Gastric emptying evaluation by ultrasound prior colonoscopy:An easy tool following bowel preparation

AIM: To investigate the gastric emptying after bowel preparation to allow general anaesthesia. METHODS: A prospective, non-comparative, and nonrandomized trial was performed and registered on Eudra CT database(2011-002953-80) and on www.trial.gov(NCT01398098). All patients had a validated indication for colonoscopy and a preparation using sodium phosphate(NaP) tablets. The day of the procedure, patients took 4 tablets with 250 mL of water every 15 min, three times. The gastric volume wasestimated every 15 min from computed antral surfaces and weight according to the formula of Perlas et al(Anesthesiology, 2009). Colonoscopy was performed within the 6 h following the last intake.RESULTS: Thirty patients were prospectively included in the study from November 2011 to May 2012. The maximum volume of the antrum was 212 mL, achieved 15 min after the last intake. 24%, 67% and 92% of subjects had an antral volume below 20 mL at 60, 120 and 150 min, respectively. 81% of patients had a Boston score equal to 2 or 3 in each colonic segment. No adverse events leading to treatment discontinuation were reported.CONCLUSION: Gastric volume evaluation appeared to be a simple and reliable method for the assessment of gastric emptying. Data allow considering the NaP tablets bowel preparation in the morning of the procedure and confirming that gastric emptying is achieved after two hours, allowing general anaesthesia.

健脾散对小鼠胃排空作用的实验研究

目的观察健脾散的胃排空作用。方法采用甲基橙排空试验方法,观察健脾散对正常小鼠胃排空及在给小鼠阿托品后使其出现胃排空抑制的影响。结果健脾散对正常小鼠胃排空有显著促进作用,并可不同程度地拮抗阿托品导致的胃排空抑制。结论健脾散具有明显的促进胃排空作用,其作用可能与影响胆碱能神经有关。

功能性消化不良在慢性乙型病毒性肝炎患者中的发病研究

目的了解慢性乙型病毒性肝炎患者合并功能性消化不良(FD)的情况,并探讨其发病相关因素。方法选取2014年1月—2016年1月包钢医院门诊确诊的慢性乙型病毒性肝炎患者130例作为观察组;选取同期我院的健康志愿者70例作为对照组。根据罗马III的功能性消化不良诊断标准进行问卷调查,对符合FD标准的慢性乙型病毒性肝炎患者进行胃镜检查以除外器质性病变,并进行幽门螺旋杆菌检查、胃排空检查及抽血检测ALT、HBV-DNA指标。结果观察组患者发生FD的机率高于对照组,差异具有统计学意义(P<0.05)。通过多元相关分析显示慢性乙型病毒性肝炎患者FD的发生与患者血清ALT增高及胃排空延迟有关。结论慢性乙型病毒性肝炎患者易患FD,并与血清ALT水平及胃排空延迟有关。