BACKGROUND The standard treatment for advanced T2 gastric cancer(GC)is laparoscopic or surgical gastrectomy(either partial or total)and D2 lymphadenectomy.A novel combined endoscopic and laparoscopic surgery(NCELS)has...BACKGROUND The standard treatment for advanced T2 gastric cancer(GC)is laparoscopic or surgical gastrectomy(either partial or total)and D2 lymphadenectomy.A novel combined endoscopic and laparoscopic surgery(NCELS)has recently been proposed as a better option for T2 GC.Here we describe two case studies demonstrating the efficacy and safety of NCELS.CASE SUMMARY Two T2 GC cases were both resected by endoscopic submucosal dissection and full-thickness resection and laparoscopic lymph nodes dissection.This method has the advantage of being more precise and minimally invasive compared to current methods.The treatment of these 2 patients was safe and effective with no complications.These cases were followed up for nearly 4 years without recurrence or metastasis.CONCLUSION This novel method provides a minimally invasive treatment option for T2 GC,and its potential indications,effectiveness and safety needs to be further evaluated in controlled studies.展开更多
BACKGROUND The management of polyps involving the appendiceal orifice(AO)presents notable challenges.Endoscopic resection is frequently hindered by operational complexities,a heightened risk of incomplete removal,and ...BACKGROUND The management of polyps involving the appendiceal orifice(AO)presents notable challenges.Endoscopic resection is frequently hindered by operational complexities,a heightened risk of incomplete removal,and an elevated risk of procedural complications,including appendicitis.Conversely,surgical resection may entail unnecessary excision of intestinal segments,leading to potential morbidity.CASE SUMMARY Here,we reported two patients who presented with polyps deeply situated within the AO,with indistinct boundaries making it challenging to ensure completeness using traditional endoscopic resection.To overcome these challenges,we em-ployed combined endo-laparoscopic surgery(CELS),achieving curative resection without postoperative complications.CONCLUSION The application of CELS in managing polyps involving the AO is emerging as a safe and effective treatment modality.展开更多
AIM:To investigate the efficacy and safety of combined phacoemulsification and goniosynechialysis with or without endoscopic cyclophotocoagulation(PGE group and PG group)for the treatment of patients with coexisting p...AIM:To investigate the efficacy and safety of combined phacoemulsification and goniosynechialysis with or without endoscopic cyclophotocoagulation(PGE group and PG group)for the treatment of patients with coexisting primary angle-closure glaucoma(PACG)and cataracts.METHODS:The clinical data of patients with PACG and cataract were retrospectively reviewed.There was a total of 88 eyes in the study and were divided into two groups,42 eyes in PGE group and 46 eyes in PG group.Surgery success cumulative survival,preoperative and postoperative intraocular pressure(IOP),number of IOPlowering medications,best corrected visual acuity(BCVA)in the two groups were observed for more than 12 mo and compared within each group and between two groups.RESULTS:The mean IOP in PGE group declined from24.9 mm Hg preoperatively to 14.1 mm Hg at the first month after operation(P<0.001)and at the last visit 16.2 mm Hg(P<0.001).Meanwhile PG group also showed significant decrease,from 24.1 mm Hg preoperatively to 13.0 mm Hg at Imo after operation(P<0.001)and 15.3 mm Hg at the last visit(P=0.004).The mean medications reliance reduced in both groups,in PGE group was reduced from 1.62 preoperatively to 0.13 at the last visit(P<0.001),in PG group from 0.87 to 0.10(P<0.001).At the last visit,BCVA increased from 0.21 to 0.60 in PGE group(P<0.001)and from 0.24 to 0.67 in PG group(P<0.001).The success rate of PGE group at 1 mo was95.2%,then decreased to 70.7%at the last visit,whereas in PG group,the success rate at 1 mo was 100%,at the last visit was 73.4%.CONCLUSION:PGE shows promise for PACG patients with cataracts to reduce IOP,lighten the medication burden and improve visual acuity,and PG still has its value in specific patients.展开更多
Colorectal diseases are increasing due to altered lifestyle,genetic,and environmental factors.Colonoscopy plays an important role in diagnosis.Advances in colonoscope(ultrathin scope,magnetic scope,capsule)and technol...Colorectal diseases are increasing due to altered lifestyle,genetic,and environmental factors.Colonoscopy plays an important role in diagnosis.Advances in colonoscope(ultrathin scope,magnetic scope,capsule)and technological gadgets(Balloon assisted scope,third eye retroscope,NaviAid G-EYE,dye-based chromoendoscopy,virtual chromoendoscopy,narrow band imaging,i-SCAN,etc.)have made colonoscopy more comfortable and efficient.Now in-vivo microscopy can be performed using confocal laser endomicroscopy,optical coherence tomography,spectroscopy,etc.Besides developments in diagnostic colonoscopy,therapeutic colonoscopy has improved to manage lower gastrointestinal tract bleeding,obstruction,perforations,resection polyps,and early colorectal cancers.The introduction of combined endo-laparoscopic surgery and robotic endoscopic surgery has made these interventions feasible.The role of artificial intelligence in the diagnosis and management of colorectal diseases is also increasing day by day.Hence,this article is to review cutting-edge developments in endoscopic principles for the management of colorectal diseases.展开更多
Combined posterior and supraglottic stenosis (CS) often presents as debilitating dysphonia or dyspnea, secondary to blunt trauma or traumatic intubation. However, CS has proven to be a late complication of chemoradiat...Combined posterior and supraglottic stenosis (CS) often presents as debilitating dysphonia or dyspnea, secondary to blunt trauma or traumatic intubation. However, CS has proven to be a late complication of chemoradiation therapy. Traditional treatment of combined posterior and supraglottic stenosis (CS) secondary to chemoradiation has been frequently complicated by poor tissue healing. This case study illustrates a novel endoscopic surgical technique employing a large laterally-based flap as a posterior glottic keel by rotating it anteroinferiorly and suturing it in place. As a result of the procedure, the bilateral vocal folds, which were midline and immobile preoperatively, regained normal motion. The supraglottic airway was also restored. Successful endoscopic treatment of CS with bilateral vocal fold immobility is possible using a large laterally-based flap, even in the face of tissue changes secondary to chemoradiation.展开更多
Endourological treatment modalities for kidney stones include extracorporeal shock wave lithotripsy （ESWL）, flexible ureteroscopy （fURS）, percutaneous nephrolithotomy （PCNL）, and laparoscopy.PCNL is currently th...Endourological treatment modalities for kidney stones include extracorporeal shock wave lithotripsy （ESWL）, flexible ureteroscopy （fURS）, percutaneous nephrolithotomy （PCNL）, and laparoscopy.PCNL is currently the recommended treatment for patients with complex renal stones. However, for complex renal stones, the residual stone after PCNL is very common, and the treatment is a sticky business.展开更多
Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The go...Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The goal remains to identify and remove benign neoplastic polyps prior to becoming invasive cancers. Polypoid lesions of the colon vary widely from hyperplastic, hamartomatous and inflammatory to neoplastic adenomatous growths. Although these lesions are all benign, they are common, with up to one-quarter of patients over 60 years old will develop pre-malignant adenomatous polyps. Colonoscopy is the most effective screening tool to detect polyps and colon cancer, although several studies have demonstrated missed polyp rates from 6%-29%, largely due to variations in polyp size. This number can be as high as 40%, even with advanced (> 1 cm) adenomas. Other factors including sub-optimal bowel preparation, experience of the endoscopist, and patient anatomical variations all affect the detection rate. Additional challenges in decision-making exist when dealing with more advanced, and typically larger, polyps that have traditionally required formal resection. In this brief review, we will explore the recent advances in polyp detection and therapeutic options.展开更多
目的:分析腹腔镜与内镜联合治疗对胆囊结石伴胆管结石患者的影响。方法:选取2022年5月—2023年5月贵州医科大学附属白云医院收治的70例胆囊结石伴胆管结石患者作为研究对象。根据随机数表法将其分为对照组和观察组,各35例。对照组给予...目的:分析腹腔镜与内镜联合治疗对胆囊结石伴胆管结石患者的影响。方法:选取2022年5月—2023年5月贵州医科大学附属白云医院收治的70例胆囊结石伴胆管结石患者作为研究对象。根据随机数表法将其分为对照组和观察组,各35例。对照组给予传统手术治疗,观察组给予腹腔镜与内镜联合治疗。比较两组术前、术后3 d疼痛情况及生活质量,围手术期指标及术后并发症。结果:术后3 d,观察组视觉模拟评分法(visual analogue scale,VAS)评分低于对照组,简明生活质量量表(the MOS item short form 36 health survey,SF-36)评分高于对照组,差异有统计学意义(P<0.05)。观察组术中出血量少于对照组,术后首次排气时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。两组术后并发症发生率比较,差异无统计学意义(P>0.05)。结论:腹腔镜与内镜联合治疗胆囊结石伴胆管结石的效果显著,具有疼痛轻、术中出血量少、术后恢复快等优点,从而能提升患者生活质量。展开更多
目的探讨在静吸复合全身麻醉中应用右美托咪啶抑制苏醒期应激反应、减少并发症、提高患者的恢复质量的有效性及可行性。方法采用双盲研究,将60例患者随机分为实验组和对照组,所有患者均采用静吸复合全身麻醉,其中实验组在麻醉过程中泵...目的探讨在静吸复合全身麻醉中应用右美托咪啶抑制苏醒期应激反应、减少并发症、提高患者的恢复质量的有效性及可行性。方法采用双盲研究,将60例患者随机分为实验组和对照组,所有患者均采用静吸复合全身麻醉,其中实验组在麻醉过程中泵注右美托咪啶,而对照组泵注生理盐水。记录苏醒期恢复过程(呼唤睁眼时间,拔管时间,完全清醒不再嗜睡时间)、苏醒期MAAS评分及VAS评分、血流动力学变化情况[麻醉前、拔管即时、拔管后30 min的心率(HR)、平均动脉压(MAP)]以及术后有无发生恶心呕吐、呼吸抑制等不良反应。结果两组患者呼唤睁眼时间、拔管时间、完全清醒不再嗜睡时间两组无显著性差异(P>0.05)。拔管后30 min VAS评分实验组较对照组明显降低(P<0.05)。拔管后5 min MAAS评分值实验组明显低于对照组(P<0.05)。两组患者麻醉前MAP、HR组间比较,差异无统计学意义(P>0.05);拔管即时、拔管后30 min与麻醉前比较,对照组MAP水平明显升高、HR明显增快(P<0.05),而实验组MAP、HR变化不明显(P>0.05);组间比较,拔管即时、拔管后30 min对照组MAP、HR均明显高于实验组(P<0.05)。对照组有7例患者出现寒颤而实验组所有患者均无出现寒颤,两组差异有统计学意义(P<0.05)。结论右美托咪啶能有效抑制静吸复合全身麻醉清醒期应激反应,减少并发症,提高患者的恢复质量,值得推广应用。展开更多
文摘BACKGROUND The standard treatment for advanced T2 gastric cancer(GC)is laparoscopic or surgical gastrectomy(either partial or total)and D2 lymphadenectomy.A novel combined endoscopic and laparoscopic surgery(NCELS)has recently been proposed as a better option for T2 GC.Here we describe two case studies demonstrating the efficacy and safety of NCELS.CASE SUMMARY Two T2 GC cases were both resected by endoscopic submucosal dissection and full-thickness resection and laparoscopic lymph nodes dissection.This method has the advantage of being more precise and minimally invasive compared to current methods.The treatment of these 2 patients was safe and effective with no complications.These cases were followed up for nearly 4 years without recurrence or metastasis.CONCLUSION This novel method provides a minimally invasive treatment option for T2 GC,and its potential indications,effectiveness and safety needs to be further evaluated in controlled studies.
基金Supported by the National High-Level Hospital Clinical Research Funding,No.2022-PUMCH-B-024 and No.2022-PUMCH-A-020Undergraduate Teaching Reform and Innovation Project,No.2022zlgc0108.
文摘BACKGROUND The management of polyps involving the appendiceal orifice(AO)presents notable challenges.Endoscopic resection is frequently hindered by operational complexities,a heightened risk of incomplete removal,and an elevated risk of procedural complications,including appendicitis.Conversely,surgical resection may entail unnecessary excision of intestinal segments,leading to potential morbidity.CASE SUMMARY Here,we reported two patients who presented with polyps deeply situated within the AO,with indistinct boundaries making it challenging to ensure completeness using traditional endoscopic resection.To overcome these challenges,we em-ployed combined endo-laparoscopic surgery(CELS),achieving curative resection without postoperative complications.CONCLUSION The application of CELS in managing polyps involving the AO is emerging as a safe and effective treatment modality.
文摘AIM:To investigate the efficacy and safety of combined phacoemulsification and goniosynechialysis with or without endoscopic cyclophotocoagulation(PGE group and PG group)for the treatment of patients with coexisting primary angle-closure glaucoma(PACG)and cataracts.METHODS:The clinical data of patients with PACG and cataract were retrospectively reviewed.There was a total of 88 eyes in the study and were divided into two groups,42 eyes in PGE group and 46 eyes in PG group.Surgery success cumulative survival,preoperative and postoperative intraocular pressure(IOP),number of IOPlowering medications,best corrected visual acuity(BCVA)in the two groups were observed for more than 12 mo and compared within each group and between two groups.RESULTS:The mean IOP in PGE group declined from24.9 mm Hg preoperatively to 14.1 mm Hg at the first month after operation(P<0.001)and at the last visit 16.2 mm Hg(P<0.001).Meanwhile PG group also showed significant decrease,from 24.1 mm Hg preoperatively to 13.0 mm Hg at Imo after operation(P<0.001)and 15.3 mm Hg at the last visit(P=0.004).The mean medications reliance reduced in both groups,in PGE group was reduced from 1.62 preoperatively to 0.13 at the last visit(P<0.001),in PG group from 0.87 to 0.10(P<0.001).At the last visit,BCVA increased from 0.21 to 0.60 in PGE group(P<0.001)and from 0.24 to 0.67 in PG group(P<0.001).The success rate of PGE group at 1 mo was95.2%,then decreased to 70.7%at the last visit,whereas in PG group,the success rate at 1 mo was 100%,at the last visit was 73.4%.CONCLUSION:PGE shows promise for PACG patients with cataracts to reduce IOP,lighten the medication burden and improve visual acuity,and PG still has its value in specific patients.
文摘Colorectal diseases are increasing due to altered lifestyle,genetic,and environmental factors.Colonoscopy plays an important role in diagnosis.Advances in colonoscope(ultrathin scope,magnetic scope,capsule)and technological gadgets(Balloon assisted scope,third eye retroscope,NaviAid G-EYE,dye-based chromoendoscopy,virtual chromoendoscopy,narrow band imaging,i-SCAN,etc.)have made colonoscopy more comfortable and efficient.Now in-vivo microscopy can be performed using confocal laser endomicroscopy,optical coherence tomography,spectroscopy,etc.Besides developments in diagnostic colonoscopy,therapeutic colonoscopy has improved to manage lower gastrointestinal tract bleeding,obstruction,perforations,resection polyps,and early colorectal cancers.The introduction of combined endo-laparoscopic surgery and robotic endoscopic surgery has made these interventions feasible.The role of artificial intelligence in the diagnosis and management of colorectal diseases is also increasing day by day.Hence,this article is to review cutting-edge developments in endoscopic principles for the management of colorectal diseases.
文摘Combined posterior and supraglottic stenosis (CS) often presents as debilitating dysphonia or dyspnea, secondary to blunt trauma or traumatic intubation. However, CS has proven to be a late complication of chemoradiation therapy. Traditional treatment of combined posterior and supraglottic stenosis (CS) secondary to chemoradiation has been frequently complicated by poor tissue healing. This case study illustrates a novel endoscopic surgical technique employing a large laterally-based flap as a posterior glottic keel by rotating it anteroinferiorly and suturing it in place. As a result of the procedure, the bilateral vocal folds, which were midline and immobile preoperatively, regained normal motion. The supraglottic airway was also restored. Successful endoscopic treatment of CS with bilateral vocal fold immobility is possible using a large laterally-based flap, even in the face of tissue changes secondary to chemoradiation.
文摘Endourological treatment modalities for kidney stones include extracorporeal shock wave lithotripsy （ESWL）, flexible ureteroscopy （fURS）, percutaneous nephrolithotomy （PCNL）, and laparoscopy.PCNL is currently the recommended treatment for patients with complex renal stones. However, for complex renal stones, the residual stone after PCNL is very common, and the treatment is a sticky business.
文摘Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The goal remains to identify and remove benign neoplastic polyps prior to becoming invasive cancers. Polypoid lesions of the colon vary widely from hyperplastic, hamartomatous and inflammatory to neoplastic adenomatous growths. Although these lesions are all benign, they are common, with up to one-quarter of patients over 60 years old will develop pre-malignant adenomatous polyps. Colonoscopy is the most effective screening tool to detect polyps and colon cancer, although several studies have demonstrated missed polyp rates from 6%-29%, largely due to variations in polyp size. This number can be as high as 40%, even with advanced (> 1 cm) adenomas. Other factors including sub-optimal bowel preparation, experience of the endoscopist, and patient anatomical variations all affect the detection rate. Additional challenges in decision-making exist when dealing with more advanced, and typically larger, polyps that have traditionally required formal resection. In this brief review, we will explore the recent advances in polyp detection and therapeutic options.
文摘目的:分析腹腔镜与内镜联合治疗对胆囊结石伴胆管结石患者的影响。方法:选取2022年5月—2023年5月贵州医科大学附属白云医院收治的70例胆囊结石伴胆管结石患者作为研究对象。根据随机数表法将其分为对照组和观察组,各35例。对照组给予传统手术治疗,观察组给予腹腔镜与内镜联合治疗。比较两组术前、术后3 d疼痛情况及生活质量,围手术期指标及术后并发症。结果:术后3 d,观察组视觉模拟评分法(visual analogue scale,VAS)评分低于对照组,简明生活质量量表(the MOS item short form 36 health survey,SF-36)评分高于对照组,差异有统计学意义(P<0.05)。观察组术中出血量少于对照组,术后首次排气时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。两组术后并发症发生率比较,差异无统计学意义(P>0.05)。结论:腹腔镜与内镜联合治疗胆囊结石伴胆管结石的效果显著,具有疼痛轻、术中出血量少、术后恢复快等优点,从而能提升患者生活质量。
文摘目的探讨在静吸复合全身麻醉中应用右美托咪啶抑制苏醒期应激反应、减少并发症、提高患者的恢复质量的有效性及可行性。方法采用双盲研究,将60例患者随机分为实验组和对照组,所有患者均采用静吸复合全身麻醉,其中实验组在麻醉过程中泵注右美托咪啶,而对照组泵注生理盐水。记录苏醒期恢复过程(呼唤睁眼时间,拔管时间,完全清醒不再嗜睡时间)、苏醒期MAAS评分及VAS评分、血流动力学变化情况[麻醉前、拔管即时、拔管后30 min的心率(HR)、平均动脉压(MAP)]以及术后有无发生恶心呕吐、呼吸抑制等不良反应。结果两组患者呼唤睁眼时间、拔管时间、完全清醒不再嗜睡时间两组无显著性差异(P>0.05)。拔管后30 min VAS评分实验组较对照组明显降低(P<0.05)。拔管后5 min MAAS评分值实验组明显低于对照组(P<0.05)。两组患者麻醉前MAP、HR组间比较,差异无统计学意义(P>0.05);拔管即时、拔管后30 min与麻醉前比较,对照组MAP水平明显升高、HR明显增快(P<0.05),而实验组MAP、HR变化不明显(P>0.05);组间比较,拔管即时、拔管后30 min对照组MAP、HR均明显高于实验组(P<0.05)。对照组有7例患者出现寒颤而实验组所有患者均无出现寒颤,两组差异有统计学意义(P<0.05)。结论右美托咪啶能有效抑制静吸复合全身麻醉清醒期应激反应,减少并发症,提高患者的恢复质量,值得推广应用。
