Preclinical Verification of Modulated Electro-Hyperthermia —Part I. In Vitro Research

Modulated electro-hyperthermia (mEHT) targets tissue’s natural electric and thermal heterogeneities to heat the cancer cells selectively. The applied 13.56 MHz radiofrequency (RF) is a carrier of the low-frequency modulation. The high-frequency part was chosen to select the malignant lesion using the specialties of the tumor: the higher conductivity and dielectric constant of the tumor than its host. The electric field selects the tumor, and the low-frequency amplitude modulation polarizes and excites the transmembrane proteins of the malignant cells. The dominant absorption of the energy by the microscopic clusters of the membrane rafts acts like nanoparticle heating. Exciting the membrane produces various apoptotic signals. The processes were modeled using silico and phantom experiments, which proved the concept. The preclinical verification was made in vitro and in vivo, and in the end, clinical proofs validated the method. Our objective is to follow all the development steps from the laboratory to the clinics in a trilogy of articles. This present is the first part, which deals with in silico, phantom, and in vitro research.

Model of Polysilicon Electro-thermal Micro Actuator and Research of Micro Scale Effect

A type of crank beam electro-thermal micro actuator was prescribed. Mechanical model of the actuator was established, and the static characteristic was analyzed.Comparing the theoretical analysis with experimental data, it is found that the thermodynamic character of material in micro actuator has a different variable regularity contrasted to that used in macro scale machines. It is the micro scale effect that results in the deviation between the simulating result and experimental results. The thermodynamic expression of polysilicon, which was fitted by means of the experimental data concerned, was used to modify the mechanical model. The modified model, in which the micro scale thermodynamic characteristic was considered, was more reasonable and could make the optimal design and control strategies analyzing the straight-line micro actuator more feasible.

ELECTRO-THERMAL EFFECTS AND DEFORMATION RESPONSE OF CARBON FIBER MAT CEMENT BEAMS

A carbon fiber mat is a sheet composed of intercrossing short carbon fibers,which has more stable and lower electrical resistivity compared with dispersed short carbon fiber mixed in cement.Thereby carbon fiber mat cement could exhibit obvious electro-thermal effect.When electrified,the temperature of composite structures made up of cement mortar and carbon fiber mat will rise rapidly.If the temperature field is not uniform,temperature difference will cause structures to deform,which can be used to adjust the deformation of structures.The temperature field and deformation response driven by the electro-thermal effects of a type of carbon fiber mat cement beams are studied.Firstly,the temperature and deformation responses are studied using theories of thermal conduction and elasticity.Secondly,experimental results are given to verify the theoretical solution.These two parts lay the foundation for temperature and deformation adjustment.

STUDY ON THE THERAPEUTIC EFFECT AND MECHANISMS OF ELECTRO-THERMAL NEEDLING FOR TREATMENT OF VULVAL LEUKOPLASIA

In the present paper,444 patients with vulvar leukoplasia were treated by selectingacupoints in the local area and along the meridian plus Qugu（CV 2）and Huiyin（CV 1）and usingelectro-thermal needling.The total effective rate was up to 100.0％and the cure rate 87.3％.Theelectro-thermal effect directly acted on the affected area but strengthened the immunologic function ofthe whole body and raised the content of serum copper.

Microstructure and wear resistance of electro-thermal explosion sprayed stellite coating used for remanufacturing

Electro-thermal explosion directional spraying was used to prepare the stellite coating on substrate of the AISI 1045 steel. The morphologies of cross-section and worn scar, porosity, distribution of elements, micro- hardness and wear resistance of the coating were determined by means of SEM, EDAX, micro-hardness tester and sliding wear tester. Because of the compact construction, good bonding and high hardness, the coating is characterized by good wear resistance. The results show that the mainly failure mode of the stellite coating is micro- plowing.

ELECTRO-THERMAL MOXIBUSTION ON ACUPOINTS FOR TREATMENT OF 98 CASES OF SCIATICA

98 patients with sciatica are treated.by stimubting acupoints using a self-made electro-thermal moxibustion instrument.Results show that 82 cases arecured,8 improved and 5 effective,with the total effective rate of 96.9％.The temperature relesed from this instrument is adjustable.The electro-thermal moxibustion therapy is short in treatment duration and rapid in taking effect.Ithas no needling-induced pain and no side-effects,and is accepted preferably by patients.

High-temperature corrosion-resistance performance of electro-thermal explosion spraying coating

As a new spraying technology used in the remanufacturing engineering, electro-thermal explosion spraying holds a lot of advantages. Electro-thermal explosion spraying coating aliquation phenomena are reduced and non-crystal, micro-crystal and millimicron-crystal and other microstructure are formed. The corrosion-resistance ability of electro-thermal explosion spraying coating in high temperature environment was surveyed respectively. SEM equipped with EDS was employed to analyze the microstructure of spraying coating before and after corrosion. The corrosion-resistance mechanism of the spraying coating was discussed.

Microstructure and Deposition Mechanism of C/SiCN Composites Prepared by Rapid Electro-thermal Pyrolysis CVD

Carbon fiber-reinforced silicon carbonitride ceramic matrix composites （C/SiCN） were prepared by rapid electro-thermal pyrolysis CVD using liquid polymer hexamethyldisilazane （HMDS, （CH3）3SiNHSi（CH3）3） as precursor. Microstructure morphology and production technique of C/SiCN composites were investigated. Scanning electron microscopy and transmission electron microscopy were respectively employed to characterize microstructures of the as-received C/SiCN composites samples. The high temperature pyrolysis of HMDS results in destruction of molecular chain, fracture of bonds, as well as liquid-gas-solid conversion from polymer to ceramic. Microstructures observation indicates that there is a high degree of coalescence between SiCN matrix and C fiber. The deposition model of liquid precursor electro-thermal pyrolysis CVD is different from that of gas precursor isothermal chemical vapor infiltration. Rapid liquid flow and slow gas diffusion are key factors for the difference of two methods. Preparation of rapid electro-thermal pyrolysis CVD consists of four steps including liquid polymer infiltration, polymer pyrolysis, rapid deposition of pyrolyzed substances and rapid densification, respectively.

Design and Fabrication of 2-DOF Micromirror Array Based on Electro-Thermal Actuators

With surface- and bulk-micromachining, an 8 × 8 mirrors array is designed, fabricated and tested, which is based on electro-thermal actuators and can be addressed individually. The micromirror is square shaped, 4-corner-actuated. Its dimension is 200 μm × 200 μm. The substrate below it is caved away to ensure a tilt at an angle as large as possible. To protect the etch-sensitive features on the front side of the wafer undamaged during wet deep silicon etch on the backside, the wax protective coating process is used. Mirror actuated by powering an alternative pair of heaters will tilt in 2-DOF. If its 4 cantilevers/heaters are powered synchronously, it will move in a piston mode. The effective arrays are more than 80% out of the three finished wafers. When the ramp voltage frequency applied to a pair of neighboring cantilevers is 5 Hz at 10 V, the average tilting angle can be ± 8°.

Study on Approach of Static Security Assessment Accounting for Electro-thermal Coupling

A static security assessment approach considering electro-thermal coupling of transmission lines is proposed in this paper. Combined with the dynamic thermal rating technology and energy forecasting, the approach can track both the electrical variables and transmission lines’ temperature varying trajectory under anticipated contingencies. Accordingly, it identifies the serious contingencies by transmission lines’ temperature violation rather than its power flow, in this case the time margin of temperature rising under each serious contingency can be provided to operators as warning information and some unnecessary security control can also be avoided. Finally, numerical simulations are carried out to testify the validity of the proposed approach.

Fast Calculation Method of Energy Flow for Combined Electro-Thermal System and Its Application

In recent years, Combined electro-thermal system has developed rapidly. In order to provide the initial data for the analysis of the combined electro-thermal system, a practical energy flow calculation method for the combined electro-thermal system is proposed in this paper. Based on the detailed analysis of the topology structure of the heating network and its hydraulic and thermodynamic model, the forward-backward sweep method for the heat flow of the heating network is established, which is more suitable for the actual radial heating network. The electric and thermal coupling model for heating source, such as thermoelectric unit and electric boiler is established, and the heat flow of heating network and the power flow of power grid are calculated orderly, thus a fast calculation method for the combined electro-thermal system is formed. What’s more, a combined electro-thermal system with two-stage peak-shaving electric boiler is used as the example system. This paper validates the effectiveness and rapidity of this method through the example system, and analyzes the influence for the energy flow of combined electro-thermal system caused by the operating parameters such as the installation location of electric boiler, the outlet water temperature of heat source and the outlet flow rate, etc.

THE FUZZY NUMERICAL VALUE SIMULATION OF NANOMETER ELECTRO-THERMAL IN HOT-WORKING

The fuzzy numerical value analysis method is adopted for the first time, which solves the problem of nanometer electro-thermal in filming process, The key technique is embodied by controlling the time distribution, temperature and press in the filming process. The concrete technique of filming is showed by establishing the fuzzy mumbership function of above three indexes, which improves the precision of the materials of nanometer electro-thermal in hot-working. At the same time, the principles of the fuzzy relationship mapping inversion （FRMI） is put forward, Therefore, the standardization and continuity can be met.

Synthesis of Ti₃SiC₂-Bicarbide Based Ceramic by Electro-Thermal Explosion

A polycrystalline dense Ti3SiC2 based ceramic material has been produced by several techniques. The effect of addition of TiC and SiC is also studied. The Ti3SiC2 material shows extraordinary electrical, thermal and mechanical properties. Furthermore, it shows a damage tolerance capability and oxidation resistance. In this work, we have synthesized Ti3SiC2 by electro-thermal explosion chemical reaction (ETE) with high current density (900 Amperes/a.u) followed by uniaxial pressure. The structural properties of the as-prepared materials are studied by x-ray diffraction (XRD), scanning electron microscope (SEM) and energy dispersive x-ray spectroscopy (EDX) techniques. The chemical cartography, imaging and electronic properties are investigated using Ultra-STEM and electron high energy loss resolution spectroscopy (EELS) techniques, respectively. The surface of Ti3SiC2 is characterized by means of X-ray photoelectron spectroscopy (XPS). High resolution C 1s, Si 2p, Ti 2p, Ti 3s core level spectra are explained in terms of crystallographic and electronic structure. Valence band spectrum is performed to confirm the validity of the theoretical calculations.

电缆终端应力锥错位缺陷对界面温度及应力分布的影响

电缆终端内部缺陷会造成终端内部电场分布不均、局部温度升高与应力分布变化,可能引发局部放电造成绝缘击穿。为研究终端应力锥错位缺陷对电缆界面温度及应力分布的影响,分别建立了电缆终端安装不足与安装过盈情况下的电缆终端错位缺陷模型,并进行电-热-力多物理场耦合仿真分析。结果表明:电缆终端绝缘屏蔽层截断处是电缆终端的薄弱部位,终端界面温度和界面压力都会在绝缘屏蔽层截断处发生突变。当电缆终端存在安装不足缺陷时,终端屏蔽层截断处与应力锥根部之间会出现电场升高区域,在安装位置为-7.5 mm时界面温度最高,绝缘界面压力值升高,且安装位置为-2.5mm时绝缘承受的压力值最大;当电缆终端存在安装过盈缺陷时,绝缘屏蔽层截断处会发生电场畸变,电场突变量随着偏移量的增加而增大,在安装位置为+5.0mm时绝缘界面压力值最大,且界面压力突变量增加发生畸变。因此,在电缆终端实际设计安装与运行维护中,额外注意应力锥错位缺陷对终端内部应力分布的影响十分必要。

电渗热固结处理顶管废弃泥浆的减量化研究

针对顶管废弃泥浆渗透性差、含水率高、承载力低等特点,采用电渗热固结法对其进行减量化研究,并探究不同温度条件下电渗热固结的处理效果。选取EKG电极板作为电极,分析在40℃、60℃、80℃等不同加热温度下,泥浆固化过程中的排水量、排水速率、温度、电流等参数的变化趋势,对比电渗热固结前后泥浆的物理力学特性变化。结果表明:电渗热固结能够有效促进泥浆的排水,提高固结效率,降低含水率,增强固化泥浆的承载力和抗剪强度;在其加热到一定程度时,裂缝进展过快,泥浆导电性减弱,加热效率降低,且加热的温度越高,加热效率越低;电渗热固结对顶管废弃泥浆减量化应用具有一定的有效性与可行性。本文的研究成果可为其实际工程应用提供借鉴与参考。

微型组合导航SIP芯片的PDN电热协同仿真与优化

随着SIP芯片逐步小型化和集成化,导致芯片对PDN的直流压降、电流密度以及系统的温升控制要求越来越高.本文通过改变载流导体的面积来改善直流压降和电流密度过高的问题,同时针对芯片温升研究通过合理优化热过孔阵列的孔径、过孔数量以及镀铜厚度来减小热阻以达到控制芯片温升的目的.仿真结果表明,增加载流导体的面积能有效降低直流压降和电流密度,且还留有很大的裕量;而热过孔阵列的合理布局能有效控制芯片温升,从而提升了芯片的功能和可靠性.

硅基三维异构集成射频微系统的多物理场耦合仿真与设计

利用硅基三维异构集成工艺设计一款射频微系统,以满足设备对射频模组高性能、小型化的需求。为了在设计初期充分评估该微系统的潜在可靠性风险,根据工艺特征以及产品在多物理场中的耦合现象,建立一种面向硅基三维异构集成工艺射频微系统的多物理场一体化仿真流程,逐一分析所涉及的电-热耦合和热-力耦合过程,预判产品在工作条件下的热学和力学特性,为设计环节提供针对性的指导,预先规避可靠性风险,从而有效提高一次性设计成功率。

不同配比下MWCNTs和H-BN改性PVB新型复合材料导热特性分析

采用溶液共混法制备了以多壁碳纳米管(MWCNTs)、六方氮化硼(H-BN)为填料,以聚乙烯醇缩丁醛(PVB)为基底的新型复合材料,通过瞬态电热技术研究了不同填料配比、不同环境温度下复合材料的导热性能。实验结果表明,随着环境温度从290K降低到10K,复合材料的热导率逐渐降低;复合材料的热导率随着MWCNTs含量的增加先增大后减小,且当MWCNTs和H-BN的质量分数比例为5∶5时导热系数达到最大值,是纯PVB的两倍。

光热转换纳米纤维膜制备与性能研究

光热转换纳米纤维膜在产业用纺织品等领域中应用广泛。文中利用静电纺丝技术制备聚偏氟乙烯(PVDF)纳米纤维膜,通过在纺丝液中掺杂硫化铋颗粒(Bi_(2)S_(3))和氧化石墨烯颗粒(GO)或纤维膜浸泡盐酸多巴胺的方式对PVDF纳米纤维膜进行改性,得到不同组分纳米纤维膜材料。从形貌、机械性能、热稳定性能、光热转换性能和耐腐蚀性能等方面进行评价,其中PDA-GO-Bi_(2)S_(3)-PVDF纳米纤维膜纤维形貌良好、直径分布均匀、力学性能优良,具有良好的光热转换性能,光热转换温度可达101℃,是未改性PVDF纳米纤维膜的两倍,同时具有良好的热稳定性和耐腐蚀性能。