Bioprinting has been widely investigated for tissue engineering and regenerative medicine applications.However,it is still difficult to reconstruct the complex native cell arrangement due to the limited printing resol...Bioprinting has been widely investigated for tissue engineering and regenerative medicine applications.However,it is still difficult to reconstruct the complex native cell arrangement due to the limited printing resolution of conventional bioprinting techniques such as extrusion-and inkjet-based printing.Recently,an electrohydrodynamic(EHD)bioprinting strategy was reported for the precise deposition of well-organized cell-laden constructs with microscale filament size,whereas few studies have been devoted to developing bioinks that can be applied for EHD bioprinting and simultaneously support cell spreading.This study describes functionalized alginate-based bioinks for microscale EHD bioprinting using peptide grafting and fibrin incorporation,which leads to high cell viability(>90%)and cell spreading.The printed filaments can be further refined to as small as 30μm by incorporating polyoxyethylene and remained stable over one week when exposed to an aqueous environment.By utilizing the presented alginate-based bioinks,layer-specific cell alignment along the printing struts could be observed inside the EHD-printed microscale filaments,which allows fabricating living constructs with cell-scale filament resolution for guided cellular orientation.展开更多
An electrohydrodynamic （EHD） method, which is based on glow discharge plasma, is presented for flow control in an S-shaped duct. The research subject is an expanding channel with a constant width and a rectangular c...An electrohydrodynamic （EHD） method, which is based on glow discharge plasma, is presented for flow control in an S-shaped duct. The research subject is an expanding channel with a constant width and a rectangular cross section. An equivalent divergence angle and basic function are introduced to build the three-dimensional model. Subsequently, the plasma physical models are simplified as the effects of electrical body force and work （done by the force） on the fluid near the wall. With the aid of FLUENT software, the source terms of momentum and energy are added to the Navier-Stokes equation. Finally, the original performance of three models （A, B and C） is studied, in which model A demonstrates better performance. Then EHD control based on model A is discussed. The results show that the EHD method is an effective way of reducing flow loss and improving uniformity at the duct exit. The innovation in this study is the assessment of the EHD control effect on the flow in an S-shaped duct. Both the parametric modeling of the S-shaped duct and the simplified models of plasma provide valuable information for future research on aircraft inlet ducts.展开更多
Electrohydrodynamic(EHD) force produced by corona discharge is considered as a new thrust for solar-powered aircraft and stratosphere balloons in near space. However, its performance at low air pressures remains to be...Electrohydrodynamic(EHD) force produced by corona discharge is considered as a new thrust for solar-powered aircraft and stratosphere balloons in near space. However, its performance at low air pressures remains to be clarified.An experiment of measuring the EHD force at 0.02 atm–1.0 atm(1 atm = 1.01325×10^(5)Pa) is carried out with the wireto-cylinder geometric structure. The ion distribution is analyzed by using the drift-diffusion model with two-dimensional numerical simulation. The experimental result shows that the EHD force is not linearly related to the corona discharge current at low air pressures. Numerical simulation finds that the proportion of ions in the counter-direction electric field increases from approximately 0.36% to 30% when the pressure drops from 1.0 atm to 0.2 atm. As a result, the EHD force with a constant power supply drops faster than the previous theoretical prediction in the ground experiment, suggesting that the consideration of counter-direction EHD force is necessary to improve the ionic wind propulsion efficiency in near-space applications.展开更多
In this study, we developed a polymeric nanofiber patch(PNP) for topical disease treatment using electrohydrodynamic atomization(EHDA). The nanofibers were prepared using various concentrations of polyvinyl alcohol(PV...In this study, we developed a polymeric nanofiber patch(PNP) for topical disease treatment using electrohydrodynamic atomization(EHDA). The nanofibers were prepared using various concentrations of polyvinyl alcohol(PVA) and tamarind seed gum and loaded with clindamycin HCl as a model drug. The precursor polymer solutions were sprayed using the EHDA technique; the EHDA processing parameters were optimized to obtain blank and drug-loaded PNPs. The skin adherence, translucence, and ventilation properties of the prepared PNPs indicated that they are appropriate for topical application. The conductivity of the polymer solution increased with increasing PVA and clindamycin concentrations, and increasing the PVA concentration enhanced the solution viscosity. Based on scanning electron microscopy analysis, the PVA concentration had a pronounced effect on the morphology of the sprayed product. Nanofibers were fabricated successfully when the solution PVA concentration was 10%, 13%, or 15%(w/v). The applied voltage significantly affected the diameters of the prepared nanofibers, and the minimum nanofiber diameter was 163.86 nm. Differential scanning calorimetry and X-ray diffraction analyses indicated that the modeldrug was dispersed in PVA in an amorphous form. The PNP prepared with a PVA:gum ratio of 9:1 absorbed water better than the PVA-only PNP and the PNP with a PVA:gum ratio of 9.5:0.5. Moreover, the PNPs loaded with clindamycin at concentrations of 1%–3% prohibited the growth of Staphylococcus aureus more effectively than clindamycin gel, a commercially available product.展开更多
A multi-layer interconnection structure is a basic component of electronic devices, and printing of the multi-layer interconnection structure is the key process in printed electronics. In this work, electrohydrodynami...A multi-layer interconnection structure is a basic component of electronic devices, and printing of the multi-layer interconnection structure is the key process in printed electronics. In this work, electrohydrodynamic direct-writing （EDW） is utilized to print the conductor-insulator--conductor multi-layer ~nterconne^ction structure. Silver ink is chosen to print the conductor pattern, and a polyvinylpyrrolidone （PVP） solution is util^zed to f^bricate the insulator layer between the bottom and top conductor patterns. The influences of EDW process parameters on the line width of the printed conductor and insulator patterns are studied systematically. The obtained ~es^l~s show that the line width of the printed structure increases with the increase of the flow rate, but decreases with the increase of applied voltage and PVP content in the solution. The average resistivity values of the bottom and top silver conductor tracks are determined to be 1.34 × 10-7 Ω.m and 1.39×10-7 Ω.m, respectively. The printed PVP layer between the two conductor tracks is well insulated, which can meet the insulation requirement of the electronic devices. This study offers an alternative, fast, and cost-effective method of fabricating conductor-insulator-conductor multi-layer interconnections in the electronic industry.展开更多
In previous studies, the nonlinear problem of electrohydrodynamic(EHD)ion drag flows in a circular cylindrical conduit has been studied by several authors. However, those studies seldom involve the computation for lar...In previous studies, the nonlinear problem of electrohydrodynamic(EHD)ion drag flows in a circular cylindrical conduit has been studied by several authors. However, those studies seldom involve the computation for large physical parameters such as the electrical Hartmann number and the magnitude parameter for the strength of the nonlinearity due to the existence of strong nonlinearity in these extreme cases. To overcome this faultiness, the newly-developed homotopy Coiflets wavelet method is extended to solve this EHD flow problem with strong nonlinearity. The validity and reliability of the proposed technique are verified. Particularly, the highly accurate homotopy-wavelet solution is obtained for extreme large parameters, which seems to be overlooked before.Discussion about the effects of related physical parameters on the axial velocity field is presented.展开更多
Nanometer powders can be produced by an electrohydrodynamic technique. The breakup mechanism of the metal droplets generated by the electrohydrodynamic technique was analysed. It showed that the applied voltage, the e...Nanometer powders can be produced by an electrohydrodynamic technique. The breakup mechanism of the metal droplets generated by the electrohydrodynamic technique was analysed. It showed that the applied voltage, the electric field Btrength, the properties of the molten metal and the volumetric flow rate of the molten metal directly effect the breat-up extent of the metal droplets.展开更多
In this Paper, we have proposed a new weighted residual method known as orthogonal collocation-based on mixed interpolation (OCMI). Mixed interpolation uses the classical polynomial approximation with two correction t...In this Paper, we have proposed a new weighted residual method known as orthogonal collocation-based on mixed interpolation (OCMI). Mixed interpolation uses the classical polynomial approximation with two correction terms given in the form of sine and cosine function. By these correction terms, we can control the error in the solution. We have applied this approach to a non-linear boundary value problem (BVP) in ODE which governs the electrohydrodynamic flow in a cylindrical conduit. The solution profiles shown in the figures are in good agreement with the work of Paullet (1999) and Ghasemi et al. (2014). Our solution is monotonic decreasing and satisfies , where, α governs the strength of non-linearity and for large values of α solutions are . The residual errors are given in Table 1 and Table 2 which are significantly small. Comparison of residual errors between our proposed method, Least square method and Homotopy analysis method is also given and shown via the Table 3 where as the profiles of the residual error are depicted in Figures 4-8. Table and graphs show that efficiency of the proposed method. The error bound and its L2-norm with relevant theorems for mixed interpolation are also given.展开更多
基金This work was financially supported by the National Key Research and Development Program of China(No.2018YFA0703003)the National Natural Science Foundation of China(No.52125501)+1 种基金the Key Research Project of Shaanxi Province(Nos.2021LLRH-08,2020GXLH-Y-021,and 2021GXLH-Z-028)the Youth InnovationTeam of Shaanxi Universities and the Fundamental Research Funds for the Central Universities.
文摘Bioprinting has been widely investigated for tissue engineering and regenerative medicine applications.However,it is still difficult to reconstruct the complex native cell arrangement due to the limited printing resolution of conventional bioprinting techniques such as extrusion-and inkjet-based printing.Recently,an electrohydrodynamic(EHD)bioprinting strategy was reported for the precise deposition of well-organized cell-laden constructs with microscale filament size,whereas few studies have been devoted to developing bioinks that can be applied for EHD bioprinting and simultaneously support cell spreading.This study describes functionalized alginate-based bioinks for microscale EHD bioprinting using peptide grafting and fibrin incorporation,which leads to high cell viability(>90%)and cell spreading.The printed filaments can be further refined to as small as 30μm by incorporating polyoxyethylene and remained stable over one week when exposed to an aqueous environment.By utilizing the presented alginate-based bioinks,layer-specific cell alignment along the printing struts could be observed inside the EHD-printed microscale filaments,which allows fabricating living constructs with cell-scale filament resolution for guided cellular orientation.
文摘An electrohydrodynamic （EHD） method, which is based on glow discharge plasma, is presented for flow control in an S-shaped duct. The research subject is an expanding channel with a constant width and a rectangular cross section. An equivalent divergence angle and basic function are introduced to build the three-dimensional model. Subsequently, the plasma physical models are simplified as the effects of electrical body force and work （done by the force） on the fluid near the wall. With the aid of FLUENT software, the source terms of momentum and energy are added to the Navier-Stokes equation. Finally, the original performance of three models （A, B and C） is studied, in which model A demonstrates better performance. Then EHD control based on model A is discussed. The results show that the EHD method is an effective way of reducing flow loss and improving uniformity at the duct exit. The innovation in this study is the assessment of the EHD control effect on the flow in an S-shaped duct. Both the parametric modeling of the S-shaped duct and the simplified models of plasma provide valuable information for future research on aircraft inlet ducts.
基金Project supported by the National Natural Science Foundation of China (Grant No. 51877111)。
文摘Electrohydrodynamic(EHD) force produced by corona discharge is considered as a new thrust for solar-powered aircraft and stratosphere balloons in near space. However, its performance at low air pressures remains to be clarified.An experiment of measuring the EHD force at 0.02 atm–1.0 atm(1 atm = 1.01325×10^(5)Pa) is carried out with the wireto-cylinder geometric structure. The ion distribution is analyzed by using the drift-diffusion model with two-dimensional numerical simulation. The experimental result shows that the EHD force is not linearly related to the corona discharge current at low air pressures. Numerical simulation finds that the proportion of ions in the counter-direction electric field increases from approximately 0.36% to 30% when the pressure drops from 1.0 atm to 0.2 atm. As a result, the EHD force with a constant power supply drops faster than the previous theoretical prediction in the ground experiment, suggesting that the consideration of counter-direction EHD force is necessary to improve the ionic wind propulsion efficiency in near-space applications.
基金the Faculty of Pharmaceutical Sci-ences,Burapha University for financial support(grant num-bers 9/2558)
文摘In this study, we developed a polymeric nanofiber patch(PNP) for topical disease treatment using electrohydrodynamic atomization(EHDA). The nanofibers were prepared using various concentrations of polyvinyl alcohol(PVA) and tamarind seed gum and loaded with clindamycin HCl as a model drug. The precursor polymer solutions were sprayed using the EHDA technique; the EHDA processing parameters were optimized to obtain blank and drug-loaded PNPs. The skin adherence, translucence, and ventilation properties of the prepared PNPs indicated that they are appropriate for topical application. The conductivity of the polymer solution increased with increasing PVA and clindamycin concentrations, and increasing the PVA concentration enhanced the solution viscosity. Based on scanning electron microscopy analysis, the PVA concentration had a pronounced effect on the morphology of the sprayed product. Nanofibers were fabricated successfully when the solution PVA concentration was 10%, 13%, or 15%(w/v). The applied voltage significantly affected the diameters of the prepared nanofibers, and the minimum nanofiber diameter was 163.86 nm. Differential scanning calorimetry and X-ray diffraction analyses indicated that the modeldrug was dispersed in PVA in an amorphous form. The PNP prepared with a PVA:gum ratio of 9:1 absorbed water better than the PVA-only PNP and the PNP with a PVA:gum ratio of 9.5:0.5. Moreover, the PNPs loaded with clindamycin at concentrations of 1%–3% prohibited the growth of Staphylococcus aureus more effectively than clindamycin gel, a commercially available product.
基金supported by the Key Program of the National Natural Science Foundation of China(Grant No.51035002)the National Natural Science Foundation of China(Grant No.51305373)the Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20120121120035)
文摘A multi-layer interconnection structure is a basic component of electronic devices, and printing of the multi-layer interconnection structure is the key process in printed electronics. In this work, electrohydrodynamic direct-writing （EDW） is utilized to print the conductor-insulator--conductor multi-layer ~nterconne^ction structure. Silver ink is chosen to print the conductor pattern, and a polyvinylpyrrolidone （PVP） solution is util^zed to f^bricate the insulator layer between the bottom and top conductor patterns. The influences of EDW process parameters on the line width of the printed conductor and insulator patterns are studied systematically. The obtained ~es^l~s show that the line width of the printed structure increases with the increase of the flow rate, but decreases with the increase of applied voltage and PVP content in the solution. The average resistivity values of the bottom and top silver conductor tracks are determined to be 1.34 × 10-7 Ω.m and 1.39×10-7 Ω.m, respectively. The printed PVP layer between the two conductor tracks is well insulated, which can meet the insulation requirement of the electronic devices. This study offers an alternative, fast, and cost-effective method of fabricating conductor-insulator-conductor multi-layer interconnections in the electronic industry.
基金the National Natural Science Foundation of China (No. 11872241)。
文摘In previous studies, the nonlinear problem of electrohydrodynamic(EHD)ion drag flows in a circular cylindrical conduit has been studied by several authors. However, those studies seldom involve the computation for large physical parameters such as the electrical Hartmann number and the magnitude parameter for the strength of the nonlinearity due to the existence of strong nonlinearity in these extreme cases. To overcome this faultiness, the newly-developed homotopy Coiflets wavelet method is extended to solve this EHD flow problem with strong nonlinearity. The validity and reliability of the proposed technique are verified. Particularly, the highly accurate homotopy-wavelet solution is obtained for extreme large parameters, which seems to be overlooked before.Discussion about the effects of related physical parameters on the axial velocity field is presented.
文摘Nanometer powders can be produced by an electrohydrodynamic technique. The breakup mechanism of the metal droplets generated by the electrohydrodynamic technique was analysed. It showed that the applied voltage, the electric field Btrength, the properties of the molten metal and the volumetric flow rate of the molten metal directly effect the breat-up extent of the metal droplets.
文摘In this Paper, we have proposed a new weighted residual method known as orthogonal collocation-based on mixed interpolation (OCMI). Mixed interpolation uses the classical polynomial approximation with two correction terms given in the form of sine and cosine function. By these correction terms, we can control the error in the solution. We have applied this approach to a non-linear boundary value problem (BVP) in ODE which governs the electrohydrodynamic flow in a cylindrical conduit. The solution profiles shown in the figures are in good agreement with the work of Paullet (1999) and Ghasemi et al. (2014). Our solution is monotonic decreasing and satisfies , where, α governs the strength of non-linearity and for large values of α solutions are . The residual errors are given in Table 1 and Table 2 which are significantly small. Comparison of residual errors between our proposed method, Least square method and Homotopy analysis method is also given and shown via the Table 3 where as the profiles of the residual error are depicted in Figures 4-8. Table and graphs show that efficiency of the proposed method. The error bound and its L2-norm with relevant theorems for mixed interpolation are also given.
