The study presents sampling interval impacts on variance components of the epoch-wise residual errors in relative GPS positioning. In the variance components estimation process, the 2-way nested ANOVA method was used....The study presents sampling interval impacts on variance components of the epoch-wise residual errors in relative GPS positioning. In the variance components estimation process, the 2-way nested ANOVA method was used. For that purpose, GPS observation data during four months at two permanent GPS stations, establishing a 40-km-long baseline as a part of the Montenegrin permanent network(Monte Pos), were used. The study results showed that there is no statistically significant impact of sampling interval changes on epoch-wise variance components related to the residual tropospheric and ionospheric delays(effect a) when it comes to such a baseline. However, it is not the case with epoch-wise variance components related to the interstation-distance-independent residual ‘far-field’ multipath effect(effect b). It turned out that the absolute values of relative differences of standard deviations of the effect a on the relative GPS coordinates(e, n and u) had maximum values 11.1%, 10.2% and 8.9%,respectively. Keeping the same order of presentation for the effect b, the values of 5.9%, 9.9% and 12.5%were obtained. In addition, absolute values of relative differences of standard deviations of horizontal and vertical position had maximum values of 3.8% and 7.7%, respectively.展开更多
Introduction: Accurate postoperative alignment and implant positioning are determinant factors for successful total knee arthroplasty (TKA). Patient-specific template (PST) is a technique that uses computer technology...Introduction: Accurate postoperative alignment and implant positioning are determinant factors for successful total knee arthroplasty (TKA). Patient-specific template (PST) is a technique that uses computer technology for the planning, deigning and production of cutting guides. This study aims to compare PST to conventional technique in terms of mechanical axis alignment and component positioning. Patients and method: 109 TKA were performed for 78 patients in 2 groups. Group A included 69 conventional TKA in 55 patients and Group B included 40 patient-specific TKA in 23 patient. Postoperative long-film X-rays were done for all patients to observe the mechanical axis, anatomical axis, lateral distal femoral mechanical angle and medial proximal tibial angle. Results: No statistically significant difference was found between the two groups regarding alignment or component positioning. Conclusion: Both techniques have shown similar results in restoring the mechanical axis and alignment after TKA. However, PST had the advantages of reduced blood loss and shorter operative time.展开更多
Objective:To determine the effect of an immunosuppressive active component (periploside A) isolated from the stem bark of Periplocae Cortex (Periploca sepium Bge.),a Chinese medicinal herb used in the treatment of rhe...Objective:To determine the effect of an immunosuppressive active component (periploside A) isolated from the stem bark of Periplocae Cortex (Periploca sepium Bge.),a Chinese medicinal herb used in the treatment of rheumatoid arthritis for centuries in China,on positive selection of thymocytes in vitro.Methods:Female C57BL/6 mice at 6 weeks of age were housed in specific pathogen-free conditions.Double-positive thymocytes from C57BL/6 mice were induced into positive selection in vitro with or without periploside A treatment.Cell viability and expression of CD69,CD4,and CD8 were analyzed by flow cytometry.Results:Flow cytometric examination of thymocyte populations revealed that the percentage of CD8+ single-positive thymocytes was decreased by periploside A upon differentiation induced by an anti-CD3 antibody.However,the percentage of CD4+ single-positive thymocytes was decreased by periploside A upon differentiation induced by phorbol 12-myristate 13-acetate/ionomycin.Expression of CD69 plays a major role in prohibiting differentiation of thymocytes.Treatment with periploside A decreased CD69 expression in thymocytes.Conclusion:These results demonstrate that periploside A influences positive selection of thymocytes in vitro.展开更多
Beam position monitors(BPMs)have been widely used in all kinds of measurement systems,feedback systems and other areas in particle accelerator field these days.The malfunction of a single BPM can cause serious consequ...Beam position monitors(BPMs)have been widely used in all kinds of measurement systems,feedback systems and other areas in particle accelerator field these days.The malfunction of a single BPM can cause serious consequences such as the failure of the orbit feedback and the transverse feedback.A troubleshooting has been made to prevent the defective BPMs from affecting the accuracy and stability of the storage ring in Shanghai Synchrotron Radiation Facility(SSRF).Different types of malfunctions have been successfully identified by using the idea of principal component analysis(PCA).展开更多
Text extraction is the key step in the character recognition;its accuracy highly relies on the location of the text region. In this paper, we propose a new method which can find the text location automatically to solv...Text extraction is the key step in the character recognition;its accuracy highly relies on the location of the text region. In this paper, we propose a new method which can find the text location automatically to solve some regional problems such as incomplete, false position or orientation deviation occurred in the low-contrast image text extraction. Firstly, we make some pre-processing for the original image, including color space transform, contrast-limited adaptive histogram equalization, Sobel edge detector, morphological method and eight neighborhood processing method (ENPM) etc., to provide some results to compare the different methods. Secondly, we use the connected component analysis (CCA) method to get several connected parts and non-connected parts, then use the morphology method and CCA again for the non-connected part to erode some noises, obtain another connected and non-connected parts. Thirdly, we compute the edge feature for all connected areas, combine Support Vector Machine (SVM) to classify the real text region, obtain the text location coordinates. Finally, we use the text region coordinate to extract the block including the text, then binarize, cluster and recognize all text information. At last, we calculate the precision rate and recall rate to evaluate the method for more than 200 images. The experiments show that the method we proposed is robust for low-contrast text images with the variations in font size and font color, different language, gloomy environment, etc.展开更多
Impact of satellite elevation cutoff angle and position dilution of precision(PDOP)mask change on epoch-wise variance components of unmodeled effects that accompany relative Global Positioning System(GPS)positioning i...Impact of satellite elevation cutoff angle and position dilution of precision(PDOP)mask change on epoch-wise variance components of unmodeled effects that accompany relative Global Positioning System(GPS)positioning is presented herein.Data used for this study refer to the winter and summer periods of the years with minimal(2008)and maximal(2013)solar activity.These data were collected every 30 s in static mode,at two permanent GPS stations located in Montenegro,establishing a mediumdistance(116-km-long)baseline with a height difference of approximately 760 m between its endpoints.The study showed that changing satellite elevation cutoff angle,with a fixed PDOP mask,affects epochwise two-way nested ANOVA estimates of variances related to the‘far-field’multipath(considered as the nested factor herein)and the combined unmodeled effect of tropospheric and ionospheric refraction(considered as the nesting factor herein).However,changing of PDOP mask,with a fixed satellite elevation cutoff angle,doesn’t affect epoch-wise two-way nested ANOVA estimate of variance of the combined unmodeled effect of tropospheric and ionospheric refraction,but,generally,affects the estimate of variance of the‘far-field’multipath(possibly mixed with a part of a‘shorter-term’ionospheric refraction),which is especially pronounced for the summer period.It should also be noted that there is a significant influence of satellite elevation cutoff angle change on both epoch-wise horizontal and vertical position accuracy,only for the summer period,especially in the presence of maximal solar activity,while there is no significant impact of PDOP mask change on epoch-wise positional accuracy.展开更多
Machine learning algorithms (MLs) can potentially improve disease diagnostics, leading to early detection and treatment of these diseases. As a malignant tumor whose primary focus is located in the bronchial mucosal e...Machine learning algorithms (MLs) can potentially improve disease diagnostics, leading to early detection and treatment of these diseases. As a malignant tumor whose primary focus is located in the bronchial mucosal epithelium, lung cancer has the highest mortality and morbidity among cancer types, threatening health and life of patients suffering from the disease. Machine learning algorithms such as Random Forest (RF), Support Vector Machine (SVM), K-Nearest Neighbor (KNN) and Naïve Bayes (NB) have been used for lung cancer prediction. However they still face challenges such as high dimensionality of the feature space, over-fitting, high computational complexity, noise and missing data, low accuracies, low precision and high error rates. Ensemble learning, which combines classifiers, may be helpful to boost prediction on new data. However, current ensemble ML techniques rarely consider comprehensive evaluation metrics to evaluate the performance of individual classifiers. The main purpose of this study was to develop an ensemble classifier that improves lung cancer prediction. An ensemble machine learning algorithm is developed based on RF, SVM, NB, and KNN. Feature selection is done based on Principal Component Analysis (PCA) and Analysis of Variance (ANOVA). This algorithm is then executed on lung cancer data and evaluated using execution time, true positives (TP), true negatives (TN), false positives (FP), false negatives (FN), false positive rate (FPR), recall (R), precision (P) and F-measure (FM). Experimental results show that the proposed ensemble classifier has the best classification of 0.9825% with the lowest error rate of 0.0193. This is followed by SVM in which the probability of having the best classification is 0.9652% at an error rate of 0.0206. On the other hand, NB had the worst performance of 0.8475% classification at 0.0738 error rate.展开更多
Fast and accurate acquisition of positive sequence components of unbalanced grid voltage is an essential requirement to ensure the safety operation of the grid-connected inverter.To improve the extraction speed of pos...Fast and accurate acquisition of positive sequence components of unbalanced grid voltage is an essential requirement to ensure the safety operation of the grid-connected inverter.To improve the extraction speed of positive sequence components of unbalanced voltage,this study proposes a sampling period delay filter(SPDF)to quickly separate positive and negative sequence components by delaying two sampling periods of grid voltage in dq frame.With the SPDF method,only one coordinate transformation is required and the computational burden can be reduced apparently.Then,the noise immunity performance of the proposed SPDF algorithm is investigated;and the corresponding solution,operation period delay filter(OPDF),can guarantee the desired fast response performance under the premise of limiting the amplified noise within the acceptable range.Finally,the feasibility and priority of the above two algorithms have been verified by the simulation and experimental results.展开更多
文摘The study presents sampling interval impacts on variance components of the epoch-wise residual errors in relative GPS positioning. In the variance components estimation process, the 2-way nested ANOVA method was used. For that purpose, GPS observation data during four months at two permanent GPS stations, establishing a 40-km-long baseline as a part of the Montenegrin permanent network(Monte Pos), were used. The study results showed that there is no statistically significant impact of sampling interval changes on epoch-wise variance components related to the residual tropospheric and ionospheric delays(effect a) when it comes to such a baseline. However, it is not the case with epoch-wise variance components related to the interstation-distance-independent residual ‘far-field’ multipath effect(effect b). It turned out that the absolute values of relative differences of standard deviations of the effect a on the relative GPS coordinates(e, n and u) had maximum values 11.1%, 10.2% and 8.9%,respectively. Keeping the same order of presentation for the effect b, the values of 5.9%, 9.9% and 12.5%were obtained. In addition, absolute values of relative differences of standard deviations of horizontal and vertical position had maximum values of 3.8% and 7.7%, respectively.
文摘Introduction: Accurate postoperative alignment and implant positioning are determinant factors for successful total knee arthroplasty (TKA). Patient-specific template (PST) is a technique that uses computer technology for the planning, deigning and production of cutting guides. This study aims to compare PST to conventional technique in terms of mechanical axis alignment and component positioning. Patients and method: 109 TKA were performed for 78 patients in 2 groups. Group A included 69 conventional TKA in 55 patients and Group B included 40 patient-specific TKA in 23 patient. Postoperative long-film X-rays were done for all patients to observe the mechanical axis, anatomical axis, lateral distal femoral mechanical angle and medial proximal tibial angle. Results: No statistically significant difference was found between the two groups regarding alignment or component positioning. Conclusion: Both techniques have shown similar results in restoring the mechanical axis and alignment after TKA. However, PST had the advantages of reduced blood loss and shorter operative time.
基金This study was supported by the National Natural Science Foundation of China(30901909).
文摘Objective:To determine the effect of an immunosuppressive active component (periploside A) isolated from the stem bark of Periplocae Cortex (Periploca sepium Bge.),a Chinese medicinal herb used in the treatment of rheumatoid arthritis for centuries in China,on positive selection of thymocytes in vitro.Methods:Female C57BL/6 mice at 6 weeks of age were housed in specific pathogen-free conditions.Double-positive thymocytes from C57BL/6 mice were induced into positive selection in vitro with or without periploside A treatment.Cell viability and expression of CD69,CD4,and CD8 were analyzed by flow cytometry.Results:Flow cytometric examination of thymocyte populations revealed that the percentage of CD8+ single-positive thymocytes was decreased by periploside A upon differentiation induced by an anti-CD3 antibody.However,the percentage of CD4+ single-positive thymocytes was decreased by periploside A upon differentiation induced by phorbol 12-myristate 13-acetate/ionomycin.Expression of CD69 plays a major role in prohibiting differentiation of thymocytes.Treatment with periploside A decreased CD69 expression in thymocytes.Conclusion:These results demonstrate that periploside A influences positive selection of thymocytes in vitro.
基金Supported by National Natural Science Foundation of China(No.11075198)
文摘Beam position monitors(BPMs)have been widely used in all kinds of measurement systems,feedback systems and other areas in particle accelerator field these days.The malfunction of a single BPM can cause serious consequences such as the failure of the orbit feedback and the transverse feedback.A troubleshooting has been made to prevent the defective BPMs from affecting the accuracy and stability of the storage ring in Shanghai Synchrotron Radiation Facility(SSRF).Different types of malfunctions have been successfully identified by using the idea of principal component analysis(PCA).
文摘Text extraction is the key step in the character recognition;its accuracy highly relies on the location of the text region. In this paper, we propose a new method which can find the text location automatically to solve some regional problems such as incomplete, false position or orientation deviation occurred in the low-contrast image text extraction. Firstly, we make some pre-processing for the original image, including color space transform, contrast-limited adaptive histogram equalization, Sobel edge detector, morphological method and eight neighborhood processing method (ENPM) etc., to provide some results to compare the different methods. Secondly, we use the connected component analysis (CCA) method to get several connected parts and non-connected parts, then use the morphology method and CCA again for the non-connected part to erode some noises, obtain another connected and non-connected parts. Thirdly, we compute the edge feature for all connected areas, combine Support Vector Machine (SVM) to classify the real text region, obtain the text location coordinates. Finally, we use the text region coordinate to extract the block including the text, then binarize, cluster and recognize all text information. At last, we calculate the precision rate and recall rate to evaluate the method for more than 200 images. The experiments show that the method we proposed is robust for low-contrast text images with the variations in font size and font color, different language, gloomy environment, etc.
文摘Impact of satellite elevation cutoff angle and position dilution of precision(PDOP)mask change on epoch-wise variance components of unmodeled effects that accompany relative Global Positioning System(GPS)positioning is presented herein.Data used for this study refer to the winter and summer periods of the years with minimal(2008)and maximal(2013)solar activity.These data were collected every 30 s in static mode,at two permanent GPS stations located in Montenegro,establishing a mediumdistance(116-km-long)baseline with a height difference of approximately 760 m between its endpoints.The study showed that changing satellite elevation cutoff angle,with a fixed PDOP mask,affects epochwise two-way nested ANOVA estimates of variances related to the‘far-field’multipath(considered as the nested factor herein)and the combined unmodeled effect of tropospheric and ionospheric refraction(considered as the nesting factor herein).However,changing of PDOP mask,with a fixed satellite elevation cutoff angle,doesn’t affect epoch-wise two-way nested ANOVA estimate of variance of the combined unmodeled effect of tropospheric and ionospheric refraction,but,generally,affects the estimate of variance of the‘far-field’multipath(possibly mixed with a part of a‘shorter-term’ionospheric refraction),which is especially pronounced for the summer period.It should also be noted that there is a significant influence of satellite elevation cutoff angle change on both epoch-wise horizontal and vertical position accuracy,only for the summer period,especially in the presence of maximal solar activity,while there is no significant impact of PDOP mask change on epoch-wise positional accuracy.
文摘Machine learning algorithms (MLs) can potentially improve disease diagnostics, leading to early detection and treatment of these diseases. As a malignant tumor whose primary focus is located in the bronchial mucosal epithelium, lung cancer has the highest mortality and morbidity among cancer types, threatening health and life of patients suffering from the disease. Machine learning algorithms such as Random Forest (RF), Support Vector Machine (SVM), K-Nearest Neighbor (KNN) and Naïve Bayes (NB) have been used for lung cancer prediction. However they still face challenges such as high dimensionality of the feature space, over-fitting, high computational complexity, noise and missing data, low accuracies, low precision and high error rates. Ensemble learning, which combines classifiers, may be helpful to boost prediction on new data. However, current ensemble ML techniques rarely consider comprehensive evaluation metrics to evaluate the performance of individual classifiers. The main purpose of this study was to develop an ensemble classifier that improves lung cancer prediction. An ensemble machine learning algorithm is developed based on RF, SVM, NB, and KNN. Feature selection is done based on Principal Component Analysis (PCA) and Analysis of Variance (ANOVA). This algorithm is then executed on lung cancer data and evaluated using execution time, true positives (TP), true negatives (TN), false positives (FP), false negatives (FN), false positive rate (FPR), recall (R), precision (P) and F-measure (FM). Experimental results show that the proposed ensemble classifier has the best classification of 0.9825% with the lowest error rate of 0.0193. This is followed by SVM in which the probability of having the best classification is 0.9652% at an error rate of 0.0206. On the other hand, NB had the worst performance of 0.8475% classification at 0.0738 error rate.
基金The work was supported by the National Natural Science Foundation of China(51707091).
文摘Fast and accurate acquisition of positive sequence components of unbalanced grid voltage is an essential requirement to ensure the safety operation of the grid-connected inverter.To improve the extraction speed of positive sequence components of unbalanced voltage,this study proposes a sampling period delay filter(SPDF)to quickly separate positive and negative sequence components by delaying two sampling periods of grid voltage in dq frame.With the SPDF method,only one coordinate transformation is required and the computational burden can be reduced apparently.Then,the noise immunity performance of the proposed SPDF algorithm is investigated;and the corresponding solution,operation period delay filter(OPDF),can guarantee the desired fast response performance under the premise of limiting the amplified noise within the acceptable range.Finally,the feasibility and priority of the above two algorithms have been verified by the simulation and experimental results.