For river basin management, the reliability of the rating curves mainly depends on the accuracy and time period of the observed discharge and water level data. In the Elbe decision support system (DSS), the rating cur...For river basin management, the reliability of the rating curves mainly depends on the accuracy and time period of the observed discharge and water level data. In the Elbe decision support system (DSS), the rating curves are combined with the HEC-6 model to investigate the effects of river engineering measures on the Elbe River system. In such situations, the uncertainty originating from the HEC-6 model is of significant importance for the reliability of the rating curves and the corresponding DSS results. This paper proposes a two-step approach to analyze the uncertainty in the rating curves and propagate it into the Elbe DSS: analytic method and Latin Hypercube simulation. Via this approach the uncertainty and sensitivity of model outputs to input parameters are successfully investigated. The results show that the proposed approach is very efficient in investigating the effect of uncertainty and can play an important role in improving decision-making under uncertainty.展开更多
The Lower Saxonian Elbe Valley Biosphere Reserve is part of the UNESCO Biosphere Reserve “Elbe River Landscape”, and used mainly for agriculture. One of tasks of the Biosphere Reserve Administration is to develop su...The Lower Saxonian Elbe Valley Biosphere Reserve is part of the UNESCO Biosphere Reserve “Elbe River Landscape”, and used mainly for agriculture. One of tasks of the Biosphere Reserve Administration is to develop sustainable forms of land use which requires comprehensive updated land cover maps. Land use maps are hard to produce because of surveying costs and time. Nevertheless, these large areas need to be monitored. TerraSAR-X images are used to establish agricultural land use maps. In this study, two areas are selected within the Elbe Biosphere Reserve situated around the oxbows Wehninger Werder and Walmsburger Werder. Multi temporal classification methods were used to identify the different crops using maximum likelihood classifier for the years 2010 and 2011. The crop classifications were used to evaluate the effect of the number of images, the necessity of polarizations, and the consequences of some missing images within the crop calendar. These classifications were analyzed to estimate producer accuracy and Kappa index for each crop besides the overall accuracy for each agricultural land use map. The study shows that using dual polarization imagery enhances producer accuracies for many crops over the single polarization imagery, and demonstrates the importance of using frequent images during the cultivation period.展开更多
Floods are one of the major hazards worldwide. They are the source of huge risks in rural and urban areas, resulting in severe impacts on the civil society, industry and the economy. The Elbe River has suffered from m...Floods are one of the major hazards worldwide. They are the source of huge risks in rural and urban areas, resulting in severe impacts on the civil society, industry and the economy. The Elbe River has suffered from many severe floods during recent decades. In this study, the zones flooded during 2011 were analyzed using TerraSAR-X images and a digital elevation model for the area in order to identify possible ways to mitigate flood hazards in the future, regarding sustainable land-use. Two study areas are investigated, around the Walmsburg oxbow and the Wehningen oxbow. These are located between Elbe-Kilometer (505-520) and (533-543), respectively, within the Lower Saxonian Elbe River Biosphere Reserve. Those areas are characterized by several types of land use, with agricultural land use being predominant. The study investigated the possibility of using a Decision-Tree object-based classifier for determining the major land uses and the extent of the inundation areas. The inundation areas identify for 2011 submerged some agricultural fields that must be added to existing flood risk maps, and future cultivation activities there prevented to avoid the possible economic losses. Furthermore, part of the residential area is located within the high flood zone, and must be included in risk maps to avoid the possible human and economic losses, to achieve sustainable land use for the areas studied.展开更多
The Digital Elevation Model （DEM） based on the historical sea-charts and on-site hydrological records were used to examine the morphological change of the Elbe River estuary. The results show that siltation predomin...The Digital Elevation Model （DEM） based on the historical sea-charts and on-site hydrological records were used to examine the morphological change of the Elbe River estuary. The results show that siltation predominated in the tidal flat in the northern estuary, with a net siltation rate of 1.8 cm· a^-1 during 1927-2006. In contrast, a continuous erosion prevailed in the main river channel, south of the estuary, with a net erosion rate of 2.5 cm· a^-1 in the same time. In addition, a seaward shift of the estuarine island has happened with the old island coalescing to the northern tidal flat and new one emerging through siltation process. The tidal asymmetry via ebbing flow （maximum at 140 cm· s^-1, and average at 76 cm· s^-1） prevailed in the tidal flat, meaning continuous aggradation northwestward, while flooding flow （maximum at 100 cm · s^-1, and average at 67 cm· s^-1） dominated in the main fiver channel with deepening thaweg at south, showing a landward sedimentation via the tidal pumping processes. This dextral extension of the estuarine morphology is due to the Coriolis force, leading to the inconsistent directions of in-out flows, which enables to facilitate the estuarine siltation. Human dredging prevailing in the estuary has dramatically altered the nature of the silted river channel to erosional since the last century net erosion rate of 3.2 cm· a^-1 This is characterized by a derived from the DEMs mapping, but only partially accounting for the dredging amount of 1994-2006, when the total dredging volume was 67 × 10^6m^3, equal to 5.9 cm·a^-1.展开更多
ONYX-015 is an attractive therapeutic adenovirus for cancer because it can selectively replicate in tumor cells and kill them. To date, clinical trials of this adenovirus have demonstrated marked safety but not potent...ONYX-015 is an attractive therapeutic adenovirus for cancer because it can selectively replicate in tumor cells and kill them. To date, clinical trials of this adenovirus have demonstrated marked safety but not potent enough when it was used alone. In this paper, we put forward a novel concept of Gene-ViroTherapy strategy and in this way, we constructed an armed therapeutic oncolytic adenovirus system, ZD55-gene, which is not only deleted of ElB 55-kD gene similar to ONYX-015, but also armed with foreign antitumor gene. ZD55-gene exhibited similar cytopathic effects and replication kinetics to that of ONYX-015 in vitro. Importantly, the carried gene is expressed and the expression level can increase with the replication of virus. Consequently, a significant antitumoral efficacy was observed when ZD55-CD/5-FU was used as an example in nude mice with subcutaneous human SW620 colon cancer. Our data demonstrated that ZD55-gene, which utilizing the Gene-ViroTherapy strategy, is more efficacious than each individual component in vivo.展开更多
随着四因素领导理论（命令型领导、交易型领导、变革型领导和授权型领导）的提出（Pearce ＆ Sims,2002）。国内外学者越来越关注被誉为“超级领导”（Manz and Sims,1991,2001）的授权型领导。然而，作为一个新兴的领导理论，目前的研...随着四因素领导理论（命令型领导、交易型领导、变革型领导和授权型领导）的提出（Pearce ＆ Sims,2002）。国内外学者越来越关注被誉为“超级领导”（Manz and Sims,1991,2001）的授权型领导。然而，作为一个新兴的领导理论，目前的研究尚不充分，尤其是国内对该领域的研究更是缺乏。本文对授权型领导的研究现状进行了回顾，并指出了未来的研究应该深入探讨的问题。展开更多
As of 2015 （UNESCO, 2015）, the over-40-year-old Convention Concerning the Protection of the World Cultural and Natural Heritage （1972） has been ratified by 191 nations, making it a universal and internationally re...As of 2015 （UNESCO, 2015）, the over-40-year-old Convention Concerning the Protection of the World Cultural and Natural Heritage （1972） has been ratified by 191 nations, making it a universal and internationally recognised instrument for the protection of cultural and natural heritage. In the meantime, 1007 World Heritage Sites have been inscribed on the World Heritage List （as of February 2015） and two sites have been delisted. This paper discusses the delisting procedure of a site from the World Heritage List based on the Operational Guidelines for the Implementation of the World Heritage Convention （henceforth OG）. First of all, the question of the possibility to delist a site from the World Heritage List, in general, is addressed. And based on this discussion, the necessity of the consent of the State Party to the WHC on whose territory the site to be delisted is located is then examined.展开更多
基金Project (No. 02CDP036) supported by the Royal Netherlands Academy of Arts and Sciences (KNAW), the Netherlands
文摘For river basin management, the reliability of the rating curves mainly depends on the accuracy and time period of the observed discharge and water level data. In the Elbe decision support system (DSS), the rating curves are combined with the HEC-6 model to investigate the effects of river engineering measures on the Elbe River system. In such situations, the uncertainty originating from the HEC-6 model is of significant importance for the reliability of the rating curves and the corresponding DSS results. This paper proposes a two-step approach to analyze the uncertainty in the rating curves and propagate it into the Elbe DSS: analytic method and Latin Hypercube simulation. Via this approach the uncertainty and sensitivity of model outputs to input parameters are successfully investigated. The results show that the proposed approach is very efficient in investigating the effect of uncertainty and can play an important role in improving decision-making under uncertainty.
文摘The Lower Saxonian Elbe Valley Biosphere Reserve is part of the UNESCO Biosphere Reserve “Elbe River Landscape”, and used mainly for agriculture. One of tasks of the Biosphere Reserve Administration is to develop sustainable forms of land use which requires comprehensive updated land cover maps. Land use maps are hard to produce because of surveying costs and time. Nevertheless, these large areas need to be monitored. TerraSAR-X images are used to establish agricultural land use maps. In this study, two areas are selected within the Elbe Biosphere Reserve situated around the oxbows Wehninger Werder and Walmsburger Werder. Multi temporal classification methods were used to identify the different crops using maximum likelihood classifier for the years 2010 and 2011. The crop classifications were used to evaluate the effect of the number of images, the necessity of polarizations, and the consequences of some missing images within the crop calendar. These classifications were analyzed to estimate producer accuracy and Kappa index for each crop besides the overall accuracy for each agricultural land use map. The study shows that using dual polarization imagery enhances producer accuracies for many crops over the single polarization imagery, and demonstrates the importance of using frequent images during the cultivation period.
文摘Floods are one of the major hazards worldwide. They are the source of huge risks in rural and urban areas, resulting in severe impacts on the civil society, industry and the economy. The Elbe River has suffered from many severe floods during recent decades. In this study, the zones flooded during 2011 were analyzed using TerraSAR-X images and a digital elevation model for the area in order to identify possible ways to mitigate flood hazards in the future, regarding sustainable land-use. Two study areas are investigated, around the Walmsburg oxbow and the Wehningen oxbow. These are located between Elbe-Kilometer (505-520) and (533-543), respectively, within the Lower Saxonian Elbe River Biosphere Reserve. Those areas are characterized by several types of land use, with agricultural land use being predominant. The study investigated the possibility of using a Decision-Tree object-based classifier for determining the major land uses and the extent of the inundation areas. The inundation areas identify for 2011 submerged some agricultural fields that must be added to existing flood risk maps, and future cultivation activities there prevented to avoid the possible economic losses. Furthermore, part of the residential area is located within the high flood zone, and must be included in risk maps to avoid the possible human and economic losses, to achieve sustainable land use for the areas studied.
基金Acknowledgements The authors are deeply indebt to the reviwers and editors and those who helped with the tide flow observations and data collection. This research is fimded by the EC Theseus Project （Grant No. 2440104）, the National and Natural Science Foundation of China （Grant No, 41271520）, and SKLEC funds （Grant No. 2012KYYW06）.
文摘The Digital Elevation Model （DEM） based on the historical sea-charts and on-site hydrological records were used to examine the morphological change of the Elbe River estuary. The results show that siltation predominated in the tidal flat in the northern estuary, with a net siltation rate of 1.8 cm· a^-1 during 1927-2006. In contrast, a continuous erosion prevailed in the main river channel, south of the estuary, with a net erosion rate of 2.5 cm· a^-1 in the same time. In addition, a seaward shift of the estuarine island has happened with the old island coalescing to the northern tidal flat and new one emerging through siltation process. The tidal asymmetry via ebbing flow （maximum at 140 cm· s^-1, and average at 76 cm· s^-1） prevailed in the tidal flat, meaning continuous aggradation northwestward, while flooding flow （maximum at 100 cm · s^-1, and average at 67 cm· s^-1） dominated in the main fiver channel with deepening thaweg at south, showing a landward sedimentation via the tidal pumping processes. This dextral extension of the estuarine morphology is due to the Coriolis force, leading to the inconsistent directions of in-out flows, which enables to facilitate the estuarine siltation. Human dredging prevailing in the estuary has dramatically altered the nature of the silted river channel to erosional since the last century net erosion rate of 3.2 cm· a^-1 This is characterized by a derived from the DEMs mapping, but only partially accounting for the dredging amount of 1994-2006, when the total dredging volume was 67 × 10^6m^3, equal to 5.9 cm·a^-1.
基金supported by the Key Project of the Chinese Academy of Sciences(No.KSCX2-3-06)the National Natural Science Foundation of China(No.30120160823)the Chinese National“863”High Tech Project Foundation grant(No.2002AA216021).
文摘ONYX-015 is an attractive therapeutic adenovirus for cancer because it can selectively replicate in tumor cells and kill them. To date, clinical trials of this adenovirus have demonstrated marked safety but not potent enough when it was used alone. In this paper, we put forward a novel concept of Gene-ViroTherapy strategy and in this way, we constructed an armed therapeutic oncolytic adenovirus system, ZD55-gene, which is not only deleted of ElB 55-kD gene similar to ONYX-015, but also armed with foreign antitumor gene. ZD55-gene exhibited similar cytopathic effects and replication kinetics to that of ONYX-015 in vitro. Importantly, the carried gene is expressed and the expression level can increase with the replication of virus. Consequently, a significant antitumoral efficacy was observed when ZD55-CD/5-FU was used as an example in nude mice with subcutaneous human SW620 colon cancer. Our data demonstrated that ZD55-gene, which utilizing the Gene-ViroTherapy strategy, is more efficacious than each individual component in vivo.
文摘随着四因素领导理论（命令型领导、交易型领导、变革型领导和授权型领导）的提出（Pearce ＆ Sims,2002）。国内外学者越来越关注被誉为“超级领导”（Manz and Sims,1991,2001）的授权型领导。然而，作为一个新兴的领导理论，目前的研究尚不充分，尤其是国内对该领域的研究更是缺乏。本文对授权型领导的研究现状进行了回顾，并指出了未来的研究应该深入探讨的问题。
文摘As of 2015 （UNESCO, 2015）, the over-40-year-old Convention Concerning the Protection of the World Cultural and Natural Heritage （1972） has been ratified by 191 nations, making it a universal and internationally recognised instrument for the protection of cultural and natural heritage. In the meantime, 1007 World Heritage Sites have been inscribed on the World Heritage List （as of February 2015） and two sites have been delisted. This paper discusses the delisting procedure of a site from the World Heritage List based on the Operational Guidelines for the Implementation of the World Heritage Convention （henceforth OG）. First of all, the question of the possibility to delist a site from the World Heritage List, in general, is addressed. And based on this discussion, the necessity of the consent of the State Party to the WHC on whose territory the site to be delisted is located is then examined.
