original German patent in 1966.These first described properties have kept Ambroxol available worldwide and over the counter in the pharmaceutical market to this day. 展开更多
关键词 protective AGENT GERMAN
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A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria
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作者 John Mitrofanis Jonathan Stone +3 位作者 Michael R.Hamblin Pierre Magistretti Alim-Louis Benabid Glen Jeffery 《Neural Regeneration Research》 SCIE CAS 2025年第4期1081-1082,共2页
Neurons are notoriously vulnerable cell types.Even the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological cond... Neurons are notoriously vulnerable cell types.Even the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper function.In most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell death.The challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological conditions.Such interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical levels.In this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective treatments.These are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model. 展开更多
关键词 protective DOSAGE DISTRESS
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1990—2020年帕米尔高原无表碛覆盖冰川变化态势研究——基于Google Earth Engine平台
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作者 陈逸青 段克勤 +1 位作者 石培宏 李朝纲 《冰川冻土》 CSCD 2024年第3期742-753,共12页
帕米尔高原是亚洲高山区最大的冰川作用中心,其冰川融水在区域水资源与水循环中发挥关键作用。然而,近年来对帕米尔高原冰川变化的认识仍存在争议,一方面认为喀喇昆仑-帕米尔高原冰川存在异常前进现象,另一方面认为帕米尔冰川正在加剧... 帕米尔高原是亚洲高山区最大的冰川作用中心,其冰川融水在区域水资源与水循环中发挥关键作用。然而,近年来对帕米尔高原冰川变化的认识仍存在争议,一方面认为喀喇昆仑-帕米尔高原冰川存在异常前进现象,另一方面认为帕米尔冰川正在加剧退缩。究其原因,一是研究时空范围不重合,二是研究中对冰川的定义有所不同。为明晰帕米尔高原无表碛覆盖冰川近30年来的时空变化情况,本研究基于Google Earth Engine(GEE)平台,利用Landsat 5 TM和Landsat 8 OLI遥感影像数据,消除掉云层遮蔽、季节性积雪和冰川表碛覆盖对无表碛覆盖冰川面积的影响,获取了帕米尔高原1990—2020年期间无表碛覆盖冰川时空变化特征。结果显示,在过去30年帕米尔高原无表碛覆盖冰川面积以116.42 km^(2)·a^(-1)的速率由(12 108.98±250.38) km^(2)缩减到(8 616.44±7.72) km^(2)。在空间上,帕米尔高原西部无表碛覆盖冰川面积总体上呈退缩趋势,而帕米尔东部无表碛覆盖冰川面积则相对稳定。特别是在2000—2010年期间,帕米尔东部无表碛覆盖冰川面积存在异常增加现象,但自2010年,冰川面积退缩加速,冰川末端前进现象已不存在。结合气候及冰川高程变化分析,冰川跃动引起的冰川厚度减薄、冰川末端前进,是1990—2010年间帕米尔高原冰川异常前进的主要原因。 展开更多
关键词 Google earth Engine 帕米尔高原 无表碛覆盖冰川 冰川异常
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Note on:“Ballistic model for the prediction of penetration depth and residual velocity in adobe:A new interpretation of the ballistic resistance of earthen masonry”
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作者 Andreas Heine Matthias Wickert 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期607-609,共3页
A recently published modeling approach for the penetration into adobe and previous approaches implicitly criticized are reviewed and discussed.This article contains a note on the paper titled“Ballistic model for the ... A recently published modeling approach for the penetration into adobe and previous approaches implicitly criticized are reviewed and discussed.This article contains a note on the paper titled“Ballistic model for the prediction of penetration depth and residual velocity in adobe:A new interpretation of the ballistic resistance of earthen masonry”(DOI:https://doi.org/10.1016/j.dt.2018.07.017).Reply to the Note from Li Piani et al is linked to this article. 展开更多
关键词 ADOBE PREDICTION earth
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Experimental and numerical study on protective effect of RC blast wall against air shock wave
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作者 Xin-zhe Nian Quan-min Xie +2 位作者 Xin-li Kong Ying-kang Yao Kui Huang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第1期567-579,共13页
Prototype experiments were carried out on the explosion-proof performance of the RC blast wall.The mass of TNT detonated in the experiments is 5 kg and 20 kg respectively.The shock wave overpressure was tested in diff... Prototype experiments were carried out on the explosion-proof performance of the RC blast wall.The mass of TNT detonated in the experiments is 5 kg and 20 kg respectively.The shock wave overpressure was tested in different regions.The above experiments were numerically simulated,and the simulated shock wave overpressure waveforms were compared with that tested and given by CONWEP program.The results show that the numerically simulated waveform is slightly different from the test waveform,but similar to CONWEP waveform.Through dimensional analysis and numerical simulation under different working conditions,the equation for the attenuation rate of the diffraction overpressure behind the blast wall was obtained.According to the corresponding standards,the degree of casualties and the damage degree of the brick concrete building at a certain distance behind the wall can be determined when parameters are set.The above results can provide a reference for the design and construction of the reinforced concrete blast wall. 展开更多
关键词 Blast wall Shock wave DIFFRACTION OVERPRESSURE protection
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