Correlation between the neuroendocrine axis,microbial species,inflammatory response,and gastrointestinal symptoms in irritable bowel syndrome

BACKGROUND This study examines the complex relationships among the neuroendocrine axis,gut microbiome,inflammatory responses,and gastrointestinal symptoms in patients with irritable bowel syndrome(IBS).The findings provide new insights into the pathophysiology of IBS and suggest potential therapeutic targets for improving patient outcomes.AIM To investigate the interactions between the neuroendocrine axis,gut microbiome,inflammation,and gastrointestinal symptoms in patients with IBS.METHODS Patients diagnosed with IBS between January 2022 and January 2023 were selected for the study.Healthy individuals undergoing routine check-ups during the same period served as the control group.Data were collected on neuroendocrine hormone levels,gut microbiome profiles,inflammatory biomarkers,and gastrointestinal symptomatology to analyze their interrelations and their potential roles in IBS pathogenesis.RESULTS IBS patients exhibited significant dysregulation of the neuroendocrine axis,with altered levels of cortisol,serotonin,and neuropeptides compared to healthy controls.The gut microbiome of IBS patients showed reduced diversity and specific alterations in bacterial genera,including Bifidobacterium,Lactobacillus,and Faecalibacterium,which were associated with neuroendocrine disturbances.Additionally,elevated levels of inflammatory markers,such as C-reactive protein,interleukin-6,and tumor necrosis factor-α,were observed and correlated with the severity of gastrointestinal symptoms like abdominal pain,bloating,and altered bowel habits.CONCLUSION The findings suggest that targeting the neuroendocrine axis,gut microbiome,and inflammatory pathways may offer novel therapeutic strategies to alleviate symptoms and improve the quality of life in IBS patients.

Constitutive relationship of ionic polymer-metal composite and static response character of its cantilever setup to voltage

As a new ionic polymer-metal composite(IPMC) for artificial muscle,the mechanical performance parameters and the relationship between the deformation and the electrical parameters of the IPMC were studied. With the digital speckle correlation method,the constitutive relationship of the IPMC was confirmed. With non-contact photography measurement,a cantilever setup was designed to confirm the relationship between the deformation of the IPMC film and the applied voltage. The relationship curve of tip displacement of the IPMC cantilever setup vs the voltage was achieved. The results indicate that the IPMC is isotropic,its elastic modulus is 232 MPa and Poisson ratio is 0.163. The curve achieved from the test of the tip displacement of the IPMC cantilever setup shows that the tip displacement reaches the maximum when the stimulated voltage is 5 V. And the tip displacement descends largely when the frequency of the applied voltage is between 30 mHz and 100 mHz.

Development of Design Response Spectra Based on Various Attenuation Relationships at Specific Location

Peninsular Malaysia is located and lies in a low seismic region. Although Malaysia is not located in the active fault seismic area, it is closed to the Sumatran active seismic zones. Tall building are fIequently felt the tremor generated fTom Sumatran subduction and fault zones especially in the west cost of Peninsular Malaysia such as Johor Bahru, Kuala Lumpur and Penang. Existing design response spectra was developed based on attenuation relationship for each subduction and fault zone. In this study, the design response spectra were developed based on various attenuation relationships for selected location in Kuala Lumpur area, namely, Mutiara Damansara, Bandar Petaling Jaya and Bandar Puteri Puchong. The development of design response spectra based on various attenuation relationships is more reliable in selecting the appropriate attenuation relationship for the study area. Seven attenuations have been chosen and results show that Megawati et al. are the most appropriate attenuation relation for fault zone, where the predicted PGA （peak ground acceleration） is 0.0187 g which is the proposed PGA value for this study area. This study also found that most of soil in the study area can be categorized into SD （stiff soil） according to site classification in the NEHRP 2000 Provision/UBC 97. Bandar petaling Jaya was found to be highest AF （amplification factor） of 3.74 for stiff soil and Mutiara Damansara with AF of 2.67 for very dense soil or soft rock. The proposed design response spectra for each location were developed based on UBC 1997 （Uniform Building Code 1997）. The peak RSA （response spectrum acceleration） of 0.30 g for soil type SD for Bandar Petaling Jaya is the maximum level of acceleration on the soil surface with a period range of 0.10 to 0.52 seconds. All these values can be used for the seismic safety evaluation of existing structures and as a guideline in designing new structures to resist future earthquake, within the study area.

Sequence Thickness and its Response to Episodic Tectonic Evolution in Paleogene Qikou Sag, Bohaiwan Basin

The sequence stratigraphy framework of Paleogene of Qikou Sag has been built in this paper. The evolution law of episodic subsidence in Qikou Sag has been expounded, with the analysis of the characteristic of sequence thickness, as well as the study of consedimental tectonic activity, subsidence history, paleogeomorphology and the coupling relationship among them. The faults controlling action was the dominant mechanism during rifting stage I , as the depression was the dominant mechanism during rifting stage III, which embodies a process from intense disparity fault depression to integral subsidence. Meanwhile, under the control of regional faulting and later stage depression, subsidence rate centers and paleogeomorphic concave centers are always corresponding to the sequence thickness centers, and the changes of subsidence centers and paleogeomorphology concave centers are consistent with the migration of thickness centers, which presents the restriction, coupling and response among them and clarifies the law that tectonic activity controls the basin fill by means of controlling the subsidence rate and paleogeomorphology from contributing factor angle. On this basis, the dynamic evolution of the composite pattern of structure-subsidence-deposition in the fault controlling actic region during the three rifting stages and their petroleum geological significance has been discussed.

Stochastic response of an axially moving viscoelastic beam with fractional order constitutive relation and random excitations

A convenient and universal residue calculus method is proposed to study the stochastic response behaviors of an axially moving viscoelastic beam with random noise excitations and fractional order constitutive relationship, where the random excitation can be decomposed as a nonstationary stochastic process, Mittag-Leffler internal noise, and external stationary noise excitation. Then, based on the Laplace transform approach, we derived the mean value function, variance function and covariance function through the Green＇s function technique and the residue calculus method, and obtained theoretical results. In some special case of fractional order derivative α , the Monte Carlo approach and error function results were applied to check the effectiveness of the analytical results, and good agreement was found. Finally in a general-purpose case, we also confirmed the analytical conclusion via the direct Monte Carlo simulation.

Morphological Characteristics of Cambodia Mekong Delta and Tonle Sap Lake and Its Response to River-Lake Water Exchange Pattern

Tonle Sap Lake is the largest river-connected lake, buffer area and ecological zone of Mekong River, which plays a huge role in dispelling flood peak and compensating water, and the conservation of biological diversity. The river-lake relationship between Mekong River and Tonle Sap Lake is unique and has always been a major focus in the international community. The land terrain and under-water topography were used to analyze the morphological characteristics of Cambodia Mekong Delta and Tonle Sap Lake. Long series of hydrological data of river-lake controlling stations were used to analyze the water level variation characteristics and water volume exchange pattern between Mekong River and Tonle Sap Lake, and the response relationship to river-lake morphological characteristics were also researched. The results show that: Cambodia Mekong Delta and Tonle Sap Lake Area is low-lying and flat with gentle channel gradient and water surface gradient, making the relationship between water level and area (or volume) smooth. The channel storage capacity of Mekong River and Tonle Sap River is not enough compared to the inflow, so vast flooding plain is extremely prone to be inundated, making the flood relationships between the left and right banks become very complicated. Tonle Sap Lake is a seasonal freshwater lake with water flowing in and flowing out, and the timing and intensity of water exchange with Mekong River are closely related to the water flow resistance at the exit section of Tonle Sap Lake and the cross-sectional area of Tonle Sap River, which can be reflected by the river-lake water level difference and the water level of Tonle Sap River. Affected by the river-lake morphological characteristics, the water exchange intensity between Mekong River and Tonle Sap Lake is great. Tonle Sap Lake not only stores 14.4% of flood volume (39.7 billion m3) from the Mekong River every year, but also supplies 29.7% of dry water (69.4 billion m3) to the Mekong River. Influenced by the adjustment of the floodplain, the water level fluctuation of Mekong River and Tonle Sap Lake is slow, and the rising and droop rates of water level are positively correlated with the floodplain storage area. The research results will help to understand the relationship mechanism between Mekong River and Tonle Sap Lake and provide a scientific basis for the comprehensive governance of Cambodia Mekong Delta and Tonle Sap Lake Area.

Enterprise innovation, corporate social responsibility and their interactive relationship: A review

Under the new normal economic growth, lack of motivation, structural imbalances in the economy, the shortage of resources, resource utilization inefficiency, environmental damage and other issues have become increasingly prominent, enterprises as the carrier of economy is one of the root of the problem. Research on enterprise innovation and corporate social responsibility issues, it is conducive to the development of enterprise itself and the transformation of Chinese economy. This paper reviewed the research status of relationships between innovation and corporate social responsibility, through comb the aspects of the definitions and evolution of enterprise innovation and social responsibility, also include both the relationship and the new way(responsible innovation) of combination of them, we found the presence of index system is not perfect, and lack of in-depth comprehensive study and opportunities for future research is prospected.

Hormesis has emerged as a more common and fundamental dose-response model than the threshold or linear-no-threshold(LNT) models

在回顾传统的有阈和线性无阈的剂量-反应关系的基础上,分析此类该模型被毒理学领域认同的主要原因和其在预测低剂量效应中的缺陷,进而提出了高剂量接触呈现抑制效应,而低剂量却呈现促进或刺激作用这一全面的激效兴奋性剂量-反应关系,弥补了现有模型的不足,并充分论证这种激效性剂量-反应关系在不同种属、接触因素和生物学终点中的普遍性,并探讨了不同物质的激效兴奋作用的可能机制以及激效兴奋模型的三大优点,最后提出了激效模型谋求广泛接受的现实困难和发展趋势。

A review of the health effects and exposure-responsible relationship of diesel particulate matter for underground mines

The increasing use of diesel-powered equipment in confined spaces(underground mines) has the potential to over expose underground miners under the threat of diesel particulate matter(DPM). Miners in underground mines can be exposed to DPM concentrations far more than works in other industries. A great number of animal and epidemiological studies have shown that both short-term and long-term DPM exposure have adverse health effect. Based on reviews of related studies, especially some recent evidence, this paper investigated the long and short-term health effects based on animal studies and epidemiological studies. The exposure-response relationship studies were also explored and compared to the current DPM regulation or standards in some countries. This paper found that the DPM health effect studies specifically for miners are not sufficient to draw solid conclusions, and a recommendation limit of DPM concentration can be put in place for better protection of miners from DPM health risk. Current animal studies lack the use of species that have similar lung functions as human for understanding the cancer mode of action in human. And finally, the DPM health hazard will continue to be a challenging topic before the mode of action and reliable exposure-response relationship are established.

DOSE RESPONSE CURVE OF ^（60）Co FOR PREMATURE CONDENSED CHROMOSOME FRAGMENTS OF HUMAN LYMPHOCYTES

The dose-response curves obtained by premature condensed chromosome (PCC)and conventional cellular genetic methods can be represented by two linear equations. The ratiO of the slopes, Kpcc/KM,, is about 28. In comparison to the conventional method, the PCC method has many advantages; e,g. it is faster, simpler, more sensitive and accurate. Its significance in the study of radiation damage is also discussed.

Interaction Relationship Between Corporate Social Responsibility and Corporate Performance:Evidence from 201 Chinese Listed Companies and Preliminary Study of Its Underlying Mechanism

Corporations actively fulfilling corporate social responsibility(CSR)is of more significance to society's sustainable development nowadays.This research discusses the interaction between CSR and corporate performance and then adopts other mediation variables to explain the underlying mechanism.The empirical analyses are performed on a sample of 201 listed Chinese firms.The result shows that CSR has a weak negative impact on corporate perfbnnance while being positively influenced by corporate performance significantly.Further study finds the reason may be CSR requires financial support,but has little to do with increasing shareholder wealth.

Local Anomalies of the Load-Unload Response of the Geomagnetic Field to Solar Wind and Earthquakes in Southwest China

Many earthquakes occurred during the period 1994 -1996 in Sichuan and Yunnan Provinces, Southwest China. Taking the process of the initial main phase recovery phase of the magnetic storm as the process of load-unload response of the geomagnetic field to the solar wind, we have estimated and analyzed the distribution in time and space of the load-unload response ratio P(z) of the storm time disturbance daily variation of the vertical component Z of the geomagnetic field at ten stations in Southwest China. We found that the area with high ratio P(z) was just the area where moderately strong earthquakes would occur from 44 days to 15 months later. The relationship between the high ratio P(z) and weather disasters in both seismic and non-seismic areas is discussed briefly.

Wavelet-Based Response Computation for Base-Isolated Structure under Seismic Excitation

This paper presents a wavelet-based approach for estimating the response of the base-isolated structure under seismic ground motions. The seismic ground motion record is expressed as the multi-scale wavelet coefficients which presents the time frequency characteristics of the seismic excitation. The wavelet domain governing differential equation between the wavelet coefficients of the excitation and response is derived. Numerical study on a one-storey base isolated structure is performed. The result shows that the wavelet based response computation method is of high precision.

供应商企业社会责任信息披露与客户稳定性

稳定的供应链关系对于经济安全平稳运行以及高质量发展意义重大,本文基于供应链关系视角考察了供应商的企业社会责任信息披露对客户稳定性的影响及其作用机理。实证结果发现:供应商企业社会责任信息披露质量与客户稳定性显著正相关,并且该影响在自愿性披露和民营企业样本中更加明显。机制检验表明,供应商企业社会责任信息披露主要通过提升信息透明度及改善公司治理来增强客户稳定性。本文将企业社会责任信息披露的经济后果拓展至供应链关系上,研究结论对供应商企业如何维护客户稳定性促进企业高质量发展具有一定启示意义。

社会治理数字化的主体伦理冲突与调适

社会治理数字化是治理主体运用数字技术对社会治理进行结构重塑与流程再造的新型治理形态。在社会治理数字化进程中,只有多元治理主体之间形成地位平等、能力提升、责任明晰、情感融洽的伦理关系,才能把数字技术的工具理性与治理主体的价值理性有机融合并激发出来,提升社会治理的效能。在现实中,技术的负面效应、主体的不完善和社会适应性的滞后,造成了治理主体之间数据垄断与地位平等、技术依赖与能力提升、机械逻辑与情感融洽、责任模糊与责任明晰的伦理冲突。调适治理主体之间的伦理冲突需要构建“权力-能力-关系-制度”的四维协同体系,即通过平衡治理主体之间的数字权力、均衡治理主体之间的数字能力、重构治理主体之间的数字关系、完善治理主体之间的数字规范,再造数字治理主体之间的伦理关系,推动社会治理的现代化发展。

研究生导师基本素质与落实立德树人职责的关系探析——基于研究生感知视角

目的:探讨导师对立德树人重视程度及其基本素质与落实立德树人职责之间的关系。方法:选取各专业各年级的研究生进行问卷调查,采用Pearson相关系数对统计数据进行分析。结果:研究生导师对立德树人职责的重视程度与其基本素质与落实立德树人职责之间存在密切的正相关关系,各项指标表现出显著性差异。结论:应进一步增强导师的思政教育意识,加强师德师风建设,并提升导师的业务能力素质。

浮动基多机悬吊系统动力耦合响应分析

为了研究浮动基多机悬吊系统在不规则波作用下的动力耦合关系,首先利用动量定理和动量矩定理建立了浮动基机器人动力学模型,其次利用达朗贝尔原理建立了悬吊系统的动力学模型,并提出了系统动力学的耦合关系分析步骤;最后结合实例,仿真分析了浮动基多机器人协调悬吊系统在不同波高、不同波长比和不同起吊速度下动力耦合响应过程。结果表明,该系统的理论研究进行了补充和完善,同时也为浮动基多机悬吊系统在实际的吊运过程中,判断安全的吊运环境提供技术支撑。

慢性肾脏病患者钾摄入量与死亡率及肾脏病进展的剂量-反应Meta分析

目的系统评价慢性肾脏病(chronic kidney disease,CKD)患者的钾摄入量与死亡率及肾脏病进展的剂量-反应关系。方法计算机检索PubMed、The Cochrane Library、EMbase、Web of Science、CNKI、WanFang Data、VIP和CBM数据库,检索关于CKD患者钾摄入量与死亡率、肾脏病进展的研究,检索时限均从建库至2023年8月31日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用R 4.2软件进行Meta分析,采用限制性立方样条函数和广义最小二乘估计方法进行剂量-反应Meta分析。结果共纳入14项队列研究,包括53694例患者。线性Meta分析结果显示:钾摄入量与CKD患者死亡风险无显著相关(RR=0.875,95%CI:0.746~1.027,P=0.100)。剂量-反应分析结果显示:CKD患者钾摄入量与全因死亡率之间存在L型非线性关系(非线性检验P=0.010);钾摄入量与CKD进展无明显的非线性趋势(非线性检验P=0.226),线性趋势结果显示CKD患者钾摄入量每增加一个单位,CKD进展风险降低21.6%(RR=0.784,95%CI:0.625~0.983,P=0.031)。结论当前证据表明过低的钾摄入量不利于降低CKD患者的死亡与肾脏病进展的风险。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。

感知父母婚姻冲突、亲子关系与青少年心理危机的关系:认知灵活性的中介作用

本研究采用多项式回归和响应面分析技术综合考察感知父母婚姻冲突、亲子关系与青少年心理危机的关系,及认知灵活性在其间的中介作用。结果显示:(1)感知父母婚姻冲突和亲子关系的综合作用可以显著预测青少年的抑郁和非自杀性自伤行为。(2)当感知父母婚姻冲突和亲子关系一致时,相较低亲子关系−高感知父母婚姻冲突,高亲子关系−低感知父母婚姻冲突的个体具有更高的认知灵活性,进而降低了抑郁和非自杀性自伤行为的发生风险。(3)当感知父母婚姻冲突和亲子关系不一致时,相较低亲子关系−低感知父母婚姻冲突,高亲子关系−高感知父母婚姻冲突的个体具有更低的认知灵活性,从而增加了抑郁和非自杀性自伤行为的发生风险。

季节性河流生态环境复苏关键问题研究

全球有超过50%的河流为季节性河流,由于气候变化、极端天气与人类活动影响,这一比例仍在上升。2023年,水利部印发《母亲河复苏行动河湖名单(2022—2025年)》,79条河流中有52条为断流河流。较之一般河流,季节性河流干湿交替的水文节律孕育了其特有的生态水文非连续响应关系。长期以来,河流研究的重点多为常年流水河流,而忽视了季节性河流。针对常年流水河流的研究结论不能直接应用于季节性河流。基于大量文献调研,从季节性河流的内涵与基本特征、生态水文响应关系、健康评估、生态流量适应性调控等4个方面,对季节性河流进行总结分析。研究表明:当前季节性河流缺乏统一的定义和内涵,季节性河流自身应有的水文情势、生态系统过程缺乏深入研究,季节性河流指示生物的确定方法不统一,缺少普遍适用的季节性河流生态系统健康评价基准,缺乏针对季节性河流适宜水量阈值的优化调控方法。在季节性河流缺乏基础理论的情况下,厘清季节性河流的基本概念,科学确定其生态水文过程,形成生态系统健康评价基准,探索生态环境复苏的水量阈值优化调控方法,是解决制约季节性河流生态环境复苏关键问题的重要途径,也是亟需研究的重点方向。