The major interest in materno-foetal relation is why fetus is not rejected by the mother, even in a different genetic background. But in this article we have been investigating about the effect(s) of maternal antigeni...The major interest in materno-foetal relation is why fetus is not rejected by the mother, even in a different genetic background. But in this article we have been investigating about the effect(s) of maternal antigenic stimulation or infection upon the active immune responses in her offspring. The results of various researchers have certainly pose significant problems as to the defense of infants against infectious agents, especially those introduced by their mothers. But we have already reported that maternal antigenic stimulation greatly suppresses the specific immune response of the offspring in a system of mouse vs. heterologous erythrocytes and other T-dependent antigens. This suppression was antigen specific and effective on 1/6 life of rodents. The mechanisms that concerned in this suppression were not antigen administered nor antibody produced in the mother. The supporting evidences were that this suppression was MHC restricted and limited in during pregnancy for induction between mother and her young. The system examined was separating genetic backgrounds that the haplotype was different in F2 family where half of the young were identical but not in remainder to the F1 mother mouse. From this backcross system, this suppression was MHC restricted, suggesting cell to cell contact with mother to her young. Moreover, cytokine level in both mother and her young, IFN-g levels was up-regulated in such a young whose mother was immunized with antigen. The significance of this phenomenon were accessed as biological and medical intervention especially for the mother and infant health care and prevention of hypersensitivities, autoimmune syndrome for her young after delivery.展开更多
目的:探索瘢痕子宫妊娠经阴道试产的可行性分析及其对应激相关因子和母婴结局的影响。方法:回顾性选取周口市中医院2020年7月至2023年4月收治的96例瘢痕子宫妊娠孕妇作为研究对象,依照实际情况及自身意愿选择不同分娩方式,分为对照组和...目的:探索瘢痕子宫妊娠经阴道试产的可行性分析及其对应激相关因子和母婴结局的影响。方法:回顾性选取周口市中医院2020年7月至2023年4月收治的96例瘢痕子宫妊娠孕妇作为研究对象,依照实际情况及自身意愿选择不同分娩方式,分为对照组和治疗组。对照组48例行剖宫产,治疗组48例行阴道分娩,对比两组应激相关因子、新生儿情况、母体并发症。结果:两组产后24 h血清血管紧张素-Ⅱ(Ang-Ⅱ)、醛固酮(ALD)、皮质醇(Cor)水平较入院时升高,治疗组低于对照组(P<0.05)。治疗组1、5 min Apgar评分高于对照组(P<0.05);经Fisher确切概率法检验,新生儿肺炎发生率2.08%(1/48)、新生儿呼吸窘迫综合征发生率0与对照组6.25%(3/48)、4.17%(2/48)经比较无差异(P>0.05)。经Fisher确切概率法检验,治疗组产后出血发生率2.08%(1/48)、产后发热发生率0、尿潴留发生率0与对照组4.17%(2/48)、4.17%(2/48)、6.25%(3/48)经比较无差异(P>0.05)。结论:瘢痕子宫妊娠经阴道试产可调节应激相关因子水平,改善新生儿情况,降低母体并发症。展开更多
文摘The major interest in materno-foetal relation is why fetus is not rejected by the mother, even in a different genetic background. But in this article we have been investigating about the effect(s) of maternal antigenic stimulation or infection upon the active immune responses in her offspring. The results of various researchers have certainly pose significant problems as to the defense of infants against infectious agents, especially those introduced by their mothers. But we have already reported that maternal antigenic stimulation greatly suppresses the specific immune response of the offspring in a system of mouse vs. heterologous erythrocytes and other T-dependent antigens. This suppression was antigen specific and effective on 1/6 life of rodents. The mechanisms that concerned in this suppression were not antigen administered nor antibody produced in the mother. The supporting evidences were that this suppression was MHC restricted and limited in during pregnancy for induction between mother and her young. The system examined was separating genetic backgrounds that the haplotype was different in F2 family where half of the young were identical but not in remainder to the F1 mother mouse. From this backcross system, this suppression was MHC restricted, suggesting cell to cell contact with mother to her young. Moreover, cytokine level in both mother and her young, IFN-g levels was up-regulated in such a young whose mother was immunized with antigen. The significance of this phenomenon were accessed as biological and medical intervention especially for the mother and infant health care and prevention of hypersensitivities, autoimmune syndrome for her young after delivery.
文摘目的:探索瘢痕子宫妊娠经阴道试产的可行性分析及其对应激相关因子和母婴结局的影响。方法:回顾性选取周口市中医院2020年7月至2023年4月收治的96例瘢痕子宫妊娠孕妇作为研究对象,依照实际情况及自身意愿选择不同分娩方式,分为对照组和治疗组。对照组48例行剖宫产,治疗组48例行阴道分娩,对比两组应激相关因子、新生儿情况、母体并发症。结果:两组产后24 h血清血管紧张素-Ⅱ(Ang-Ⅱ)、醛固酮(ALD)、皮质醇(Cor)水平较入院时升高,治疗组低于对照组(P<0.05)。治疗组1、5 min Apgar评分高于对照组(P<0.05);经Fisher确切概率法检验,新生儿肺炎发生率2.08%(1/48)、新生儿呼吸窘迫综合征发生率0与对照组6.25%(3/48)、4.17%(2/48)经比较无差异(P>0.05)。经Fisher确切概率法检验,治疗组产后出血发生率2.08%(1/48)、产后发热发生率0、尿潴留发生率0与对照组4.17%(2/48)、4.17%(2/48)、6.25%(3/48)经比较无差异(P>0.05)。结论:瘢痕子宫妊娠经阴道试产可调节应激相关因子水平,改善新生儿情况,降低母体并发症。
