THE USEFULNESS OF ^(99)Tc-PMT DELAYED HEPATOBILIARY IMAGING IN THE DIAGNOSIS OF SMALL HEPATOCELLULAR CARCINOMA

This investigation was aimed to assess the usefulness of delayed hepalobillary Imaging in the diagnosis of small hepatocellular carcinoma (HCC). Sixty-two patients with this hepatic cancer were Included in the study. 56 males and 6 females, with a mean age of 50. 6 yr. (32 - 72 years old). All patients were performed by surgery, verified histologically, and these tumors were smaller than 5 cm. Liver scans were performed 5 minutes, 2 hours and 5 hours after the administration of radlopharmaceutices. In 31 of the 62 patients (50%), the tumor exhibited equal radioactivity uptake or greater radioactivity uptake than the surrounding liver in delayed imaging. And the sensitivity was 33. 3% (2/6), 41.2% (7/17), 60.0% (9/15) and 54.2% (13/24) In the tumor size was ≤2 cm, 2-3cm, 3-4 cm and 4 - 5 cm, respectively. The smallest mass to be detected was only 1. 2 cm. The uptake of radiopharmaceutic was nonsignificantly related to serum AFP level and hepatic cirrhosis (P>0. 05). These results show that 99-Tc-PMT delayed hepatobiliary imaging can be useful in the diagnosis of small hepatocellular carcinoma.

DETECTION OF CANCER-ASSOCIATED ANTIGEN IN FECES USING MONOCLONAL ANTIBODIES IN THE DIAGNOSIS OF COLON CARCINOMA

Monoclonal antibodies against colon and pancreatic cancer, CL-2, CL-3, PS-9, PS-10, were used to detect the associated antigens in feces of patients with gastrointestinal carcinoma and non-cancer diseases. Binding inhibition test by SABC-ELISA method were performed for the measurement of the antigen level. Results showed that the associated antigen detected in feces of patients with colon cancer were significantly higher than that of non-cancer disease or normal subjects. The positive rates were 61.1% as detected with CL-2; 53.4% with CL-3; 55.0%, PS-9; and 53.3% PS-10 in cancer patients while that in normal subjects were 7%; 9%; 8%; and 8% respectively. When 'cocktail' of CL-2, PS-9 and PS-10 were used, the positive rates were 92.5% in colon cancer and 14% in normal subjects. In seven out of the sixty patients with colon cancer studied who were graded as Dukes A, the results were all positive. The results seem superior to the serologic detection and may provide a promising new approach in the early diagnosis of colon cancer.

Diagnostic challenges in alcohol use disorder and alcoholic liver disease

Alcohol use disorders represent a heterogeneous spectrum of clinical manifestations that have been defined by the Diagnostic and Statistical Manual of Mental Disorders-5. Excessive alcohol intake can lead to damage of various organs, including the liver. Alcoholic liver disease includes different injuries ranging from steatosis to cirrhosis and implicates a diagnostic assessment of the liver disease and of its possible complications. There is growing interest in the possible different tools for assessing previous alcohol consumption and for establishing the severity of liver injury, especially by noninvasive methods.

The enlightenment and application of“Laxative method used in early stage of Febrile Disease”in treating COVID-19

The theory of the TCM laxative method is rich in content.Doctors of past dynasties have used it to treat febrile diseases.And the theory of“Laxative method used in early stage of Febrile Disease”has been praised by later generations.It advocates chasing away evil influence early and paying attention to the laxative method to prevent the spread of disease.the Novel Coronavirus(COVID-19)Infectious Pneumonia belongs to the category of"epidemic"in traditional Chinese medicine.The reasonable application of the cathartic is an important way to provide a way out for evil.However,don’t be blind to use laxative method,you should get it at the right time.The treatment of COVID-19 has different solution at different stages.You should adapt to the changes of the disease to use cathartic.A case in here is attached for reference.

Use of Whole-Exome Sequencing for the Diagnosis of Atypical Birte-Hogge-Dubé Syndrome

Destruction of the lung parenchyma may result in the forma- tion of cysts, cavities and bullae. Definition of the type of destructive lesion is best achieved by high-resolution computed tomography （HRCT） scans of the chest （Trotman- Dickenson, 2014）. The loss of lung parenchyma may result in respiratory compromise and pneumothoraces. In the case of cystic lung destruction, multiple causes have been identified, with the cysts being a manifestation of inherited and non- inherited diseases （Sahn and Heffner, 2000）. Compared with sporadic cases, familial lung cysts/spontaneous pneumothorax are rare and are manifestation of some Mendelian genetic diseases.

Therapeutic role of template-based lymphadenectomy in urothelial carcinoma of the upper urinary tract

Lymphadenectomy for urothelial carcinoma of the upper urinary tract has attracted the attention of physicians. The mapping study of lymphatic spread has shown that a relatively wide area should comprise the regional nodes for tumors of the right renal pelvis or the right upper two-thirds of the ureter. A prospective study showed that an anatomical templatebased lymphadenectomy significantly improved patient survival in tumors of the renal pelvis. This benefit was more evident for patients with p T2 stage tumors or higher. The risk of regional node recurrence is significant reduced by template-based lymphadenectomy,which is likely to be associated with improved patient survival. The removal of lymph node micrometastases is assumed to be the reason for therapeutic benefit following lymphadenectomy. The number of resected lymph nodes can be used to assess the quality of lymphadenectomy,but not to determine the extent of lymphadenectomy. The guidelines currently recommend lymphadenectomy for patients with muscle-invasive disease,even though the current recommendation grades are still low. The present limitation of lymphadenectomy is the lack of standardization of the extent of lymphadenectomy and the randomized trials. Further studies are warranted to collect the evidence to support lymphadenectomy.

Effect of Qinling granule in treatment of 102 patients with chronic hepatitis B

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A Regularized LSTM Method for Predicting Remaining Useful Life of Rolling Bearings

Rotating machinery is important to industrial production. Any failure of rotating machinery, especially the failure of rolling bearings, can lead to equipment shutdown and even more serious incidents. Therefore, accurate residual life prediction plays a crucial role in guaranteeing machine operation safety and reliability and reducing maintenance cost. In order to increase the forecasting precision of the remaining useful life(RUL) of the rolling bearing, an advanced approach combining elastic net with long short-time memory network(LSTM) is proposed, and the new approach is referred to as E-LSTM. The E-LSTM algorithm consists of an elastic mesh and LSTM, taking temporal-spatial correlation into consideration to forecast the RUL through the LSTM. To solve the over-fitting problem of the LSTM neural network during the training process, the elastic net based regularization term is introduced to the LSTM structure.In this way, the change of the output can be well characterized to express the bearing degradation mode. Experimental results from the real-world data demonstrate that the proposed E-LSTM method can obtain higher stability and relevant values that are useful for the RUL forecasting of bearing. Furthermore, these results also indicate that E-LSTM can achieve better performance.

^(99)Tc同位素扫描诊断食管裂孔疝及GER的临床观察

本文采用^(99)Tc同位素扫描对12例食管裂孔疝行术前和术后检查.结果证明^(99)Tc同位素扫描可确定GER的程度.这对术式的选择,术后疗效的评定都是一项客观指标.同时还介绍了同位素扫描对GER的诊断,评价,食管裂孔疝与GER的关系.

Prognostic Condition Monitoring for Wind Turbine Drivetrains via Generator Current Analysis

Maintenance costs account for a significant portion of the total cost of electricity generated by wind turbines.Currently in the wind power industry,maintenance is mainly performed on regular schedules or when significant damage occurs in a wind turbine making it inoperable,instead of being determined by the actual condition of the wind turbine.Among the total maintenance costs,approximately 25%~35%is related to regularly scheduled preventive maintenance and 65%~75%to unscheduled corrective maintenance.To reduce the failure rate and level and maintenance costs and improve the availability,reliability,safety,and lifespans of wind turbines,it is desirable to perform condition-based predictive maintenance for wind turbines,which will require a high-fidelity online prognostic condition monitoring system(CMS)for fault diagnosis and prognosis and remaining useful life(RUL)prediction of wind turbines.Most of the existing wind turbine CMSs are based on vibration monitoring and have no or limited capability in fault prognosis and RUL prediction.Compared to vibration monitoring,the prognostic condition monitoring techniques based on generator current signal analysis proposed recently have significant advantages in terms of cost,hardware complexity,implementation,and reliability.This paper discusses the principles and challenges of using generator current signals for prognostic condition monitoring of wind turbine drivetrains and presents an overview of recent advancements in this area.