As an advanced process detection technology, electrical impedance tomography(EIT) has wide application prospects and advantages in medical imaging diagnosis. However, a series of issues need to be addressed before app...As an advanced process detection technology, electrical impedance tomography(EIT) has wide application prospects and advantages in medical imaging diagnosis. However, a series of issues need to be addressed before applying EIT for bedside monitoring. Medical diagnosis and bedside monitoring are dynamic measuring process, where the positions of measuring electrodes and the shape of the detected field are changing dynamical. Due to the inability to cope with the changeable electrode positions and various dynamic fields, existing EIT systems are mainly used for industrial detection in condition of static measurement and visualization. In this paper, we investigate the dynamic measurement and visualization of human breast in EIT field, describe the design of the measuring sensor system, and expound the measuring principle. The main component of the hardware system is a builtin servo electrical resistance tomography sensor with capacitive sliding rod, which can adapt to the crowd of different chest contour and the change of chest shape in the dynamic process of breathing.The corresponding measuring principle is extracting all real-time positions of measuring electrodes,then obtaining the dynamic boundary, finally dividing the detection field rapidly. Experimental results confirmed that the proposed system can obtain real-time location of boundary sensor and dynamically solve the problem of arbitrary-shape boundary measurement. The imaging results validate the availability of designed sensor system and the effectiveness of the corresponding measuring principle.展开更多
细胞定向行为在皮肤、骨骼等修复和再生中起着非常重要的作用.本文首次采用交流阻抗传感技术实时监测人真皮成纤维细胞(HFF)和人永生化表皮细胞(Ha Ca T)在纳米沟槽(宽度:200 nm,周期:400 nm,深度:70 nm)上的定向行为.结果表明,HFF细胞...细胞定向行为在皮肤、骨骼等修复和再生中起着非常重要的作用.本文首次采用交流阻抗传感技术实时监测人真皮成纤维细胞(HFF)和人永生化表皮细胞(Ha Ca T)在纳米沟槽(宽度:200 nm,周期:400 nm,深度:70 nm)上的定向行为.结果表明,HFF细胞在纳米沟槽上先进行定向排列,再发生胞体的延长;Ha Ca T细胞无定向行为的产生,其粘附和铺展得到了延缓.与平面电极相比,HFF细胞在纳米沟槽上产生的交流阻抗信号(NI值)更大,前期定向排列比后期胞体延长引起的NI值变化更显著,且NI值与定向排列的细胞百分比之间存在着良好的线性关系;Ha Ca T细胞在纳米沟槽上的NI值更小,且粘附比铺展过程对NI值变化的影响更大.本文的研究将为复合型细胞传感器的发展提供思路和支持.展开更多
基金Supported by the National Natural Science Foundation of China(61573251)
文摘As an advanced process detection technology, electrical impedance tomography(EIT) has wide application prospects and advantages in medical imaging diagnosis. However, a series of issues need to be addressed before applying EIT for bedside monitoring. Medical diagnosis and bedside monitoring are dynamic measuring process, where the positions of measuring electrodes and the shape of the detected field are changing dynamical. Due to the inability to cope with the changeable electrode positions and various dynamic fields, existing EIT systems are mainly used for industrial detection in condition of static measurement and visualization. In this paper, we investigate the dynamic measurement and visualization of human breast in EIT field, describe the design of the measuring sensor system, and expound the measuring principle. The main component of the hardware system is a builtin servo electrical resistance tomography sensor with capacitive sliding rod, which can adapt to the crowd of different chest contour and the change of chest shape in the dynamic process of breathing.The corresponding measuring principle is extracting all real-time positions of measuring electrodes,then obtaining the dynamic boundary, finally dividing the detection field rapidly. Experimental results confirmed that the proposed system can obtain real-time location of boundary sensor and dynamically solve the problem of arbitrary-shape boundary measurement. The imaging results validate the availability of designed sensor system and the effectiveness of the corresponding measuring principle.
文摘细胞定向行为在皮肤、骨骼等修复和再生中起着非常重要的作用.本文首次采用交流阻抗传感技术实时监测人真皮成纤维细胞(HFF)和人永生化表皮细胞(Ha Ca T)在纳米沟槽(宽度:200 nm,周期:400 nm,深度:70 nm)上的定向行为.结果表明,HFF细胞在纳米沟槽上先进行定向排列,再发生胞体的延长;Ha Ca T细胞无定向行为的产生,其粘附和铺展得到了延缓.与平面电极相比,HFF细胞在纳米沟槽上产生的交流阻抗信号(NI值)更大,前期定向排列比后期胞体延长引起的NI值变化更显著,且NI值与定向排列的细胞百分比之间存在着良好的线性关系;Ha Ca T细胞在纳米沟槽上的NI值更小,且粘附比铺展过程对NI值变化的影响更大.本文的研究将为复合型细胞传感器的发展提供思路和支持.
