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Generation and regulation of electromagnetic pulses generated by femtosecond lasers interacting with multitargets
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作者 Ya-Dong Xia De-Feng Kong +14 位作者 Qiang-You He Zhen Guo Dong-Jun Zhang Tong Yang Hao Cheng Yu-Ze Li Yang Yan Xiao Liang Ping Zhu Xing-Long Xie Jian-Qiang Zhu Ting-Shuai Li Chen Lin Wen-Jun Ma Xue-Qing Yan 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第1期96-107,共12页
Ultrashort and powerful laser interactions with a target generate intense wideband electromagnetic pulses(EMPs).In this study,we report EMPs generated by the interactions between petawatt(30 fs,1.4×10^(20) W/cm^(... Ultrashort and powerful laser interactions with a target generate intense wideband electromagnetic pulses(EMPs).In this study,we report EMPs generated by the interactions between petawatt(30 fs,1.4×10^(20) W/cm^(2))femtosecond(fs)lasers with metal flat,plastic flat,and plastic nanowire-array(NWA)targets.Detailed analyses are conducted on the EMPs in terms of their spatial distribution,time and frequency domains,radiation energy,and protection.The results indicate that EMPs from metal targets exhibit larger amplitudes at varying angles than those generated by other types of targets and are enhanced significantly for NWA targets.Using a plastic target holder and increasing the laser focal spot can significantly decrease the radiation energy of the EMPs.Moreover,the composite shielding materials indicate an effective shielding effect against EMPs.The simulation results show that the NWA targets exert a collimating effect on thermal electrons,which directly affects the distribution of EMPs.This study provides guidance for regulating EMPs by controlling the laser focal spot,target parameters,and target rod material and is beneficial for electromagnetic-shielding design. 展开更多
关键词 electromagnetic pulses Laser plasma interaction electromagnetic shielding Electron distribution
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Spatial and temporal evolution of electromagnetic pulses from solid target irradiated with multi-hundred-terawatt laser pulse inside target chamber
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作者 何强友 邓志刚 +12 位作者 张智猛 夏亚东 张博 孟令彪 贺书凯 黄华 杨雷 刘红杰 范伟 林晨 周维民 李廷帅 颜学庆 《Plasma Science and Technology》 SCIE EI CAS CSCD 2024年第2期62-69,共8页
Giant electromagnetic pulses(EMPs) induced by high-power laser irradiating solid targets interfere with various experimental diagnoses and even damage equipment,so unveiling the evolution of EMPs inside the laser cham... Giant electromagnetic pulses(EMPs) induced by high-power laser irradiating solid targets interfere with various experimental diagnoses and even damage equipment,so unveiling the evolution of EMPs inside the laser chamber is crucial for designing effective EMP shielding.In this work,the transmission characteristics of EMPs as a function of distances from the target chamber center(TCC) are studied using B-dot probes.The mean EMP amplitude generated by picosecond laser-target interaction reaches 561 kV m^(-1),357 kV m^(-1),395 kV m^(-1),and 341 kV m^(-1)at 0.32 m,0.53 m,0.76 m,and 1 m from TCC,which decreases dramatically from 0.32 m to 0.53 m.However,it shows a fluctuation from 0.53 m to 1 m.The temporal features of EMPs indicate that time-domain EMP signals near the target chamber wall have a wider full width at half maximum compared to that close to TCC,mainly due to the echo oscillation of electromagnetic waves inside the target chamber based on simulation and experimentation.The conclusions of this study will provide a new approach to mitigate strong electromagnetic pulses by decreasing the echo oscillation of electromagnetic waves inside the target chamber during laser coupling with targets. 展开更多
关键词 TARGET electromagnetic pulses spatial distribution
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Electromagnetic pulses produced by a picosecond laser interacting with solid targets
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作者 牛爱慧 康宁 +5 位作者 许国潇 谢佳节 滕建 刘会亚 孙明营 李廷帅 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第5期430-436,共7页
A high-power laser ablating solid targets induces giant electromagnetic pulses(EMPs),which are intimately pertinent to laser parameters,such as energy and pulse width.In this study,we reveal the features of EMPs gener... A high-power laser ablating solid targets induces giant electromagnetic pulses(EMPs),which are intimately pertinent to laser parameters,such as energy and pulse width.In this study,we reveal the features of EMPs generated from a picosecond(ps)laser irradiating solid targets at the SG-Ⅱpicosecond petawatt(PSPW)laser facility.The laser energy and pulse,as well as target material and thickness,show determinative effects on the EMPs’amplitude.More intense EMPs are detected behind targets compared to those at the other three positions,and the EMP amplitude decreases from 90.09 kV/m to 17.8 kV/m with the gold target thickness increasing from 10μm to 20μm,which is suppressed when the laser pulse width is enlarged.The results are expected to provide more insight into EMPs produced by ps lasers coupling with targets and lay the foundation for an effective EMP shielding design in high-power laser infrastructures. 展开更多
关键词 LASER electromagnetic pulse TARGET PROTON
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Electromagnetic Pulses Generated From Laser Target Interactions at Shenguang Ⅱ Laser Facility 被引量:4
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作者 杨进文 李廷帅 +6 位作者 易涛 王传珂 杨鸣 杨为明 刘慎业 江少恩 丁永坤 《Plasma Science and Technology》 SCIE EI CAS CSCD 2016年第10期1044-1048,共5页
Significant electromagnetic pulses (EMP) can be generated by the intensive laser irradiating solid targets in inertial confinement fusion (ICF). To evaluate the EMP intensity and distribution in and outside the la... Significant electromagnetic pulses (EMP) can be generated by the intensive laser irradiating solid targets in inertial confinement fusion (ICF). To evaluate the EMP intensity and distribution in and outside the laser chamber, we designed and fabricated a discone antenna with ultra-wide bands of over 10 GHz. The return loss (Sn parameter) of this antenna was below -10 dB and could even achieve under -30 dB at 3.1 GHz. The EMP intensity in this study at 80 cm and 40 cm away from the target chamber center (TCC) reached 400 kV/m and 2000 kV/m. The current results are expected to offer preliminary information to study physics regarding laser plasma interactions and will also lay experimental foundation for EMI shielding design to protect various diagnostics. 展开更多
关键词 electromagnetic pulses discone antenna Shenguang II laser facility inertial confinement fusion
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Gene Expression Changes in the Pituitary Gland of Rats Exposed to Electromagnetic Pulses 被引量:1
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作者 QI YuHong LIANG Jun +4 位作者 HIM YanPing DING GuiRong LIU JunYe SU XiaoMing GUO GuoZhen 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2011年第5期560-568,共9页
Objective We examined alterations in the expression of tumorigenesis‐related genes in the pituitary gland of rats exposed to electromagnetic pulses (EMP).Methods The global gene expression profiles of the pituitary... Objective We examined alterations in the expression of tumorigenesis‐related genes in the pituitary gland of rats exposed to electromagnetic pulses (EMP).Methods The global gene expression profiles of the pituitary gland in EMP‐exposed and control groups were detected by cDNA microarray analysis.We then validated and further investigated the reduced expression of two tumorigenesis‐related genes,Pten,and Jund,by assessing their mRNA and protein expression by quantitative real‐time‐PCR,western blotting,and immunohistochemistry in the pituitary gland of rats 6 months after exposure to EMP.Results EMP exposure induced genome‐wide gene expression changes in the rat pituitary gland.There was decreased expression of the Pten and Jund mRNAs and proteins in EMP‐exposed rats compared with in unexposed control animals.Conclusion EMP exposure alters the expression of tumorigenesis‐related genes in the pituitary gland.These tumorigenesis‐related genes are potentially involved in the development of pituitary gland tumors in rats. 展开更多
关键词 TUMORIGENESIS electromagnetic pulses Pituitary gland PTEN JUND
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Analysis of electromagnetic pulses generated from ultrashort laser irradiation of solid targets at CLAPA 被引量:1
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作者 Yi-Lin Xu Dong-Yu Li +9 位作者 Ya-Dong Xia Si-Yuan Zhang Min-Jian Wu Tong Yang Jun-Gao Zhu Hao Cheng Chuan-Ke Wang Chen Lin Ting-Shuai Li Xue-Qing Yan 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第2期489-495,共7页
Electromagnetic pulses(EMPs)produced by the interaction of a TW femtosecond laser with solid targets at the Compact Laser Plasma Accelerator(CLAPA)are measured and interpreted.The statistical results confirm that the ... Electromagnetic pulses(EMPs)produced by the interaction of a TW femtosecond laser with solid targets at the Compact Laser Plasma Accelerator(CLAPA)are measured and interpreted.The statistical results confirm that the intensities of the EMPs are closely related to both target material and thickness.The signal of the titanium target is more abundant than that of the copper target with the same thickness,and the intensity of EMP is positively correlated with the target thickness for aluminium foil.With the boosted EMP radiations,the energy of accelerated protons is also simultaneously enhanced.In addition,EMPs emitted from the front of the target exceed those from the rear,which are also pertinent to the specific target position.The resonant waveforms in the target chamber are analyzed using the fast Fourier transform,and the local resonance and the attenuation lead to changes of the frequency spectra of EMPs with variation of detecting positions,which is well supported by the modeling results.The findings are beneficial to gaining insight into the mechanism of EMP propagation in a typical target chamber and providing more information for EMP shielding design. 展开更多
关键词 laser driven proton accleration electromagnetic pulses LASER TARGET
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Spatial and temporal evolution of electromagnetic pulses generated at Shenguang-Ⅱseries laser facilities 被引量:2
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作者 Qiangyou HE Ning KANG +10 位作者 Lei REN Chao TIAN Chuanke WANG Zhimeng ZHANG Dongxiao LIU Lei YANG Huiya LIU Mingying SUN Baoqiang ZHU Weimin ZHOU Tingshuai LI 《Plasma Science and Technology》 SCIE EI CAS CSCD 2021年第11期35-41,共7页
The distribution and sources of EMPs produced at Shenguang-Ⅱ(SG-Ⅱ)series laser facilities are systematically investigated.The results indicate that the EMP amplitudes in the SG-Ⅱps PW laser are very strong,one orde... The distribution and sources of EMPs produced at Shenguang-Ⅱ(SG-Ⅱ)series laser facilities are systematically investigated.The results indicate that the EMP amplitudes in the SG-Ⅱps PW laser are very strong,one order higher than those from the SG-Ⅱlaser facility.EMPs outside the target chamber decrease exponentially with the distance from the measuring points to the target chamber center at the two laser facilities.Moreover,EMPs can be remarkably reduced when the picosecond laser together with the nanosecond laser is incident to targets compared to the SG-Ⅱps PW laser alone.The resulting conclusions are expected to offer experimental supports for further effective EMPs shielding design and achievement in high-power laser facilities. 展开更多
关键词 LASER electromagnetic pulse TARGET INTENSITY
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Simulation of electromagnetic pulses generated by escaped electrons in a high-power laser chamber 被引量:1
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作者 Hanbing JIN Cui MENG +2 位作者 Yunsheng JIANG Ping WU Zhiqian XU 《Plasma Science and Technology》 SCIE EI CAS CSCD 2018年第11期45-52,共8页
Intensive electromagnetic pulses (EMPs) can be generated when a high-power laser strikes a target. The transient electromagnetic field can have an intensity of up to several hundred kV m- 1 with a broad frequency of... Intensive electromagnetic pulses (EMPs) can be generated when a high-power laser strikes a target. The transient electromagnetic field can have an intensity of up to several hundred kV m- 1 with a broad frequency of up to several gigahertz, which may affect diagnostics and interfere with, or even damage, electronic equipment. In this paper, the process in which hot electrons produced by the laser-target interaction radiate EMPs is studied and simulated. The physical process is divided into three stages which are: the production of hot electrons; the escape of hot electrons; and the generation of EMPs. Instead of using a general finite difference time domain (FDTD) method to solve the Maxwell equations, a particle-in-cell method together with a time- biased FDTD method is applied in EMP simulation to restrain high-frequency noise. The results show that EMPs are stronger with higher laser intensity and larger target size. 展开更多
关键词 laser plasma PARTICLE-IN-CELL electromagnetic pulse
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Effect and mechanism of on-chip electrostatic discharge protection circuit under fast rising time electromagnetic pulse
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作者 Mao Xinyi Chai Changchun +3 位作者 Li Fuxing Lin Haodong Zhao Tianlong Yang Yintang 《强激光与粒子束》 CAS CSCD 北大核心 2024年第10期44-52,共9页
The electrostatic discharge(ESD)protection circuit widely exists in the input and output ports of CMOS digital circuits,and fast rising time electromagnetic pulse(FREMP)coupled into the device not only interacts with ... The electrostatic discharge(ESD)protection circuit widely exists in the input and output ports of CMOS digital circuits,and fast rising time electromagnetic pulse(FREMP)coupled into the device not only interacts with the CMOS circuit,but also acts on the protection circuit.This paper establishes a model of on-chip CMOS electrostatic discharge protection circuit and selects square pulse as the FREMP signals.Based on multiple physical parameter models,it depicts the distribution of the lattice temperature,current density,and electric field intensity inside the device.At the same time,this paper explores the changes of the internal devices in the circuit under the injection of fast rising time electromagnetic pulse and describes the relationship between the damage amplitude threshold and the pulse width.The results show that the ESD protection circuit has potential damage risk,and the injection of FREMP leads to irreversible heat loss inside the circuit.In addition,pulse signals with different attributes will change the damage threshold of the circuit.These results provide an important reference for further evaluation of the influence of electromagnetic environment on the chip,which is helpful to carry out the reliability enhancement research of ESD protection circuit. 展开更多
关键词 fast rising time electromagnetic pulse damage effect electrostatic discharge protection circuit damage location prediction
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Laser produced electromagnetic pulses: generation, detection and mitigation 被引量:8
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作者 Fabrizio Consoli Vladimir TTikhonchuk +32 位作者 Matthieu Bardon Philip Bradford David CCarroll Jakub Cikhardt Mattia Cipriani Robert JClarke Thomas ECowan Colin NDanson Riccardo De Angelis Massimo De Marco Jean-Luc Dubois Bertr Etchessahar Alejro Laso Garcia David IHillier Ales Honsa Weiman Jiang Viliam Kmetik Josef Krása Yutong Li FredériéLubrano Paul McKenna Josefine Metzkes-Ng Alexre Poyé Irene Prencipe Piotr Ra¸czka Rol ASmith Roman Vrana Nigel CWoolsey Egle Zemaityte Yihang Zhang Zhe Zhang Bernhard Zielbauer David Neely 《High Power Laser Science and Engineering》 SCIE CAS CSCD 2020年第2期88-146,共59页
This paper provides an up-to-date review of the problems related to the generation,detection and mitigation of strong electromagnetic pulses created in the interaction of high-power,high-energy laser pulses with diffe... This paper provides an up-to-date review of the problems related to the generation,detection and mitigation of strong electromagnetic pulses created in the interaction of high-power,high-energy laser pulses with different types of solid targets.It includes new experimental data obtained independently at several international laboratories.The mechanisms of electromagnetic field generation are analyzed and considered as a function of the intensity and the spectral range of emissions they produce.The major emphasis is put on the GHz frequency domain,which is the most damaging for electronics and may have important applications.The physics of electromagnetic emissions in other spectral domains,in particular THz and MHz,is also discussed.The theoretical models and numerical simulations are compared with the results of experimental measurements,with special attention to the methodology of measurements and complementary diagnostics.Understanding the underlying physical processes is the basis for developing techniques to mitigate the electromagnetic threat and to harness electromagnetic emissions,which may have promising applications. 展开更多
关键词 electromagnetic pulses high-power lasers DIAGNOSTICS mitigation techniques
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Characterization of electromagnetic pulses via arrays on ShenGuang-III laser facility laser 被引量:4
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作者 杨鸣 李廷帅 +6 位作者 王传珂 杨进文 杨为明 易涛 刘慎业 江少恩 丁永坤 《Chinese Optics Letters》 SCIE EI CAS CSCD 2016年第10期67-72,共6页
Intensive electromagnetic pulses (EMPs) can be generated from interaction of the ultra-intense lasers and solid targets in inertial confinement fusion (ICF), which will detrimentally affect the data acquisition fr... Intensive electromagnetic pulses (EMPs) can be generated from interaction of the ultra-intense lasers and solid targets in inertial confinement fusion (ICF), which will detrimentally affect the data acquisition from some elec- tric components. A diagnostic system for EMP measurement inside and outside the ShenGuang-III facility is designed and fabricated in this study. The experimental results indicate that the peak magnitude of EMP reaches up to 3210.7 kV/m and 6.02 T. The received signals depend most on the antenna and target types. The half-hohlraum generates a more intensive EMP radiation than that from the other targets, and the large planar and medium discone capture much stronger signals than the other antennas, In addition, the mechanisms of EMP generation from different targets are discussed. The resulting conclusion are expected to provide the experimental basis for further EMP shielding design. 展开更多
关键词 ANTENNAS Data acquisition electromagnetic pulse Inertial confinement fusion
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Development of gated fiber detectors for laser-induced strong electromagnetic pulse environments 被引量:8
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作者 Po Hu Zhi-Guo Ma +5 位作者 Kai Zhao Guo-Qiang Zhang De-Qing Fang Bao-Ren Wei Chang-Bo Fu Yu-Gang Ma 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2021年第6期36-44,共9页
With the development of laser technologies,nuclear reactions can happen in high-temperature plasma environments induced by lasers and have attracted a lot of attention from different physical disciplines.However,studi... With the development of laser technologies,nuclear reactions can happen in high-temperature plasma environments induced by lasers and have attracted a lot of attention from different physical disciplines.However,studies on nuclear reactions in plasma are still limited by detecting technologies.This is mainly due to the fact that extremely high electromagnetic pulses(EMPs)can also be induced when high-intensity lasers hit targets to induce plasma,and then cause dysfunction of many types of traditional detectors.Therefore,new particle detecting technologies are highly needed.In this paper,we report a recently developed gated fiber detector which can be used in harsh EMP environments.In this prototype detector,scintillating photons are coupled by fiber and then transferred to a gated photomultiplier tube which is located far away from the EMP source and shielded well.With those measures,the EMPs can be avoided which may result that the device has the capability to identify a single event of nuclear reaction products generated in laser-induced plasma from noise EMP backgrounds.This new type of detector can be widely used as a time-of-flight(TOF)detector in high-intensity laser nuclear physics experiments for detecting neutrons,photons,and other charged particles. 展开更多
关键词 Gated fiber detector Radiation detection High-intensity laser Strong electromagnetic pulses
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Cable coupling response in metal cavity under X-ray irradiation
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作者 Mao-Xing Zhang Lan-Feng Yuan +1 位作者 Cui Meng Yi-Nong Liu 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第10期110-120,共11页
This study investigates the coupling response of cables inside a metal cavity under X-ray irradiation using the finite-difference time-domain method,particle simulation method,and transmission-line equation to solve t... This study investigates the coupling response of cables inside a metal cavity under X-ray irradiation using the finite-difference time-domain method,particle simulation method,and transmission-line equation to solve the electromagnetic field inside the cavity and load voltage at the cable terminal under X-ray excitation.The results show that under a strong ionizing radiation environment of 1 J/cm^(2),a strong electromagnetic environment is generated inside the cavity.The cable shielding layer terminal couples a voltage of 15.32 V,whereas the core wire terminal couples a voltage of 0.31 V.Under strong X-ray irradiation,the metal cavity not only fails to provide electromagnetic shielding,but also introduces new electromagnetic interference.This study also provides a method for reducing the number of emitted electrons by adding low-Z materials,which can effectively reduce the coupled electric field and voltage. 展开更多
关键词 Ionizing radiation Metal cavity System-generated electromagnetic pulse Transmission-line model
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Detecting the meteoroid by measuring the electromagnetic waves excited by the collision between the hypervelocity meteoroid and spacecraft
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作者 Bo LIU Heng ZHANG +3 位作者 Bin XU Zhengzheng MA Hui LI Wenshan DUAN 《Plasma Science and Technology》 SCIE EI CAS CSCD 2022年第11期70-77,共8页
The electromagnetic pulse excited by the collision between a hypervelocity meteoroid and a spacecraft is studied both numerically and theoretically.It is found that there are two kinds of electromagnetic pulse.The hig... The electromagnetic pulse excited by the collision between a hypervelocity meteoroid and a spacecraft is studied both numerically and theoretically.It is found that there are two kinds of electromagnetic pulse.The high-frequency electromagnetic pulse may be excited by the sum of all the electric dipoles.Each electron can be considered as an electric dipole.The low-frequency electromagnetic pulse is produced by the Langmuir oscillation of electrons.The energy flux density and the duration time of the excited low-frequency electromagnetic pulse by the meteoroid are also studied in the present paper.It is shown that the energy flux density increases as either the impact speed or the mass of the meteoroid increases.It is also shown that the duration time decreases as both the impact speed and the mass of the meteoroid increase.By measuring the strength and the duration time of the electromagnetic pulse excited by the collision between the hypervelocity meteoroid and spacecraft,we can estimate the speed and the mass of the hypervelocity meteoroid,which will be helpful in space flight and space exploration. 展开更多
关键词 PLASMA electromagnetic pulses hypervelocity impact PIC simulation
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Detrimental Effect of Electromagnetic Pulse Exposure on Permeability of In Vitro Blood-brain-barrier Model 被引量:10
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作者 ZHOU Jia Xing DING Gui Rong +3 位作者 ZHANG Jie ZHOU Yong Chun ZHANG Yan Jun GUO Guo Zhen 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2013年第2期128-137,共10页
Objective To study the effect of electromagnetic pulse (EMP) exposure on permeability of in vitro blood-brain-barrier (BBB) model. Methods An in vitro BBB model, established by co-culturing brain microvascular end... Objective To study the effect of electromagnetic pulse (EMP) exposure on permeability of in vitro blood-brain-barrier (BBB) model. Methods An in vitro BBB model, established by co-culturing brain microvascular endothelial cells (BMVEC) and astroglial cells (AC) isolated from rat brain, was exposed to EMP at 100 kV/m and 400 kV/m, respectively. Permeability of the model was assayed by measuring the transendothelial electrical resistance (TEER) and the horseradish peroxidase (HRP) transmission at different time points. Levels of BBB tight junction-related proteins were measured at O, 1, 2, 4, 8, 12, 16, 20, 24 h after EMP exposure by Western blotting. Results The TEER level was lower in BBB model group than in control group at 12 h after EMP, exposure which returned to its normal level at 24 h. The 24 h recovery process was triphasic and biphasic respectively after EMP exposure at 100 kV/m and 400 kV/m. Following exposure to 400 kV/m EMP, the HRP permeability increased at 1-12 h and returned to its normal level at 24 h. Western blotting showed that the claudin-5 and ZO-1 protein levels were changed after EMP exposure. Conclusion EMP exposure at 100 kV/m and 400 kV/m can increase the permeability of in vitro BBB model and BBB tight junction-related proteins such as ZO-1 and claudin-5 may change EMP-induced BBB permeability. 展开更多
关键词 electromagnetic pulse BLOOD-BRAIN-BARRIER PERMEABILITY TEER HRP ZO-1 CLAUDIN-5
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Effect of Electromagnetic Pulse Exposure on Brain Micro Vascular Permeability in Rats 被引量:10
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作者 GUI-RONG DING KANG-CHU LI +5 位作者 XIAO-WU WANG YONG-CHUN ZHOU LIAN-BO QIU JUAN TAN SHENG-LONG XU AND GUO-ZHEN GUO 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2009年第3期265-268,共4页
Objective To observe the effect of electromagnetic pulse (EMP) exposure on cerebral micro vascular permeability in rats. Methods The whole-body of male Sprague-Dawley rats were exposed or sham exposed to 200 pulses or... Objective To observe the effect of electromagnetic pulse (EMP) exposure on cerebral micro vascular permeability in rats. Methods The whole-body of male Sprague-Dawley rats were exposed or sham exposed to 200 pulses or 400 pulses (1 Hz) of EMP at 200 kV/m. At 0.5, 1, 3, 6, and 12 h after EMP exposure, the permeability of cerebral micro vascular was detected by transmission electron microscopy and immunohistochemistry using lanthanum nitrate and endogenous albumin as vascular tracers, respectively. Results The lanthanum nitrate tracer was limited to the micro vascular lumen with no lanthanum nitrate or albumin tracer extravasation in control rat brain. After EMP exposure, the lanthanum nitrate ions reached the tight junction, basal lamina and pericapillary tissue. Similarly, the albumin immunopositive staining was identified in pericapillary tissue. The changes in brain micro vascular permeability were transient, the leakage of micro vascular vessels appeared at 1 h, and reached its peak at 3 h, and nearly recovered at 12 h, after EMP exposure. In addition, the leakage of micro vascular was more obvious after exposure of EMP at 400 pulses than after exposure of EMP at 200 pulses. Conclusion Exposure to 200 and 400 pulses (1 Hz) of EMP at 200 kV/m can increase cerebral micro vascular permeability in rats, which is recoverable. 展开更多
关键词 electromagnetic pulse PERMEABILITY Cerebral micro vascular RATS
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Low-frequency pulsed electromagnetic field pretreated bone marrow-derived mesenchymal stem cells promote the regeneration of crush-injured rat mental nerve 被引量:12
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作者 NaRi Seo Sung-Ho Lee +5 位作者 Kyung Won Ju JaeMan Woo BongJu Kim SoungMin Kim Jeong Won Jahng Jong-Ho Lee 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第1期145-153,共9页
Bone marrow-derived mesenchymal stem cells (BMSCs) have been shown to promote the regeneration of injured peripheral nerves. Pulsed electromagnetic field (PEMF) reportedly promotes the proliferation and neuronal d... Bone marrow-derived mesenchymal stem cells (BMSCs) have been shown to promote the regeneration of injured peripheral nerves. Pulsed electromagnetic field (PEMF) reportedly promotes the proliferation and neuronal differentiation of BMSCs. Low-frequency PEMF can induce the neuronal differentiation of BMSCs in the absence of nerve growth factors. This study was designed to investigate the effects of low-frequency PEMF pretreatment on the proliferation and function of BMSCs and the effects of low-frequency PEMF pre-treated BMSCs on the regeneration of injured peripheral nerve using in vitro and in vivo experiments.In in vitro experiments, quantitative DNA analysis was performed to determine the proliferation of BMSCs, and reverse transcription-polymerase chain reaction was performed to detect S100 (Schwann cell marker), glial fibrillary acidic protein (astrocyte marker), and brain-derived neurotrophic factor and nerve growth factor (neurotrophic factors) mRNA expression. In the in vivo experiments, rat models of crush-injured mental nerve established using clamp method were randomly injected with low-frequency PEMF pretreated BMSCs, unpretreated BMSCs or PBS at the injury site (1 × 106 cells). DiI-labeled BMSCs injected at the injury site were counted under the fluorescence microscope to determine cell survival. One or two weeks after cell injection, functional recovery of the injured nerve was assessed using the sensory test with von Frey filaments. Two weeks after cell injection, axonal regeneration was evaluated using histomorphometric analysis and retrograde labeling of trigeminal ganglion neurons. In vitro experiment results revealed that low-frequency PEMF pretreated BMSCs proliferated faster and had greater mRNA expression of growth factors than unpretreated BMSCs. In vivo experiment results revealed that compared with injection of unpretreated BMSCs, injection of low-frequency PEMF pretreated BMSCs led to higher myelinated axon count and axon density and more DiI-labeled neurons in the trigeminal ganglia, contributing to rapider functional recovery of injured mental nerve. These findings suggest that low-frequency PEMF pretreatment is a promising approach to enhance the efficacy of cell therapy for peripheral nerve injury repair. 展开更多
关键词 nerve regeneration mesenchymal stem cells low-frequency pulsed electromagnetic field peripheral nerve injury crush-injured mental nerve
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Effect of Electromagnetic Pulse Exposure on Permeability of Blood-testicle Barrier in Mice 被引量:5
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作者 XIAO-WU WANG GUI-RONG DING +4 位作者 CHANG-HONG SHI TAO ZHAO JIE ZHANG LI-HUA ZENG Guo-ZHEN GUO 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2008年第3期218-221,共4页
Objective To study the effect of electromagnetic pulse (EMP) exposure on the permeability of blood-testicle barrier (BTB) in mice. Methods Adult male BALB/c mice were exposed to EMP at 200 kV/m for 200 pulses with... Objective To study the effect of electromagnetic pulse (EMP) exposure on the permeability of blood-testicle barrier (BTB) in mice. Methods Adult male BALB/c mice were exposed to EMP at 200 kV/m for 200 pulses with 2 seconds interval. The mice were injected with 2% Evans Blue solution through caudal vein at different time points after exposure, and the permeability of BTB was monitored using a fluorescence microscope. The testis sample for the transmission electron microscopy was prepared at 2 h after EMP exposure. The permeability of BTB in mice was observed by using Evans Blue tracer and lanthanum nitrate tracer. Results After exposure, cloudy Evans Blue was found in the testicle convoluted seminiferous tubule of mice. Lanthanum nitrate was observed not only between testicle spermatogonia near seminiferous tubule wall and sertoli cells, but also between sertoli cells and primary spermatocyte or secondary spermatocyte. In contrast, lanthanum nitrate in control group was only found in the testicle sertoli cells between seminiferous tubule and near seminifdrous tubule wall. Conclusion EMP exposure could increase the permeability of BTB in the mice. 展开更多
关键词 electromagnetic pulse (EMP) Blood-testicle barrier (BTB) LANTHANUM Evans Blue PERMEABILITY MICE
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Analysis of the damage threshold of the GaAs pseudomorphic high electron mobility transistor induced by the electromagnetic pulse 被引量:4
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作者 席晓文 柴常春 +3 位作者 刘阳 杨银堂 樊庆扬 史春蕾 《Chinese Physics B》 SCIE EI CAS CSCD 2016年第8期458-462,共5页
An electromagnetic pulse(EMP)-induced damage model based on the internal damage mechanism of the Ga As pseudomorphic high electron mobility transistor(PHEMT) is established in this paper. With this model, the rela... An electromagnetic pulse(EMP)-induced damage model based on the internal damage mechanism of the Ga As pseudomorphic high electron mobility transistor(PHEMT) is established in this paper. With this model, the relationships among the damage power, damage energy, pulse width and signal amplitude are investigated. Simulation results show that the pulse width index from the damage power formula obtained here is higher than that from the empirical formula due to the hotspot transferring in the damage process of the device. It is observed that the damage energy is not a constant, which decreases with the signal amplitude increasing, and then changes little when the signal amplitude reaches up to a certain level. 展开更多
关键词 PHEMT electromagnetic pulse damage threshold empirical formula
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The Effects of High-intensity Pulsed Electromagnetic Field on Proliferation and Differentiation of Neural Stem Cells of Neonatal Rats in vitro 被引量:8
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作者 蒙德鹏 许涛 +2 位作者 郭风劲 印卫锋 彭涛 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2009年第6期732-736,共5页
The effects of high-intensity pulsed electromagnetic stimulation (HIPEMS) on proliferation and differentiation of neonatal rat neural stem cells in vitro were investigated. Neural stem cells derived from neonatal ra... The effects of high-intensity pulsed electromagnetic stimulation (HIPEMS) on proliferation and differentiation of neonatal rat neural stem cells in vitro were investigated. Neural stem cells derived from neonatal rats were exposed to 0.1 Hz, 0.5–10 Tesla (T) [8 groups of B–I, respectively], 5 stimuli of HIPEMF. The sham exposure controls were correspondingly established. Inverted phase contrast microscope was used to observe the cultured cells, MTT assay to detect the viability of the cells as expressed by absorbance (A) value, and flow cytometry to measure differentiation of neural stem cells. The results showed that A values of neural stem cells in both 3.0 T and 4.0 T groups were significantly higher than the other groups 24 to 168 h post HPEMS, indicating a strong promotion of the growth of neural stem cells (P〈0.05). The A values of neural stem cells in the 6.0 T, 8.0 T, and 10.0 T groups were lower than the sham exposure control group, indicating a restraint of the growth of neural stem cells. The rate of neuron-specific enolase-positive neurons revealed by flow cytometry in HPEMS groups was the same as that in control group (P〉0.05). It was suggested that 0.1 Hz, 5 pulses stimulation of HPEMS within certain scale of intensity (0.5–10.0 T), significantly promoted the growth of neural stem cells with the rational intensity being 4.0 T. 展开更多
关键词 neural stem cells high-intensity pulsed electromagnetic field cell proliferation RAT
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