Objective:To observe the clinical effect and protection of vascular endothelium of Zhixin-kang Capsule (ZXKC) in middle-aged and old people with unstable effort angina and hyperlipidemia. Methods: Sixty-five patients ...Objective:To observe the clinical effect and protection of vascular endothelium of Zhixin-kang Capsule (ZXKC) in middle-aged and old people with unstable effort angina and hyperlipidemia. Methods: Sixty-five patients with unstable effort angina were randomly divided into ZXKC group (34 cases) and control group (31 cases). Conventional western medical therapy was given to both groups, with ZXKC group receiving additional ZXKC treatment. Data of 20 healthy persons were taken as normal group. Forty-eight patients with hyperlipidemia were divided into ZXKC group treated with ZXKC (31 cases) and control group treated with Yixintong (17 cases). The changes of clinical symptoms and laboratory indexes in all the patients were observed before and after treatment. Results: In patients with unstable effort angina, the efficacy of treatment of ZXKC, the withdrawal rate of nitroglycerin, the relieving of symptoms, the improvement of the electrocardiogram, the counts of circulating endothelial cells, the content of platelet P-selectin, the content of plasma endothelin (ET), the activity of superoxide dismutase (SOD) and the activity of malonyldialdehyde (MDA) were all better than those in the control group. In patients with hyperlipidemia, there was no significant difference in lipids reduction between ZXKC group and the control group. In both groups, the total cholesterol (TC), triglyceride (TG), low density lipo-protein-cholesterol (LDL-C), lipoprotein(a) [Lp(a)] , ET, oxidized low density lipoprotein, MDA, arte-riosclerotic index (AI) all lowered obviously, while the SOD, HDL-C and calcitonin gene-related peptide (CGRP) were all elevated markedly. In the ZXKC group, the nitric oxide(NO) increased significantly whereas the ET/CGRP and ET/NO decreased markedly. The total effective rate in symptom relieving, the markedly effective rate, the reduction of TC, ET and ET/CGRP, and the elevation of SOD in ZXKC group were all superior to those in the control group. Conclusion: ZXKC could effectively resist myocardial ischemia, relieve angina, reduce blood lipids, protect vascular endothelial cells, inhibit the activation of platelets, and resist lipid peroxidation.展开更多
目的观察运动试验诱发的心肌缺血能否减轻随后运动试验引起的心肌缺血的严重程度及降低心律失常的发生率。方法稳定型劳力性心绞痛患者40例,依序进行两次平板运动试验。两次运动量相同,两次运动间隔12 m in。对比两次ST段压低1 mm出现时...目的观察运动试验诱发的心肌缺血能否减轻随后运动试验引起的心肌缺血的严重程度及降低心律失常的发生率。方法稳定型劳力性心绞痛患者40例,依序进行两次平板运动试验。两次运动量相同,两次运动间隔12 m in。对比两次ST段压低1 mm出现时间(1 mm STD时间);ST段压低大于1mm持续时间(总缺血时间);ST段压低最大程度(最大STD);ST段恢复1 mm的时间(1 mm恢复时间);表现缺血的导联数(1 mm STD导联数);心律失常及心绞痛发生情况。结果与第1次运动试验相比,第2次运动试验的1 mm STD时间从490 s延长到620 s(P<0.001);总缺血时间从510 s减少到350 s(P<0.001);最大STD从3.1 mm降至1.2 mm,两次比较差异有显著性(P<0.001);1 mm恢复时间从420 s缩短到180 s(P<0.001);1 mm STD导联数从4.2个减少到2.3个(P<0.01)。40例患者中35例首次运动中发作心绞痛,其中30例再次运动中症状明显减轻,5例未发作心绞痛。第1次运动试验后心律失常的发生率62.5%(25例),而第2次运动试验后心律失常的发生率为20%(8例)。结论重复运动试验作为临床心肌缺血预适应的方法可提高稳定型劳力性心绞痛患者的缺血阈值,增强心肌对缺氧的耐受,减轻心肌损伤程度,降低心律失常的发生率。展开更多
基金This study was funded by Natural Science Foundation of Shandong Province (No. Y97C22058)
文摘Objective:To observe the clinical effect and protection of vascular endothelium of Zhixin-kang Capsule (ZXKC) in middle-aged and old people with unstable effort angina and hyperlipidemia. Methods: Sixty-five patients with unstable effort angina were randomly divided into ZXKC group (34 cases) and control group (31 cases). Conventional western medical therapy was given to both groups, with ZXKC group receiving additional ZXKC treatment. Data of 20 healthy persons were taken as normal group. Forty-eight patients with hyperlipidemia were divided into ZXKC group treated with ZXKC (31 cases) and control group treated with Yixintong (17 cases). The changes of clinical symptoms and laboratory indexes in all the patients were observed before and after treatment. Results: In patients with unstable effort angina, the efficacy of treatment of ZXKC, the withdrawal rate of nitroglycerin, the relieving of symptoms, the improvement of the electrocardiogram, the counts of circulating endothelial cells, the content of platelet P-selectin, the content of plasma endothelin (ET), the activity of superoxide dismutase (SOD) and the activity of malonyldialdehyde (MDA) were all better than those in the control group. In patients with hyperlipidemia, there was no significant difference in lipids reduction between ZXKC group and the control group. In both groups, the total cholesterol (TC), triglyceride (TG), low density lipo-protein-cholesterol (LDL-C), lipoprotein(a) [Lp(a)] , ET, oxidized low density lipoprotein, MDA, arte-riosclerotic index (AI) all lowered obviously, while the SOD, HDL-C and calcitonin gene-related peptide (CGRP) were all elevated markedly. In the ZXKC group, the nitric oxide(NO) increased significantly whereas the ET/CGRP and ET/NO decreased markedly. The total effective rate in symptom relieving, the markedly effective rate, the reduction of TC, ET and ET/CGRP, and the elevation of SOD in ZXKC group were all superior to those in the control group. Conclusion: ZXKC could effectively resist myocardial ischemia, relieve angina, reduce blood lipids, protect vascular endothelial cells, inhibit the activation of platelets, and resist lipid peroxidation.
文摘目的观察运动试验诱发的心肌缺血能否减轻随后运动试验引起的心肌缺血的严重程度及降低心律失常的发生率。方法稳定型劳力性心绞痛患者40例,依序进行两次平板运动试验。两次运动量相同,两次运动间隔12 m in。对比两次ST段压低1 mm出现时间(1 mm STD时间);ST段压低大于1mm持续时间(总缺血时间);ST段压低最大程度(最大STD);ST段恢复1 mm的时间(1 mm恢复时间);表现缺血的导联数(1 mm STD导联数);心律失常及心绞痛发生情况。结果与第1次运动试验相比,第2次运动试验的1 mm STD时间从490 s延长到620 s(P<0.001);总缺血时间从510 s减少到350 s(P<0.001);最大STD从3.1 mm降至1.2 mm,两次比较差异有显著性(P<0.001);1 mm恢复时间从420 s缩短到180 s(P<0.001);1 mm STD导联数从4.2个减少到2.3个(P<0.01)。40例患者中35例首次运动中发作心绞痛,其中30例再次运动中症状明显减轻,5例未发作心绞痛。第1次运动试验后心律失常的发生率62.5%(25例),而第2次运动试验后心律失常的发生率为20%(8例)。结论重复运动试验作为临床心肌缺血预适应的方法可提高稳定型劳力性心绞痛患者的缺血阈值,增强心肌对缺氧的耐受,减轻心肌损伤程度,降低心律失常的发生率。
