Hypoglycemic Effect of Radix Et Rhizoma Salviae Miltiorrhizae,Guixi Green Tea and Their Compatibility on Mice

[Objectives]To explore the hypoglycemic effect of Radix Et Rhizoma Salviae Miltiorrhizae,Guixi green tea and their compatibility on mice,so as to provide more options for the adjuvant treatment of diabetes and improve the comprehensive utilization value of Guixi green tea.[Methods]After being fed adaptively for 7 d,60 SPF-grade male mice were intraperitoneally injected with alloxouracil(180 mg/kg)to induce hyperglycemia model,from which 35 mice with a successful model were selected.They were randomly divided into 5 groups(Danshen group,green tea group,compatible group,positive control group and blank control group),with 7 animals in each group.The mice in all groups were administered according to the dose of 200 mg/kg once a day for 15 d.After the last administration,their body weight was measured on the 15 th day after fasting for 12 h,and their fasting blood glucose was measured by tail clipping.[Results]After modeling,the mice in each group showed typical hyperglycemia symptoms,namely obvious polydipsia,polyphagia,polyuria and weight loss.Compared with the blank control group,Danshen group and green tea group had obvious hypoglycemic effect(P<0.05),and compatible group had significant hypoglycemic effect(P<0.01).Compared with the blank control group,the weight loss of diabetic mice could also be inhibited in green tea group and compatible group(P<0.05).[Conclusions]Danshen,Guixi green tea and their compatibility had the effect of lowering blood sugar,among which the compatible group had the most obvious effect.

Effects of Radix Puerariae, Radix Rehmanniae and Their Compatibility on Blood Glucose and Blood Lipids in Mice

[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fasting blood glucose of mice were measured after 7 and 14 d of administration,and the biochemical indicators of blood lipids(TC,HDL-C,and LDL-C)were detected after 14 d of administration.[Results]Compared with the Radix Puerariae group and Radix Rehmanniae group,the compatibility group(1:2)had the best hypoglycemic effect(P<0.05),and TC and LDL-C in the compatibility group(2:1)significantly decreased(P<0.05),while HDL-C in the compatibility group(1:1)significantly increased(P<0.05).[Conclusions]Radix Puerariae,Radix Rehmanniae and their combination can reduce the blood glucose of diabetic mice.The compatibility group(1:2)had a significant hypoglycemic effect(P<0.05),and LDL-C in the compatibility group(2:1)significantly declined,while HDL-C in the compatibility group(1:1)rose significantly.

Rapid evolution of T2/S-RNase genes in Fragaria linked to multiple transitions from self-incompatibility to self-compatibility

The T2/RNase gene family is widespread in eukaryotes,and particular members of this family play critical roles in the gametophytic self-incompatibility(GSI) system in plants.Wild diploid strawberry(Fragaria)species have diversified their sexual systems via self-incompatible and self-compatible traits,yet how these traits evolved in Fragaria remains elusive.By integrating the published and de novo assembled genomes and the newly generated RNA-seq data,members of the RNase T2 gene family were systematically identified in six Fragaria species,including three self-incompatible species(Fragaria nipponica,Fragaria nubicola,and Fragaria viridis) and three self-compatible species(Fragaria nilgerrensis,Fragaria vesca,and Fragaria iinumae).In total,115 RNase T2 genes were identified in the six Fragaria genomes and can be classified into three classes(Ⅰ-Ⅲ) according to phylogenetic analysis.The identified RNase T2 genes could be divided into 22 homologous gene sets according to amino acid sequence similarity and phylogenetic and syntenic relationships.We found that extensive gene loss and pseudogenization coupled with small-scale duplications mainly accounted for variations in the RNase T2 gene numbers in Fragaria.Multiple copies of homologous genes were mainly generated from tandem and segmental duplication events.Furthermore,we newly identified five S-RNase genes in three self-incompatible Fragaria genomes,including two in F.nipponica,two in F.viridis,and one in F.nubicola,which fit for typical features of a pistil determinant,including highly pistil-specific expression,highly polymorphic proteins and alkaline isoelectric point(pI),while no S-RNase genes were found in all three selfcompatible Fragaria species.Surprisingly,these T2/S-RNase genes contain at least one large intron(>10 kb).This study revealed that the rapid evolution of T2/S-RNase genes within the Fragaria genus could be associated with its sexual mode,and repeated evolution of the self-compatible traits in Fragaria was convergent via losses of S-RNase.

Epidemiological Investigation of Brucellosis Spondylitis and Optimal Selection of Clinical Drug Compatibility, Treatment Course and Treatment Plan

Background: Brucellosis is a zoonotic endemic disease, the main source of infection is infected cattle, sheep, pigs and their products. In recent years, the global incidence of brucellosis spondylitis has increased year by year, and it has spread from pastoral areas to semi-agricultural and semi-pastoral areas, agricultural areas and cities. It has changed from a mainly occupational disease to a mainly food-borne disease, and it is also a zoonotic specific spinal infectious disease that WHO and governments around the world pay great attention to. Due to the low cure rate and high recurrence rate of traditional drug therapy regimen. Therefore, to carry out epidemiological investigation and Related research on clinical drug therapy of brucellosis spondylitis has practical significance for improving diagnosis rate, cure rate and reducing recurrence rate. Objective: To analyze the epidemiological characteristics of Brucellosis spondylitis and explore the choice of drugs and the best drug treatment plan, so as to provide scientific basis for improving the prevention and control of the disease and treatment effect. Methods: Clinical epidemiodogical materials were collected from 113 patients with brucellar spondylitis. All these patients were divided into 5 different groups according to 5 kinds of drugs adopted respectively, and then the patients were given different course of treatment. Results: In the 113 patients, brucellar spondylitis morbility of female patients were higher than that of male ones, and the morbility of Bashang were higher than that of Baxia. These patients were infected mainly through browsing and breeding beasts. Lumbars were the major focus of infection. It was very comnlon that two adjacent lumbars were involved in concurrently. L4 was the most common infection location and its demolishment was most serious. The curative effect of group treated with doxycycline was better than that of group treated without doxycycline. If the course of treatment Was increased, the curative effect Was not increased obviously. Conclusions: There are characteristic features in clinical epidemiology of brucell spondylitis. Doxycycline + Rifampicin + Sulfamethoxazole was used as the preferred antibiotic. Using antibiotics adequately and jointly by two courses of treatment for a long time is the most reasonable way to treat the disease and prevent the disease from recurrence.

Enhancing the compatibility of the amyloid-dye hybrid nanostructure for improved photo-biocatalysis

Artificial photosynthesis is significant for renewable energy generation,sustainable development,and environmental protection.Dye-protein hybrids are promising for developing photosynthesis mimics(e.g.,photo-biocatalysis),but their performances are far lower than the plant photosystems,partially because of the incompatibility between dye and the protein matrix that limits excited state electron transfer of the included dyes.Here,using ThT-insulin amyloid assembly as a model system,we proposed that increasing the dye-protein compatibility could lead to the improved photo-biocatalytic performance.A ThT derivative,ThTPD,was designed with the same electron acceptor but extended π-conjugated donor structure.When integrated into the insulin amyloid,the extended π-conjugated donor structure allowed increased binding affinity and energy with the amyloid matrix,thus better electron transport to the mediator to drive the photocatalytic reaction.Meanwhile,compared with ThT, ThTPD exhibited improved light absorption and longer excited state lifetime.The photo-biocatalytic performance of ThTPD-insulin amyloid was greatly improved as compared with that of ThT in reduced nicotinamide adenine dinucleotide(NADH) regeneration.When integrating with NADH-dependent L-glutamate reductase,the efficiency of the ThTPD-insulin amyloid hybrid was 2.8-fold higher than that of ThT in glutamate generation,showing promising feature in biocatalytic solar-to-chemical conversion.

Exploring the compatibility theory of traditional Chinese medicine formulae:the disassembled prescriptions study

Traditional Chinese medicine(TCM)has become very popular in the treatment of complex diseases worldwide in recent decades.Despite the promising performance of TCM,how herbs work synergistically in a formula and their therapeutic targets remain ambiguous.This largely limits the correct use and modernization of TCM formulas clinically.The study of disassembled prescriptions is important for investigating the compatibility theory of Chinese medicines.By dissecting the mechanisms of TCM formulae,the compatibility principles of some well-known formulae,such as Realgar-Indigo naturalis,have been elucidated to a certain extent.In this review,several common methods of disassembled prescription studies are summarized,including those of single herb or mineral,sub-prescription,active ingredients or effective parts,large formulae,and systems pharmacology studies,as well as the methods of grouping based on the properties or efficacy of Chinese medicines,in order to provide evidence for formulae study.Moreover,some challenges to be addressed in disassembled prescriptions studies have been identified in this review.

Compatibility Rules of Prescriptions of Tibetan Medicine Polygonatum cirrhifolium Based on Data Mining

[Objectives]To study the prescription compatibility rules of the Tibetan medicine Polygonatum cirrhifolium(Polygonati Rhizoma,Huangjing)based on data mining,so as to provide data support for clinical application and new drug development.[Methods]Prescriptions containing Tibetan medicine Huangjing were collected from Tibetan Medicine Prescriptions Encyclopedia and Tibetan Medicine Classic Literature Collection.The Traditional Chinese Medicine Inheritance Computing System(TCMICS 3.0)and R version 4.1.3 were used to mine and analyze the compatibility rules of prescriptions containing Tibetan medicinal material Huangjing,the rules of medication for high-frequency diseases,and the association rules of various medicinal materials.[Results]A total of 124 prescriptions were collected from the classic literature of Tibetan medicine,and the frequency statistical analysis showed that drugs compatible with Huangjing(≥15)included Tianmendong(Root of Cochinchinese Asparagus)(80),Mirabilis himalaica(Edgew.)Heimerl(Himalayan purple jasmine)(72),Jili(Tribuli Fructus)(70),Tibetan Aoruqin(Vicatia coniifolia)(58),Baidoukou(Round Cardamom Fruit)(47),Hezi(Chebulae Fructus)(45),Shouzhangshen(Rhizome of Conic Gymnadenia)(28),Yuganzi(Phyllanthi Fructus)(26),Pomegranate(25),Maohezi(Terminaliae Belliricae Fructus)(24),Zicaorong(Lacca)(23),Rougui(Cinnamomi Cortex)(15).The main diseases were yellow water disease(20),gynecological diseases(19),kidney cold disease(17),and other Tibetan medicine diseases.Association rule analysis showed that the drug combinations with the highest frequency were Huangjing—Tianmendong,Huangjing—Himalayan purple jasmine,and Huangjing—Jili.[Conclusions]The frequency of combined use of Tibetan medicine Huangjing with dry yellow water,tonifying kidney and diuresis,nourishing health,and treating gynecological diseases is relatively high.

Compatibility Rules of Prescriptions of Tibetan Medicinal Material Mirabilis himalaica(Edgew.)Heimerl Based on Data Mining

[Objectives]To study the prescription compatibility rules of the Tibetan medicinal material Mirabilis himalaica(Edgew.)Heimerl(Himalayan purple jasmine)based on data mining,and to provide reference for clinical application and new drug development.[Methods]The literature data were collected and the prescriptions containing Himalayan purple jasmine were sorted and classified by Microsoft Excel 2019 software.The Traditional Chinese Medicine Inheritance Computing System(TCMICS 3.0)was used to statistically analyze the high-frequency drugs and core drug combinations,the frequency of disease treatment,and the rules of"tastes transforming flavors"of drugs.The FP-tree algorithm was used to analyze the association rules among various Tibetan medicinal materials in the prescriptions,and different supports were set to analyze the compatibility rules of the prescriptions.[Results]There were a total of 129 prescriptions containing Himalayan purple jasmine,297 medicinal materials used in combination with it,and 34 Tibetan medicinal materials with a frequency of≥15.The medicinal flavors were mostly sweet,bitter,and pungent.Among the three flavors,bitterness and sweetness were the majority.At the same time,the medicinal properties were blunt,soft,cool,and warm.A total of 130 kinds of diseases were involved,among which 8 kinds of diseases such as gynecology,kidney cold and yellow water disease had a high frequency.Through association rule analysis,33 commonly used core drug combinations were obtained.The support,confidence,and frequency of the five drug combinations[Jili(Tribuli Fructus),Huangjing(Polygonati Rhizoma),Tianmendong(Root of Cochinchinese Asparagus),and Tibetan Aoruqin(Vicatia coniifolia)]→Himalayan purple jasmine were the basic prescription of Tibetan medicine Wudagen Powder.The drug combinations with higher confidence included Bibo(Piperis Longi Fructus)→Himalayan purple jasmine,Pomegranate(Punica granatum→Himalayan purple jasmine,Baidoukou(Round Cardamom Fruit)→Himalayan purple jasmine,Hezi(Chebulae Fructus)→Himalayan purple jasmine.Jili(Tribuli Fructus)→Himalayan purple jasmine,Huangjing(Polygonati Rhizoma)→Himalayan purple jasmine and Tianmendong(Root of Cochinchinese Asparagus)→Himalayan purple jasmine had highest frequency.[Conclusions]Through the TCMICS,this paper analyzed the compatibility rules of commonly used drugs containing Himalayan purple jasmine and the characteristics of the main diseases.It can be seen that Himalayan purple jasmine is sweet in taste and warm in nature.It assists sovereign drugs in the form of ministerial drugs,which enhances the effect of regulating"long"and nourishing,and plays the role of regulating"long",dispelling cold,and reconciling various drugs,which embodies the compatibility rules of sovereign and ministerial drugs of Tibetan medicines.The main diseases of Himalayan purple jasmine are related to"long"regulation,and it is mostly used in the treatment of gynecological diseases after being combined with other drugs to form a prescription.Most drugs in the prescriptions are sweet,which is the therapeutic principle of regulating"long"and nourishing,and verifies the scientific and rational principle of clinical use of Tibetan medicine.In the prescription,the medicinal properties include both warm and cool,and the medicinal taste is sweet and bitter,which is in line with the compatibility theory of"tastes transforming flavors"in traditional Tibetan medicine prescriptions.

Compatibility mechanism of Chinese medicine formula:state of the art and perspectives

Traditional Chinese medicine(TCM)has been practiced in China and surrounding countries for thousands of years and has gradually attracted the attention of Western countries.After reasonable compatibility,TCMs could play the key role of enhancing efficacy and reducing toxicity,which has significant therapeutic advantages in the treatment of complex diseases in clinical practice.While the TCM compatibility is not the simple addition of drugs.Under the appropriate dosage ratio,multiple TCMs can play a synergistic role to realize the overall regulation of TCM treatment.Therefore,it is of critical essential to study the compatibility of TCM formula to promote TCM modernization,new drug development and clinical application.Recently,under the guidance of TCM theory,many researches on the composition,pharmacodynamic activity and pharmacokinetic properties of TCM formula have emerged by integrating new technologies and new methods,revealing the scientific connotation of the compatibility of TCM formula from different perspectives and levels.This paper introduces the research progress of compatibility rules from different levels of compatibility,compatibility for synergistic enhancement and detoxification,and application of cutting-edge technology,with representative cases,in order to provide ideas and references for further study on TCM compatibility.

蒲公英、忍冬藤抗菌活性组分及配伍研究

为了探寻蒲公英和忍冬藤高效抗菌活性组分及其配伍活性,试验以蒲公英和忍冬藤为研究对象,通过70%乙醇提取、大孔树脂D101柱层析和抗菌活性跟踪相结合的方式优选各自的高效抗菌活性组分,并对这些组分进行总黄酮、有机酸和多酚含量分析和活性配伍研究。结果表明蒲公英和忍冬藤的高效抗菌活性组分分离工艺为:先用70%乙醇回流提取,浓缩后用大孔树脂D101柱层析,70%或50%乙醇洗脱部位即为它们的高效抗菌活性组分。这些组分对9种供试病原菌都具有较强的广谱抗菌性,蒲公英的最小抑菌浓度(MIC)和最小杀菌浓度(MBC)分别约为1.95 mg/mL和15.63 mg/mL,忍冬藤的MIC和MBC分别约为1.95 mg/mL和31.25 mg/mL。且含量分析显示,蒲公英高效抗菌活性组分黄酮和多酚含量相对较高,忍冬藤高效抗菌活性组分多酚含量相对较高。配伍研究发现,当蒲公英高效抗菌活性部位与少量忍冬藤水洗脱部位(16∶1~4∶1)或其高效抗菌部位(16∶1~1∶1)配伍使用时,对部分供试菌的抗菌活性存在一定的相加作用。说明所得的蒲公英和忍冬藤高效抗菌活性组分提取分离工艺简单、易得,广谱抗菌作用强,合适的配伍使用可以实现更好的抗菌作用。

基于Comsol软件的电磁兼容课程案例式教学设计

该文介绍基于Comsol软件的电磁兼容课程案例式教学方法。通过案例教学和仿真,学生将理论知识应用于实际问题,深入理解电磁兼容的概念和原理。通过仿真案例的可视化结果,学生直观地理解电磁辐射和传导,观察不同参数对电磁兼容性的影响。结果表明,仿真案例具有直观性和可视化等优势,同时又有简化模型、缺乏实际操作经验和对计算机的依赖等局限性。在设计仿真案例时,要充分发挥其优势,规避不足,为学生的学习提供实践性、直观性和灵活性,培养学生的工程设计与研发能力。

危险废物渗滤液阳离子和应力作用下膨润土化学相容性研究

膨润土因其优异的防渗性能被用于危险废物填埋场防渗屏障的构筑,但其防渗性能通常会受到渗滤液和应力的影响。通过渗滤液采样分析设置不同浓度阳离子溶液,系统探究实际渗滤液组分对膨润土防渗性能的影响规律;选用Ca^(2+)作为特征阳离子研究不同应力条件下膨润土渗透系数变化规律;同时结合Zeta电位和DLVO理论计算,阐明渗滤液组分和应力作用对膨润土化学相容性影响规律。结果表明,渗滤液中Al^(3+)、Fe^(3+)、Zn^(2+)、Ni^(2+)、Cu^(2+)、Fe^(2+)、Mn^(2+)浓度为0~0.20 mmol/L时,对膨润土膨胀特性和渗透特性影响较小。Mg^(2+)、Ca^(2+)、K^(+)、Na^(+)浓度为0.20~50 mmol/L时,Ca^(2+)对膨润土膨胀特性和渗透特性影响较大,Ca^(2+)浓度由1 mmol/L上升到50 mmol/L时,渗透系数由1.15×10^(−7)cm/s急速上升到6.34×10^(−6)cm/s。Ca^(2+)浓度和应力通常通过影响水化后膨润土孔隙比进而影响其渗透特性,相同Ca^(2+)浓度条件下,渗透系数随应力增加而逐渐降低。Zeta电位和DLVO理论分析表明,Ca^(2+)浓度增大会导致膨润土表面负电势减弱,引起膨润土双电层厚度减小,使膨润土中蒙脱石的层间距变小,导致膨润土膨胀特性和渗透特性降低。因此,填埋过程中应优化危险废物固化稳定化工艺,从源头减少渗滤液中Ca^(2+)浓度;同时还应研发新型膨润土复合材料,提高膨润土在Ca^(2+)等高浓度盐溶液中的防渗性能,防控危险废物填埋场渗漏风险。

面向多目标优化主动运维的电能表远程在线评价系统设计

针对传统电能表远程在线评价系统中存在的系统建造成本耗费较大、评价结构过于繁琐等问题,从评价系统的构建和评价算法两方面开展研究。在评价系统的设计方面,加入反馈,使得该评价系统不仅可以整合各项评价指标进行规律化的采集,还可以对评价指标进行实时反馈,提高了评价的效率和评价信息传输的效率。在评价算法方面,基于解耦评价算法对电能表的运行状态和采集数据进行评价,对数据信息进行归纳处理,并根据大量的数据样本进行条理化分析评价。通过仿真实验可知,硬件反馈线路的数据传输效率高达98.6%,具有很好的传输能力。

聚丙烯/木粉复合材料的制备及性能

分别采用聚丙烯的固相接枝共聚物和熔融接枝共聚物作为聚丙烯/木粉复合材料的界面改性剂,研究两种多单体接枝共聚物用量对复合材料界面结构、拉伸性能、弯曲性能、抗冲击性能等的影响,并根据拉伸性能数据计算复合材料的界面黏结强度。结果表明:两种多单体接枝共聚物均能有效地提高复合材料的力学性能,并维持良好的热稳定性;随多单体接枝共聚物用量的增加,复合材料的力学性能提高,当多单体接枝共聚物用量为5 phr时,复合材料的界面相容性较稳定,力学性能最佳,界面黏结强度参数从2.56升至3.50以上,表明复合材料具有较强的界面黏结强度。

绿色金融支持和美乡村建设的机制与路径研究

新时代新征程,建设宜居宜业和美乡村,对于满足国民对美好生活的新需求、提高乡村社会文明程度、推进农业农村现代化,进而全面建成社会主义现代化强国具有重要意义。这一目标的实现需要打造生态优质的“宜居”乡村、生产兴旺的“宜业”乡村、生活幸福的“和美”乡村。然而目前和美乡村建设面临着生态环境与经济发展相冲突及乡村建设资金短板尚未解决的现实挑战,为此本文提出要借助绿色金融之手来解决这些问题。绿色金融可以通过政府引导的积累机制与市场参与的投资机制,促进产业生态化与生态产业化实现生态补偿和修复及经营和权属交易。此外,借助绿色金融工具可以降低交易成本,从而实现乡村治理的激励相容,最终达成宜居宜业和美乡村建设的目标。

氧化石墨烯对天然水硬性石灰水化及力学性能的影响

石质文物是一类重要的文化遗产,然而裂隙会导致其产生失稳、渗水、风化等病害,因此,开发一种合适的灌浆材料用于石质文物裂隙修复具有重要意义。本文将氧化石墨烯(GO)掺入天然水硬性石灰(NHL2)制备灌浆材料,采用SEM、TG、XRD和FT-IR等测试研究了GO掺量对NHL2水化进程及水化产物的影响,通过力学性能测试和模拟灌浆试验评价了该材料用于石质文物灌浆加固的可行性。结果表明:添加GO可加速NHL2的水化进程,促进规整致密的花状聚集态水化产物的形成;当GO掺量为0.05%(质量分数)时,试样的水化产物含量最多,力学性能最好,28 d抗压强度和抗折强度分别达2.83和1.63 MPa,相比空白试样分别提高了19.91%和23.40%。此外,灌浆材料与砂岩之间具有优异的黏结强度,两者界面结合紧密,兼容性良好。本研究为石质文物的裂隙灌浆加固提供了参考。

适用于LAS系统的全液体隔离液体系

固井施工过程中,在注入水泥浆前,需要先泵入一定量的隔离液,在海洋固井现场施工作业过程中,隔离液配制一般需要繁重的人工劳作,劳动强度大,作业效率低,加量不准确。为解决上述问题,用液体添加剂代替固体添加剂,通过LAS材料添加系统将材料混配作业,从传统的重体力劳动转化为智能化操作,降低作业强度,提高固井作业效率与降低人员成本。通过反相乳液聚合制备了一种液体隔离剂C-S70L,以它为主剂,构建了一套适用于液体加料系统(LAS)的隔离液体系。该体系推荐使用温度为20~120℃,适用密度为1.30~1.70 g/cm^(3);具有良好的悬浮稳定性(热滚后无沉降)、流变可调、失水可控以及相容性好的特点。

高灵敏微波载荷卫星出舱电缆及舱体屏蔽的EMC设计

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