A performance-based hybrid deep learning model for predicting TBM advance rate using Attention-ResNet-LSTM

The technology of tunnel boring machine(TBM)has been widely applied for underground construction worldwide;however,how to ensure the TBM tunneling process safe and efficient remains a major concern.Advance rate is a key parameter of TBM operation and reflects the TBM-ground interaction,for which a reliable prediction helps optimize the TBM performance.Here,we develop a hybrid neural network model,called Attention-ResNet-LSTM,for accurate prediction of the TBM advance rate.A database including geological properties and TBM operational parameters from the Yangtze River Natural Gas Pipeline Project is used to train and test this deep learning model.The evolutionary polynomial regression method is adopted to aid the selection of input parameters.The results of numerical exper-iments show that our Attention-ResNet-LSTM model outperforms other commonly-used intelligent models with a lower root mean square error and a lower mean absolute percentage error.Further,parametric analyses are conducted to explore the effects of the sequence length of historical data and the model architecture on the prediction accuracy.A correlation analysis between the input and output parameters is also implemented to provide guidance for adjusting relevant TBM operational parameters.The performance of our hybrid intelligent model is demonstrated in a case study of TBM tunneling through a complex ground with variable strata.Finally,data collected from the Baimang River Tunnel Project in Shenzhen of China are used to further test the generalization of our model.The results indicate that,compared to the conventional ResNet-LSTM model,our model has a better predictive capability for scenarios with unknown datasets due to its self-adaptive characteristic.

Evaluation of oxaliplatin and tigio combination therapy in locally advanced gastric cancer

BACKGROUND Locally advanced gastric cancer(LAGC)is a common malignant tumor.In recent years,neoadjuvant chemotherapy has gradually become popular for the treatment of LAGC.AIM To investigate the efficacy of oxaliplatin combined with a tigio neoadjuvant chemotherapy regimen vs a conventional chemotherapy regimen for LAGC.METHODS Ninety patients with LAGC were selected and randomly divided into control and study groups with 45 patients in each group,according to the numerical table method.The control group was treated with conventional chemotherapy,and the study group was treated with oxaliplatin combined with tigio-neoadjuvant che-motherapy.The primary outcome measures were the clinical objective response rate(ORR)and surgical resection rate(SRR),whereas the secondary outcome measures were safety and Karnofsky Performance Status score.RESULTS The ORR in the study group was 80.00%,which was significantly higher than that of the control group(57.78%).In the study group,SRR was 75.56%,which was significantly higher than that of the control group(57.78%).There were 15.56%adverse reactions in the study group and 35.56%in the control group.These differences were statistically significant between the two groups.CONCLUSION The combination of oxaliplatin and tigio before surgery as neoadjuvant chemotherapy for patients with LAGC can effectively improve the ORR and SRR and is safe.

Application of several optimization techniques for estimating TBM advance rate in granitic rocks

This study aims to develop several optimization techniques for predicting advance rate of tunnel boring machine(TBM)in different weathered zones of granite.For this purpose,extensive field and laboratory studies have been conducted along the 12,649 m of the Pahang-Selangor raw water transfer tunnel in Malaysia.Rock properties consisting of uniaxial compressive strength(UCS),Brazilian tensile strength(BTS),rock mass rating(RMR),rock quality designation(RQD),quartz content(q)and weathered zone as well as machine specifications including thrust force and revolution per minute(RPM)were measured to establish comprehensive datasets for optimization.Accordingly,to estimate the advance rate of TBM,two new hybrid optimization techniques,i.e.an artificial neural network(ANN)combined with both imperialist competitive algorithm(ICA)and particle swarm optimization(PSO),were developed for mechanical tunneling in granitic rocks.Further,the new hybrid optimization techniques were compared and the best one was chosen among them to be used for practice.To evaluate the accuracy of the proposed models for both testing and training datasets,various statistical indices including coefficient of determination(R^2),root mean square error(RMSE)and variance account for(VAF)were utilized herein.The values of R^2,RMSE,and VAF ranged in 0.939-0.961,0.022-0.036,and 93.899-96.145,respectively,with the PSO-ANN hybrid technique demonstrating the best performance.It is concluded that both the optimization techniques,i.e.PSO-ANN and ICA-ANN,could be utilized for predicting the advance rate of TBMs;however,the PSO-ANN technique is superior.

RECENT ADVANCES IN HYDRATE-BASED TECHNOLOGIES FOR NATURAL GAS STORAGE——A REVIEW

Interest in the possibility of storing and transporting natural gas in the form of clathrate hydrates has been increasing in recent years, particularly in some gas-importing and exporting countries.The technologies necessary for realizing this possibility may be classified into those relevant to the four serial processes (a) the formation of a hydrate, (b) the processing (dewatering, pelletizing, etc. ) of the formed hydrate, (c) the storage and transportation of the processed hydrate, and (d) the regasification (dissociation) of the hydrate. The technological development of any of these processes is still at an early stage. For hydrate formation, for example, various rival operations have been proposed. However,many of them have never been subjected to actual tests for practical use. More efforts are required for examining the different hydrate-formation technologies and for rating them by comparison. The general design of the processing of the formed hydrate inevitably depends on both the hydrate-formation process and the storage/transportation process, hence it has a wide variability. The major uncertainty in the storage-process design lies in the as-yet unclarified utility of the "self-preservation" effect of the naturalgas hydrates. The process design as well as the relevant cost evaluation should strongly depend on whether the hydrates are well preserved at atmospheric pressure in large-scale storage facilities. The regasification process has been studied less extensively than the former processes. The state of the art of the technological development in each of the serial processes is reviewed, placing emphasis on the hydrate formation process.

Prediction of face advance rate and determination of the operation efficiency in retreat longwall mining panel using rock engineering system

A new approach for prediction of face advance rete (FAR) prior to mining operation and determination of the operation efficiency after mining operation in retreat longwall mining panel is presented based upon the concepts of rock engineering system (RES). For this purpose, six longwall panels considered in Parvadeh-I coal mine. Seven major effective parameters on FAR was selected including coal mine roof rating, gas propagation, safety factor of longwall face, ratio of joint spacing to cutting depth at longwall face, longwall face inclination, panel width, floor rock mass rating. To performance evaluation of the presented model, the relationship between the average vulnerability indexes of advance operation with FAR was determined in considered panels with coefficient of determination (R2) equal to 0.884 that indicate relatively acceptable correlation and compatibility. Investigations of the research indicated that it is possible to determine the actual operation efficiency under fair conditions by a RES-based model. The inevitable reduction of FAR for each longwall panel was determined by presented model that the difference amount between the maximum possible practical face advance rate (FARmpp) and recorded actual face advance rate (FARa) indicate the operation efficiency. Applied approach in this paper can be used to prediction of FAR in retreat longwall mining panel for same conditions that can have many benefits, including better and more accurate planning for the sales market and mine operation. Also, presented method in this paper can be applied as a useful tool to determination of actual operation efficiency for other sections and extraction methods in coal mines.

High-dose-rate intraluminal brachytherapy during preoperative chemoradiation for locally advanced rectal cancers

AIM:To determine the feasibility and safety of high dose rate intraluminal brachytherapy(HDR-ILBT) boost during preoperative chemoradiation for rectal cancer.METHODS:Between 2008 and 2009,thirty-six patients with locally advanced rectal cancer(≥ T3 or N+),were treated initially with concurrent capecitabine(825 mg/m2 oral twice daily) and pelvic external beam radiotherapy(EBRT)(45 Gy in 25 fractions),then were randomized to group A;HDR-ILBT group(n = 17) to receive 5.5-7 Gy×2 to gross tumor volume(GTV) and group B;EBRT group(n = 19) to receive 5.4 Gy×3 fractions to GTV with EBRT.All patients underwent total mesorectal excision.RESULTS:Grade 3 acute toxicities were registered in 12 patients(70.6%) in group A and in 8(42.1%) in group B.Complete pathologic response of T stage(ypT0) in group A was registered in 10 patients(58.8%) and in group B,3 patients(15.8%) had ypT0(P < 0.0001).Sphincter preservation was reported in 6/9 patients(66.7%) in group A and in 5/10 patients(50%) in group B(P < 0.01).Overall radiological response was 68.15% and 66.04% in Group A and B,respectively.During a median follow up of 18 mo,late grade 1 and 2 sequelae were registered in 3 patients(17.6%) and 4 patients(21.1%) in the groups A and B,respectively.CONCLUSION:HDR-ILBT was found to be effective dose escalation technique in preoperative chemoradiation for rectal cancers,with higher response rates,downstaging and with manageable acute toxicities.

New endoscopy advances to refine adenoma detection rate for colorectal cancer screening:None is the winner

Colorectal cancer(CRC) is the third most common cancer in males and second in females, and globally the fourth cause for cancer death worldwide. Oncological screening of CRC has a major role in the management of the disease and it is mostly performed by colonoscopy. Anyway, effectiveness of endoscopic screening for CRC strictly depends on adequate detection and removal of potentially precancerous lesions, and accuracy of colonoscopy in detection of adenomas is still suboptimal. For this reason, several technological advances have been implemented in order to improve the diagnostic sensitivity of colonoscopy in adenoma detection. Among these:(1) Visual technologies such as chromoendoscopy and narrow band imaging;(2) optical innovation as high definition endoscopy, full-spectrum endoscopy or Third Eye Retroscope; and(3) mechanical advances as Cap assisted colonoscopy, Endocuff, Endoring and G-Eye endoscope. All these technologies advances have been tested over time by clinical studies with mixed results. Which of them is more likely to be successful in the next future?

Some recent advances in ab initio calculations of nonradiative decay rates of point defects in semiconductors

In this short review,we discuss a few recent advances in calculating the nonradiative decay rates for point defects in semiconductors.We briefly review the debates and connections of using different formalisms to calculate the multi-phonon processes.We connect Dr.Huang's formula with Marcus theory formula in the high temperature limit,and point out that Huang's formula provide an analytical expression for the phonon induced electron coupling constant in the Marcus theory formula.We also discussed the validity of 1D formula in dealing with the electron transition processes,and practical ways to correct the anharmonic effects.

The Impact of Rate of Feeding Advancement after Early Initiation of Enteral Nutrition in Critically Ill, Underweight Patients: A Single-Center Retrospective Chart Review

Background: The optimal rate of feeding advancement after initiation of early enteral nutrition (EEN) for underweight, critically ill patients is unknown. Methods: We conducted a retrospective chart review in intensive care unit (ICU) patients with a body mass index (BMI) < 20.0 kg/m2. Patients were categorized into Group R, which reached the energy target within 3 days of EEN initiation, and Group S, which reached the energy target 4 or more days after EEN initiation. Results: A total of 65 patients with a median age of 73 years were included in the study. No significant differences were observed between the two groups for all-cause mortality, ICU-free days, or length of hospital stay. Ventilator-free days (VFDs) were significantly fewer in Group R than in Group S (18.0 [0.0 - 22.0] vs. 21.0 [16.3 - 24.8] days;P = 0.046). A significantly higher number of patients requiring mechanical ventilation (MV) at hospital discharge were observed in Group R than in Group S (29% vs. 8%;P = 0.030). Multivariable analyses with adjustment for confounders found that days required to reach target energy intake after EEN initiation were significantly and independently associated with the requirement for MV at hospital discharge, but not with VFDs. Conclusion: A slow rate of feeding advancement after initiation of EEN in critically ill patients having a BMI of <20.0 kg/m2 might be associated with a reduced requirement for MV at hospital discharge. These results require confirmation in a large multicenter trial of underweight, critically ill patients.

Benefit of neoadjuvant concurrent chemoradiotherapy for locally advanced perihilar cholangiocarcinoma

To clarify the role of neoadjuvant concurrent chemoradiotherapy (NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma (CCA).METHODSWe retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients received NACCRT and 45 patients did not received NACCRT. Patients with locally advanced perihilar CCA requiring NACCRT were defined as follows: (1) a mass involving unilateral branches of the portal vein or hepatic artery with insufficient volume of the anticipated remnant lobe; or (2) an infiltrating mass in the main portal vein that was too long for reconstruction, identified at preoperative staging.RESULTSThe median disease-free survival (DFS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 26.0 and 15.1 mo, respectively (P = 0.91). The median overall survival (OS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 32.9 and 27.1 mo, respectively (P = 0.26). The NACCRT group showed a downstaging tendency compared to the non-NACCRT group as compared with the tumor stage confirmed by histological examination after surgery and the tumor stage confirmed by imaging test at the time of diagnosis (P = 0.01).CONCLUSIONNACCRT does not prolong DFS and OS in localized or locally advanced perihilar CCA. However, NACCRT may allow tumor downstaging and improve tumor resectability.

Postoperative sequential chemotherapy and radiotherapy for locally advanced gastric cancer

Objective The aim of the study was to evaluate the role of postoperative sequential chemotherapy and radiotherapy in patients with locally advanced gastric cancer.Methods From January 2003 to December 2010, 146 gastric cancer patients at our institution(Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China) received postoperative sequential chemotherapy and radiotherapy after radical surgery. Radiotherapy was administered as a dose of 4500 cGy in 25 fractions. For patients with positive margins, the dose was raised to 5040 cGy in 28 fractions. Three cycles of m FOLFOX or PF(cisplatin, 5-fluorouracil) chemotherapy regimen were applied before and after radiotherapy. Three-and 5-year survival rates were analyzed; any adverse effects with respect to hematology, hepatic and renal function, or the gastrointestinal tract that occurred during the treatment were evaluated.Results This cohort consisted of non-metastatic patients: 104 men and 42 women with a median age of 51.0 years. The full course of sequential chemotherapy and radiotherapy(4500–5040 cGy) was completed by 129 patients(88.4%). Seventeen regional relapses(9.8%) and 46 distant relapses(23.8%) were recorded. Fifty patients(34.2%) died during follow-up. The 3-and 5-year overall survival rates(OS) were 60% and 54%, and disease-free survival rates(DFS) were 53% and 47%, respectively. There were no significant differences in survival rate with respect to age, sex, histopathology, N stage, site of the tumor, or margin status. Multivariate analysis showed that only the depth of tumor invasion(T stage) was an independent prognostic factor for OS(P = 0.009) and DFS(P = 0.006). The rates of grades 3 and 4 neutropenia and vomiting were 9.6% and 3.4%, respectively, during the treatment.Conclusion Postoperative sequential chemotherapy with an m FOLFOX or PF regimen and radiotherapy were found to be an effective means of treating advanced gastric cancer patients with T3–T4 disease. The adverse effects of this treatment were tolerable.

Fine analysis on advanced detection of transient electromagnetic method

Fault fracture zones and water-bearing bodies in front of the driving head are the main disasters in mine laneways,thus it is important to perform their advanced detection and prediction in advance in order to provide reliable technical support for the excavation.Based on the electromagnetic induction theory,we analyzed the characteristics of primary and secondary fields with a positive and negative wave form of current,proposed the fine processing of the advanced detection with variation rate of apparent resistivity and introduced in detail the computational formulae and procedures.The result of physical simulation experiments illustrate that the tectonic interface of modules can be judged by first-order rate of apparent resistivity with a boundary error of 5%,and the position of water body determined by the fine analysis method agrees well with the result of borehole drilling.This shows that in terms of distinguishing structure and aqueous anomalies,the first-order rate of apparent resistivity is more sensitive than the secondorder rate of apparent resistivity.However,some remaining problems are suggested for future solutions.

Clinical analysis of PF plus concurrent radiotherapy in locally advanced nasopharyngeal carcinoma

Objective： The prognosis of patients with nasopharyngeal carcinoma （NPC） depends on the stage of the disease at diagnosis. Unfortunately, at diagnosis, most of patients have locally advanced, non-metastatic stage III or IVa disease. The study was to evaluate the efficacy and toxicities of cisplatin plus 5-fluorouracil combined with concurrent radiotherapy for locally advanced nasopharyngeal carcinoma. Methods： Sixty-six patients with locally advanced nasopharyngeal carcinoma received chemotherapy of cisplatin plus 5-fluorouracil jointing concurrent radiotherapy; concurrent radiotherapy started on day 1 in the first cycle of chemotherapy of PF, 5-fluorouraci1500 mg/m^2 intravenous infusion on days 1-5, cisplatin 80 mg/m2 intravenous infusion on days 1-3, 21 days for a cycle, a total of three cycles; nasopharyngeal lesions and positive lymph node were given a total amount of 70 Gy, prophylactic neck radiation were given the amount of 50 Gy, radiotherapy five times a week, Gy/f. Results： All patients who can be evaluated, the response rate （RR） was 100%; 1-, 3- and 5-year overall survival （OS） were 100%, 86.4%, 21.2%, respectively; 3-year, 5-year disease-free survival （DFS） were 72.7% and 18.2%, respective- ly; the average survival time and median survival time were 49.0 months and 48.5 months, respectively; the average survival time and median survival time of DFS were 46.1 months and 46.5 months, respectively. Conclusion： For patients with locally advanced nasopharyngeal carcinoma, who accepted RT combining concurrent chemotherapy of cisplatin plus 5-fluorouracil, clinical efficacy is satisfaction and toxicities could be tolerated.

Advances in Research of Cutting Breeding Technology of Xanthoceras sorbifolium Bunge

Cutting breeding is an important method of asexual reproduction of Xanthoceras sorbifolium Bunge.At present,it has been found that the factors influencing the cuttings of X.sorbifolium mainly include cutting material type,substrate type,cutting season,cutting material length and thickness,mother tree age,cutting material pretreatment method,hormone species concentration and soaking time.Besides,different regions,control conditions,and germplasm types have different cutting rooting rates.This paper introduced some of the problems in the cuttings of X.sorbifolium,and came up with some recommendations to provide a reference for the future research and technical promotion of X.sorbifolium cuttings.

Study on the characteristics of ground pressure behaviors in working face with great mining height at different advance speeds by similarity model experiment

Presently most of research results on strata behaviors were concluded under the normal （moderate） advance rate conditions. Comparing with normal advance rate, fast advance rate and slow advance rate may cause some new changes of strata behaviors. The characteristics of ground pressure behaviors in working face with great mining height at different forward speeds were studied by similarity model experiment in laboratory. Its conclusion provides a theoretic basis for ground pressure controlling.

自拟健脾除积方联合信迪利单抗及化疗对晚期非小细胞肺癌患者的影响

目的:探讨自拟健脾除积方联合信迪利单抗及化疗对晚期非小细胞肺癌患者疾病控制率、中医症候积分及不良反应的影响。方法:选取2020年10月—2022年10月在我院就诊的102例晚期非小细胞肺癌患者,随机分为观察组和对照组,每组各51例,对照组在吉西他滨+顺铂化疗的基础上给予信迪利单抗,观察组在对照组基础上联合自拟健脾除积方治疗。比较两组患者临床疗效、治疗前后中医症候积分、肿瘤标志物水平及不良反应。结果:观察组有效率和疾病控制率明显高于对照组(P<0.05);观察组和对照组治疗后中医症候积分均显著低于治疗前;治疗后,观察组中医症候积分显著低于对照组(P<0.05)。两组治疗后血清铁蛋白(SF)、鳞状细胞癌抗原(SCCA)及癌胚抗原(CEA)水平均显著低于同组治疗前,观察组SF、SCCA、CEA水平均显著低于对照组。观察组白细胞计数减少、恶心、呕吐症状总发生率显著低于对照组(P<0.05)。结论:自拟健脾除积方联合信迪利单抗对晚期非小细胞肺癌患者治疗效果较好,可改善患者中医症候,具有较高的安全性。

秦望广场塔楼沉降后浇带提前封闭技术研究

研究目的:带超高层物业开发的大型地下综合体,为了不影响裙房和地下室提前投入使用,需要研究超高层建筑沉降后浇带提前封闭可行性,通过杭州富阳秦望广场通道工程实际项目,采用有限元整体建模分析,提出了残余沉降差计算方法,利用试桩静载试验P-S曲线确定了桩基线刚度参数,推导出沉降后浇带提前封闭楼层,通过实际监测数据,对理论计算结果进行对比验证。研究结论:(1)试桩线刚度与单桩承载力特征值比值在76~119之间,与传统经验值100倍单桩承载力特征值相比,试桩结果离散性较大;(2)塔楼总沉降量与楼层数关系不大,与桩基线刚度取值关系较大;(3)塔楼桩基采用相同线刚度,楼层数与总沉降量成正比;(4)塔楼沉降呈线性发展趋势,理论计算与监测数据基本一致,因成桩工艺控制不稳定,导致工程桩线刚度有离散性,理论计算沉降速率与监测相比均偏小,导致后浇带提前封闭楼层判断有误差;(5)本研究成果可为超高层建筑提前封闭沉降后浇带设计提供参考。

血小板/淋巴细胞比值对晚期结肠癌化疗患者1年内死亡的预测价值

目的探讨血小板/淋巴细胞比值(platelet to lymphocyte ratio,PLR)对晚期结肠癌化疗患者1年内死亡的预测价值。方法选取2021年3月至2023年3月在吉林市中心医院确诊的晚期结肠癌且接受化疗患者166例,随访1年,发生死亡72例为死亡组,存活94例为生存组。对比两组患者的临床病理学资料及PLR、癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原(carbohydrate antigen,CA)199、CA724及CA153水平。晚期结肠癌患者1年内发生死亡的影响因素采用多因素Logistic回归分析,受试者操作特征(receiver operating characteristic,ROC)曲线评价PLR对晚期结肠癌患者1年内发生死亡的预测价值。结果入组患者1年内死亡率为43.37%。与生存组比较,死亡组患者的性别、年龄、肿瘤淋巴结转移分类(tumor node metastasis classification,TNM)分期、所在结肠部位、化疗疗程数、癌症史差异无统计学意义(P>0.05),糖尿病史、吸烟史、PLR、CEA、CA199、CA724、CA153水平差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,PLR(OR=1.056,95%CI:1.000~1.116)、CEA(OR=20.122,95%CI:2.602~155.617)、CA199(OR=1.227,95%CI:1.069~1.408)、CA724(OR=1.864,95%CI:1.174~2.962)及CA153(OR=1.741,95%CI:1.108~2.737)水平是晚期结肠癌化疗患者1年内死亡的危险因素(P<0.05)。ROC曲线结果表明,PLR水平预测晚期结肠癌化疗患者1年内死亡的曲线下面积为0.79,敏感度及特异性分别为52.78%和95.74%。结论晚期结肠癌化疗1年内死亡患者,PLR水平明显高于生存患者,PLR水平在评估晚期结肠癌化疗1年内死亡时有一定的参考价值。

腹腔镜胃癌根治术中左侧入路法与托出式胰后入路法治疗进展期近端胃癌的疗效

目的研究腹腔镜胃癌根治术中左侧入路法与托出式胰后入路法在治疗进展期近端胃癌中的疗效。方法回顾性分析106例行腹腔镜胃癌根治术的进展期近端胃癌患者临床资料,根据患者手术入路方式,将其分为左侧入路组(n=46)与托出式胰后入路组(n=60),比较2组围术期相关指标,随访1年,绘制生存曲线,比较2组术后生存情况。结果托出式胰后入路组患者手术时间短于左侧入路组,术中出血量少于左侧入路组,淋巴结清扫个数多于左侧入路组,差异具有统计学意义(P<0.05);2组切口长度、引流管拔除时间、营养管时间、术后肛门首次排气时间、开始流质饮食时间、术后首次下床活动时间以及术后住院时间比较,差异均无统计学意义(P>0.05)。2组术后并发症发生率比较,差异无统计学意义(P>0.05)。托出胰后入路组与左侧入路组患者术后1年生存时间比较,差异无统计学意义(P>0.05)。结论与腹腔镜下左侧入路相比,托出式胰后入路手术操作更为简单,能有效缩短手术时间,控制术中出血量,但2种术式对进展期近端胃癌患者近期疗效及远期生存情况的影响相似。

中国高龄产妇产后抑郁检出率的Meta分析

背景随着我国经济的高速发展和现代人生育观念的转变,高龄产妇的数量正在逐年增加。相较于适龄产妇,高龄产妇更可能因自身、家庭、工作等原因产生抑郁症状。目的系统评价我国高龄产妇(分娩时年龄≥35岁)产后抑郁检出率,为早期预防和干预提供相关依据。方法在中国知网、万方数据知识服务平台、维普网、中国生物医学文献数据库和PubMed、Cochrane Library、Embase、Web of Science数据库中以主题词和自由词相结合的方式检索与中国高龄产妇产后抑郁检出率相关的文献,检索时限为数据库建库至2023年7月。文献筛选、资料提取和质量评价过程由2名研究员独立进行。使用Stata 16.0软件进行数据分析。结果共纳入21篇文献,样本量合计5163例。Meta分析结果显示,我国高龄产妇产后抑郁总检出率为20.0%(95%CI=17.4%~22.6%)。亚组分析结果显示,年龄<40岁高龄产妇产后抑郁检出率为19.5%(95%CI=13.8%~25.3%),≥40岁为40.3%(95%CI=11.4%~69.3%);文化程度高中以上为19.7%(95%CI=11.7%~27.7%),高中及以下为30.7%(95%CI=19.1%~42.3%);初产妇为21.1%(95%CI=14.4%~27.9%),经产妇为16.2%(95%CI=12.9%~19.6%);自然分娩为16.4%(95%CI=12.2%~20.6%),剖宫产为27.8%(95%CI=20.9%~34.8%);新生儿性别男性为20.7%(95%CI=15.6%~25.8%),女性为27.3%(95%CI=20.5%~34.0%);有妊娠并发症为38.7%(95%CI=22.6%~54.8%),无妊娠并发症为11.7%(95%CI=7.6%~15.8%);有不良孕产史为29.5%(95%CI=17.9%~41.1%),无不良孕产史为27.7%(95%CI=16.6%~38.8%);发表年份为2020年以前为18.0%(95%CI=16.5%~19.4%),发表年份为2020年及以后为19.5%(95%CI=18.0%~21.0%);调查地区北方为20.4%(95%CI=18.2%~22.6%),南方为18.2%(95%CI=17.0%~19.4%);爱丁堡产后抑郁量表(EPDS)评分≥13分为20.0%(95%CI=18.5%~21.5%),≥10分为16.9%(95%CI=15.2%~18.5%)。Egger’s检验(t=1.76,P=0.095)和Begg’s检验(Z=1.48,P=0.147)提示不存在明显发表偏倚。结论我国高龄产妇产后抑郁检出率较高(20.0%),其中年龄≥40岁、文化程度高中及以下、初产妇、剖宫产、新生儿性别为女性、有妊娠并发症、有不良孕产史、发表年份为2020年及以后、调查地区为北方、EPDS评分≥13分的高龄产妇产后抑郁检出率较高,应重视以上高龄产妇的心理状况,并制定相应的预防和干预措施。