Nicolau syndrome(NS) is a rare cutaneous adverse reaction after intra-muscular or intra-articular injection. Clinical features of NS are presented by three typical phases(initial, acute and necrotic phases). The cause...Nicolau syndrome(NS) is a rare cutaneous adverse reaction after intra-muscular or intra-articular injection. Clinical features of NS are presented by three typical phases(initial, acute and necrotic phases). The cause of NS is acute vasospasm, inflammation of arteries and thromboembolic occlusion of arteriole related various drugs. Many results of laboratory test, imaging studiesand histopathology are reported and are associated with disease status. Three phase treatment is recommended for the patients with NS. Initially pain control and rule out differential diagnosis and in acute phase steroid therapy, heparin and pentoxifylline are useful. In necrotic phase, surgical treatment is needed depending on size of the affected site. NS is not well understood so far, however three phase treatment could lead to good result on basis of literature review.展开更多
Introduction:Nicolau syndrome is a rare complication following intramuscular injections of various drugs.It is characterized by severe pain,skin and sometimes muscle necrosis after drug injection.However the pathogene...Introduction:Nicolau syndrome is a rare complication following intramuscular injections of various drugs.It is characterized by severe pain,skin and sometimes muscle necrosis after drug injection.However the pathogenesis of Nicolau syndrome remains unclear.Case presentation:A 35-year-old female presented with an painful necrotic ulcer who developed Nicolau syndrome after an intramuscular injection of metamizole in her right thigh due to reccurent episodes of back pain.This reaction is typical for Nicolau syndrome.Discussion:The most common finding of Nicolau syndrome in the early period was severe pain at the injection site.Other common findings were skin discoloration,tenderness,and swelling;indurated livedoid plaques;and erythematous,ecchymotic and purpuric patches.The histopathological results of the case with Nicolau syndrome showed formation of ulceration and fat necrosis.Conclusion:Although Nicolau syndrome is an uncommon cutaneous adverse reaction,clinicians should be aware of this complication to prevent or minimize the severity of Nicolau syndrome.展开更多
文摘Nicolau syndrome(NS) is a rare cutaneous adverse reaction after intra-muscular or intra-articular injection. Clinical features of NS are presented by three typical phases(initial, acute and necrotic phases). The cause of NS is acute vasospasm, inflammation of arteries and thromboembolic occlusion of arteriole related various drugs. Many results of laboratory test, imaging studiesand histopathology are reported and are associated with disease status. Three phase treatment is recommended for the patients with NS. Initially pain control and rule out differential diagnosis and in acute phase steroid therapy, heparin and pentoxifylline are useful. In necrotic phase, surgical treatment is needed depending on size of the affected site. NS is not well understood so far, however three phase treatment could lead to good result on basis of literature review.
文摘Introduction:Nicolau syndrome is a rare complication following intramuscular injections of various drugs.It is characterized by severe pain,skin and sometimes muscle necrosis after drug injection.However the pathogenesis of Nicolau syndrome remains unclear.Case presentation:A 35-year-old female presented with an painful necrotic ulcer who developed Nicolau syndrome after an intramuscular injection of metamizole in her right thigh due to reccurent episodes of back pain.This reaction is typical for Nicolau syndrome.Discussion:The most common finding of Nicolau syndrome in the early period was severe pain at the injection site.Other common findings were skin discoloration,tenderness,and swelling;indurated livedoid plaques;and erythematous,ecchymotic and purpuric patches.The histopathological results of the case with Nicolau syndrome showed formation of ulceration and fat necrosis.Conclusion:Although Nicolau syndrome is an uncommon cutaneous adverse reaction,clinicians should be aware of this complication to prevent or minimize the severity of Nicolau syndrome.
