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Assessment of Bisphenol A(BPA) neurotoxicity in vitro with mouse embryonic stem cells 被引量:10
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作者 Nuoya Yin Xinglei Yao +2 位作者 Zhanfen Qin Yuan-Liang Wang Francesco Faiola 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2015年第10期181-187,共7页
The adverse effects of environmental pollution on our well-being have been intensively studied with many in vitro and in vivo systems. In our group, we focus on stem cell toxicology due to the multitude of embryonic s... The adverse effects of environmental pollution on our well-being have been intensively studied with many in vitro and in vivo systems. In our group, we focus on stem cell toxicology due to the multitude of embryonic stem cell(ESC) properties which can be exerted in toxicity assays. In fact, ESCs can differentiate in culture to mimic embryonic development in vivo, or specifically to virtually any kind of somatic cells. Here, we used the toxicant Bisphenol A(BPA), a chemical known as a hazard to infants and children, and showed that our stem cell toxicology system was able to efficiently recapitulate most of the toxic effects of BPA previously detected by in vitro system or animal tests. More precisely, we demonstrated that BPA affected the proper specification of germ layers during our in vitro mimicking of the embryonic development, as well as the establishment of neural ectoderm and neural progenitor cells. 展开更多
关键词 Bisphenol A(BPA) Stem cell toxicology Neurotoxicity embryonic stem cells(ESCs) developmental toxicity Neural ectoderm
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