Efficacy ofβ2-adrenergic receptor agonist combined with corticosteroid in the treatment of children with cough variant asthma

BACKGROUND Cough variant asthma(CVA)is one of the most common respiratory diseases in children,which has a serious impact on the quality of life and daily activities of children.For severe CVA,immunomodulatory drugs are needed.AIM To evaluate the efficacy of salmeterol combined with budesonide in the treatment of pediatric CVA.METHODS 130 children with CVA from January 2020 to December 2022 were prospectively selected and randomly divided into an observation group(salmeterol combined with budesonide)and a control group(budesonide combined with a placebo).Compare the clinical efficacy of two groups before and after intervention.The evaluation parameters include cough frequency score,nocturnal cough arousal,and lung function indicators.Serum inflammatory markers,immune function markers and airway anatomical indicators were also measured.RESULTS After the intervention,the total effective rate of the observation group was significantly higher than that of the control group,and the cough frequency score and the night cough wake rate of the observation group were lower than that of the control group,with a statistically significant difference.In addition,the changes of lung function indicators,serum markers and immune function markers in the observation group were better than those in the control group.CONCLUSION The clinical efficacy of salmeterol combined with Budesonide in the treatment of CVA is better than that of Budesonide alone.

Editor's Choice—Meta analysis of acupuncture efficacy for the treatment of nervous system diseases

Meta analysis of randomized, controlled, clinical studies of acupuncture for the treatment of nervous system diseases has demonstrated that acupuncture effectively treats optic atrophy and depression. However, the quality of selected studies is low and evidence is inadequate. Therefore,

Analysis of surgical indication and efficacy in hypertensive intracerebral hemorrhage

Objective To analyze the clinical data of patients who suffered from hypertensive intra cerebral hemorrhage (HICH) in West China Hospital of Sichuan University from 2006 to 2009,to evaluate the efficacy and prognosis of surgical treatment and conservative treatment in HICH, to investigate the surgical and

Clinical efficacy of the method of Liangxuesanyu stasis on patients with severe pneumonia based on the theory of "Yure"

Objective:To explore the clinical effect of the method of Liangxuesanyu stasis on the patients with severe pneumonia and its mechanism.Methods:From March 2018 to October 2019,60 patients who met the diagnosis criteria of severe pneumonia were selected from the Department of critical medicine,Affiliated Hospital of Nanjing University of traditional Chinese medicine.They were divided into 30 Chinese medicine groups and 30 control groups according to the random number table method.Patients in both groups were given conventional Western medicine treatment such as anti-infection,phlegm elimination,nutritional support,and respiratory support.Patients in the Chinese medicine group were added Liangxuesanyu Granules(shuiniujiao 20g,zhidahuang 10g,taoren 10g,shengdi 20g,mudanpi 10g,chishao 15g,danshen 20g),Wash with warm water to 200ml,and take 100ml orally or nasally each morning and evening.The course of treatment is 14 days.The differences in respiratory function,inflammatory response,and mortality at 28 days were compared between the two groups of patients before and on the 7th and 14th days after treatment.Results:The oxygenation index(PO2/FiO2)of the Chinese medicine group was significantly higher than that of the control group at the 7th day after treatment(P<0.01).The tracheal intubation rate,Murray score,WBC,TNF-α,and PCT were all lower than those of the control group.(P<0.05);On the 14th day after treatment,the oxygenation index(PO2/FiO2)of the Chinese medicine group was higher than the control group(P<0.05),the TNF-αwas lower than the control group(P<0.05),and the Murray score was significantly lower than the control group(P<0.01);The mechanical ventilation time of the Chinese medicine group was lower than that of the control group(P<0.05),and the length of hospital stay and 28-day mortality were not significantly different from those of the control group(P>0.05).Conclusion:The intervention of Liangxuesanyu method in the treatment of severe pneumonia can effectively reduce the inflammatory response of patients,improve the oxygenation level and reduce the time of mechanical ventilation.

Clinical Study on Effect of Osteoking (恒古骨伤愈合剂) in Preventing Postoperational Deep Venous Thrombosis in Patients with Intertrochanteric Fracture

Objective： To evaluate the effect of Osteoking （恒古骨伤愈合剂） in preventing postoperational deep venous thrombosis （DVT） in patients with intertrochanteric fracture （ITF）. Methods： With prospective and randomized controlled clinical design adopted, 62 patients with ITF after operation were assigned into 2 groups, the tested group and the control group, Osteoking （25 ml every other day） and Sanchidansheng tablets （三七丹参片, 3 tablets thrice a day） were given orally to them respectively for 10 days. Difference of round length of thighs and shanks between two sides were measured on the 10th day and Doppler ultrasonic examination on the fractured leg was carried out. Results： The occurrence rate of DVT in the tested goup was 9.4%, which was lower than that in the control group （30.0%, P〈0.05）. All the difference of round lengths, either that of the thigh or the shank, was less in the tested group than that in the control group, showing statistical significance （P〈0.05）. Conclusion： Osteoking has a satisfactory effect in preventing postoperational DVT in patients with ITF.

Efficacy and safety analysis of the combination of cladribine,cytarabine,granulocyte colony stimulating factor( CLAG ) regime in patients with refractory or relapsed acute myeloid leukemia

Objective To analyze efficacy and safety of CLAG regimen in patients with refractory or relapsed acute myeloid leukemia(AML).Methods Efficacy and adverse events of patients with refractory or relapsed AML who were treated with one course of CLAG from April 1st,2014 through December 9th,2015 in our hospital were retrospectively reviewed.Results Thirty-three