Characteristics and demographic factors of traditional Chinese medicine constitution types among elderly individuals in China:A national multistage cluster random study Author links open overlay panel

Objective:To reveal the distribution characteristics and demographic factors of traditional Chinese medicine(TCM)constitution among elderly individuals in China.Methods: Elderly individuals from seven regions in China were selected as samples in this study using a multistage cluster random sampling method.The basic information questionnaire and Constitution in Chinese Medicine Questionnaire(Elderly Edition)were used.Descriptive statistical analysis,chi-squared tests,and binary logistic regression analysis were used.Results: The single balanced constitution(BC)accounted for 23.9%.The results of the major TCM constitution types showed that BC(43.2%)accounted for the largest proportion and unbalanced constitutions ranged from 0.9%to 15.7%.East China region(odds ratio[OR]=2.097;95%confidence interval[CI],1.912 to 2.301),married status(OR=1.341;95%CI,1.235 to 1.457),and managers(OR=1.254;95%CI,1.044 to 1.505)were significantly associated with BC.Age>70 years was associated with qi-deficiency constitution and blood stasis constitution(BSC).Female sex was significantly associated with yang-deficiency constitution(OR=1.646;95%CI,1.52 to 1.782).Southwest region was significantly associated with phlegm-dampness constitution(OR=1.809;95%CI,1.569 to 2.086).North China region was significantly associated with inherited special constitution(OR=2.521;95%CI,1.569 to 4.05).South China region(OR=2.741;95%CI,1.997 to 1.3.763),Central China region(OR=8.889;95%CI,6.676 to 11.835),senior middle school education(OR=2.442;95%CI,1.932 to 3.088),and managers(OR=1.804;95%CI,1.21 to 2.69)were significantly associated with BSC.Conclusions: This study defined the distribution characteristics and demographic factors of TCM constitution in the elderly population.Adjusting and improving unbalanced constitutions,which are correlated with diseases,can help promote healthy aging through the scientific management of these demographic factors.

Nomogram prediction model called“ADPLCP”for predictinglinezolid-associated thrombocytopenia in elderly individuals

Background:Linezolid-associated thrombocytopenia(LAT)leads to drug withdrawal associated with a poor prognosis.Some risk factors for LAT have been identified;however,the sample size of previous studies was small,data from elderly individuals are limited,and a simple risk score scale was not established to predict LAT at anearly stage,making it difficult to identify and intervene in LAT at an early stage.Methods:In this single-center retrospective case-control study,we enrolled elderly patients treated with linezolidin the intensive care unit from January 2015 to December 2020.All the data of enrolled patients,includingdemographic information and laboratory findings at baseline,were collected.We analyzed the incidence andrisk factors for LAT and established a nomogram risk prediction model for LAT in the elderly population.Results:A total of 428 elderly patients were enrolled,and the incidence of LAT was 35.5%(152/428).Age≥80 years old(OR=1.980;95%CI:1.179–3.325;P=0.010),duration of linezolid≥10 days(OR=1.100;95%CI:1.050–1.152;P<0.0001),platelet count at baseline(100–149×10^(9)/L vs.≥200×10^(9)/L,OR=8.205,95%CI:4.419–15.232,P<0.0001;150–199×10^(9)/L vs.≥200×10^(9)/L,OR=3.067,95%CI:1.676–5.612,P<0.001),leukocytecount at baseline≥16×10^(9)/L(OR=2.580;95%CI:1.523–4.373;P<0.0001),creatinine clearance<50 mL/min(OR=2.323;95%CI:1.388–3.890;P=0.001),and total protein<60 g/L(OR=1.741;95%CI:1.039–2.919;P=0.035)were associated with LAT.The nomogram prediction model called“ADPLCP”(age,duration,platelet,leukocyte,creatinine clearance,protein)was established based on logistic regression.The area under the curve(AUC)of ADPLCP was 0.802(95%CI:0.748–0.856;P<0.0001),with 78.9%sensitivity and 69.2%specificity(cut-off was 108).Risk stratification for LAT was performed based on“ADPLCP.”Total points of<100 were defined as low risk,and the possibility of LAT was<32.0%.Total points of 100–150 were defined as medium risk,and the possibility of LAT was 32.0–67.5%.A total point>150 was defined as high risk,and the probability ofLAT was>67.5%.Conclusions:We created the ADPLCP risk score scale to predict the occurrence of LAT in elderly individuals.ADPLCP is simple and feasible and is helpful for the early determination of LAT to guide drug withdrawal orearly intervention.

Analysis of metabolic characteristics of metabolic syndrome in elderly patients with gastric cancer by non-targeted metabolomics

BACKGROUND The relationship between metabolic syndrome(MetS)and gastric cancer(GC),which is a common metabolic disease,has attracted much attention.However,the specific metabolic characteristics of MetS in elderly patients with GC remain unclear.AIM To investigate the differentially abundant metabolites and metabolic pathways between preoperative frailty and MetS in elderly patients with GC based on nontargeted metabolomics techniques.METHODS In this study,125 patients with nonfrail nonmeal GC were selected as the control group,and 50 patients with GC in the frail group were selected as the frail group.Sixty-five patients with GC combined with MetS alone were included in the MetS group,and 50 patients with GC combined with MetS were included in the MetS group.Nontargeted metabolomics techniques were used to measure plasma metabolite levels by ultrahigh-performance liquid chromatography-mass spectrometry.Multivariate statistical analysis was performed by principal component analysis,orthogonal partial least squares,pattern recognition analysis,cluster analysis,and metabolic pathway annotation.RESULTS A total of 125 different metabolites,including amino acids,glycerophospholipids,sphingolipids,fatty acids,sugars,nucleosides and nucleotides,and acidic compounds,were identified via nontargeted metabolomics techniques.Compared with those in the control group,there were 41,32,and 52 different metabolites in the MetS group,the debilitated group,and the combined group,respectively.Lipid metabolites were significantly increased in the MetS group.In the weak group,amino acids and most glycerol phospholipid metabolites decreased significantly,and fatty acids and sphingosine increased significantly.The combined group was characterized by significantly increased levels of nucleotide metabolites and acidic compounds.The alanine,aspartic acid,and glutamate metabolic pathways were obviously enriched in the asthenic group,and the glycerol and phospholipid metabolic pathways were obviously enriched in the combined group.CONCLUSION Elderly GC patients with simple frailty,simple combined MetS,and frailty combined with MetS have different metabolic characteristics,among which amino acid and glycerophospholipid metabolite levels are significantly lower in frail elderly GC patients,and comprehensive supplementation of fat and protein should be considered.Many kinds of metabolites,such as amino acids,lipids,nucleotides,and acidic compounds,are abnormally abundant in patients with MetS combined with fthenia,which may be related to tumor-related metabolic disorders.