AIM: To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn&...AIM: To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease (CD) and ulcerative colitis (UC).展开更多
BACKGROUND Tracheoesophageal fistulas(TEFs)can be described as a pathological communication between the trachea and the esophagus.According to their origin,they may be classified as benign or malignant.Benign TEFs occ...BACKGROUND Tracheoesophageal fistulas(TEFs)can be described as a pathological communication between the trachea and the esophagus.According to their origin,they may be classified as benign or malignant.Benign TEFs occur mostly as a consequence of prolonged mechanical ventilation,particularly among patients exposed to endotracheal cuff overinflation.During the severe acute respiratory syndrome coronavirus 2 virus pandemic,the amount of patients requiring prolonged ventilation rose,which in turn increased the incidence of TEFs.CASE SUMMARY We report the cases of 14 patients with different comorbidities such as being overweight,or having been diagnosed with diabetes mellitus or systemic hypertension.The most common symptoms on arrival were dyspnea and cough.In all cases,the diagnosis of TEFs was made through upper endoscopy.Depending on the location and size of each fistula,either endoscopic or surgical treatment was provided.Eight patients were treated endoscopically.Successful closure of the defect was achieved through over the scope clips in two patients,while three of them required endoscopic metal stenting.A hemoclip was used to successfully treat one patient,and it was used temporarily for another patient pended surgery.Surgical treatment was performed in patients with failed endoscopic management,leading to successful defect correction.Two patients died before receiving corrective treatment and four died later on in their clinical course due to infectious complications.CONCLUSION The incidence of TEFs increased during the coronavirus disease 2019 pandemic(from 0.5%to 1.5%).We believe that endoscopic treatment should be considered as an option for this group of patients,since evidence reported in the literature is still a growing area.Therefore,we propose an algorithm to lead intervention in patients presenting with TEFs due to prolonged intubation.展开更多
基金Supported by TAMOP-4.2.2.A-11/1/KONV-2012-0035,TA-MOP-4.2.2-A-11/1/KONV-2012-0052 TAMOP-4.2.2.A-11/1/KONV-2012-0073OTKA Research Proposal PD 105948(PI:Klaudia Farkas)
文摘AIM: To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease (CD) and ulcerative colitis (UC).
文摘BACKGROUND Tracheoesophageal fistulas(TEFs)can be described as a pathological communication between the trachea and the esophagus.According to their origin,they may be classified as benign or malignant.Benign TEFs occur mostly as a consequence of prolonged mechanical ventilation,particularly among patients exposed to endotracheal cuff overinflation.During the severe acute respiratory syndrome coronavirus 2 virus pandemic,the amount of patients requiring prolonged ventilation rose,which in turn increased the incidence of TEFs.CASE SUMMARY We report the cases of 14 patients with different comorbidities such as being overweight,or having been diagnosed with diabetes mellitus or systemic hypertension.The most common symptoms on arrival were dyspnea and cough.In all cases,the diagnosis of TEFs was made through upper endoscopy.Depending on the location and size of each fistula,either endoscopic or surgical treatment was provided.Eight patients were treated endoscopically.Successful closure of the defect was achieved through over the scope clips in two patients,while three of them required endoscopic metal stenting.A hemoclip was used to successfully treat one patient,and it was used temporarily for another patient pended surgery.Surgical treatment was performed in patients with failed endoscopic management,leading to successful defect correction.Two patients died before receiving corrective treatment and four died later on in their clinical course due to infectious complications.CONCLUSION The incidence of TEFs increased during the coronavirus disease 2019 pandemic(from 0.5%to 1.5%).We believe that endoscopic treatment should be considered as an option for this group of patients,since evidence reported in the literature is still a growing area.Therefore,we propose an algorithm to lead intervention in patients presenting with TEFs due to prolonged intubation.
