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The Immediate Analgesic Effect and Impact on Gait Function of Transcutaneous Electrical Nerve Stimulation in Late-Stage Elderly Individuals with Knee Pain: Examination of Gait Function Using an IoT-Based Gait Analysis Device
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作者 Taisuke Ito 《Open Journal of Therapy and Rehabilitation》 2024年第2期185-195,共11页
Purpose: This study verified the effects of transcutaneous electrical nerve stimulation (TENS), which can be worn during walking and exercise, in elderly individuals with late-stage knee pain who exercise regularly. M... Purpose: This study verified the effects of transcutaneous electrical nerve stimulation (TENS), which can be worn during walking and exercise, in elderly individuals with late-stage knee pain who exercise regularly. Methods: Thirty-two late-stage elderly individuals were evaluated for knee pain during rest, walking, and program exercises, with and without TENS. Gait analysis was performed using an IoT-based gait analysis device to examine the effects of TENS-induced analgesia on gait. Results: TENS significantly reduced knee pain during rest, walking, and programmed exercises, with the greatest analgesic effect observed during walking. The greater the knee pain without TENS, the more significant the analgesic effect of TENS. A comparison of gait parameters revealed a significant difference only in the gait cycle time, with a trend towards faster walking with TENS;however, the effect was limited. Conclusion: TENS effectively relieves knee pain in late-stage elderly individuals and can be safely applied during exercise. Pain management using TENS provides important insights into the implementation of exercise therapy in this age group. 展开更多
关键词 Late-Stage Elderly Knee Joint Pain Exercise Transcutaneous electrical Stimulation IoT-Based Gait Analysis device
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A Novel Analytical Model for Surface Electrical Field Distribution and Optimization of TFSOI RESURF Devices 被引量:1
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作者 何进 张兴 +1 位作者 黄如 王阳元 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2001年第4期402-408,共7页
A novel analytical model for the thin film silicon on insulator (TFSOI) reduced surface field (RESURF) devices has been proposed.Based on the 2-D Poisson equation solution,the analytical expressions for the surface po... A novel analytical model for the thin film silicon on insulator (TFSOI) reduced surface field (RESURF) devices has been proposed.Based on the 2-D Poisson equation solution,the analytical expressions for the surface potential and field distributions are derived.From this analysis,the optimum design condition for the maximum breakdown voltage is obtained.The dependence of the maximum breakdown voltage on the drift region length is examined and the relationship between the critical doping concentration and the front- and back- interface oxide layer thickness is discussed.The numerical simulation performed by the advanced semiconductor simulation tool,DESSIS-ISE,has been shown to support the analytical results. 展开更多
关键词 TFSOI RESURF devices surface electric field distribution potential profile breakdown voltage optimum design
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The Research and Application of the Anti-Interference Techniques of Electronic Device in Power System 被引量:1
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作者 吴维宁 张文亮 +1 位作者 吴峡 李建建 《Electricity》 2001年第4期40-43,共4页
This paper presents the study and application of the electronic device anti-interference techniques underhigh voltage and/or heavy current electro-magnetic circumstance in power system.[
关键词 electric power system electronic measurement and/or control device anti-interference measures
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SOLIDWORKS Electrical在通过式脚踏封口机自动化改造设计中的应用
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作者 董改花 赵家硕 +1 位作者 王晓兰 郭秀华 《工业控制计算机》 2024年第6期90-92,共3页
小型企业塑封工艺中通过式脚踏封口机应用广泛,但在塑封重型工件时,工人操作非常费力且次品率高,无法保障塑封质量,为此对其进行机构优化与软硬件设计自动化改造。利用SOLIDWORKS Electrical快速建立3D虚拟电气配盘与生成各类BOM清单,... 小型企业塑封工艺中通过式脚踏封口机应用广泛,但在塑封重型工件时,工人操作非常费力且次品率高,无法保障塑封质量,为此对其进行机构优化与软硬件设计自动化改造。利用SOLIDWORKS Electrical快速建立3D虚拟电气配盘与生成各类BOM清单,大大缩短了研发周期,安装人员还可以根据虚拟电气装配路径进行准确安装。最终设计出结构合理,满足生产工艺要求的自动化装置,企业以极少改造成本提质增效,为机电一体化装置自动化设计提供了一个高效开发途径。 展开更多
关键词 脚踏封口机 自动化改造 SOLIDWORKS electrical
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Electrical bistable devices using composites of zinc sulfide nanoparticles and poly-(N-vinylcarbazole) 被引量:2
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作者 曹亚鹏 胡煜峰 +8 位作者 李剑焘 叶海航 吕龙锋 宁宇 鲁启鹏 唐爱伟 娄志东 侯延冰 滕枫 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第3期298-301,共4页
N-dodecanethiol capped zinc sulfide(Zn S) nanocrystals were synthesized by the one-pot approach and blended with poly(N-vinylcarbazole)(PVK) to fabricate electrical bistable devices. The corresponding devices di... N-dodecanethiol capped zinc sulfide(Zn S) nanocrystals were synthesized by the one-pot approach and blended with poly(N-vinylcarbazole)(PVK) to fabricate electrical bistable devices. The corresponding devices did exhibit electrical bistability and negative differential resistance(NDR) effects. A large ON/OFF current ratio of 104 at negative voltages was obtained by applying different amplitudes of sweeping voltage. The observed conductance switching and the negative differential resistance are attributed to the electric-field-induced charge transfer between the nanocrystals and the polymer,and the charge trapping/detrapping in the nanocrystals. 展开更多
关键词 electrical bistable devices ON/OFF current ratio electric-field-induced charge transfer trapping/detrapping
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LOW POTENTIAL ELECTROPOLYMERIZATION OF ANISOTROPIC CONDUCTIVE POLYTHIOPHENE FILMS AND FABRICATION OF ELECTRICAL DEVICES 被引量:1
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作者 Xiao-bo Wan Yun Lu +3 位作者 Xiao-rong Liu Liang Zhou Shi Jin Gi Xue Department of Polymer Science and Engineering, the State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 1999年第2期99-111,共13页
The Complexation of thiophene with a Lewis acid with moderate acidity as a solvent, such as BF3-ethyl ether (BFEE) remarkedly lowered the electrochemical polymerization potential. The positively charged metal surface ... The Complexation of thiophene with a Lewis acid with moderate acidity as a solvent, such as BF3-ethyl ether (BFEE) remarkedly lowered the electrochemical polymerization potential. The positively charged metal surface of electrode in the process of electrochemical deposition enhanced the coordination interaction between pi-electrons of thiophene unit and the metal, which makes thiophene rings lie parallel to the surface of electrode, resulting in a highly ordered polymeric structure. Because of the large intra-chain transfer integrals, the transport of charge is believed to be principally along the conjugated chains, which is much greater than the inter-chain hopping. The specific electrical resistance across the polythiophene film thickness is more than 10(4) times than that along the surface plane of the film. In this paper we review the recent development of polymerization technique by low potential electrochemical method performed in our lab and several electrical devices in which the compact polythiophene films, such as anionic and cationic sieves, and laminate film junction of undoped polythiophene derivatives were used. 展开更多
关键词 conductive polymer POLYTHIOPHENE ANISOTROPY electric device film junction
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The action mechanism of the work done by the electric field force on moving charges to stimulate the emergence of carrier generation/recombination in a PN junction
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作者 Lingyun GUO Yizhan YANG +1 位作者 Wanli YANG Yuantai HU 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第6期1001-1014,共14页
It is discovered that the product of the current and the electric field in a PN junction should be regarded as the rate of work(power)done by the electric field force on moving charges(hole current and electron curren... It is discovered that the product of the current and the electric field in a PN junction should be regarded as the rate of work(power)done by the electric field force on moving charges(hole current and electron current),which was previously misinterpreted as solely a Joule heating effect.We clarify that it is exactly the work done by the electric field force on the moving charges to stimulate the emergence of non-equilibrium carriers,which triggers the novel physical phenomena.As regards to Joule heat,we point out that it should be calculated from Ohm’s law,rather than simply from the product of the current and the electric field.Based on this understanding,we conduct thorough discussion on the role of the electric field force in the process of carrier recombination and carrier generation.The thermal effects of carrier recombination and carrier generation followed are incorporated into the thermal equation of energy.The present study shows that the exothermic effect of carrier recombination leads to a temperature rise at the PN interface,while the endothermic effect of carrier generation causes a temperature reduction at the interface.These two opposite effects cause opposite heat flow directions in the PN junction under forward and backward bias voltages,highlighting the significance of managing device heating phenomena in design considerations.Therefore,this study possesses referential significance for the design and tuning on the performance of piezotronic devices. 展开更多
关键词 piezoelectric semiconductor(PS) work done by electric field force thermal effect piezotronic device resistivity conductivity
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Electrically driven uniaxial stress device for tuning in situ semiconductor quantum dot symmetry and exciton emission in cryostat
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作者 Hao Chen Xiuming Dou +1 位作者 Kun Ding Baoquan Sun 《Journal of Semiconductors》 EI CAS CSCD 2019年第7期75-79,共5页
Uniaxial stress is a powerful tool for tuning exciton emitting wavelength, polarization, fine-structure splitting (FSS), and the symmetry of quantum dots (QDs). Here, we present a technique for applying uniaxial stres... Uniaxial stress is a powerful tool for tuning exciton emitting wavelength, polarization, fine-structure splitting (FSS), and the symmetry of quantum dots (QDs). Here, we present a technique for applying uniaxial stress, which enables us in situ to tune exciton optical properties at low temperature down to 15 K with high tuning precision. The design and operation of the device are described in detail. This technique provides a simple and convenient approach to tune QD structural symmetry, exciton energy and biexciton binding energy. It can be utilized for generating entangled and indistinguishable photons. Moreover, this device can be employed for tuning optical properties of thin film materials at low temperature. 展开更多
关键词 UNIAXIAL stress electrically DRIVEN device low temperature quantum DOTS thin film materials
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Effect of Organic Dopants in Dimetallophthalocyanine Thin Films: Application to Optoelectronic Devices
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作者 María Elena Sánchez-Vergara Santiago Osorio-Lefler +1 位作者 Pablo Osorio-Lefler José Ramón álvarez-Bada 《Advances in Materials Physics and Chemistry》 2019年第4期71-88,共18页
Semiconductor films of organic, doped dimetallophthalocyanine M2Pcs (M = Li, Na) on different substrates were prepared by synthesis and vacuum evaporation. Tetrathiafulvalene (TTF) and tetracyanoquinodimethane (TCNQ) ... Semiconductor films of organic, doped dimetallophthalocyanine M2Pcs (M = Li, Na) on different substrates were prepared by synthesis and vacuum evaporation. Tetrathiafulvalene (TTF) and tetracyanoquinodimethane (TCNQ) were used as dopants and the structure and morphology of the semiconductor films were studied using IR spectroscopy, X-ray diffraction (XRD), Scanning Electron Microscopy (SEM) and Energy Dispersive X-Ray Spectroscopy (EDS). The absorption spectra recorded in the ultraviolet-visible region for the deposited films showed the Q and Soret bands related to the electronic π-π* transitions in M2Pc molecules. Optical characterization of the films indicates electronic transitions characteristic of amorphous thin films with optical bandgaps between 1.2 and 2.4 eV. Finally, glass/ITO/doped M2Pc/Ag thin-film devices were produced and their electrical behavior was evaluated by using the four-tip collinear method. The devices manufactured from Na2Pc have a small rectifying effect, regardless of the organic dopant used, while the device manufactured from Li2Pc-TCNQ presents ohmic-like behavior at low voltages, with an insulating threshold around 19 V. Parameters such as the hole mobility (μ), the concentration of thermally-generated holes (p0), the concentration of traps per unit of energy (P0) and the total trap concentration (Nt(e)) were also determined for the Li2Pc-TTF device. 展开更多
关键词 ORGANIC SEMICONDUCTORS THIN Films Optical PROPERTIES electrical PROPERTIES OPTOelectrONIC devices
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Effects of medically generated electromagnetic interference from medical devices on cardiac implantable electronic devices: A review
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作者 Walker Barmore Himax Patel +2 位作者 Cassandra Voong Caroline Tarallo Joe B Calkins Jr 《World Journal of Cardiology》 2022年第8期446-453,共8页
As cardiac implantable electronic devices(CIED)become more prevalent,it is important to acknowledge potential electromagnetic interference(EMI)from other sources,such as internal and external electronic devices and pr... As cardiac implantable electronic devices(CIED)become more prevalent,it is important to acknowledge potential electromagnetic interference(EMI)from other sources,such as internal and external electronic devices and procedures and its effect on these devices.EMI from other sources can potentially inhibit pacing and trigger shocks in permanent pacemakers(PPM)and implantable cardioverter defibrillators(ICD),respectively.This review analyzes potential EMI amongst CIED and left ventricular assist device,deep brain stimulators,spinal cord stimulators,transcutaneous electrical nerve stimulators,and throughout an array of procedures,such as endoscopy,bronchoscopy,and procedures involving electrocautery.Although there is evidence to support EMI from internal and external devices and during procedures,there is a lack of large multicenter studies,and,as a result,current management guidelines are based primarily on expert opinion and anecdotal experience.We aim to provide a general overview of PPM/ICD function,review documented EMI effect on these devices,and acknowledge current management of CIED interference. 展开更多
关键词 electromagnetic interference Pacemaker Implantable cardioverter defibrillator Permanent pacemakers Cardiac implantable electronic devices Left ventricular assist device Endoscopy BRONCHOSCOPY electrOCAUTERY Capsule endoscopy Transcutaneous electrical nerve stimulators unit Spinal cord stimulator
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Methods and Results of Assessment of the Pulse Electrical Disturbances Influence on. Digital Devices Functioning
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作者 Yury Parfenov Boris Titov Leonid Zdoukhov 《Journal of Physical Science and Application》 2013年第6期392-399,共8页
Two methods of calculating the parameters and characterizing the degree of pulse electrical disturbances influence on digital devices functioning, both analytical and numerical, are considered here. The analytical met... Two methods of calculating the parameters and characterizing the degree of pulse electrical disturbances influence on digital devices functioning, both analytical and numerical, are considered here. The analytical method permits one to assess the error occurrence probability in transmitting the data packets considering the dependence on the signal pulses energies-to-pulse disturbances energies ratio and the disturbances repetition frequency-to-data transmission rate ratio and also the dependence on the bits quantity in the packet. The numerical method allows one to assess the specific effect of the repetitive pulse disturbance influence on the digital devices functioning (the number of errors in transmitted data packets, transmission rate, etc.) depending on such factors as the repetition frequency, the disturbance waveform and duration, the mode of data coding, etc.. 展开更多
关键词 Pulse electrical disturbance digital device assessment of influence.
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Design of an Electrically Written and Optically Read Non-volatile Memory Device Employing BiFeO3/Au Heterostructures with Strong Absorption Resonance
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作者 肖鹏博 张伟 +2 位作者 曲天良 黄云 胡绍民 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第7期67-70,共4页
Exploiting new concepts for dense, fast, and nonvolatile random access memory with reduced energy consump- tion is a significant issue for information technology. Here we design an 'electrically written and optically... Exploiting new concepts for dense, fast, and nonvolatile random access memory with reduced energy consump- tion is a significant issue for information technology. Here we design an 'electrically written and optically read' information storage device employing BiFeO3/A u heterostruetures with strong absorption resonance. The electro- optic effect is the basis for the device design, which arises from the strong absorption resonance in BiFeO3/Au heterostructures and the electrically tunable significant birefringence of the BiFeO3 film. We first construct a sim- ulation calculation of the BiFeO3/Au structure spectrum and identify absorption resonance and electro-optical modulation characteristics. Following a micro scale partition, the surface reflected light intensity of different polarization units is calculated. The results depend on electric polarization states of the BiFeO3 film, thus BiFeO3/Au heterostructures can essentially be designed as a type of electrically written and optically read infor- mation storage device by utilizing the scanning near-field optical microscopy technology based on the conductive silicon cantilever tip with nanofabricated aperture. This work will shed light on information storage technology. 展开更多
关键词 BFO Design of an electrically Written and Optically Read Non-volatile Memory device Employing BiFeO3/Au Heterostructures with Strong Absorption Resonance
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A new analytical model of high voltage silicon on insulator(SOI) thin film devices 被引量:5
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作者 胡盛东 张波 李肇基 《Chinese Physics B》 SCIE EI CAS CSCD 2009年第1期315-319,共5页
A new analytical model of high voltage silicon on insulator (SOI) thin film devices is proposed, and a formula of silicon critical electric field is derived as a function of silicon film thickness by solving a 2D Po... A new analytical model of high voltage silicon on insulator (SOI) thin film devices is proposed, and a formula of silicon critical electric field is derived as a function of silicon film thickness by solving a 2D Poisson equation from an effective ionization rate, with a threshold energy taken into account for electron multiplying. Unlike a conventional silicon critical electric field that is constant and independent of silicon film thickness, the proposed silicon critical electric field increases sharply with silicon fihn thickness decreasing especially in the case of thin films, and can come to 141V/μm at a film thickness of 0.1 μm which is much larger than the normal value of about 30 V/μm. From the proposed formula of silicon critical electric field, the expressions of dielectric layer electric field and vertical breakdown voltage (VB,V) are obtained. Based on the model, an ultra thin film can be used to enhance dielectric layer electric field and so increase vertical breakdown voltage for SOI devices because of its high silicon critical electric field, and with a dielectric layer thickness of 2 μm the vertical breakdown voltages reach 852 and 300V for the silicon film thicknesses of 0.1 and 5μm, respectively. In addition, a relation between dielectric layer thickness and silicon film thickness is obtained, indicating a minimum vertical breakdown voltage that should be avoided when an SOI device is designed. 2D simulated results and some experimental results are in good agreement with analytical results. 展开更多
关键词 silicon critical electric field breakdown voltage thin silicon layer SOI high voltage device
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Mobile Based Electricity Bill Deposit System through UML 被引量:1
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作者 Pawan Kumar Chaurasia Vipin Saxena 《Journal of Software Engineering and Applications》 2011年第3期187-190,共4页
The present paper deals with a model design through Unified Modeling Language (UML) for a mobile based elec-tricity bill deposit system. Due to complex life style of people this model is proposed in the form of UML Cl... The present paper deals with a model design through Unified Modeling Language (UML) for a mobile based elec-tricity bill deposit system. Due to complex life style of people this model is proposed in the form of UML Class, Sequence and Use Case diagrams. For implementation of proposed model, a real case study of Uttar Pradesh Electricity Bill deposit System is considered. By the use of this model, one can display the status of deposited electricity bill on a hand held mobile device system. 展开更多
关键词 UML MOBILE device electricity BILL UML Class UML SEQUENCE & UML Use CASES
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Traction power substation balance and losses estimation in AC railways using a power transfer device through Monte Carlo analysis 被引量:1
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作者 Vitor A.Morais Antonio P.Martins 《Railway Engineering Science》 2022年第1期71-95,共25页
The high dynamic power requirements present in modern railway transportation systems raise research challenges for an optimal operation of railway electrification. This paper presents a Monte Carlo analysis on the app... The high dynamic power requirements present in modern railway transportation systems raise research challenges for an optimal operation of railway electrification. This paper presents a Monte Carlo analysis on the application of a power transfer device installed in the neutral zone and exchanging active power between two sections. The main analyzed parameters are the active power balance in the two neighbor traction power substations and the system power losses. A simulation framework is presented to comprise the desired analysis and a universe of randomly distributed scenarios are tested to evaluate the effectiveness of the power transfer device system. The results show that the density of trains and the relative branch length of a traction power substation should be considered in the evaluation phase of the best place to install a power transfer device, towards the reduction of the operational power losses, while maintaining the two substations balanced in terms of active power. 展开更多
关键词 electric traction systems Monte Carlo analysis Power transfer device Power quality Railway power systems Smart railways
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Weak Gate Effect in 1,3-Benzenedithiol Molecular Device
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作者 苏文勇 罗毅 《Chinese Physics Letters》 SCIE CAS CSCD 2010年第4期246-249,共4页
We introduce a full interaction Hamiltonian method to the generalized quantum chemical approach and apply it to investigate the electron tunneling properties of 1,3-benzenedithiol molecular device. The weak gate effec... We introduce a full interaction Hamiltonian method to the generalized quantum chemical approach and apply it to investigate the electron tunneling properties of 1,3-benzenedithiol molecular device. The weak gate effect we calculate is consistent with the experiment. The asymmetric current character mainly comes from the asymmetry of the molecule and the nonlinear responding to the gate electric field. 展开更多
关键词 Condensed matter: electrical magnetic and optical electronics and devices Surfaces interfaces and thin films
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Development of a Measurement Software for the Characterization of WORM Devices for Novel Memory Storage Applications
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作者 Mirko Congiu Miguel H. Boratto +1 位作者 Paride Pica Carlos F. O. Graeff 《Journal of Computer and Communications》 2018年第9期1-13,共13页
We hereby propose a software solution to perform high quality electrical measurements for the characterization of WORM (write-once read many), a new generation memory device which is being intensively studied for non-... We hereby propose a software solution to perform high quality electrical measurements for the characterization of WORM (write-once read many), a new generation memory device which is being intensively studied for non-volatile data storage. The as-proposed software is completely based on .NET framework and sample C# code. The paper performed a relevant measurement based on this software. Working WORM devices, based on a polymeric matrix embedded with gold and copper sulfide nanoparticles, have been used for test measurements. The aim of this paper is to show the main steps to develop a fully working measurement software without using any expensive dedicated software. 展开更多
关键词 WORM MEMRISTOR electrical MEASUREMENTS MEMORY deviceS
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System for the Management of the Continuity of Use of Medical Devices in Hospitals
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作者 Manuela Stroili Elena Pavan +1 位作者 Marino Gorela Fulvio Kenda 《Journal of Electrical Engineering》 2016年第1期34-41,共8页
The Technical Services and the Medical Administration of the Hospitals of Trieste have been working for years to ensure the optimal functioning of the Surgery, Intensive Care, Diagnostics and Research Services offered... The Technical Services and the Medical Administration of the Hospitals of Trieste have been working for years to ensure the optimal functioning of the Surgery, Intensive Care, Diagnostics and Research Services offered to the Patients and to the University in an 800-bed hospital complex, transforming and innovating the buildings and support installations. We have dedicated special attention to the technologies necessary to guarantee the continuity of the power supply to the electromedical devices, increasingly numerous in highly specialized hospitals. We report the power of the generator sets and the UPS and our opinion that their power must be related to the overall consumption of the hospital, with a reserve margin. 展开更多
关键词 Generator set UPS hospital planning design and development electrical system Master University HTA healthtechnology management and assessment safety hospital medical devices.
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Engineering Geometric Electrodes for Electric Field-Enhanced High-Performance Flexible In-Plane Micro-Supercapacitors
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作者 Jihong Kim Sung Min Wi +9 位作者 Jong-Guk Ahn Sangjun Son Hee Young Lim Yeonsu Park Hye Ji Eun Jong Bae Park Hyunseob Lim Sangyeon Pak A-Rang Jang Young-Woo Lee 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2023年第4期114-120,共7页
In plane micro-supercapacitors that are miniaturized energy storage components have attracted significant attention due to their high power densities for various ubiquitous and sustainable device systems as well as th... In plane micro-supercapacitors that are miniaturized energy storage components have attracted significant attention due to their high power densities for various ubiquitous and sustainable device systems as well as their facile integration on various flexible/wearable platform.To implement the micro-supercapacitors in various practical applications that can accompany solid state or gel electrolyte and flexible substrates,ions must be readily transported to electrodes for achieving high power densities.Herein,we show large enhancement in electrochemical properties of flexible,inplane micro-supercapacitor using sharp-edged interdigitated electrode design,which was simply fabricated through direct laser scribing method.The sharp-edged electrodes allowed strong electric field to be induced at the corners of the electrode fingers which led to the greater accumulation of ions near the surface of electrode,significantly enhancing the energy storage performance of micro-supercapacitors.The electric field-enhanced in-plane micro-supercapacitor showed the volumetric energy density of 1.52 Wh L^(−1)and the excellent cyclability with capacitive retention of 95.4%after 20000 cycles.We further showed various practicability of our sharp-edged design in micro-supercapacitors by showing circuit applicability,mechanical stability,and air stability.These results present an important pathway for designing electrodes in various energy storage devices. 展开更多
关键词 electric field enhancement flexible energy storage device microsupercapacitors sharp electrodes
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Emerging trends in materials and devices-based electric stimulation therapy for tumors
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作者 Shiwang Xie Jing Huang +3 位作者 Andreia Trindade Pereira Lingling Xu Dan Luo Zhou Li 《BMEMat(BioMedical Engineering Materials)》 2023年第3期101-122,共22页
Electrical stimulation(ES),as one of the physical therapy modalities for tumors,has attracted extensive attention of researchers due to its promising efficacy.With the continuous development of material science,nanote... Electrical stimulation(ES),as one of the physical therapy modalities for tumors,has attracted extensive attention of researchers due to its promising efficacy.With the continuous development of material science,nanotechnology,and micro/nano processing techniques,novel electroactive nanomaterials and delicately designed devices have emerged to realize innovative ES therapies,which provide more possibilities and approaches for tumor treatment.Meanwhile,exploring the molecular biological mechanisms underlying different ES modalities affecting tumor cells and their immune microenvironment is also an unresolved hotspot emerging from the current biomedical engineering research.Focusing on the above research interests,in this review,we systematically summarized the effects of different ES parameters on the subcellular structure of tumor cells and the tumor immune microenvironment(TIME)in conjunction with the involved signaling pathways.In addition,we also reviewed the latest progress in novel self-powered devices and electroactive nanomaterials for tumor therapy.Finally,the prospects for the development of electrostimulation tumor therapy are also discussed,bringing inspiration for the development of new physical therapy strategies in the future. 展开更多
关键词 cancer therapy electrical stimulation electroactive materials self-powered device
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