Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects ...Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice model.MFGM was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body weight.Results demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(IL)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including IL-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula occludens-1.Furthermore,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A expressions.The increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain extent.In summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of GPRs.These findings suggest that MFGM may be useful as a promising functional ingredient against CMA.展开更多
BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation...BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation in the pathogenesis of AD is becoming more and more important.AIM To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in patients.METHODS A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November 2020.Collect cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other data.Multivariate logistic regression analysis was used to determine independent prog-nostic factors.the modified Rankin scale(mRS)was used to determine whether the prognosis was good.The correlation between drug treatment and prognostic mRS score was tested by the rank sum test.RESULTS Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD patients.Multivariate logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of AD.The number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T lymphocytes may have predictive value for the poor prognosis of AD.It is recommended that the proportion of T lymphocytes<55%is used as the cut-off threshold for predicting the poor prog-nosis of AD.The early and continuous drug treatment is associated with a good prognosis.展开更多
The global supply chain is based on the global distribution of materials,technology,capital,labor,and markets and thus cannot be altered by political motives.KEEPING a sound and stable global supply chain will benefit...The global supply chain is based on the global distribution of materials,technology,capital,labor,and markets and thus cannot be altered by political motives.KEEPING a sound and stable global supply chain will benefit not only China and America,but also the world at large.Janet Yellen,U.S.secretary of treasury,has realized the devastating consequences of decoupling U.S.economy from Chinese economy when she spoke at John Hopkins Institute on April 20,2023.Yellen said,“The United States will assert ourselves when our vital interests are at stake.But we do not seek to decouple our economy from China’s.A full separation of our economies would be disastrous for both countries.It would be destabilizing for the rest of the world.”展开更多
Owing to a series of impacts of the "9·11 terrorist attack," the accounting scandals of big companies, Iraq War and the SARS crisis in the past two years, the world economy that might have rebounded for...Owing to a series of impacts of the "9·11 terrorist attack," the accounting scandals of big companies, Iraq War and the SARS crisis in the past two years, the world economy that might have rebounded forcefully has been on a wavering process of slow recovery.展开更多
The Institute of Industrial Economics at the Chinese Academy of Social Sciences and China Business Journal jointly conducted an online survey on the thinking and research of China’s young economists on the country’s...The Institute of Industrial Economics at the Chinese Academy of Social Sciences and China Business Journal jointly conducted an online survey on the thinking and research of China’s young economists on the country’s economic issues. The survey lasted from June 17 to June 26,2009.展开更多
The year 1993 was the fifteenth of China’s reform and opening to the outside. Its economy sustained double digit growth for two years running. Last year, domestic GNP was RMB3,138 billion, a 13.4 percent increase com...The year 1993 was the fifteenth of China’s reform and opening to the outside. Its economy sustained double digit growth for two years running. Last year, domestic GNP was RMB3,138 billion, a 13.4 percent increase compared with the previous year’s 13.2 percent.展开更多
It was approved by the State Council in1984 to establish economic andtechnological development zones in 14coastal port cities to function as windows forthose cities to attract foreign investment,introduce advanced tec...It was approved by the State Council in1984 to establish economic andtechnological development zones in 14coastal port cities to function as windows forthose cities to attract foreign investment,introduce advanced technology andmanagement methods and expand the export-oriented economy. Since 1992, 18 otherdevelopment zones have been approved bythe Council, increasing the number of suchzones to 32.展开更多
This paper constructs the index system by means of quantitative analysis. We choose the coordination degree of Yunnan province from 2012 to 2015. The regional cultural and economic development in Yunnan's frontier...This paper constructs the index system by means of quantitative analysis. We choose the coordination degree of Yunnan province from 2012 to 2015. The regional cultural and economic development in Yunnan's frontier are analyzed so that we can provide the reference for the sustainable development of Yunnan's frontier and realize the coordinated development of culture in Yunnan's frontier and economic system in order. The results show that the culture and economy in Yunnan's frontier are coupled with formation of the coordinated development of culture and economy; economic development is the main reason to promote the coordinated development of culture and economy in Yunnan's frontier, and it contributes to the main force of improving the coordinated development of evolution types; the coordinated development degree of the overall level is low and still in the China's backward level.展开更多
1.This study is one of The Applied Economic Institutes Linkages Project(AERIL)which is funded by theCanadian International Development Agency(CIDA)and jiontly managed by The Conference Board of Canada(CBOC)and the Int...1.This study is one of The Applied Economic Institutes Linkages Project(AERIL)which is funded by theCanadian International Development Agency(CIDA)and jiontly managed by The Conference Board of Canada(CBOC)and the International Trade Research Institute in China.It is jointly implemented by the Institute ofEconomic Research of the Chinese State Planning Commission and the North—South Institute of Canada。展开更多
基金supported by the National Key Research and Development Program of China(Grant No.2019YFC1605000)National Natural Science Foundation of China(Grant No.31871806)the Beijing Livestock Industry Innovation Team(BAIC05-2023)。
文摘Milk fat globule membrane(MFGM),which contains abundant glycoproteins and phospholipids,exerts beneficial effects on intestinal health and immunomodulation.The aim of this study was to evaluate the protective effects and possible underlying mechanisms of MFGM on cow’s milk allergy(CMA)in aβ-lactoglobulin(BLG)-induced allergic mice model.MFGM was supplemented to allergic mice induced by BLG at a dose of 400 mg/kg body weight.Results demonstrated that MFGM alleviated food allergy symptoms,decreased serum levels of lipopolysaccharide,pro-inflammatory cytokines,immunoglobulin(Ig)E,Ig G1,and Th2 cytokines including interleukin(IL)-4,while increased serum levels of Th1 cytokines including interferon-γand regulatory T cells(Tregs)cytokines including IL-10 and transforming growth factor-β.MFGM modulated gut microbiota and enhanced intestinal barrier of BLG-allergic mice,as evidenced by decreased relative abundance of Desulfobacterota,Rikenellaceae,Lachnospiraceae,and Desulfovibrionaceae,while increased relative abundance of Bacteroidetes,Lactobacillaceae and Muribaculaceae,and enhanced expressions of tight junction proteins including Occludin,Claudin-1 and zonula occludens-1.Furthermore,MFGM increased fecal short-chain fatty acids(SCFAs)levels,which elevated G protein-coupled receptor(GPR)43 and GPR109A expressions.The increased expressions of GPR43 and GPR109A induced CD103+dendritic cells accumulation and promoted Tregs differentiation in mesenteric lymph node to a certain extent.In summary,MFGM alleviated CMA in a BLG-induced allergic mice model through enhancing intestinal barrier and promoting Tregs differentiation,which may be correlated with SCFAs-mediated activation of GPRs.These findings suggest that MFGM may be useful as a promising functional ingredient against CMA.
基金Supported by the National Natural Science Foundation of China,No.3206080019 and No.32060182Science and Technology Support Plan of Guizhou Province in China,No.[2020]4Y129Qiannan Prefecture Science and Technology Plan Project,No.[2022]01.
文摘BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation in the pathogenesis of AD is becoming more and more important.AIM To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in patients.METHODS A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November 2020.Collect cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other data.Multivariate logistic regression analysis was used to determine independent prog-nostic factors.the modified Rankin scale(mRS)was used to determine whether the prognosis was good.The correlation between drug treatment and prognostic mRS score was tested by the rank sum test.RESULTS Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD patients.Multivariate logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of AD.The number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T lymphocytes may have predictive value for the poor prognosis of AD.It is recommended that the proportion of T lymphocytes<55%is used as the cut-off threshold for predicting the poor prog-nosis of AD.The early and continuous drug treatment is associated with a good prognosis.
文摘The global supply chain is based on the global distribution of materials,technology,capital,labor,and markets and thus cannot be altered by political motives.KEEPING a sound and stable global supply chain will benefit not only China and America,but also the world at large.Janet Yellen,U.S.secretary of treasury,has realized the devastating consequences of decoupling U.S.economy from Chinese economy when she spoke at John Hopkins Institute on April 20,2023.Yellen said,“The United States will assert ourselves when our vital interests are at stake.But we do not seek to decouple our economy from China’s.A full separation of our economies would be disastrous for both countries.It would be destabilizing for the rest of the world.”
文摘Owing to a series of impacts of the "9·11 terrorist attack," the accounting scandals of big companies, Iraq War and the SARS crisis in the past two years, the world economy that might have rebounded forcefully has been on a wavering process of slow recovery.
文摘The Institute of Industrial Economics at the Chinese Academy of Social Sciences and China Business Journal jointly conducted an online survey on the thinking and research of China’s young economists on the country’s economic issues. The survey lasted from June 17 to June 26,2009.
文摘The year 1993 was the fifteenth of China’s reform and opening to the outside. Its economy sustained double digit growth for two years running. Last year, domestic GNP was RMB3,138 billion, a 13.4 percent increase compared with the previous year’s 13.2 percent.
文摘It was approved by the State Council in1984 to establish economic andtechnological development zones in 14coastal port cities to function as windows forthose cities to attract foreign investment,introduce advanced technology andmanagement methods and expand the export-oriented economy. Since 1992, 18 otherdevelopment zones have been approved bythe Council, increasing the number of suchzones to 32.
基金supported by General Project of China’s National Social Science Fund "The generation logic and governance paradigm of China’s frontier social problems" (Grant No. 16BZZ037)Planning Project of Philosophy and Social Science of Yunnan Province "Research on the refinement of Frontier’s social governance in the era of big data"
文摘This paper constructs the index system by means of quantitative analysis. We choose the coordination degree of Yunnan province from 2012 to 2015. The regional cultural and economic development in Yunnan's frontier are analyzed so that we can provide the reference for the sustainable development of Yunnan's frontier and realize the coordinated development of culture in Yunnan's frontier and economic system in order. The results show that the culture and economy in Yunnan's frontier are coupled with formation of the coordinated development of culture and economy; economic development is the main reason to promote the coordinated development of culture and economy in Yunnan's frontier, and it contributes to the main force of improving the coordinated development of evolution types; the coordinated development degree of the overall level is low and still in the China's backward level.
文摘1.This study is one of The Applied Economic Institutes Linkages Project(AERIL)which is funded by theCanadian International Development Agency(CIDA)and jiontly managed by The Conference Board of Canada(CBOC)and the International Trade Research Institute in China.It is jointly implemented by the Institute ofEconomic Research of the Chinese State Planning Commission and the North—South Institute of Canada。
