Background:Sudden unexpected death of epilepsy(SUDEP)is a severe outcome of epilepsy.This study aimed to report the clinical and pathological findings in patients with SUDEP.Methods:The record of patients with sudden ...Background:Sudden unexpected death of epilepsy(SUDEP)is a severe outcome of epilepsy.This study aimed to report the clinical and pathological findings in patients with SUDEP.Methods:The record of patients with sudden death was screened.When the reason of death matched with the definition of SUDEP,the clinical and pathological data were analyzed.Eleven patients with SUDEP were included in the study.Results:Eight patients died after a generalized tonic-clonic seizure,seizures were induced by emotional changes in five patients,four cases were found dead in bed.Carbamazepine was prescribed in six patients.The autopsy showed brain edema and pulmonary edema in all eleven patients.Loss of neurons and gliosis were presented in some brains of SUDEP subjects.The main pathological changes in SUDEP include brain edema,pulmonary edema,loss of neurons and gliosis.Conclusions:Risk factors for SUDEP in the study are generalized tonic-clonic seizure,emotional disturbance and carbamazepine treatment.展开更多
基金the National Natural Science Foundation of China(81671286,81871019)Key-project of Social undertakings and people’s livelihood security of Chongqing Science&Technology Commission(cstc2017shms-zdyfX0009)Scientific Research Project of Chongqing Municipal Education Commission(KJ1702011).
文摘Background:Sudden unexpected death of epilepsy(SUDEP)is a severe outcome of epilepsy.This study aimed to report the clinical and pathological findings in patients with SUDEP.Methods:The record of patients with sudden death was screened.When the reason of death matched with the definition of SUDEP,the clinical and pathological data were analyzed.Eleven patients with SUDEP were included in the study.Results:Eight patients died after a generalized tonic-clonic seizure,seizures were induced by emotional changes in five patients,four cases were found dead in bed.Carbamazepine was prescribed in six patients.The autopsy showed brain edema and pulmonary edema in all eleven patients.Loss of neurons and gliosis were presented in some brains of SUDEP subjects.The main pathological changes in SUDEP include brain edema,pulmonary edema,loss of neurons and gliosis.Conclusions:Risk factors for SUDEP in the study are generalized tonic-clonic seizure,emotional disturbance and carbamazepine treatment.
