Observation on Therapeutic Effects of Electroacupuncture on Polycystic Ovary Syndrome of Kidney Deficiency and Phlegm Dampness Type and Oxidative Stress Level

Objective:To observe the clinical effect of electroacupuncture on improving polycystic ovary syndrome(PCOS)of kidney deficiency and phlegm dampness type and serum oxidative stress level.Methods:There were 68 patients with polycystic ovary syndrome were randomly divided into observation group(34 cases)and the control group(34 cases),The observation group was treated by electroacupuncture,while the control group was treated by placebo electroacupuncture.Combined with the evaluation of menstrual cycle,menstrual color,quality,quantity and TCM symptom integral index,the difference of curative effect between the two groups was observed,and the levels of peripheral blood,sex hormones,insulin resistance and oxidative stress were detected before and after treatment for 3 months.Results:The total effective rate in the observation group was better than that in the control group(P<0.01);After intervention,serum LH,FSH,E_(2) and LH/FSH in the observation group were significantly different from those before intervention.The D values of serum LH,FSH,LH/FSH and E_(2) before and after intervention were significantly different between the two groups(P<0.01);Comparing the level of androgen,the serum A4 and T in the observation group were significantly different from those before intervention(P<0.01);After intervention,there was a significant difference in serum A4 and T between the two groups(P<0.01),and there was a significant difference in D value between the two groups before and after intervention;There was a difference in insulin resistance in the observation group before and after intervention(P<0.05),and there was a significant difference in D value between the two groups before and after intervention(P<0.01);After the intervention,the serum SOD,MDA,ROS in the observation group were significantly different from those before the intervention;After intervention,the results of serum SOD and ROS in the observation group were significantly different from those in the control group;There was no significant difference in serum MDA results.There were significant differences in SOD,MDA,ROS between the two groups before and after intervention.Conclusion:Electroacupuncture can improve oxidative stress injury,insulin resistance and hyperandrogenism in PCOS patients.

Efficacy of the method of tonifying Qi,resolving phlegm and eliminating stasis in thetreatment of AECOPD:A meta analysis

Objective:To systematically evaluate the efficacy and safety of the method of tonifying qi,resolving phlegm and eliminating stasis in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods:Search the China Knowledge Network(CNKI),VIP Chinese Science and Technology Journal Database(VIP),Wanfang Data Knowledge Service Platform,China Biomedical Literature Database(CBM),PubMed,Embase,Cochrane Library,and select the databases that meet the requirements for tonifying qi,resolving phlegm and eliminating stasis.The stasis method in the treatment of AECOPD was included in the standard literature,and RevMan 5.4 software was used for statistical analysis.Results:A total of 10 articles were included,with a total of 854 patients,435 in the treatment group and 419 in the control group.Systematic analysis shows that the method of tonifying qi,resolving phlegm and eliminating stasis combined with conventional Western medicine treatment of AECOPD is significantly different in total clinical effective rate than conventional Western medicine treatment alone[OR=3.98,95%CI(2.23,7.11),P<0.00001];In terms of lung function,FEV1/FVC[MD=6.08,95%CI(5.01,7.15),P<0.00001],FEV1[MD=0.07,95%CI(0.01,0.13),P=0.02],FEV1%[MD=4.56,95%CI(3.09,6.02),P<0.00001]is significantly higher than the control group;arterial oxygen partial pressure(PaO_(2))[MD=18.47,95%CI(16.77,20.16),P<0.00001]Significant improvement compared to the control group;arterial partial pressure of carbon dioxide(PaCO_(2))[MD=-7.48,95%CI(-8.7,-6.26),P<0.00001]was significantly lower than the control group.Conclusion:The current evidence shows that the method of tonifying qi,resolving phlegm and eliminating stasis combined with conventional Western medicine treatment of chronic obstructive pulmonary disease in acute exacerbations can improve clinical efficacy and improve the quality of life of patients.

Clinical Analysis of Dispelling Wind,Eliminating Lung and Relieving Cough Combined with Western Medicine in the Treatment of Cough Variant Asthma in Children

Objective:This study mainly explores the clinical effect of dispelling wind,eliminating lung and relieving cough combined with western medicine in the treatment of cough variant asthma.Methods:80 children with cough variant asthma accepted by our hospital from January 2018 to December 2020 were randomly selected for the study and divided into two groups.One group was the reference group(40 cases)treated with procaterol hydrochloride tablets and montelukast sodium,and the other group was the research group(40 cases)・The method of eliminating wind,eliminating lung and relieving cough was combined with procaterol hydrochloride tablets and montelukast sodium to observe and compare the curative effects of the two groups.Results:There was no significant difference in TCM symptom score and eosinophil(EOS)count between the two groups before treatment(P>0.05);After treatment,the TCM symptom scores of coughs,pharyngeal itching,expectoration,nasal congestion and nasal itching in the research group were lower than those in the reference group,and the EOS count was lower than that in the reference group(P<0.05);The effective rate of research group was higher than that of reference group(P<0.05).Conclusions:For children with cough variant asthma,Qufeng Sufei cough relieving method combined with procaterol hydrochloride and montelukast sodium can improve children's symptoms and reduce eosinophil count.

Setting up the Goal of Eliminating Outbreaks of Blue-green Alga, Innovating the Idea of Controlling the Taihu Lake, and Ensuring the Safety of Water Supply in the Taihu Lake

Since the water supply crisis in the Taihu Lake on May 29,2007,the control of the Taihu Lake has achieved remarkable results,and the eutrophication has been greatly reduced.Existing problems are as follows:outbreaks of blue-green alga still appear seriously every year,and there is no goal to eliminate outbreaks of blue-green alga;the load into the lake greatly exceeds the environmental capacity;reed wetlands are greatly reduced;there is still the possibility of a water supply crisis;the research of eliminating outbreak of blue-green alga is weak.In this paper,the experience of controlling the Taihu Lake is summarized,and the ultimate goals of eliminating eutrophication and outbreaks of blue-green alga and restoring wetlands and biodiversity are proposed.Control measures are proposed,such as deepening the promotion of the lake chief system,establishing the lake chief system in an all-round way,and increasing applied scientific and technological efforts and capital investment.The necessity and possibility of further controlling the Taihu Lake to eliminate outbreaks of blue-green alga should be recognized.Relying on controlling eutrophication alone cannot eliminate outbreaks of blue-green alga.The point that phosphorus control is the key to eliminate outbreaks of blue-green alga is not suitable for the Taihu Lake.The integration ideas of"three types"of technologies should be innovated.The first one is"double reduction and double increase"measures to eliminate eutrophication,of which"double reduction"is to reduce external point sources and non-point sources and internal blue-green alga in sediment;for external sources,the treatment standard of sewage plants should be paid special attention to.The second one is"double algae removal"measures to salvage blue-green alga,suppresses and kills algae.The blue-green alga on the surface,middle and bottom of water should be thoroughly salvaged and eliminated from various water areas.The third one is"double restoration"measures to restore wetlands and biodiversity.The area of wetlands should be restored to the area from the 1960s to the 1970s before outbreaks of blue-green alga,and vegetation coverage reaches 25%-30%.The Taihu Lake is controlled in different waters to ensure water supply safety in water sources.Five suggestions are proposed,such as revising the"Overall Plan for the Comprehensive Treatment of Water Environment in the Taihu Lake Basin"again,incorporating the goal of eliminating outbreaks of blue-green alga in the plan,setting up this research topic,greatly improving sewage treatment standards in local legislation.

健脾祛痰法治疗血脂异常研究概况

血脂异常在我国普遍存在,中医药干预血脂异常越来越得到人们的重视。中医学认为脾主运化水谷精微,脂质亦需要脾的运化功能布散周身。脾气虚则脾失健运,清气不升,浊阴独留,生湿生痰;痰湿进一步阻碍气机,影响脾胃运化,使脾虚更甚,加重脂浊,浸润血脉。近年来健脾祛痰法被越来越多地应用于血脂异常的防治中,且在临床中收到不错的疗效。

2013-2020年广西重点种鸡场禽白血病净化效果分析

按照检测-淘汰-分群-再检测-再淘汰的原则,建立“生物安全+病原监测+淘汰”模式对2013—2020年广西11家重点种鸡场的种公鸡、种母鸡、育成鸡和雏鸡采集精液、蛋清、泄殖腔拭子、胎粪等样品进行禽白血病病原检测;公鸡和母鸡同时采集血浆蛋白进行禽白血病病毒(ALV)分离。通过多方式联合净化禽白血病,ALV阳性率逐年下降,净化效果非常显著。其中公鸡精液中ALV阳性率由2013年的7.45%下降到2020年的0.14%,母鸡蛋清样本ALV阳性率由2013年12.32%下降到2020年0.23%,雏鸡胎粪ALV阳性率由2018年3.60%下降到2020年0.47%。公鸡血浆蛋白病毒检出率由2013年的3.46%下降到2020年的0.78%,母鸡血浆蛋白病毒检出率由2013年的2.22%下降到2020年的0.20%。可以看出ALV净化效果非常显著,说明所建立的禽白血病净化方法在广西行之有效。

微波辐照对小米印度谷螟卵灭除效果及品质影响的研究

[目的]印度谷螟(Plodia interpunctella)在小米中繁殖能力很强,对小米的破坏性很大,主要使用的化学药剂熏蒸防治方法易引起环境污染、药剂残留、印度谷螟的抗药性增强等一系列的问题。微波技术可用于防治粮食虫害且绿色环保。本研究旨在获得微波辐照对小米印度谷螟卵灭除效果及品质影响的研究。[方法]采用微波160、320、480、640和800 W的功率和5、10、15、20、25和30 s的时间辐照小米,通过测量小米0、3、5、8、10 cm深度的印度谷螟卵的存活率和小米温度,观测微波辐照在小米不同深度的灭卵效果和微波在小米中的传播规律。同时测量微波辐照后小米的黏滞特性、色度和含水率,观测微波辐照对小米品质的影响。[结果]相同功率和时间的微波辐照小米,深度越小处印度谷螟卵存活率越低,灭卵效果越好。160W30s和320W15s低强度微波直接辐照印度谷螟卵,卵的外部形态基本保持不变,无法灭卵;采用800W15s、640W20s、480W25s微波辐照能有效消灭小米0 cm(平铺)处卵;800W20s、640W25s、480W30s辐照能有效消灭小米3 cm深度处卵;800W30s高强度微波辐照后,小米5 cm深度卵的存活率为25%,8、10 cm深处卵的存活率仍相对较高,灭卵效果不佳。相同功率和时间的微波辐照小米,深度越大处小米内部温度越小,且小米内部温度随深度以指数规律衰减。640W30s微波辐照后小米峰值粘度和衰减值升高,480W25s、800W25s和800W30s微波辐照后小米的糊化温度升高;除800W30s高强度处理外,微波辐照对小米色度无明显影响;微波辐照后小米含水率降低,为小米储藏创造了更好的条件。640W30s微波辐照提升了小米的食用品质,而800W25s和800W30s高强度辐照降低小米品质。[结论]小米深度是影响微波辐照灭卵效果的重要因素,微波辐照灭卵小米深度不宜超过3 cm。采用640W30s微波辐照厚度3 cm内的小米,既能有效灭卵又能提升小米的品质。本研究为微波技术防治小米储藏虫害,减少经济损失提供科学依据。

香菇糖蛋白对大鼠铅中毒的改善作用

目的:通过优化提取工艺获得具有促排铅功能的香菇糖蛋白,探讨其对醋酸铅诱导铅中毒大鼠的防治效果。方法:利用热水浸提去除蛋白以及层析技术获得香菇糖蛋白纯品,利用红外光谱分析、单糖组成、N端氨基酸及内部氨基酸序列分析技术鉴定了香菇糖蛋白的分子特性。将63只雄性SD大鼠随机分为9组,即空白对照组、模型组、阳性对照组、香菇糖蛋白处理组(4、8、160 mg/kg)和香菇子实体处理组(4、12、36 g/kg),通过腹腔注射醋酸铅制备大鼠铅中毒模型,连续给药30 d,观察大鼠的外观表现,检测体重变化、血液和脏器中的铅含量以及生化指标。结果:提纯的香菇糖蛋白(LEPP)经过单糖组成分析发现其是由葡萄糖、甘露糖、半乳糖、葡萄糖醛酸、木糖、岩藻糖、核糖、半乳糖醛酸、阿拉伯糖、鼠李糖组成,氨基酸序列分析发现其N端序列为MPEQVVVADA,说明香菇糖蛋白具有多糖和蛋白的成分。动物实验表明,香菇糖蛋白能够促进铅中毒大鼠的体重增长,显著降低血液和肝脏中铅的含量(P<0.05),具有排除铅在肝脏中的沉积作用,显著提高血清中超氧化物歧化酶(Superoxide Dismutase,SOD)和过氧化氢酶(Catalase,CAT)的活性(P<0.05),降低丙二醛(Malondialdehyde,MDA)的含量(P<0.05),提高机体的抗氧化能力,同时香菇糖蛋白还可以降低血液中谷草转氨酶(Glutamic Oxaloacetic Transaminase,AST)和谷丙转氨酶(Glutamic-Pyruvic Transaminase,ALT)的水平,具有保护肝脏的作用。结论:香菇糖蛋白可以排除体内的重金属铅,有效地改善大鼠的铅中毒症状。

补肾化痰通脉法治疗颈动脉粥样硬化不稳定斑块临床观察

目的 观察补肾化痰通脉法干预颈动脉粥样硬化不稳定斑块的临床疗效。方法 选择2020年12月—2021年12月太仓市中医医院收治的78例明确诊断颈动脉不稳定斑块患者为研究对象,采用随机数字表法将其分成对照组和试验组,各39例。其中对照组予西药干预;试验组在对照组的基础上加入补肾化痰通脉颗粒。观察每组颈动脉粥样硬化不稳性斑块的变化,同时检测血脂指标水平以及评定中医证候积分并进行对比分析。结果 两组颈动脉内中膜厚度和最大斑块大小明显改善,但两组间的最大斑块面积差异无统计学意义(P>0.05);两组血脂水平均改善,且试验组优于对照组(P<0.05);两组中医证候积分均降低,且试验组明显优于对照组(P<0.05)。结论 补肾化痰通脉法可能通过改善患者颈动脉内中膜厚度、血脂水平,控制颈动脉粥样硬化病变的进展。

绿色信贷政策与污染型僵尸企业治理:淘汰与转型的双重效应

以2007年绿色信贷政策出台为事件构造了准自然实验,基于中国工业企业数据库,采用双重差分法考察了绿色信贷政策对污染型僵尸企业的淘汰效应与转型效应及其影响机制。实证结果发现,政策显著增加了污染型僵尸企业的退出概率,且对于存续的污染型僵尸企业生产率提升具有显著的促进作用。绿色信贷政策淘汰效应的作用机制,来自融资可得性降低和融资成本增加导致的银行信贷资源配置合理化的影响;绿色信贷政策转型效应的作用机制,来自政策强化外部监督引致的代理成本下降。异质性分析发现,绿色信贷政策的淘汰效应和转型效应在环境规制强度较高、市场化水平较高的地区以及劳动力密集较低行业更显著,且淘汰效应在非国有企业更显著,转型效应在国有企业更显著。将绿色信贷政策与解决僵尸企业难题的有效结合,加快转变经济发展方式,对如何缓解信贷资源错配,加快推进僵尸企业治理提出相应的政策建议。

化痰通络颗粒治疗不同中医证型稳定型心绞痛的疗效观察

目的:探讨化痰通络颗粒治疗不同中医证型稳定型心绞痛(SAP)的疗效差异。方法:纳入219例瘀证SAP患者,并根据中医证型分为气虚血瘀组53例、痰瘀互结组63例、气滞血瘀组56例、痰浊闭阻组47例,另纳入50例瘀证SAP患者为对照组。所有患者均接受常规治疗,除对照组外,其余患者均在常规治疗基础上予化痰通络颗粒治疗,连续治疗4周。观察治疗前后中医证候疗效、心绞痛情况、心功能、脂代谢、凝血功能。结果:治疗后,气虚血瘀组、痰瘀互结组、气滞血瘀组、痰浊闭阻组患者疗效均优于对照组(P<0.05),且痰瘀互结组和痰浊闭阻组患者疗效均优于气虚血瘀组和气滞血瘀组(P<0.05)。治疗后,5组患者心绞痛症状积分均低于治疗前(P<0.05),且气虚血瘀组、痰瘀互结组、气滞血瘀组、痰浊闭阻组患者心绞痛症状积分均低于对照组(P<0.05),痰瘀互结组、痰浊闭阻组患者心绞痛症状积分均低于气虚血瘀组和气滞血瘀组(P<0.05)。治疗后,5组患者左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)均低于治疗前,射血分数(EF)、每搏输出量(SV)均高于治疗前(P<0.05),且痰瘀互结组、痰浊闭阻组患者LVEDD、LVESD均低于对照组,EF、SV均高于对照组(P<0.05)。治疗前痰浊闭阻组、痰瘀互结组患者总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)水平均高于气虚血瘀组、气滞血瘀组、对照组;治疗后,5组患者TC、TG、LDL均低于治疗前,HDL均高于治疗前(P<0.05)。治疗后,5组患者纤维蛋白原(FIB)、凝血酶时间(TT)均低于治疗前,活化部分凝血活酶时间(APTT)均高于治疗前,且痰瘀互结组、痰浊闭阻组患者FIB、TT水平均低于气虚血瘀组、气滞血瘀组和对照组(P<0.05)。结论:化痰通络颗粒治疗不同中医证型的稳定型心绞痛均有一定效果,联合西医治疗应用优于单独西医治疗,且其更适用于痰瘀互结证和痰浊闭阻证两种证型。

浅析前胡之推陈致新功用

前胡味苦、辛,性微寒,归肺经,《神农本草经》《本草经集注》等均记载其有推陈致新功效,可祛除在表之水饮,解在表之邪气,从而达到“推陈”之功,且其味甘可健中焦,补益胃气,故在祛除病理产物的同时还具有补益之功。柴胡、前胡均能疗伤寒寒热,发表散风,推陈致新,清里散结,而前胡更偏于除里之痰饮水气,散表之风邪,其与半夏相配能制痰饮痞结,降逆化浊;与黄芩相配可泻厥阴伏火;与桂枝相配能散表之风邪;与生姜相配意在温胃化饮。前胡之推陈致新功用既体现在气机层面,可理气、散气,对不同程度的气机瘀滞、气机凝结等均有效;又表现在活血通脉方面,在理气的基础上,通行血脉,活血化瘀。散气、活血均是“推陈”的体现,“陈”包括机体的病理产物如痰浊、水饮、瘀血、滞气、燥矢等,推出体内陈旧之代谢废物,促使新生之物产生,从而使机体达到气血通畅、五脏安和的状态。

陈博来基于“肾为生痰之本”辨治肾虚痰阻型腰痛

肾主水,为先天之本,对于体内津液的运行输布具有重要作用,且肾与水腑膀胱互为表里,通过冲脉与“水谷之海”的胃有经络上的联系,故肾在痰的生成中起着关键作用。陈博来教授认为,肾虚痰阻型腰痛为本虚标实之证,“痰阻”为其标,“肾虚”为其本,临床以腰骶钝痛、痛处固定、腰部僵硬、肢体麻木或偏枯为主要特点,兼见腰膝酸软、喜按喜揉等表现。肾虚痰阻型腰痛的治疗可基于“肾为生痰之本”,以补肾祛痰为法,拟定理痰汤(主要组成药物为芡实、半夏、黑芝麻、柏子仁、白芍、陈皮、茯苓等)为基础方,针对不同兼症辅以健脾、宣肺等药进行加减治疗。其辨治思路可为临床中医治疗腰痛提供参考。

从“痰湿内蕴”论治冠状动脉粥样硬化性心脏病

摘冠状动脉粥样硬化性心脏病(简称冠心病)是由冠状动脉粥样硬化引起血管狭窄,心肌缺血缺氧的临床常见综合征。痰湿内蕴是冠心病早期较为常见的重要病机,临床常见胸闷、心痛、肢体困乏、头重如裹、眩晕、恶心、脘腹痞闷、脉滑等表现。古代医家很早就对痰湿之邪与胸闷、心痛之间的关系有了深刻的认知,并各有阐释。痰湿之邪不仅作为重要的病理因素引起冠心病的发病、发展,更是作为独立的病理产物影响着本病的预后与转归,痰湿内蕴作为本病的重要病机贯穿疾病发生发展的始终,并且作为独立的病理因素引起痰气阻滞、血脉瘀阻、痰火酿毒、痰湿困脾等复杂兼证,按照中医辨证论治的基本原则,其具体治法则以燥湿化痰为要,根据其兼证的不同分别施以理气、活血、解毒、健脾等法辅之。临床诊疗案例显示,以燥湿化痰为法治疗冠心病疗效确切,在减轻患者胸闷、胸痛等不适的同时,使痰湿引起的头昏体重、乏力等症状有了明显的改善。文章梳理“痰湿内蕴”理论的起源、发展与完善,剖析“痰湿内蕴”这一重要病机在冠心病的发病、转归中的重要意义,总结燥湿化痰类药物在冠心病治疗中的相关研究与应用,以期为中医中药防治冠心病的临床应用提供更可靠的理论依据。

医院丙肝微消除模式的建立与应用成效

目的建立医院丙肝微消除模式并分析其在丙肝防治工作中的应用成效。方法以广西贵港市某三甲医院为例,通过部门分工、协调合作、能力建设多方面构建丙肝微消除模式,分析项目实施前(2021年)、项目实施后(2022年)两组抗-HCV筛查率、HCV RNA检测率、DAA治疗率、丙肝治愈人数的变化。结果2022年与2021年相比,抗-HCV筛查率由78.8%上升到81.2%,HCV RNA检测率由75.1%上升到97.8%,DAA治疗率由19.4%上升到57.3%,差异均具有统计学意义(P<0.05);丙肝治愈人数由61人上升到231人,成效明显。结论在医院建立丙肝微消除模式可显著提高抗-HCV筛查率、HCV RNA检测率、DAA治疗率,促进更多丙肝患者的治愈,有助于加快中国丙肝消除战略的进程,值得推广应用。

10%烟嘧磺隆OF防除玉米田间杂草的研究

[目的]研究10%烟嘧磺隆OF防除我国玉米(Zea mays)主产区田间杂草的效果。[方法]以新型环境友好型的新制剂10%烟嘧磺隆OF为供试药剂,于2009年在我国具有代表性的4个玉米主产区进行玉米田除草药效试验。[结果]10%烟嘧磺隆OF对玉米田1年生杂草具有良好的防除效果且对玉米生长安全,推荐使用剂量375～525 ml/hm2。[结论]该研究为10%烟嘧磺隆OF进一步推广应用提供参考。

皖产桐桔梗祛痰、平喘、止咳、抗炎有效部位筛选

目的:揭示皖产桐桔梗发挥祛痰、平喘、止咳、抗炎活性的有效部位。方法:采用回流提取法和大孔吸附树脂技术制备桐桔梗不同提取分离部位;采用小鼠酚红祛痰模型筛选桐桔梗祛痰有效部位;采用磷酸组胺联合氯化乙酰胆碱致小鼠哮喘模型筛选桐桔梗平喘有效部位;采用浓氨水喷雾致小鼠咳嗽模型筛选桐桔梗止咳有效部位;采用二甲苯致小鼠耳廓肿胀炎性反应模型筛选桐桔梗抗炎有效部位。结果:桐桔梗乙醇提取物、20%乙醇洗脱部位、70%乙醇洗脱部位均显示出不同程度的祛痰、平喘、止咳、抗炎作用,其中桐桔梗70%乙醇洗脱部位的活性最强,且呈量效关系。桐桔梗70%乙醇洗脱部位可显著增加小鼠气管酚红排泄量(P<0.001),显著延长磷酸组胺联合氯化乙酰胆碱致哮喘小鼠的引喘潜伏期并减少小鼠抽搐跌倒只数(P<0.001),明显延长浓氨水引咳小鼠的咳嗽潜伏期(P<0.001)并改善其肺部组织损伤,显著降低浓氨水引咳小鼠的咳嗽次数及其血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、IL-6的水平(P<0.001),显著降低二甲苯致耳廓肿胀小鼠的耳廓肿胀度及其血清中TNF-α、IL-1β、IL-6的水平(P<0.01,P<0.001)。结论:70%乙醇洗脱部位是桐桔梗发挥祛痰、平喘、止咳、抗炎作用的主要活性部位,为阐明桐桔梗药效物质基础及作用机制提供数据支撑。

毛静远教授治疗心肌桥致难治性心绞痛经验

心肌桥导致的难治性心绞痛常给患者带来沉重的躯体和精神负担,中医药治疗能够进一步改善症状,提高生活质量。现总结毛静远教授治疗心肌桥致难治性心绞痛经验,毛教授认为该病病机以血瘀为始动环节,因实致虚,本虚以阴虚为主,血瘀、痰热为标,治疗应注重养阴,兼用活血、化痰、清热,同时须注意顾护调理,避免心衰等并发症的发生。

不同产地半夏主要药理作用分析

[目的]比较不同产地半夏主要药理作用,为半夏的质量评价和临床用药提供试验依据。[方法]分别对国内6个主产区(湖北天门、江苏南通、河南唐河、四川蓬溪、河北安国、贵州赫章)半夏进行主要药效研究,采用气管酚红排泌法、浓氨水引咳法、冰醋酸致小鼠扭体、二甲苯致小鼠耳肿胀试验方法建立痰液分泌模型、咳嗽模型、镇痛模型及炎症模型,探讨不同产地半夏的祛痰、镇咳、镇痛及抗炎作用的差异。[结果]在止咳祛痰作用方面,贵州赫章、江苏南通、四川蓬溪3个产区半夏能够明显增加小鼠气管酚红排泌量,显著减少小鼠咳嗽次数及延长咳嗽潜伏期(P<0.01);在镇痛抗炎作用方面,四川蓬溪、湖北天门、河南唐河3个产区半夏均能够明显延长疼痛潜伏期及减少扭体次数,显著降低小鼠耳肿胀度(P<0.01);贵州赫章、河北安国产半夏镇痛抗炎作用次之,江苏南通产半夏镇痛抗炎作用弱于其他产地。[结论]6个产区半夏均有不同程度的祛痰、镇咳、镇痛、抗炎作用,其中贵州赫章、江苏南通、四川蓬溪3个产区半夏在止咳祛痰作用明显优于湖北天门、河南唐河、河北安国;在镇痛抗炎作用方面,四川蓬溪、湖北天门所产半夏强于其他产地。

通络平喘方治疗儿童咳嗽变异性哮喘的临床应用研究

[目的]观察通络平喘方治疗咳嗽变异性哮喘(cough variant asthma,CVA)的疗效及作用机制。[方法]将72例CVA患儿随机分为2组,试验组和对照组各36例。试验组予通络平喘方口服,对照组予氨溴特罗+孟鲁司特钠口服,均治疗2周,比较患者用药前后症状积分、外周血嗜酸性粒细胞(eosinophils,EOS)、血清总免疫球蛋白E(immunoglobulin E,IgE)、白细胞介素-4(interleukin-4,IL-4)、干扰素-γ(interferon-γ,IFN-γ)的变化。[结果]用药后两组患儿的症状积分较前均有改善(P<0.01),试验组明显优于对照组(P<0.01,P<0.05);试验组总有效率为94.44%,明显优于对照组80.56%(P<0.05);试验组的起效时间明显短于对照组(P<0.05)。与本组用药前比较,两组患儿EOS、IgE、IL-4水平均有所降低(P<0.01);IFN-γ水平有所升高(P<0.01),两组间比较差异无统计学意义(P>0.05)。随访3个月,试验组复发率为15%,对照组复发率为33%,差异有统计学意义(P<0.01)。[结论]通络平喘方可有效治疗CVA,可明显改善患儿的咳嗽及相关症状,降低CVA的复发率,作用机制与降低炎症因子水平有关。