Exercise has long been known for its active role in improving physical fitness and sustaining health.Regular moderate-intensity exercise improves all aspects of human health and is widely accepted as a preventative an...Exercise has long been known for its active role in improving physical fitness and sustaining health.Regular moderate-intensity exercise improves all aspects of human health and is widely accepted as a preventative and therapeutic strategy for various diseases.It is well-documented that exercise maintains and restores homeostasis at the organismal,tissue,cellular,and molecular levels to stimulate positive physiological adaptations that consequently protect against various pathological conditions.Here we mainly summarize how moderate-intensity exercise affects the major hallmarks of health,including the integrity of barriers,containment of local perturbations,recycling and turnover,integration of circuitries,rhythmic oscillations,homeostatic resilience,hormetic regulation,as well as repair and regeneration.Furthermore,we summarize the current understanding of the mechanisms responsible for beneficial adaptations in response to exercise.This review aimed at providing a comprehensive summary of the vital biological mechanisms through which moderate-intensity exercise maintains health and opens a window for its application in other health interventions.We hope that continuing investigation in this field will further increase our understanding of the processes involved in the positive role of moderate-intensity exercise and thus get us closer to the identification of new therapeutics that improve quality of life.展开更多
To study the effects of a chocolate bar supplementation before exercise on improving recovery of physiological and metabolic changes induced by exercise, 16 male students aged 18-20 years voluntarily served as subject...To study the effects of a chocolate bar supplementation before exercise on improving recovery of physiological and metabolic changes induced by exercise, 16 male students aged 18-20 years voluntarily served as subjects. A crossover design was employed. Each subject took part in two trials and ran an hour on a treadmill with the intensity of keeping heart rate at 148-150 min for each trial. Results showed that plasma glucose levels of subjects increased significantly (5.42±0.83 mmol/L) at 15 min after ingestion of a chocolate bar and maintained in moderate high levels (4.92 ±0.57 mmol/L) until 30 min after an hour's running while the glucose levels were low and dropped to under normal ranges (3.84 ± 0.31 mmol/L) at 30 min after exercise as they were with a supplement of placebo. Results of plasma FFA, blood lactate and plasma urea nitrogen levels and RPE all indicated that chocolate bar supplementation before exercise benefits to create the necessary prerequisite for exercise and recovery展开更多
Objective To determine the effect of the phosphodiesterase-5 inhibitor sildenafil compared with placebo on exercise capacity and clinical status in HFPEF. Design Multicenter, double-blind, placebo-controlled, paralle...Objective To determine the effect of the phosphodiesterase-5 inhibitor sildenafil compared with placebo on exercise capacity and clinical status in HFPEF. Design Multicenter, double-blind, placebo-controlled, parallel-group, randomized clinical trial of 216 sta- ble outpatients with HF, ejection fraction ≥ 50%, elevated N-terminal brain-type natriuretic peptide or elevat- ed invasively measured filling pressures, and reduced exercise capacity. Participants were randomized from October 2008 through February 2012 at 26 centers in North America. Follow-up was through August 30, 2012.展开更多
基金Among these,patents were licensed to Bayer(WO2014020041-A1 and WO2014020043-A1)Bristol-Myers Squibb(WO2008057863-A1)+4 种基金Osasuna Therapeutics(WO2019057742A1)Pharmamar(WO2022049270A1 and WO2022048775-A1)Raptor Pharmaceuticals(EP2664326-A1)Samsara Therapeutics(GB202017553D0)Therafast Bio(EP3684471A1).The other authors declare that they have no competing interests.
文摘Exercise has long been known for its active role in improving physical fitness and sustaining health.Regular moderate-intensity exercise improves all aspects of human health and is widely accepted as a preventative and therapeutic strategy for various diseases.It is well-documented that exercise maintains and restores homeostasis at the organismal,tissue,cellular,and molecular levels to stimulate positive physiological adaptations that consequently protect against various pathological conditions.Here we mainly summarize how moderate-intensity exercise affects the major hallmarks of health,including the integrity of barriers,containment of local perturbations,recycling and turnover,integration of circuitries,rhythmic oscillations,homeostatic resilience,hormetic regulation,as well as repair and regeneration.Furthermore,we summarize the current understanding of the mechanisms responsible for beneficial adaptations in response to exercise.This review aimed at providing a comprehensive summary of the vital biological mechanisms through which moderate-intensity exercise maintains health and opens a window for its application in other health interventions.We hope that continuing investigation in this field will further increase our understanding of the processes involved in the positive role of moderate-intensity exercise and thus get us closer to the identification of new therapeutics that improve quality of life.
文摘To study the effects of a chocolate bar supplementation before exercise on improving recovery of physiological and metabolic changes induced by exercise, 16 male students aged 18-20 years voluntarily served as subjects. A crossover design was employed. Each subject took part in two trials and ran an hour on a treadmill with the intensity of keeping heart rate at 148-150 min for each trial. Results showed that plasma glucose levels of subjects increased significantly (5.42±0.83 mmol/L) at 15 min after ingestion of a chocolate bar and maintained in moderate high levels (4.92 ±0.57 mmol/L) until 30 min after an hour's running while the glucose levels were low and dropped to under normal ranges (3.84 ± 0.31 mmol/L) at 30 min after exercise as they were with a supplement of placebo. Results of plasma FFA, blood lactate and plasma urea nitrogen levels and RPE all indicated that chocolate bar supplementation before exercise benefits to create the necessary prerequisite for exercise and recovery
文摘Objective To determine the effect of the phosphodiesterase-5 inhibitor sildenafil compared with placebo on exercise capacity and clinical status in HFPEF. Design Multicenter, double-blind, placebo-controlled, parallel-group, randomized clinical trial of 216 sta- ble outpatients with HF, ejection fraction ≥ 50%, elevated N-terminal brain-type natriuretic peptide or elevat- ed invasively measured filling pressures, and reduced exercise capacity. Participants were randomized from October 2008 through February 2012 at 26 centers in North America. Follow-up was through August 30, 2012.
