Oral malignant acanthosis nigricans associated with endometrial adenocarcinoma

We report a 59-year-old patient with malignant acanthosis nigricans associated with metastasis of endometrial carcinoma. The patient presented papillomatosis lesions that appeared to be benign on multiple skins of body folds, particularly on lips. The lesions in lips and axilla had histological characteristic appearances of acanthosis nigricans, while the masses in abdomen and pelvis were metastasis endometrial adenocarcinoma. The article highlights the importance of biopsy and histopathological diagnosis in presumed benign lesions and the role of doctors in screening for body internal tumors.

恶性黑棘皮病

报告1例恶性黑棘皮病。患者男,24岁。全身褶皱部位皮肤变黑、增厚2个月。皮肤科检查:全身褶皱部位皮肤色素加深、粗糙,呈天鹅绒样增厚,以颈部、腋下及会阴部为重;腋下散在乳头状赘生物。右侧锁骨上可触及一增大淋巴结。胃镜示胃窦、胃体、十二指肠球部壁黏膜粗糙、充血、水肿、糜烂,可见散在溃疡。胃部组织病理检查示低分化腺癌。胸部及腹部CT平扫+增强检查提示多发转移的可能性大。诊断:恶性黑棘皮病;胃低分化腺癌。