期刊文献+
共找到3,396篇文章
< 1 2 170 >
每页显示 20 50 100
Two-sample Mendelian randomization analysis of causal relationship between eczema and autoimmune diseases
1
作者 CHEN Chunli YAN Siyu +4 位作者 WAN Bangbei YU Yangyiyi ZENG Jinrong TAN Lina LU Jianyun 《中南大学学报(医学版)》 CAS CSCD 北大核心 2024年第6期932-942,共11页
Objective:The causal relationship between eczema and autoimmune diseases has not been previously reported.This study aims to evaluate the causal relationship between eczema and autoimmune diseases.Methods:The two‐sam... Objective:The causal relationship between eczema and autoimmune diseases has not been previously reported.This study aims to evaluate the causal relationship between eczema and autoimmune diseases.Methods:The two‐sample Mendelian randomization(MR)method was used to assess the causal effect of eczema on autoimmune diseases.Summary data from the Genome-Wide Association Study Catalog(GWAS)were obtained from the Integrative Epidemiology Unit(IEU)database.For eczema and autoimmune diseases,genetic instrument variants(GIVs)were identified according to the significant difference(P<5×10−8).Causal effect estimates were generated using the inverse‐variance weighted(IVW)method.MR Egger,maximum likelihood,MR-PRESSO,and MR-RAPS methods were used for alternative analyses.Sensitivity tests,including heterogeneity,horizontal pleiotropy,and leave-one-out analyses,were performed.Finally,reverse causality was assessed.Results:Genetic susceptibility to eczema was associated with an increased risk of Crohn’s disease(OR=1.444,95%CI 1.199 to 1.738,P<0.001)and ulcerative colitis(OR=1.002,95%CI 1.001 to 1.003,P=0.002).However,no causal relationship was found for the other 6 autoimmune diseases,including systemic lupus erythematosus(SLE)(OR=0.932,P=0.401),bullous pemphigoid(BP)(OR=1.191,P=0.642),vitiligo(OR=1.000,P=0.327),multiple sclerosis(MS)(OR=1.000,P=0.965),ankylosing spondylitis(AS)(OR=1.001,P=0.121),rheumatoid arthritis(RA)(OR=1.000,P=0.460).Additionally,no reverse causal relationship was found between autoimmune diseases and eczema.Conclusion:Eczema is associated with an increased risk of Crohn’s disease and ulcerative colitis.No causal relationship is found between eczema and SLE,MS,AS,RA,BP,or vitiligo. 展开更多
关键词 eczema atopic eczema autoimmune diseases Crohn’s disease ulcerative colitis Mendelian randomization
下载PDF
Efficacy of acupoint injection in the treatment of chronic eczema and its influence on peripheral blood T cells
2
作者 Hui-Hui Gan Gao Yang Ting-Ting Shen 《World Journal of Clinical Cases》 SCIE 2024年第17期3019-3026,共8页
BACKGROUND Chronic eczema significantly impacts daily life,social interactions,and quality of life;however,no curative treatment has been identified.AIM To determine the clinical efficacy of acupoint injection for chr... BACKGROUND Chronic eczema significantly impacts daily life,social interactions,and quality of life;however,no curative treatment has been identified.AIM To determine the clinical efficacy of acupoint injection for chronic eczema and its influence on peripheral blood T cells.METHODS Eighty patients with chronic eczema treated at our hospital between June 2022 and March 2023 were randomly assigned to a control group(n=40),which received conventional Western medicine treatment,or an observation group(n=40),which received routine Western medicine treatment plus acupoint injection of triamcinolone acetonide.Response and adverse reaction rates,as well as differences in the levels of serum cytokines IFN-γ,IL-2,IL-4,and IL-10 before and after treatment were investigated.RESULTS No difference in overall response rates were found between the observation and control groups(100%vs 90%,respectively;P>0.05);however,the observation group had a higher marked response rate than the control group(87.5%vs 52.5%;P<0.05).Both groups had decreased Eczema Area and Severity Index scores and increased pruritus after treatment(P<0.05),particularly in the observation group(P<0.05).The observation group had an adverse reaction rate of 2.5%(1/40),which did not differ significantly from that of the control group(P>0.05).The observation group exhibited higher post-treatment INF-γand IL-2 but lower IL-4 levels than the control group(P<0.05);however,no significant inter-group difference was observed in post-treatment IL-10 levels(P>0.05).CONCLUSION Acupoint injection of triamcinolone acetonide is safe and effective in treating chronic eczema.Its therapeutic mechanism is related to the regulation of peripheral blood T cell levels,inhibition of inflammatory reactions,and mitigation of immune imbalance. 展开更多
关键词 eczema Acupoint injection T cells Immune imbalance
下载PDF
Association of eczema with risk of pan-cancers:a two-sample Mendelian randomization study
3
作者 Xixi Zhao Xinyu He +7 位作者 Xiaoxiao Liu Shangyi Geng Yuchen Wang Yongze Dang Ruijuan Zhang Xinran Huang Wei Guo Hongbing Ma 《Oncology and Translational Medicine》 CAS 2024年第6期262-271,共10页
Background:Both eczema and tumor are associated with immune disorders.Although several investigations have observed the rela-tionship between eczema and certain cancers,evidence for causality is lacking.Methods:We con... Background:Both eczema and tumor are associated with immune disorders.Although several investigations have observed the rela-tionship between eczema and certain cancers,evidence for causality is lacking.Methods:We conducted a two-sample Mendelian randomization(MR)study to examine and explore the genetic association between eczema and pan-cancers.Upon satisfying the three core assumptions of MR,we analyzed the causality between eczema and 15 site-specific cancers utilizing an inverse variance weighted method.We verified the results through a series of sensitivity and reverse direction analyses.The exposure and outcome datasets were substituted from the FinnGen and genome-wide association studies catalog data-bases.A meta-analysis on primary and validation analyses was performed to combine the estimates of MR study.Results:Based on the MR analysis results,eczema was associated with an increased risk of lung cancer(odds ratio[OR]=1.0427,95%confidence interval[CI]=1.0082–1.0783,P=0.0148)and brain cancer(OR=1.0285,95%CI=1.0120–1.0452,P=0.0007)and de-creased risk of colorectal cancer(OR=0.9324,95%CI=0.8774–0.9909,P=0.0242)and malignant neoplasm of the kidney(OR=0.9323,95%CI=0.8834–0.9839,P=0.0108).The sensitivity analysis indicated that the results were stable and reliable,and the reverse MR analyses demonstrated no causation between the cancers of interest and eczema.Conclusions:Our results identified eczema as a genetic risk factor for lung and brain cancer and a protective factor for colorectal cancer and malignant neoplasm of the kidney.No connection was observed between eczema and other cancers.Further evidence from epide-miological and mechanistic studies is needed to elucidate these findings in detail. 展开更多
关键词 Causal relationship eczema Mendelian randomization Pan-cancer Genome-wide association study
下载PDF
Eczema Herpeticum in Pediatrics: A Case Report
4
作者 Ghizlane Kassal Soufiane El Moussaoui +1 位作者 Widad Lahmini Mounir Bourrous 《Open Journal of Pediatrics》 2024年第6期981-987,共7页
Background: One of the most common viral infections occurring in atopic dermatitis (AD) patients is eczema herpeticum (EH): herpes simplex virus (HSV) skin infection. Despite being comparatively uncommon affecting jus... Background: One of the most common viral infections occurring in atopic dermatitis (AD) patients is eczema herpeticum (EH): herpes simplex virus (HSV) skin infection. Despite being comparatively uncommon affecting just 3% of AD patients, EH can progress from a local disease to a potentially fatal systemic infection. Up till now, the pathophysiology of EH is mainly unclear. Case Report: We report the case of a 2-year-old boy who was well-vaccinated and had a history of untreated atopic dermatitis from infancy and presented to the emergency department with increasingly itchy diffuse lesions, red eyes, profuse tearing, chills and malaise. The diagnosis of EH with bilateral ocular involvement was highly suspected. The patient had received intravenous acyclovir with a notable clinical improvement and a complete remission at the two-week follow-up. 展开更多
关键词 Atopic Dermatitis eczema Herpeticum Herpes Simplex Virus ACYCLOVIR
下载PDF
Clinical Efficacy of Huanglian Ointment in the Treatment of Chronic Eczema
5
作者 Xintong Fu 《Journal of Clinical and Nursing Research》 2024年第6期382-386,共5页
Objective:To investigate and analyze the clinical efficacy of Huanglian ointment in the treatment of chronic eczema.Methods:114 cases of chronic eczema patients admitted to the Department of Dermatology of our hospita... Objective:To investigate and analyze the clinical efficacy of Huanglian ointment in the treatment of chronic eczema.Methods:114 cases of chronic eczema patients admitted to the Department of Dermatology of our hospital from January 2023 to January 2024 were selected as the study subjects.They were divided into a study group(n=57)and a reference group(n=57)using the double-blind method.The study group was treated with dialyzed Huanglian ointment,while the reference group was treated with conventional treatment.Symptom scores,inflammatory levels,treatment effects,and immune indexes of the two groups were similar before treatment.Results:After treatment,the symptom scores of the study group were significantly lower than those in the reference group(P<0.05).Besides,the interleukin-2(IL-2),tumor necrosis factor-a(TNF-a),interferon-(IFN-),and other inflammatory indicators of the study group were significantly better than those of the reference group(P<0.05).The total efficacy of treatment in the study group was significantly higher than that in the reference group(P<0.05).Furthermore,after treatment,the immunity indexes such as CD3+,CD4+,and CD8+of the study group were significantly better than those of the reference group,(P<0.05).Conclusion:Huanglian ointment is extremely effective for treating chronic eczema so this treatment program should be popularized. 展开更多
关键词 Huanglian ointment Chronic eczema TREATMENT
下载PDF
萆薢渗湿汤对急性湿疹小鼠模型的作用机制研究
6
作者 陈小娟 贾颖 《辽宁中医药大学学报》 CAS 2025年第1期36-39,共4页
目的探讨萆薢渗湿汤对急性湿疹小鼠模型的治疗效果及作用机制。方法选用SPF级KM雄性小鼠60只,适应性喂养7 d后随机分成6组,每组10只,采用涂抹2,4-二硝基氯苯丙酮溶液的方法进行造模,分为正常对照组、模型对照组、强的松阳性药物组[药物... 目的探讨萆薢渗湿汤对急性湿疹小鼠模型的治疗效果及作用机制。方法选用SPF级KM雄性小鼠60只,适应性喂养7 d后随机分成6组,每组10只,采用涂抹2,4-二硝基氯苯丙酮溶液的方法进行造模,分为正常对照组、模型对照组、强的松阳性药物组[药物剂量为10 mg/(kg·d),相当于临床剂量的10倍]、萆薢渗湿汤低、中、高剂量组(药物剂量分别为0.70、1.40、2.80 g/kg,相当于临床等效剂量的0.5、1、2倍)。模型激发后24 h,强的松阳性药物组,萆薢渗湿汤高、中、低剂量组小鼠每日分别通过灌胃给予相应药物0.1 mL/10 g,连续给药7 d,给予正常对照组和模型对照组纯化水,在此期间正常喂养。观察各组小鼠的一般情况、耳朵皮损的改善情况、脾脏指数并采用ELISA法检测各组小鼠体内肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-2(interleukin-2,IL-2)、白细胞介素-4(interleukin-4,IL-4)。结果与正常对照组比较,模型对照组小鼠右耳重量、厚度均显著增加(P<0.01,P<0.01),左耳厚度、重量变化不显著;与模型对照组比较,强的松阳性药物组与萆薢渗湿汤高中剂量组的右耳重量显著减轻(P<0.01),强的松阳性药物组和萆薢渗湿汤高剂量组的右耳厚度显著降低(P<0.01),强的松阳性药物组和萆薢渗湿汤各剂量组左耳重量、厚度变化均不显著。与正常对照组比较,模型对照组小鼠脾脏指数显著升高(P<0.01);与模型对照组比较,强的松阳性药物组与萆薢渗湿汤高剂量组脾脏指数显著降低(P<0.05,P<0.01)。与正常对照组比较,模型对照组小鼠血清中IL-2、IL-4、TNF-α含量均显著升高(P<0.01);与模型对照组比较,强的松阳性药物组和萆薢渗湿汤各剂量组小鼠血清中IL-2、IL-4、TNF-α含量显著下降(P<0.01)。结论萆薢渗湿汤可以治疗小鼠急性湿疹模型的皮肤炎症,其机制可能与降低小鼠血清中炎症因子L-2、IL-4、TNF-α的含量有关。 展开更多
关键词 萆薢渗湿汤 急性湿疹 抗炎 IL-2 IL-4 TNF-α
下载PDF
从“肝脾-玄府”论治小儿湿疹经验探析
7
作者 胡利梅 冷丽 +3 位作者 周体群 左金兰 陈晶晶 梁梦 《亚太传统医药》 2025年第1期83-86,共4页
小儿湿疹是儿科常见的过敏性炎症疾病,“肝常有余”“脾常不足”及“玄府失调”是导致小儿湿疹发生乃至缠绵难愈的重要病机。冷丽主任医师从协调“肝脾-玄府”功能入手,通过疏利肝脏、调和脾胃、畅达玄府治疗小儿湿疹,疗效明显。总结冷... 小儿湿疹是儿科常见的过敏性炎症疾病,“肝常有余”“脾常不足”及“玄府失调”是导致小儿湿疹发生乃至缠绵难愈的重要病机。冷丽主任医师从协调“肝脾-玄府”功能入手,通过疏利肝脏、调和脾胃、畅达玄府治疗小儿湿疹,疗效明显。总结冷丽主任医师治疗小儿湿疹的经验和思路,为小儿湿疹中医药治疗提供新的思路。 展开更多
关键词 小儿湿疹 肝脾失调 玄府 中医药 治疗
下载PDF
健脾除湿汤联合卤米松乳膏治疗慢性湿疹临床研究
8
作者 章昭敏 黄贤亮 《新中医》 2025年第1期86-90,共5页
目的:观察健脾除湿汤联合卤米松乳膏治疗慢性湿疹的疗效。方法:选取2021年10月—2023年12月湖州市第一人民医院收治的80例慢性湿疹患者,按随机数字表法分为观察组与对照组各40例。对照组予以卤米松乳膏治疗,观察组在对照组基础上联合健... 目的:观察健脾除湿汤联合卤米松乳膏治疗慢性湿疹的疗效。方法:选取2021年10月—2023年12月湖州市第一人民医院收治的80例慢性湿疹患者,按随机数字表法分为观察组与对照组各40例。对照组予以卤米松乳膏治疗,观察组在对照组基础上联合健脾除湿汤治疗。比较2组临床疗效及不良反应发生情况,比较2组治疗前后中医证候积分、湿疹面积和严重程度指数(EASI)、疼痛视觉模拟评分法(VAS)评分、白三烯B4(LTB4)、白三烯C4(LTC4)水平的变化。结果:观察组临床疗效总有效率为92.50%(37/40),对照组75.00%(30/40),2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候主症、次症积分均较治疗前下降(P<0.05),观察组中医证候主症、次症积分均低于对照组(P<0.05)。治疗后,2组EASI、VAS评分均较治疗前下降(P<0.05),观察组EASI、VAS评分均低于对照组(P<0.05)。治疗后,2组LTB4、LTC4水平均较治疗前下降(P<0.05),观察组LTB4、LTC4水平均低于对照组(P<0.05)。观察组不良反应发生率为20.00%(8/40),对照组为25.00%(10/40),2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:健脾除湿汤联合卤米松乳膏治疗慢性湿疹可有效抑制炎症反应,缓解湿疹严重程度及瘙痒程度,改善临床症状,疗效确切。 展开更多
关键词 慢性湿疹 健脾除湿汤 卤米松 中医证候积分 湿疹面积和严重程度指数
下载PDF
Study on effect of Traditional Chinese Medicine Jianpi Chushi decoction and ointment on chronic eczema 被引量:8
9
作者 Hui-Lei Wan Hui-Zhi Chen Xiu-Qin Shi 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2016年第9期897-900,共4页
Objective:To study the effects of Traditional Chinese Medicine Jianpi Chushi decoction and ointment on chronic eczema.Methods:DNCB acetone solution was used to sensitize the skin of back and ears of 36 rats in order t... Objective:To study the effects of Traditional Chinese Medicine Jianpi Chushi decoction and ointment on chronic eczema.Methods:DNCB acetone solution was used to sensitize the skin of back and ears of 36 rats in order to establish chronic eczema model.A total of 36 rats were divided into four groups of 9 randomly including oral medicine group,external inunctum group,combination therapy group,and model control group respectively.Besides,the blank group of 4 healthy rats were set.The oral medicine group was given Traditional Chinese Medicine Jianpi Chushi decoction [(Poria cocos,Chinese yam,Cortex dictamni,Zaocys dhumnade,Rhizoma atractylodis,Pericarpium citri reticulatae,Scutellaria baicalensis,Radix Sophorae Flavescentis,Raw Radix Paeoniae Alba,Licorice roots(Northwest Origin)] by gastric infusion(1.6 g/m L·5 m L/d); the external inunctum group was given Qingpeng ointment on the skin,the combination therapy group was given Jianpi Chushi decoction by gastric infusion and Qingpeng ointment combination therapy.The model control group was given normal saline(NS) of the same volume by gastric infusion and vaseline on skin.Continuous administration 15 d and stopped for 3 d.The thickness difference and weight difference of left and right ear of every group were measured and the degree of ear swelling were evaluated.The CD4^+ and CD8^+ content and the IL-2,IL-4 level of serum were detected,and the inflammatory cells counts of back skin were recorded.Results:After treatment,the degree of ear swelling of oral medicine group,external inunctum group and combination therapy group significant decreased compared with model control group(P<0.05).The CD4^+,CD8^+ cell content and IL-2 level of oral medicine group,external inunctum group,combination therapy group and model control group significant decreased compared with blank group,and IL-2 level and the inflammatory cells count increased.After 15 d of treatment,the CD4^+,CD8^+ cell content and IL-2 level of serum of oral medicine group,external inunctum group and combination therapy group raised and the IL-4 level and the inflammatory cells count had significant decreased compared with model control group,and the effect of combination therapy group was more obvious(P<0.05).Conclusions:Qral Jianpi Chushi decoction could treat chronic eczema effectively,and oral Chinese medicine combined with ointment could enhance and speed up the efficacy. 展开更多
关键词 CHRONIC eczema Rat Jianpi Chushi DECOCTION Qingpeng OINTMENT Combination THERAPY
下载PDF
Association between Fine Particulate Air Pollution and Outpatient Visits for Eczema in Beijing, China: A Time-series Analysis 被引量:7
10
作者 WANG Xiao Wen TIAN Yao Hua +6 位作者 CAO Ya Ying SONG Jing LI Man WU Yao WANG Meng Ying HUANG Zhe HU Yong Hua 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2019年第8期624-627,共4页
Eczema is a very common inflammatory skin disease characterized by patches of erythematous,itchy, cracked, and scaly skin.According to the 2010 Global Burden of Disease Study, the global prevalence of eczema is 3.33% ... Eczema is a very common inflammatory skin disease characterized by patches of erythematous,itchy, cracked, and scaly skin.According to the 2010 Global Burden of Disease Study, the global prevalence of eczema is 3.33% and the leading cause of skin condition-based disability-adjusted life years is eczema[1].The large health burden brought about by eczema suggests high direct medical costs and health care utilization[2].Thus, eczema prevention is of great importance in efforts to eliminate the public health burden of the disease. 展开更多
关键词 Fine PARTICULATE Air Pollution OUTPATIENT VISITS eczema BEIJING
下载PDF
Low-dose intralesional injection of 5-fluorouracil and triamcinolone reduces tissue resident memory T cells in chronic eczema 被引量:6
11
作者 Yun Wu Guo-Jiang Wang +6 位作者 Hui-Qiong He Hai-Hong Qin Wen-Tong Shen Yue Yu Xun Zhang Mao-Lin Zhou Jian-Biao Fei 《World Journal of Clinical Cases》 SCIE 2022年第1期166-176,共11页
BACKGROUND Tissue resident memory T(TRM)cells have been reported to play a significant role in the pathogenesis and relapse of chronic eczema.AIM To compare the efficacy and safety of the intralesional injection of 5-... BACKGROUND Tissue resident memory T(TRM)cells have been reported to play a significant role in the pathogenesis and relapse of chronic eczema.AIM To compare the efficacy and safety of the intralesional injection of 5-fluorouracil(5-FU)and triamcinolone(TA)with those associated with TA alone for the treatment of chronic eczema.METHODS A total of 168 patients were randomized to 5-FU+TA or TA groups and received a one-time intralesional injection of 5-FU+TA or TA only.Biopsies were collected before and 2 wk after treatment for evaluation of histopathological changes.All patients were followed up monthly for up to 1 year.RESULTS No serious adverse event was observed in either group.Although the mean atopic dermatitis severity index scores and effective rates were comparable between the two groups after 2 wk of treatment,the relapse rate was significantly lower in the 5-FU+TA group than in the TA group.Histological examination showed significantly fewer CD8^(+)and CD103^(+)T cells but not CD4^(+)T cells in the 5-FU+TA group.CONCLUSION One-time intralesional injection of 5-FU+TA is effective and safe for chronic eczema treatment and can further reduce the retention of T_(RM) cells in the lesional skin and the relapse rate of chronic eczema. 展开更多
关键词 Chronic eczema 5-FLUOROURACIL TRIAMCINOLONE Intralesional injection Tissue resident memory T cell
下载PDF
Research Progress of Cymbaria mongolica Maxim.in the Treatment of Chronic Eczema 被引量:3
12
作者 Gerile Jinbao +2 位作者 Wuyuntana Wulangerile Sarentuya 《Medicinal Plant》 CAS 2020年第3期21-23,共3页
Chronic eczema is a kind of skin disease which is difficult to treat.It is easy to occur repeatedly,and itching is intolerable during the attack,which seriously affects the daily life of patients.Through the review of... Chronic eczema is a kind of skin disease which is difficult to treat.It is easy to occur repeatedly,and itching is intolerable during the attack,which seriously affects the daily life of patients.Through the review of the treatment of chronic eczema with Mongolian medicine Cymbaria mongolica Maxim.,it has the advantages of improving the cure rate and the quality of life,and reducing the recurrence rate,and so on,which provides a scientific basis for the promotion and further research of traditional Mongolian medicine Cymbaria mongolica Maxim. 展开更多
关键词 Cymbaria mongolica Maxim. TREATMENT Chronic eczema PROGRESS
下载PDF
Atopic eczema treatment now and in the future:Targeting the skin barrier and key immune mechanisms in human skin 被引量:5
13
作者 David C Bell Sara J Brown 《World Journal of Dermatology》 2017年第3期42-51,共10页
The skin facilitates a number of key roles but its functioning can be impaired by disease. Atopic eczema is a chronic inflammatory disease where the skin barrier has become leaky, and inflammation occurs. It affects u... The skin facilitates a number of key roles but its functioning can be impaired by disease. Atopic eczema is a chronic inflammatory disease where the skin barrier has become leaky, and inflammation occurs. It affects up to 20% of children and 3% of adults worldwide, manifesting as red itchy patches of skin with varying severity. This review aims to investigate the leaky skin barrier and immune mechanisms from the perspective of potential novel treatments. The complexity of atopic eczema as a disease is what makes it difficult to treat. Genome-wide association studies have highlighted possible genetic variations associated with atopic eczema, however in some cases, individuals develop the disease without these genetic risk factors. Loss of function mutations in the filaggrin gene are one of these associations and this is plausible due to its key role in barrier function. The Th2 immune response is the link with regards to the immune mechanisms as atopic inflammation often occurs through increased levels of interleukin(IL)-4 and IL-13. Eczematous inflammation also creates susceptibility to colonisation and damage by bacteria such as Staphylococcus aureus. Potential novel treatments are becoming ever more specific, offering the hope of fewer side effects and better disease control. The best new treatments highlighted in this review target the immune response with human beta defensin 2, phosphodiesterase-4 inhibitors and monoclonal antibodies all showing promise. 展开更多
关键词 ATOPIC eczema Novel TREATMENT FILAGGRIN Skin barrier IMMUNE DYSFUNCTION
下载PDF
Shizhenqing granule stimulates the hypothalamic-pituitary-adrenal axis and reduces serum pro-inflammatory factors in a rat model with chronic eczema 被引量:1
14
作者 Jinrui Lu Xiaoyan Liu +1 位作者 Yao Xiao Shuran Ma 《Journal of Traditional Chinese Medical Sciences》 2020年第4期386-392,共7页
Objective:In this study,we examined the effects of Shizhenqing granule(SZQG)on hypothalamicpituitary-adrenal(HPA)axis and serum inflammatory factors in a rat model of chronic eczema,in order to explore the mechanism o... Objective:In this study,we examined the effects of Shizhenqing granule(SZQG)on hypothalamicpituitary-adrenal(HPA)axis and serum inflammatory factors in a rat model of chronic eczema,in order to explore the mechanism of action of SZQG in treatment of this disease.Methods:Sixty SpragueeDawley male rats were randomly divided into six groups(with 10 rats per group):blank group;model group;positive control group(prednisone);and the low-,medium-,and high-dose SZQG groups.Except for the blank group,rats in all other groups were treated with 2,4-dinitrochlorobenzene to induce chronic eczema.These rats were administered prednisone or SZQG for 7 consecutive days after successful establishment of the chronic eczema model,and samples were collected 12 h after the last administration.The degree of skin lesions and the changes in serum levels of corticotropin-releasing hormone(CRH),adrenocorticotropic hormone(ACTH),cortisol(CORT),interleukin(IL)-4,interferon(IFN)-g,IL-25,and IL-31 among the groups were compared.Results:SZQG effectively increased the levels of CRH,ACTH,and CORT,which decreased in the serum of rats with chronic eczema,stimulated the function of the HPA axis,and promoted the expression of glucocorticoids.SZQG reduced the serum levels of inflammatory factors including IL-4,IL-25 and IL-31,which were overexpressed in rats with chronic eczema,and increased those of anti-inflammatory factor IFN-g,thereby alleviating the inflammatory symptoms and itching,and ameliorating the clinical symptoms of chronic eczema.Conclusion:SZQG effectively alleviates skin lesions in the chronic eczema rat model by stimulating the function of the HPA axis. 展开更多
关键词 Shizhenqing granule Chronic eczema Hypothalamic-pituitary-adrenal axis Inflammatory factors
下载PDF
Use of specific acupuncture techniques in lingering nummular eczema:A case report 被引量:1
15
作者 Junxiang Wang Liangxiao Ma +1 位作者 Mohammad Reza Afshari Fard Ali Mohammadi 《Journal of Traditional Chinese Medical Sciences》 2021年第2期166-170,共5页
Background:Nummular eczema(NE)is an inflammatory skin disease characterized by pruritic coinshaped lesions and a long-lasting and easy-relapsing course,which severely decreases patients’quality of life.This case was ... Background:Nummular eczema(NE)is an inflammatory skin disease characterized by pruritic coinshaped lesions and a long-lasting and easy-relapsing course,which severely decreases patients’quality of life.This case was designed to observe the effects of specific acupuncture techniques on pruritic NE management.Case presentation:A 22-year-old female was first diagnosed with pruritic NE three years earlier.No allergies were found in the patch test;while emotional stress would trigger and aggravate the NE.External application of 0.1%tacrolimus failed to reverse this condition over a long period of treatment.Treatment&outcomes:An individualized acupuncture treatment protocol was identified.Half needling and encircling needling were applied at local eczematous lesions,with routine needling at meridian points,once per week,for 12 treatment sessions.All outcome measures,including the Eczema Area and Severity Index,Visual Analogue Scale score for pruritus,Self-Rating Anxiety Score,and Dermatology Quality Life Index,substantially improved over 6 months from pre-treatment to 3 months posttreatment.Conclusion:Acupuncture might be a promising non-pharmacological treatment method for patients with NE,especially for those with emotional stress.A randomized controlled trial with an adequate sample size and rigorous study design is required to verify the results of the study. 展开更多
关键词 Nummular eczema PRURITUS Anxiety Acupuncture techniques Half needling(Banci) Encircling needling(Weici)
下载PDF
FDA说2个eczema药物已被要求在标签上增注“该药长期使用有增加癌症的危险”的黑色警告
16
《中国新药杂志》 CAS CSCD 北大核心 2005年第7期911-911,共1页
这2个药物分别是Novartis的Elidel和Fujisawa的Protopic。这2个药物都是皮肤病药物,用于治疗造成瘙痒的干燥和皮鳞状症(scaly),FDA说该2个药物应在其他药物治疗eczema都无效时才可使用,对于免疫力低下的患者应禁用。Novartis和Fuji... 这2个药物分别是Novartis的Elidel和Fujisawa的Protopic。这2个药物都是皮肤病药物,用于治疗造成瘙痒的干燥和皮鳞状症(scaly),FDA说该2个药物应在其他药物治疗eczema都无效时才可使用,对于免疫力低下的患者应禁用。Novartis和Fujisawa曾被要求报告该2个药物的致癌情况,共有29例癌症报告被提出,其中大多数为皮肤癌和淋巴癌。FDA已要求进行10年期的人体临床试验来确定这些产品是否真与癌症的发生有关。Novartis和Fujisawa已同意进行该项临床试验。 展开更多
关键词 FDA eczema药物 长期用药 癌症 黑色警告 皮肤病
下载PDF
Zhang Zhili's Experience in Treatment of Eczema
17
作者 王萍 张芃 梁世伟 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2001年第3期193-197,共5页
Prof. Zhang Zhili has practised traditional medicine for more than 40 years, hence an accumulation of rich clinical experience. As we have been fortunately guided by him in medical practice we would like to share with... Prof. Zhang Zhili has practised traditional medicine for more than 40 years, hence an accumulation of rich clinical experience. As we have been fortunately guided by him in medical practice we would like to share with readers his experience in treatment of eczema as follows:Analyses of PathogenesisProf. Zhang holds that eczema is often caused by both endogenic and exogenic pathogens conflicting in skin and muscles: endogenic factors refer to improper diet or over-intake of irritative foods which may hurt the spleen and stomach, resulting in dysfunction of the spleen in transport and, as a result, leading to the accumulation of dampness-heat in the body; and exogenic factors refer to the invasion of exogenic pathogenic wind, dampness and heat. Moreover, a prolonged course of the illness may exhaust yin and blood and, consequently, turn pathogenic dryness factor into wind-evil. In the case of children, it is mostly caused by pathogenic heat stagnating in the gastrointestinal region due to weak congenital resistance and improper diet. 展开更多
关键词 ADULT CHILD Diagnosis Differential Drugs Chinese Herbal eczema FEMALE Humans Male Medicine Chinese Traditional
下载PDF
The Association of Autism Spectrum Disorders and Symptoms of Asthma, Allergic Rhinoconjunctivitis and Eczema among Japanese Children Aged 3 - 6 Years
18
作者 Daisuke Hori Hiromasa Tsujiguchi +16 位作者 Yasuhiro Kambayashi Toshio Hamagishi Masami Kitaoka Junko Mitoma Hiroki Asakura Fumihiko Suzuki Enoch Olando Anyenda Nguyen Thi Thu Thao Yohei Yamada Satoko Tamai Koichiro Hayashi Yuri Hibino Aki Shibata Takiko Sagara Shinichiro Sasahara Ichiyo Matsuzaki Hiroyuki Nakamura 《Health》 2017年第8期1235-1250,共16页
There is insufficient epidemiological evidence on the relationship between autism spectrum disorder (ASD) and allergic diseases. We performed a cross-sectional survey to elucidate the associations between them using v... There is insufficient epidemiological evidence on the relationship between autism spectrum disorder (ASD) and allergic diseases. We performed a cross-sectional survey to elucidate the associations between them using validated screening tools. The participants were children aged 3 - 6 years attending kindergarten or nursery school in Shika Town, Japan (n = 417;valid response rate = 80.4%). Autism spectrum features were scored on the Social Communication Questionnaire (SCQ). Allergic symptoms (asthma, allergic rhinoconjunctivitis, and eczema) were determined according to the criteria of the International Study of Asthma and Allergies in Childhood. A total of 15 children (4.5%) had an SCQ score of 11 points or higher. The prevalence of symptoms was 14.7% for asthma, and 5.3% for allergic rhinoconjunctivitis, and 11.4% for eczema. Logistic regression indicated that symptoms of eczema were significantly associated with SCQ scores of 11 points or higher [odds ratio (OR), 4.38;95% confidence interval (CI), 1.41 - 13.59]. The association persisted after adjustment for age, sex, and BMI (OR, 3.84;95% CI, 1.20 - 12.24). Moreover, asthmatic symptoms were significantly associated with male sex (OR, 2.09;95% CI, 1.12 - 3.92) and overweight status (OR, 2.45;95% CI, 1.03 - 5.83). This suggests that higher SCQ scores, which imply more autism spectrum features, are associated with higher prevalence of eczema symptoms. While no causal relationships can be made, ASD might be associated with eczema. 展开更多
关键词 ASTHMA AUTISM Spectrum DISORDER eczema Early Screening Social Communication QUESTIONNAIRE
下载PDF
Fifty-six Cases of Stubborn Eczema Treated by Oral Administration and Topical Application of Herbal Medicine
19
作者 罗维丹 WuChenglin +1 位作者 邬成霖 董敏华 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2001年第4期259-260,共2页
Eczema is a kind of very common dermatopathy. The cases with a long course of illness and hard to be cured are termed as stubborn eczema. We have obtained good results in its treatment since 1995 with the Chu Shi Tan... Eczema is a kind of very common dermatopathy. The cases with a long course of illness and hard to be cured are termed as stubborn eczema. We have obtained good results in its treatment since 1995 with the Chu Shi Tang (除湿汤Dampness-Clearing Decoction) for oral intake and the Fu Fang Ku Shen Xi Ye (复方苦参洗液) for topical application. The following is a clinical report for treating 56 patients with stubborn eczema. 展开更多
关键词 Administration Oral Administration Topical ADOLESCENT Adult Aged CHILD Child Preschool Drugs Chinese Herbal eczema Female Humans Male Middle Aged
下载PDF
Study on the clinical correlation between serum total IgE level and peripheral blood eosinophil count in patients with eczema
20
作者 Meng-Ge Zhang Yue-Xuan Gao +3 位作者 Meng Tan Zhi-Min Wu Wen-Yu Wang Xing-Wu Duan 《Journal of Hainan Medical University》 2022年第13期32-36,共5页
Objective:To explore the correlation between the expression of serum total IgE level and peripheral blood EOS count in patients with eczema and the severity of clinical eczema.Methods:The EASI and pruritus VAS score w... Objective:To explore the correlation between the expression of serum total IgE level and peripheral blood EOS count in patients with eczema and the severity of clinical eczema.Methods:The EASI and pruritus VAS score were used to evaluate the disease severity of 100 patients with eczema.According to the EASI score,patients with eczema were divided into three groups:mild(<7 points)、moderate(7-15 points)and severe(>15 points).At the same time,the serum total IgE level and peripheral blood EOS count were tested before and after the 4-week Chinese medicine treatment.Results:The serum total IgE level of 42%of eczema patients increased,and the peripheral blood EOS count increased in 26%.In the three groups of mild,moderate,and severe,as the severity of eczema increased,the level of serum total IgE and peripheral blood EOS count continued to increase,and the positive rate increased significantly(all P<0.05).In terms of correlation analysis,the study showed that in patients with eczema total IgE level and EASI score(r=0.421,P<0.01),EOS count and EASI score(r=0.326,P<0.01),EOS count and pruritus VAS score(r=0.529,P<0.01)all show relatively weak positive correlation;and a high proportion of patients had the same changes in IgE and EOS after treatment(82%of IgE is consistent with EASI,76%of EOS is consistent with EASI).Conclusion:This study shows that the total IgE level and EOS count of patients with eczema are positively correlated with the severity of eczema,but at the same time this correlation is relatively limited.In clinical practice,it is necessary to combine the dynamic changes of the individual's own indicators in order to diagnose,comprehensively treat and evaluate eczema.Provide greater reference value in other aspects. 展开更多
关键词 eczema IGE EOS SEVERITY CORRELATION
下载PDF
上一页 1 2 170 下一页 到第
使用帮助 返回顶部