Research questions. How does a virtual bronchoscopy navigation system (VBNS) improve prediction of candidate bronchus across a range of doctors investigating a range of lesions with Endobronchial ultrasound (EBUS) gui...Research questions. How does a virtual bronchoscopy navigation system (VBNS) improve prediction of candidate bronchus across a range of doctors investigating a range of lesions with Endobronchial ultrasound (EBUS) guide sheath? To what extent do benefits of virtual bronchoscopic pre-procedure navigation apply to experienced versus inexperienced bron- choscopists? Methods: Using archived EBUS Guide sheath cases, a comparison was made between identified candidate 4th order bronchus by Computerised tomography (CT) evaluation versus that identified after virtual path creation. Results: From 7 archived cases, 14 doctors identified the correct bronchus in 94 of 98 assessments (95%). Percentage of cases where there was an improvement in localisation by 2 or more 4th order bronchi was 39.8% overall (28.6% – 51.0%), 26.6 for experienced and 53.1 for inexperienced bronchoscopists (p < 0.02). The absolute mean number of 4th order bronchi different between CT and VBNS was 2.0 ± 2.6 overall, 1.2 (range 0-6) for experienced, and 2.8 (range 0-11) for inexperienced bronchoscopists. Virtual Path software calculation time was 8.1 ± 2.7 minutes, compared to 3.6 ± 2.1 minutes by CT. Conclusion: VBNS allowed rapid accurate assessment with minimal software training. Greatest benefits in reduction of procedure time were obtained in inexperienced bronchoscopists, and VBNS could allow more rapid skill development in EBUS GS in these doctors.展开更多
目的:探讨手绘导航在肺外周结节患者行支气管镜肺活检中的应用价值及其对支气管镜到达活检部位时间的影响因素。方法:回顾性分析2022年8月—2023年3月在宜昌市中心人民医院呼吸内镜中心接受径向超声引导下经支气管镜肺活检的116例肺外...目的:探讨手绘导航在肺外周结节患者行支气管镜肺活检中的应用价值及其对支气管镜到达活检部位时间的影响因素。方法:回顾性分析2022年8月—2023年3月在宜昌市中心人民医院呼吸内镜中心接受径向超声引导下经支气管镜肺活检的116例肺外周结节患者,根据术前是否采用手绘导航规划路径,分为手绘导航联合径向超声组(手绘导航+RP-EBUS-GS组,n=60)和径向超声组(RP-EBUS-GS组,n=56),对比分析手绘导航在支气管镜肺活检中的应用效果。采用单因素及多因素Logistic回归分析手绘导航对支气管镜到达活检部位时间的影响因素。结果:手绘导航+RP-EBUS-GS组支气管镜到达活检部位时间明显短于RP-EBUS-GS组(6.32±3.10 min vs 8.89±4.09 min,P<0.001)。以支气管镜到达活检部位时间为因变量,单因素分析结果显示,两组患者性别、结节与支气管关系、所在支气管分级及是否应用手绘导航有明显差异(均P<0.05);多因素Logistic结果显示,所在支气管分级及是否应用手绘导航是支气管镜到达活检部位时间的独立影响因素(均P<0.05)。结论:手绘导航在肺外周结节患者行支气管镜肺活检中可明显缩短支气管镜到达活检部位的时间,具有很好的临床应用价值。肺外周结节所在支气管分级及是否应用手绘导航是支气管镜到达肺活检部位时间的独立影响因素。展开更多
目的探讨导向鞘引导的超声支气管镜检查技术在诊断外周肺结节中的临床应用及安全性。方法回顾性分析2018年1月至2019年9月在空军军医大学唐都医院呼吸与危重症医学科气管镜室接受导向鞘引导超声支气管镜肺活检术(endobronchial ultrason...目的探讨导向鞘引导的超声支气管镜检查技术在诊断外周肺结节中的临床应用及安全性。方法回顾性分析2018年1月至2019年9月在空军军医大学唐都医院呼吸与危重症医学科气管镜室接受导向鞘引导超声支气管镜肺活检术(endobronchial ultrasonography with a guide sheath transbronchial lung biopsy,EBUS-GS-TBLB)检查的患者67例,研究EBUS-GS-TBLB对外周肺结节病理活检诊断阳性率及其影响因素。结果EBUS-GS-TBLB对外周肺结节的总诊断率为70.15%,其中病灶支气管征阳性患者的诊断率为80.49%,明显高于支气管征阴性患者,差异有统计学意义(χ2=5.393,P<0.05);病灶大小、位置、与胸膜的距离及病灶类型对EBUS-GS-TBLB病理活检诊断率的影响均无显著统计学差异。结论与常规支气管镜检查相比,EBUS-GS-TBLB在提高活检诊断阳性率、降低活检风险方面具有明显优势,值得在临床推广应用,且EBUS-GS-TBLB活检阳性率在支气管征阳性患者中表现出显著优势,从而有利于从优选择肺外周结节病理活检方法,以达到提高肺癌早期诊断率的目的。展开更多
Objective:Fluoroscopy guidance is generally required for endobronchial ultrasonography with guide sheath(EBUS-GS)in peripheral pulmonary lesions(PPLs).Virtual bronchoscopic navigation(VBN)can guide the bronchoscope by...Objective:Fluoroscopy guidance is generally required for endobronchial ultrasonography with guide sheath(EBUS-GS)in peripheral pulmonary lesions(PPLs).Virtual bronchoscopic navigation(VBN)can guide the bronchoscope by creating virtual images of the bronchial route to the lesion.The diagnostic yield and safety profiles of VBN without fluoroscopy for PPLs have not been evaluated in inexperienced pulmonologist performing EBUS-GS.Methods:Between January 2016 and June 2017,consecutive patients with PPLs referred for EBUS-GS at a single cancer center were enrolled.The diagnostic yield as well as safety profiles was retrospectively analyzed,and our preliminary experience was shared.Results:A total of 109 patients with 109 lesions were included,99(90.8%)lesions were visible on EBUS imaging.According to the procedure time needed to locate the lesion on EBUS,24.8%(27/109)were deemed technically difficult procedures;however,no significant relationships were identified between candidate parameters and technically difficult procedures.The overall diagnosis yield was 74.3%(81/109),and the diagnostic yield of malignancy was 83.7%(77/92).Lesions larger than 20 mm[odds ratio(OR),2.758;95%confidence interval(95%CI),1.077-7.062;P=0.034]and probe of within type(OR,3.174;95%CI,1.151-8.757,P=0.026)were independent factors leading to a better diagnostic yield in multivariate analysis.About 30 practice procedures were needed to achieve a stable diagnostic yield,and the proportion of technically difficult procedures decreased and stabilized after 70 practice procedures.Regarding complications,one patient(0.9%)had intraoperative hemorrhage(100 mL)which was managed under endoscopy.Conclusions:VBN without fluoroscopy guidance is still useful and safe for PPLs diagnosis,especially for malignant diseases when performed by pulmonologist without previous experience of EBUS-GS.VBN may simplify the process of lesion positioning and further multi-center randomized studies are warranted.展开更多
目的：探讨肺部超声检查在左侧双腔支气管导管（LDLT）定位中的作用和可行性。方法：共纳入需单肺通气的ASAⅠ~Ⅱ级胸科手术成年患者80例,男61例,女19例,年龄36~79岁,平均（62±10）岁。随机分为超声组和临床组,每组各40例。临床组...目的：探讨肺部超声检查在左侧双腔支气管导管（LDLT）定位中的作用和可行性。方法：共纳入需单肺通气的ASAⅠ~Ⅱ级胸科手术成年患者80例,男61例,女19例,年龄36~79岁,平均（62±10）岁。随机分为超声组和临床组,每组各40例。临床组通过呼吸音和气道压定位,将左侧或右侧单肺通气时仅通气侧有呼吸音且气道压〈40 cm H_2O评估为导管位置合适。超声组通过超声检查患者双侧胸膜及膈肌的相对运动及气道压定位,将左侧或右侧单肺通气时仅通气侧有胸膜和膈肌运动且气道压〈40 cm H_2O评估为导管位置合适。最后经纤维支气管镜判断导管准确位置。结果：通过纤维支气管镜验证,临床组和超声组LDLT定位合适例数分别为24例（60.0%）和33例（82.5%）,差异有统计学意义（P〈0.05）;临床组判断LDLT位置的特异度为6.25%,准确率为62.5%,阳性预测值为61.5%,而超声组特异度为28.6%,准确率为87.5%,阳性预测值为86.8%,两组准确率和阳性预测值比较差异有统计学意义（P〈0.05）。结论：超声检查肺运动联合气道压监测的方法能提高LDLT定位合适的成功率,其判断LDLT位置的准确率和阳性预测值较高,在纤维支气管镜不具备或不合适的情况下,是LDLT插管定位的另一较好选择。展开更多
文摘Research questions. How does a virtual bronchoscopy navigation system (VBNS) improve prediction of candidate bronchus across a range of doctors investigating a range of lesions with Endobronchial ultrasound (EBUS) guide sheath? To what extent do benefits of virtual bronchoscopic pre-procedure navigation apply to experienced versus inexperienced bron- choscopists? Methods: Using archived EBUS Guide sheath cases, a comparison was made between identified candidate 4th order bronchus by Computerised tomography (CT) evaluation versus that identified after virtual path creation. Results: From 7 archived cases, 14 doctors identified the correct bronchus in 94 of 98 assessments (95%). Percentage of cases where there was an improvement in localisation by 2 or more 4th order bronchi was 39.8% overall (28.6% – 51.0%), 26.6 for experienced and 53.1 for inexperienced bronchoscopists (p < 0.02). The absolute mean number of 4th order bronchi different between CT and VBNS was 2.0 ± 2.6 overall, 1.2 (range 0-6) for experienced, and 2.8 (range 0-11) for inexperienced bronchoscopists. Virtual Path software calculation time was 8.1 ± 2.7 minutes, compared to 3.6 ± 2.1 minutes by CT. Conclusion: VBNS allowed rapid accurate assessment with minimal software training. Greatest benefits in reduction of procedure time were obtained in inexperienced bronchoscopists, and VBNS could allow more rapid skill development in EBUS GS in these doctors.
文摘目的:探讨手绘导航在肺外周结节患者行支气管镜肺活检中的应用价值及其对支气管镜到达活检部位时间的影响因素。方法:回顾性分析2022年8月—2023年3月在宜昌市中心人民医院呼吸内镜中心接受径向超声引导下经支气管镜肺活检的116例肺外周结节患者,根据术前是否采用手绘导航规划路径,分为手绘导航联合径向超声组(手绘导航+RP-EBUS-GS组,n=60)和径向超声组(RP-EBUS-GS组,n=56),对比分析手绘导航在支气管镜肺活检中的应用效果。采用单因素及多因素Logistic回归分析手绘导航对支气管镜到达活检部位时间的影响因素。结果:手绘导航+RP-EBUS-GS组支气管镜到达活检部位时间明显短于RP-EBUS-GS组(6.32±3.10 min vs 8.89±4.09 min,P<0.001)。以支气管镜到达活检部位时间为因变量,单因素分析结果显示,两组患者性别、结节与支气管关系、所在支气管分级及是否应用手绘导航有明显差异(均P<0.05);多因素Logistic结果显示,所在支气管分级及是否应用手绘导航是支气管镜到达活检部位时间的独立影响因素(均P<0.05)。结论:手绘导航在肺外周结节患者行支气管镜肺活检中可明显缩短支气管镜到达活检部位的时间,具有很好的临床应用价值。肺外周结节所在支气管分级及是否应用手绘导航是支气管镜到达肺活检部位时间的独立影响因素。
文摘目的探讨导向鞘引导的超声支气管镜检查技术在诊断外周肺结节中的临床应用及安全性。方法回顾性分析2018年1月至2019年9月在空军军医大学唐都医院呼吸与危重症医学科气管镜室接受导向鞘引导超声支气管镜肺活检术(endobronchial ultrasonography with a guide sheath transbronchial lung biopsy,EBUS-GS-TBLB)检查的患者67例,研究EBUS-GS-TBLB对外周肺结节病理活检诊断阳性率及其影响因素。结果EBUS-GS-TBLB对外周肺结节的总诊断率为70.15%,其中病灶支气管征阳性患者的诊断率为80.49%,明显高于支气管征阴性患者,差异有统计学意义(χ2=5.393,P<0.05);病灶大小、位置、与胸膜的距离及病灶类型对EBUS-GS-TBLB病理活检诊断率的影响均无显著统计学差异。结论与常规支气管镜检查相比,EBUS-GS-TBLB在提高活检诊断阳性率、降低活检风险方面具有明显优势,值得在临床推广应用,且EBUS-GS-TBLB活检阳性率在支气管征阳性患者中表现出显著优势,从而有利于从优选择肺外周结节病理活检方法,以达到提高肺癌早期诊断率的目的。
基金This study was supported by Beijing Municipal Hospital Scientific Research Cultivation Program(No.PX2016057).We thank Xiaoping Kang for her help in data analysis.
文摘Objective:Fluoroscopy guidance is generally required for endobronchial ultrasonography with guide sheath(EBUS-GS)in peripheral pulmonary lesions(PPLs).Virtual bronchoscopic navigation(VBN)can guide the bronchoscope by creating virtual images of the bronchial route to the lesion.The diagnostic yield and safety profiles of VBN without fluoroscopy for PPLs have not been evaluated in inexperienced pulmonologist performing EBUS-GS.Methods:Between January 2016 and June 2017,consecutive patients with PPLs referred for EBUS-GS at a single cancer center were enrolled.The diagnostic yield as well as safety profiles was retrospectively analyzed,and our preliminary experience was shared.Results:A total of 109 patients with 109 lesions were included,99(90.8%)lesions were visible on EBUS imaging.According to the procedure time needed to locate the lesion on EBUS,24.8%(27/109)were deemed technically difficult procedures;however,no significant relationships were identified between candidate parameters and technically difficult procedures.The overall diagnosis yield was 74.3%(81/109),and the diagnostic yield of malignancy was 83.7%(77/92).Lesions larger than 20 mm[odds ratio(OR),2.758;95%confidence interval(95%CI),1.077-7.062;P=0.034]and probe of within type(OR,3.174;95%CI,1.151-8.757,P=0.026)were independent factors leading to a better diagnostic yield in multivariate analysis.About 30 practice procedures were needed to achieve a stable diagnostic yield,and the proportion of technically difficult procedures decreased and stabilized after 70 practice procedures.Regarding complications,one patient(0.9%)had intraoperative hemorrhage(100 mL)which was managed under endoscopy.Conclusions:VBN without fluoroscopy guidance is still useful and safe for PPLs diagnosis,especially for malignant diseases when performed by pulmonologist without previous experience of EBUS-GS.VBN may simplify the process of lesion positioning and further multi-center randomized studies are warranted.
文摘目的：探讨肺部超声检查在左侧双腔支气管导管（LDLT）定位中的作用和可行性。方法：共纳入需单肺通气的ASAⅠ~Ⅱ级胸科手术成年患者80例,男61例,女19例,年龄36~79岁,平均（62±10）岁。随机分为超声组和临床组,每组各40例。临床组通过呼吸音和气道压定位,将左侧或右侧单肺通气时仅通气侧有呼吸音且气道压〈40 cm H_2O评估为导管位置合适。超声组通过超声检查患者双侧胸膜及膈肌的相对运动及气道压定位,将左侧或右侧单肺通气时仅通气侧有胸膜和膈肌运动且气道压〈40 cm H_2O评估为导管位置合适。最后经纤维支气管镜判断导管准确位置。结果：通过纤维支气管镜验证,临床组和超声组LDLT定位合适例数分别为24例（60.0%）和33例（82.5%）,差异有统计学意义（P〈0.05）;临床组判断LDLT位置的特异度为6.25%,准确率为62.5%,阳性预测值为61.5%,而超声组特异度为28.6%,准确率为87.5%,阳性预测值为86.8%,两组准确率和阳性预测值比较差异有统计学意义（P〈0.05）。结论：超声检查肺运动联合气道压监测的方法能提高LDLT定位合适的成功率,其判断LDLT位置的准确率和阳性预测值较高,在纤维支气管镜不具备或不合适的情况下,是LDLT插管定位的另一较好选择。
