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Study on Capillary Zone Electrophoretic Separation of Chlorpheniramine Enantiomers with β-Cyclodextrin
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作者 李方 靳慧 +1 位作者 顾峻岭 傅若农 《Journal of Beijing Institute of Technology》 EI CAS 1997年第1期52-58,共7页
The chlorpheniramine enantiomers were separated with capillary zone electrophoresis using β-cyclodextrin as the chiral selector.The effects of the concentration of β-cyclodextrin, the electrolyte pH and organic modi... The chlorpheniramine enantiomers were separated with capillary zone electrophoresis using β-cyclodextrin as the chiral selector.The effects of the concentration of β-cyclodextrin, the electrolyte pH and organic modifier(urea) on the difference in apparent electrophoretic mobilities of the enantiomels were investigated. 展开更多
关键词 capillary zone electrophoresis ENANTIOSEPARATION enantiomers cydodextrin
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Direct detection of tryptophan enantiomers in urine using the chiral recognition of cyclodextrin by capillary electrophoresis 被引量:1
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作者 FANG Mei 《Journal of Chemistry and Chemical Engineering》 2009年第12期60-62,共3页
Racemic tryptophan was separated with resolution 1.3 by CE. In 10 mM H2PO4 containing triethanolamine salt of pH2.8 ahnost saturated α-CD was used as chiral reagent. For the first time L- and D-tryptophan enantiomers... Racemic tryptophan was separated with resolution 1.3 by CE. In 10 mM H2PO4 containing triethanolamine salt of pH2.8 ahnost saturated α-CD was used as chiral reagent. For the first time L- and D-tryptophan enantiomers in human urine can be detected in 20 minute without pretreatment. 展开更多
关键词 tryptophan enantiomers: capillary electrophoresis
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Stereoselective HPLC Assay of TJ0711 Enantiomers by Precolumn Derivatization with GITC Using UV Detection and Its Application in Pharmacokinetics in Rats 被引量:3
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作者 孙淑萍 斯陆勤 +2 位作者 范昭泽 裘军 李高 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2009年第4期427-430,共4页
This investigation describes a new precise, sensitive and accurate stereoselective RP-HPLC method for determination of the enantiomers of a novel α- and β-receptor blocking agent, 1-[4-(2-methoxyethyl) phenoxy]-3-... This investigation describes a new precise, sensitive and accurate stereoselective RP-HPLC method for determination of the enantiomers of a novel α- and β-receptor blocking agent, 1-[4-(2-methoxyethyl) phenoxy]-3-[[2-(2- methoxyphenoxy) ethyl]amino]-2-propanol (T J0711), in rat plasma. GITC was used for precolunm derivatization of T J0711 enantiomers. Enantiomeric resolution was achieved on a Eurospher-100 C18 column (250 mm×4.6 mm ID, 5-μm particle size), with UV detection at 255 nm, and the mobile phase consisted of acetonitrile and water (58:42, v/v) containing 0.02% glacial acetic acid (v/v). Using the chromatographic conditions described, T J0711 enantiomers were well resolved with mean retention time of 10.2 and 11.5 min, respectively. Linear response (r〉0.999) was observed over the range of 0.125-12.5 μg/mL of TJ0711 hydrochloride enantiomers. The mean relative standard deviation (RSD%) of the results of within-day precision was ≤ 10%. The proposed method was found to be suitable and accurate for the quantitative determination of T J0711 enantiomers in rat plasma, and it can be used in pharmacokinetic studies. 展开更多
关键词 TJ0711 STEREOSELECTIVE HPLC enantiomers GITC PHARMACOKINETICS
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Analysis of species-dependent hydrolysis and protein binding of esmolol enantiomers 被引量:3
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作者 Yi-Hong Tanga,b,1,Jun-Yan Wanga,1,Hai-Hong Hua,Tong-Wei Yaoa,Su Zenga,n aDepartment of Pharmaceutical Analysis and Drug Metabolism,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,Zhejiang 310058,People’s Republic of China bShanghai Institute of Technology,Shanghai 201418,People’s Republic of China 《Journal of Pharmaceutical Analysis》 SCIE CAS 2012年第3期220-225,共6页
The stereoselective hydrolysis of esmolol in whole blood and in its separated components from rat,rabbit and human was investigated.Blood esterase activities were variable in different species in the order of rat>r... The stereoselective hydrolysis of esmolol in whole blood and in its separated components from rat,rabbit and human was investigated.Blood esterase activities were variable in different species in the order of rat>rabbit>human.Rat plasma showed the high esterase activity and had no stereoselectivity to enantiomers.Rabbit red blood cell(RBC) membrane,RBC cytosol and plasma all hydrolyzed esmolol but with different esterase activity,whereas the hydrolysis in RBC membrane and cytosol showed significant stereoselectivity towards R-(+)-esmolol.Esterase in RBC cytosol from human blood mainly contributed to the esmolol hydrolysis,which was demonstrated with no stereoselctivity.Esterase in human plasma showed a low activity,but a remarkable stereoselectivity with R-(+)-esmolol.In addition,the protein concentration affected the hydrolysis behavior of esmolol in RBC suspension.Protein binding of esmolol enantiomers in human plasma,human serum albumin(HSA) and α;-acid glycoprotein(AGP) revealed that there was a significant difference in bound fractions between two enantiomers,especially for AGP.Our results indicated that the stereoselective protein binding might play a role in the different hydrolysis rates of esmolol enantiomers in human plasma. 展开更多
关键词 Esmolol enantiomers Species-dependent Stereoselective hydrolysis Protein binding
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Chiral ionic liquids as chiral selectors for separation of tryptophan enantiomers by ligand exchange chromatography 被引量:2
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作者 杨艳霞 李静 蒋新宇 《Journal of Central South University》 SCIE EI CAS 2013年第5期1173-1177,共5页
Chiral ionic liquids (CILs) containing imidazolium cations and L-Proline (L-Pro) anions were applied as chiral selector to separate tryptophan (Trp) enantiomers on a C18 column by ligand exchange chromatography. Sever... Chiral ionic liquids (CILs) containing imidazolium cations and L-Proline (L-Pro) anions were applied as chiral selector to separate tryptophan (Trp) enantiomers on a C18 column by ligand exchange chromatography. Several factors influencing Trp enantiomers separation, such as alkyl chain length of CILs, concentrations of Cu2+ and CILs, pH of the mobile phase, flow rate, organic solvent and temperature, were studied. Under the optimal conditions, the Trp enantiomers could be successfully separated within 21 min with the resolution of 2.30. At the same time, some thermodynamical parameters were obtained. The experimental results show that the enthalpy values of the Trp enantiomers are negative, indicating that the separation process is exothermic. And the enthalpy values of D-Trp are larger than those of L-Trp, which indicates that L-Trp could form more stable ternary complexes with tryptophan enantiomers. 展开更多
关键词 chiral ionic liquids chiral separation ligand exchange chromatography tryptophan enantiomers
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Chiral extraction of ketoprofen enantiomers with chiral selector tartaric esters 被引量:2
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作者 周丹 刘佳佳 +1 位作者 唐课文 黄可龙 《Journal of Central South University of Technology》 EI 2007年第3期353-356,共4页
Distribution behavior of ketoprofen enantiomers was examined in methanol aqueous and organic solvent mixture containing tartaric esters. The influence of length of alkyl chain of tartaric esters, concentration of L-ta... Distribution behavior of ketoprofen enantiomers was examined in methanol aqueous and organic solvent mixture containing tartaric esters. The influence of length of alkyl chain of tartaric esters, concentration of L-tartaric esters and methanol aqueous, kind of organic solvent on partition ratio and separation factors was investigated. The results show that L-tartaric and D-tartaric esters have different chiral recognition abilities. S-ketoprofen is easily extracted by L-tartaric esters, and R-ketoprofen is easily extracted by D-tartaric esters. L-tartaric esters form more stable diastereomeric complexes with S-enantiomer than that with R-enantiomer. This distribution behavior is consistent with chiral recognition mechanism. With the increase of the concentration of tartaric ester from 0 to 0.3 mol/L, partition coefficient K and separation factor a increase. Also, the kind of organic solvent and the concentration of the methanol aqueous have significant influence on K and a. 展开更多
关键词 chiral extraction KETOPROFEN enantiomER tartaric ester partition coefficient separation factor
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Separation and determination of acetyl-glutamine enantiomers by HPLC–MS and its application in pharmacokinetic study 被引量:1
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作者 Xiaoxiao Zhang Lei Gao +1 位作者 Zunjian Zhang Yuan Tian 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2017年第5期303-308,共6页
A high-performance liquid chromatography coupled with mass spectrometry(HPLC–MS) method was established for the separation and determination of acetyl-glutamine enantiomers(acetylL-glutamine and acetylD-glutamine) si... A high-performance liquid chromatography coupled with mass spectrometry(HPLC–MS) method was established for the separation and determination of acetyl-glutamine enantiomers(acetylL-glutamine and acetylD-glutamine) simultaneously. Baseline separation was achieved on Chiralpak AD-H column(250 mm ×4.6 mm, 5 μm). n-Hexane(containing 0.1% acetic acid) and ethanol(75:25, v/v) were used as mobile phase at a flow rate of 0.6 m L/min. The detection was operated in the negative ion mode with an ESI source. [M-H]-m/z187.0540 for enantiomers and [M-H]-m/z 179.0240 for aspirin(IS) were selected as detecting ions. The linear range of the calibration curve for each enantiomer was 0.05–40 μg/m L. The precision of this method at concentrations of 0.5–20 μg/m L was within 7.23%, and the accuracy was 99.81%–107.81%. The precision at LOQ(0.05 μg/m L) was between 16.28% and 17.56%, which was poor than that at QC levels. The average extraction recovery was higher than 85% for both enantiomers at QC levels. The pharmacokinetics of enantiomers was found to be stereoselective. There was not chiral inversion in vivo or in vitro between enantiomers. 展开更多
关键词 HPLC–MS Acetyl-glutamine enantiomers SEPARATION Pharmacokinetics Chiral inversion
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Separation of Enantiomers of Clopidogrel on Chiral Stationary Phases by Packed Column Supercritical Fluid Chromatography 被引量:3
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作者 Khagga Bhavyasri D. Rambabu +1 位作者 P. S. S. Prasad V. Murali Balaram 《American Journal of Analytical Chemistry》 2013年第1期51-55,共5页
A packed column supercritical fluid chromatography (SFC) method for the separation of clopidogrel enantiomers on a chiral stationary phase and CO2 with modifier as mobile phase has been developed at an analytical scal... A packed column supercritical fluid chromatography (SFC) method for the separation of clopidogrel enantiomers on a chiral stationary phase and CO2 with modifier as mobile phase has been developed at an analytical scale. Among 11 different 2 stationary phases the Chiral cel OD-H column showed by far the best separation properties. The influence of different modifiers, injection solvents, temperature, and pressure, and density of the fluid, respectively, on the separation behaviour has been studied. It was found that the separation behaviour strongly depends on the type of modifier and the modifier content. Temperature and pressure are of less influence. 展开更多
关键词 Chiral Stationary PHASES SFC enantiomER Separation SUPERCRITICAL Fluid CHROMATOGRAPHY CLOPIDOGREL
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Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells: an insight into the efflux-metabolism alliance 被引量:1
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《中国药理学通报》 CAS CSCD 北大核心 2015年第B11期211-211,共1页
Aim The present study developed a CYP3A4-expressed Caco-2 monolayer model at which effects of the efflux-metabolism alliance on the transport and uptake of clausenamide(CLA) enantiomers as CYP3A4 substrates were inv... Aim The present study developed a CYP3A4-expressed Caco-2 monolayer model at which effects of the efflux-metabolism alliance on the transport and uptake of clausenamide(CLA) enantiomers as CYP3A4 substrates were investigated. The apparent permeability coefficients (Papp) of ( - ) and ( + )CLA were higher in the ab- sorptive direction than those in the secretory direction with efflux ratios(ER) of 0. 709 ± 0.411 and 0. 867± 0. 250 ( Х10^-6 -1 cm · s ), respectively. Their bidirectional transports were significantly reduced by (75.6 ± 87.5)% af- ter treatment with verapamil ( a P-glycoprotein inhibitor) that increased the rate of metabolism by CYP3 A4, whereas the CYP3A4 inhibitor ketoconazole treatment markedly enhanced the basolateral to apical flux of ( - ) and ( + ) CLA with ERs being 2. 934 ± 1. 432 and 1. 877 ± 0. 148 ( Х 10^-6 cm/s) respectively. These changes could be blocked by the duel CYP3A4/P-glycoprotein inhibitor cyclosporine A, consequently, Papp values for CLA enanti- omers in both directions were significantly greater than those obtained by using verapamil or ketoconazole, and their ERs were similar to those following ( - ) or ( + )-isomer treatment alone. Furthermore, the uptake of ( - )CLA was more than that of ( + )CLA in the transfected cells. Incubation with ketoeonazole decreased the intracellular concentrations of the two enantiomers. This effect disappeared in the presence of a CYP3A4 inducer dexametha- sone. These results indicated that CYP3A4 could influence P-gp efflux, transport and uptake of CLA enantiomers as CYP3A4 substrates and that a duel inhibition to CYP3A4/ P-glycoprotein could enhance their absorption and bioavailability, which provides new insight into the efflux-metabolism alliance and will benefit the clinical pharma- cology of (?) CLA as a candidate drug for treatment of Alzheimer' s disease. 展开更多
关键词 CLAUSENAMIDE enantiomers CYTOCHROME P450 3A4 P-GLYCOPROTEIN CACO-2 cell line
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Kinetic study on reactive extraction of phenylalanine enantiomers with BINAP-copper complexes 被引量:1
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作者 唐课文 罗菁菁 +3 位作者 张盼良 易健民 华杰 杨长安 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2015年第1期57-63,共7页
Enantioselective liquid–liquid extraction has attracted considerable attention for its potential use in largescale production. Kinetic data are needed for the reliable scale-up of the process. This paper reports the ... Enantioselective liquid–liquid extraction has attracted considerable attention for its potential use in largescale production. Kinetic data are needed for the reliable scale-up of the process. This paper reports the kinetic study of reactive extraction of phenylalanine(Phe) enantiomers with BINAP–copper complex(BINAP–Cu) as a chiral selector. The theory of extraction accompanied by a chemical reaction was applied.The effects of agitation speed, interfacial area, p H value of aqueous phase, initial concentration of Phe enantiomers and initial concentration of BINAP–Cu on the specific rate of extraction were investigated. The forward rate constants of the reactions in the reactive extraction process are 7.93 × 10-5m5/2·mol-1/2·s-1for D-Phe and 1.29 × 10-4m5/2·mol-1/2·s-1for L-Phe. 展开更多
关键词 KINETICS Amino acids Modeling Liquid–liquid extraction enantiomers
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Equilibrium Studies on Liquid-Liquid Reactive Extraction of Phenylsuccinic Acid Enantiomers Using Hydrophilicβ-CD Derivatives Extractants 被引量:1
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作者 唐课文 苗家兵 +1 位作者 周涛 刘永兵 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2011年第3期397-403,共7页
This paper deals with the enantioseparation of phenylsuccinic acid(H2A)enantiomers by liquid-liquid reactive extraction usingβ-CD derivatives as aqueous selectors.Cyclodextrin and its derivatives can interact with gu... This paper deals with the enantioseparation of phenylsuccinic acid(H2A)enantiomers by liquid-liquid reactive extraction usingβ-CD derivatives as aqueous selectors.Cyclodextrin and its derivatives can interact with guest molecules selectively to form complexes with different stabilities.Cyclodextrin derivatives are not soluble in organic liquids,but highly soluble in water.In this work,hydroxypropyl-β-cyclodextrin(HP-β-CD),hydroxyethyl- β-cyclodextrin(HE-β-CD)and methyl-β-cyclodextrin(Me-β-CD)were selected as chiral selectors in aqueous phase for the reactive extraction of phenylsuccinic acid enantiomers from organic phase to aqueous phase.The results show that the efficiency of the extraction depends,often strongly,on a number of process variables,including the types of organic solvents andβ-CD derivatives,the concentrations of the extractants and H2A enantiomers,pH and temperature.HP-β-CD,HE-β-CD and Me-β-CD have stronger recognition abilities for R-phenylsuccinic acid than for S-phenylsuccinic acid.Among the three kinds ofβ-CD derivatives,HP-β-CD has the strongest separation ability. Excellent enantioseparation was achieved under the optimal conditions of pH of 2.5 and temperature of 5°C with a maximum enantioselectivity(a)of 2.38.Reactive extraction of enantiomers with hydrophilicβ-CD derivatives is of strong chiral separation ability and can be hopeful for separations of various enantiomers at a large-scale. 展开更多
关键词 solvent extraction enantiomer resolution β-CD derivatives phenylsuccinic acid enantiomers
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Separation of tryptophan enantiomers with molecularly imprinted polypyrrole electrode column 被引量:1
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作者 Chen, Zhi Dong Wei, Jing Xuan +1 位作者 Wang, Wen Chang Kong, Yong 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第3期353-356,共4页
In this study,we have fabricated molecularly imprinted polypyrrole(PPy) packed electrode columns and investigated their effects on separation of tryptophan(Trp) enantiomers by using potential control.The results indic... In this study,we have fabricated molecularly imprinted polypyrrole(PPy) packed electrode columns and investigated their effects on separation of tryptophan(Trp) enantiomers by using potential control.The results indicate that the imprinted PPy electrode columns could efficiently enhance the L-Trp uptake and separate Trp enantiomers effectively,implying the great potential for the enantioselective recognition of other amino acids enantiomers. 展开更多
关键词 POLYPYRROLE Electrode column Molecular imprinting Tryptophan enantiomers
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Preparative Resolution of Gatifloxacin Enantiomers with Pre-Column Esterification Strategy and Comparing Their Enantioselectivity to Bacteria and Antibody 被引量:1
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作者 ZHANG Chi Jian LEI Hong Tao +4 位作者 HUANG Xiao Long LIU Ying Ju CAI Kai XU Zhen Lin SUN Yuan Ming 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2015年第2期157-160,共4页
Gatifloxacin (GFX) is a kind of chiral fluoroquinolones compound due to the methyl group at the C-3 position of the piperazine ring[1]. Although the enantiomers of GFX show similar levels of antimicrobial activity a... Gatifloxacin (GFX) is a kind of chiral fluoroquinolones compound due to the methyl group at the C-3 position of the piperazine ring[1]. Although the enantiomers of GFX show similar levels of antimicrobial activity and pharmacokinetics[2], the other biological activities (i.e., toxicity or enantioselective recognition to various receptors in vivo) of GFX enantiomers have not yet been studied. With this in mind, we developed a rapid and cost-effective high performance liquid chromatographic (HPLC) separation procedure for GFX enantiomers with a pre-column esterification strategy. 展开更多
关键词 Preparative Resolution of Gatifloxacin enantiomers with Pre-Column Esterification Strategy and Comparing Their Enantioselectivity to Bacteria and Antibody DEA than
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Enantioselective extraction of mandelic acid enantiomers based on chiral ligand exchange 被引量:1
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作者 唐课文 黄可龙 《Journal of Central South University of Technology》 2005年第2期123-128,共6页
Based on the chiral ligand exchange, the distribution behavior of mandelic acid enantiomers, and the partition of Cu2+ at different pH values were studied in a water/alcohol two-phase system containing Cu2+ and N-n-(... Based on the chiral ligand exchange, the distribution behavior of mandelic acid enantiomers, and the partition of Cu2+ at different pH values were studied in a water/alcohol two-phase system containing Cu2+ and N-n-(dodecyl-L-proline(A).) The influences of the solvent sort, the pH value, the concentrations of Cu2+ and chiral ligand on the partition coefficient(K) and separation factor(α) were discussed. The experimental results show that the A formed has more stable ternary complex with D-mandelic acid enantiomer than with L-mandelic acid enantiomer. There is an important influence of the pH value on K and α. When the pH values are less than 3.5, the formation of binary complexes is thermodynamically unfavourable. K and α become maximum when pH values are above 3.5 and the molar ratio of the chiral ligand to Cu2+ is 2∶1. 展开更多
关键词 ligand exchange EXTRACTION chiral separation mandelic acid enantiomers
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Preparation of insoluble β-CD polymer and its application to enantiomers and isomers separation 被引量:1
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作者 YI Jian ming 1,TANG Kuo wen 2 (1.College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China 2.Department of Chemical Engineering, Yueyang Normal University, Yueyang 414000, China) 《Journal of Central South University of Technology》 EI 2001年第1期57-59,共3页
An insoluble β-cyclodextrin polymer cross-linked with epichlorohydrin was prepared, and its structure was identified with infrared spectrum. Colloid stationary phase was prepared by dissolving the polymer in the mixe... An insoluble β-cyclodextrin polymer cross-linked with epichlorohydrin was prepared, and its structure was identified with infrared spectrum. Colloid stationary phase was prepared by dissolving the polymer in the mixed solvent of diisopropyl ether, methylene dichloride and benzene and treated for 0.5 h by ultrasonication, and then was coated on a fused silica capillary column. The optimun reaction conditions are as follows: the mole ratio of epichlohydrin to β-cyclodextrin is 12.1:1, reacting at 65 °C for 24 h. The Chromatographic performance such as column efficiency, thermal stabilities and polarity were studied, two kinds of disubstituted benzene isomers and eight pairs of enantiomers were separated on the capillary column. The results show that the β-cyclodextrin polymer is suitable for use as a capillary gas chromatographic stationary phase, and possess excellent chromatographic properties in separating enantiomers and position isomers. 展开更多
关键词 insoluble β cyclodextrin polymer capillary gas chromatography enantiomER position isomer SEPARATION
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Enantioselective extraction of terbutaline enantiomers by lipophilic tartaric acid 被引量:2
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作者 TANG Ke-wen(唐课文) ZHOU Chun-shan(周春山) 《Journal of Central South University of Technology》 2003年第1期44-48,共5页
Distribution behavior of terbutaline enantiomers was examined in the aqueous and organic solvent of a two-phase system containing L-dibenzoyltartaric acid and lipophilic phase transfer reagent of Na-tetraphenylborate.... Distribution behavior of terbutaline enantiomers was examined in the aqueous and organic solvent of a two-phase system containing L-dibenzoyltartaric acid and lipophilic phase transfer reagent of Na-tetraphenylborate. The influences of pH, organic solvents, concentrations of Na-tetraphenylborate and L-dibenzoyltartaric acid on the partition coefficients and enantioselectivity of terbutaline enantiomers, were investigated. The results show that tetraphenylborate lipophilic anion and terbutaline enantiomers form two lipophilic salt complexes , which facilitates the solubility of the enantiomers in the organic phase. L-dibenzoyltartaric acid forms more stable complexes with enantiomer Ⅱ than with enantiomer I . Enantioselectivity and partition coefficient increase with the addition of the length of alkyl chain of alcohols. pH and concentrations of lipophilic anion and L-dibenzoyltartaric acid influence them obviously and differently. 展开更多
关键词 L-dibenzoyltartaric acid TERBUTALINE enantiomers CHIRAL EXTRACTION
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High performance liquid chromatographic separation of clausenamide enantiomers with chiral-AGP stationary phase
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作者 Yan Wang Qing Qiang Yao Mu Zou Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第7期860-863,共4页
A method of high performance liquid chromatographic separation of clausenamide enantiomers with chiral-AGP(α_1-acid glycoprotein) stationary phases has been established.The absolute configurations of(-)clausenami... A method of high performance liquid chromatographic separation of clausenamide enantiomers with chiral-AGP(α_1-acid glycoprotein) stationary phases has been established.The absolute configurations of(-)clausenamide and(+)clausenamide are 3S, 4R,5R,6S and 3R,4S,5S,6R,respectively.The present method has been used to analyze the(-)clausenamide and(+)clausenamide and its analogues such as the major metabolite and synthetic derivatives of clausenamide. 展开更多
关键词 enantiomers (-)Clausenamide (+)Clausenamide Chiral-AGP HPLC
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THE SEPARATIONS OF ENANTIOMERS OF α—SUBSTITUTED-(2—PYRIDYL)—METHYLAMINES ON A CHIRASIL-VAL CAPILLARY COLUMN
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作者 Lan Jun WU Ai Qiao MI Yao Zhong JLANG Chengdu Institute of Organic Chemistry Academia Sinica,Chengdu 610015 《Chinese Chemical Letters》 SCIE CAS CSCD 1991年第3期243-244,共2页
Enantiomers of a-substituted-(2-pyridyl)-methylarfdnes uere separated on SC -7 gas chromatograph with a 20m×0.25mm Chirasil-Val capIlary column,Carrier gas was nitro- gen or hydrogen.The resolution factors(ri.s) ... Enantiomers of a-substituted-(2-pyridyl)-methylarfdnes uere separated on SC -7 gas chromatograph with a 20m×0.25mm Chirasil-Val capIlary column,Carrier gas was nitro- gen or hydrogen.The resolution factors(ri.s) were 1.02 to 1.06.Enantiomers of pyridyl anines were separated to and near to base line. 展开更多
关键词 VAL SUBSTITUTED THE SEPARATIONS OF enantiomers OF METHYLAMINES ON A CHIRASIL-VAL CAPILLARY COLUMN PYRIDYL
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Development of a UHPLC-MS/MS method for the quantification of ilaprazole enantiomers in rat plasma and its pharmacokinetic application
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作者 Fengting Ou Ying Zhou +4 位作者 Jinxiu Lei Su Zeng Fuhai Wu Ning Zhang Lushan Yu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2020年第6期617-623,共7页
In Korea and China,ilaprazole is a widely used proton pump inhibitor in the treatment of gastric ulcers.In this study,a specific and sensitive LC-MS/MS method has been developed and validated for the quantification of... In Korea and China,ilaprazole is a widely used proton pump inhibitor in the treatment of gastric ulcers.In this study,a specific and sensitive LC-MS/MS method has been developed and validated for the quantification of ilaprazole enantiomers in the rat plasma,using R-lansoprazole as the internal standard.The enantioseparation was achieved on a CHIRALPAK AS-RH column(4.6 mm×150 mm,i.d.5 mm),with a mobile phase composed of 10 m M ammonium acetate aqueous solution and acetonitrile(60:40,V/V),at a flow-rate of 0.5 m L/min.The method was validated over the concentration range of 0.5 e300 ng/m L for both,R-and S-ilaprazole.The lower limit of quantification was 0.5 ng/m L for both enantiomers.The relative standard deviation(RSD)of intra-and inter-day precision of R-ilaprazole and S-ilaprazole was less than 10.9%,and the relative error accuracy(RE)ranged fromà0.5%e2.0%.Finally,the method was successfully evaluated in rats in a stereoselective pharmacokinetic study of the ilaprazole racemate. 展开更多
关键词 Ilaprazole enantiomER LC-MS/MS PHARMACOKINETICS
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Synthesis and Characterization of Both Enantiomers of a Chiral C_(60) Derivative Bearing the 1, 1'-Binaphthyl Group
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作者 Chuan Feng CHEN Gai Jiao JI +1 位作者 Ji Sheng LI Dao Ben ZHU(Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080) 《Chinese Chemical Letters》 SCIE CAS CSCD 1998年第10期931-934,共4页
Both enantiomers R-1 and S-1 of a chiral C60 derivative were synthesized by the reactions of C60 with 1, 1'-bi-2-naphthol bis(azidoacetates) and characterized by FD-MS, fT-IR,1H NMR, 13C NMR, UV-VIS, CD spectra.
关键词 chiral C_(60) derivative 1 1'-bi-2-naphthol enantiomer synthesis CD spectrum
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