OBJECTIVE：To elucidate the distribution of abnormally activated brain regions in depressive patients during emotional perception processing using activation likelihood estimation,a quantitative meta-analytic techniqu...OBJECTIVE：To elucidate the distribution of abnormally activated brain regions in depressive patients during emotional perception processing using activation likelihood estimation,a quantitative meta-analytic technique.DATA SOURCES：Computer-based online retrieval was conducted using the PscyINFO,Pubmed and CNKI databases,searching literature from the establishment of each database until June 2010.STUDY SELECTION：Inclusion criteria：（1） studies examined emotion perception tasks using func-tional magnetic resonance imaging; （2） studies indicated regional brain activation abnormalities in depressive patients compared with controls in standard Talairach or MNI coordinates.Any analyzed coordinates based on the MNI system were converted to Talairach space with icbm2tal software.The map of activation likelihood estimation was finally created through the Gaussian smooth （full-width half-maximum=8 mm）,permutation test and corrected for multiple comparisons using the false discovery rate method （q=0.05） with Ginger-ALE 2.0 software.MAIN OUTCOME MEASURES：Activation of brain regions in patients.RESULTS：Seventeen studies were identified,involving a total of 261 patients,273 healthy controls and 201 foci.Meta-analysis revealed a dysfunctional emotion regulation loop in depressive patients,comprised of the prefrontal cortex,the basal ganglia and the limbic lobe,in which the amygdala was a key component.During emotion processing,the left prefrontal cortex and basal ganglia were hy-poactive among depressive patients,whereas the opposite change was found in the limbic lobe.CONCLUSION：Abnormal connections among the prefrontal cortex,basal ganglia and limbic lobe may be involved in the pathophysiology of depressive disorder.展开更多
Aesthetic evaluations,including beauty and attractiveness,have an important role in our lives.Despite its importance in our every-day life,enough attention has not been devoted to the assessment of place attractivenes...Aesthetic evaluations,including beauty and attractiveness,have an important role in our lives.Despite its importance in our every-day life,enough attention has not been devoted to the assessment of place attractiveness in previous studies.We assume that changes in elements of square attractiveness are associated with changes in brain functional connectivity patterns.In this study,we have tried to explore the relationship between elements of square attractiveness and individuals’emotional perception as well as the brain mechanism involved in the process of cognitive development.There has been a focus on using objective measures of physiological rather than using self-reported data of an individual’s emotions because people cannot understand their emotions properly and it is needed to compare self-report emotions with physiological processes.Classification of the five main elements of attractiveness was performed using the Delphi technique.Subsequently,twenty-four healthy young adults were exposed to the visual stimuli consists of five elements.A 32-channel EEG system was used to record the brain activities of participants while watching the stimuli.The subjects’feelings about valence and arousal levels of the elements were evaluated using the Self-Assessment Manikin(SAM)technique.The findings showed that“visual openness”is the most important element to increase the square attractiveness of everyday landscape in residential areas.The analysis revealed a significant difference(p=0.048)in arousal ratings between more attractive(more openness)(M=4.77)and less attractive(less openness)(M=4.52).Attractiveness elements of the stimuli have a region-specific association with brain functional connectivity networks.This pattern is mainly found in the functional connections between central parts of the brain.展开更多
Facial and vocal expressions are essential modalities mediating the perception of emotion and social communication. Nonetheless, currently little is known about how emotion perception and its neural substrates differ ...Facial and vocal expressions are essential modalities mediating the perception of emotion and social communication. Nonetheless, currently little is known about how emotion perception and its neural substrates differ across facial expression and vocal prosody. To clarify this issue, functional MRI scans were acquired in Study 1, in which participants were asked to discriminate the valence of emotional expression （angry, happy or neutral） from facial, vocal, or bimodal stimuli. In Study 2, we used an affective priming task （unimodal materials as primers and bimodal materials as target） and participants were asked to rate the intensity, valence, and arousal of the targets. Study 1 showed higher accuracy and shorter response latencies in the facial than in the vocal modality for a happy expression. Whole-brain analysis showed enhanced activation during facial compared to vocal emotions in the inferior temporal-occipital regions. Region of interest analysis showed a higher percentage signal change for facial than for vocal anger in the superior temporal sulcus. Study 2 showed that facial relative to vocal priming of anger had a greater influence on perceived emotion for bimodal targets, irrespective of the target valence. These findings suggest that facial expression is associated with enhanced emotion perception compared to equivalent vocal prosodies.展开更多
基金the National Natural Science Foundation of China,No.30870686Science and Technology Research and Development Program of Shaanxi Province,No.2009K1601Innovation Funds of the First Affiliated Hospital of School of Medicine,Xi'an Jiaotong University,No.2009YK7
文摘OBJECTIVE：To elucidate the distribution of abnormally activated brain regions in depressive patients during emotional perception processing using activation likelihood estimation,a quantitative meta-analytic technique.DATA SOURCES：Computer-based online retrieval was conducted using the PscyINFO,Pubmed and CNKI databases,searching literature from the establishment of each database until June 2010.STUDY SELECTION：Inclusion criteria：（1） studies examined emotion perception tasks using func-tional magnetic resonance imaging; （2） studies indicated regional brain activation abnormalities in depressive patients compared with controls in standard Talairach or MNI coordinates.Any analyzed coordinates based on the MNI system were converted to Talairach space with icbm2tal software.The map of activation likelihood estimation was finally created through the Gaussian smooth （full-width half-maximum=8 mm）,permutation test and corrected for multiple comparisons using the false discovery rate method （q=0.05） with Ginger-ALE 2.0 software.MAIN OUTCOME MEASURES：Activation of brain regions in patients.RESULTS：Seventeen studies were identified,involving a total of 261 patients,273 healthy controls and 201 foci.Meta-analysis revealed a dysfunctional emotion regulation loop in depressive patients,comprised of the prefrontal cortex,the basal ganglia and the limbic lobe,in which the amygdala was a key component.During emotion processing,the left prefrontal cortex and basal ganglia were hy-poactive among depressive patients,whereas the opposite change was found in the limbic lobe.CONCLUSION：Abnormal connections among the prefrontal cortex,basal ganglia and limbic lobe may be involved in the pathophysiology of depressive disorder.
文摘Aesthetic evaluations,including beauty and attractiveness,have an important role in our lives.Despite its importance in our every-day life,enough attention has not been devoted to the assessment of place attractiveness in previous studies.We assume that changes in elements of square attractiveness are associated with changes in brain functional connectivity patterns.In this study,we have tried to explore the relationship between elements of square attractiveness and individuals’emotional perception as well as the brain mechanism involved in the process of cognitive development.There has been a focus on using objective measures of physiological rather than using self-reported data of an individual’s emotions because people cannot understand their emotions properly and it is needed to compare self-report emotions with physiological processes.Classification of the five main elements of attractiveness was performed using the Delphi technique.Subsequently,twenty-four healthy young adults were exposed to the visual stimuli consists of five elements.A 32-channel EEG system was used to record the brain activities of participants while watching the stimuli.The subjects’feelings about valence and arousal levels of the elements were evaluated using the Self-Assessment Manikin(SAM)technique.The findings showed that“visual openness”is the most important element to increase the square attractiveness of everyday landscape in residential areas.The analysis revealed a significant difference(p=0.048)in arousal ratings between more attractive(more openness)(M=4.77)and less attractive(less openness)(M=4.52).Attractiveness elements of the stimuli have a region-specific association with brain functional connectivity networks.This pattern is mainly found in the functional connections between central parts of the brain.
基金supported by the National Natural Science Foundation of China(31371042 and 31671164)
文摘Facial and vocal expressions are essential modalities mediating the perception of emotion and social communication. Nonetheless, currently little is known about how emotion perception and its neural substrates differ across facial expression and vocal prosody. To clarify this issue, functional MRI scans were acquired in Study 1, in which participants were asked to discriminate the valence of emotional expression （angry, happy or neutral） from facial, vocal, or bimodal stimuli. In Study 2, we used an affective priming task （unimodal materials as primers and bimodal materials as target） and participants were asked to rate the intensity, valence, and arousal of the targets. Study 1 showed higher accuracy and shorter response latencies in the facial than in the vocal modality for a happy expression. Whole-brain analysis showed enhanced activation during facial compared to vocal emotions in the inferior temporal-occipital regions. Region of interest analysis showed a higher percentage signal change for facial than for vocal anger in the superior temporal sulcus. Study 2 showed that facial relative to vocal priming of anger had a greater influence on perceived emotion for bimodal targets, irrespective of the target valence. These findings suggest that facial expression is associated with enhanced emotion perception compared to equivalent vocal prosodies.
