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Energy Consumption Analysis and Optimization of Electric Submersible Pump System
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作者 Lingyu Li 《Engineering(科研)》 CAS 2023年第5期269-274,共6页
Electric submersible pumps account for a considerable proportion in the development of the Bohai Oilfield. Improving the system efficiency of the electric submersible pump wells, ensuring that the units operate in the... Electric submersible pumps account for a considerable proportion in the development of the Bohai Oilfield. Improving the system efficiency of the electric submersible pump wells, ensuring that the units operate in the high-efficiency zone, is essential. Analysis shows that the efficiency of the electric submersible pump system depends on the wear and tear of each component of the submersible pump equipment, the setting of operational parameters, and more importantly, the production status and daily management level of the oil well. Therefore, improving the structural performance of the submersible pump product, optimizing the parameters setting of the oil well, strengthening daily management, establishing a scientific management system, and improving the production management process and system can effectively improve the production efficiency and economic benefits of the oil well, and further achieve the goal of energy saving and emission reduction. In addition, it is necessary to actively promote the concept and technology of energy saving and emission reduction, encourage oilfield enterprises to explore effective measures to reduce the energy consumption of the electric submersible pump system by strengthening the scientific management system, and achieve a green, low-carbon, and high-quality development of oilfield production to achieve the unity of economic benefits, social benefits, and environmental benefits. This article applies the above measures in the P oilfield to achieve energy optimization of submersible electric pump systems, reducing the daily power consumption of single well submersible electric pump systems by 371 kWh per day, increasing the submersible electric pump's lifespan by 200 days, generating considerable project benefits. 展开更多
关键词 Offshore Oil Fields Electric Submersible Pumps System energy Consump-tion System Efficiency energy Conservation and Consumption Reduction
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Modulatory Effects of Compound Polysaccharide Erweikang on the Immune Function o f Mice 被引量:2
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作者 杜光 马宝瑕 +1 位作者 张锐 孙明辉 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2002年第3期221-223,共3页
In order to study the modulatory effects of compound polysaccharide Erweikang on the immune function of the immunosuppressive mice, the positive immune modulati on of Erweikang at different doses and different time p... In order to study the modulatory effects of compound polysaccharide Erweikang on the immune function of the immunosuppressive mice, the positive immune modulati on of Erweikang at different doses and different time points was compared when n ormal saline and cyclophosphamide served as controls. The results showed that di fferent doses of Erweikang could effectively reverse the decreased induction lev els of NK, IL 2, γ IFN and the contents of TNF and IgG of the immunosu ppressive mice after administration of Erweikang for 7 to 14 days. It was sugges ted that compound polysaccharide Erweikang presents positive immune modulation i n dose and time dependent manners. 展开更多
关键词 compound polysaccharide Erweikang immune func tion mice immunosuppressive
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Stability of Boundary Feedback Control Based on Weighted Lyapunov Function in Networks of Open Channels 被引量:4
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作者 CEN Li-Hui XI Yu-Geng 《自动化学报》 EI CSCD 北大核心 2009年第1期97-102,共6页
Lyapunov 功能在串联为二条开的隧道的盒子基于熵的加权的和被构造,它被 Saint-Venant 方程描述。边界反馈控制器的一个班被介绍借助于 Lyapunov 设计途径在平衡点的一位邻居保证本地靠近环的 asymptotic 稳定性。
关键词 Saint-Venant方程 LYAPUNOV函数 渐近稳定度 边界反馈控制
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Early rehabilitation improves neurofunctional outcome after surgery in children with spinal tumors 被引量:4
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作者 Nezire Kose Ozge Muezzinoglu +3 位作者 Sevil Bilgin Sevilay Karahan Ilkay Is kay Burcak Bilginer 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第2期129-134,共6页
To investigate the effect of early rehabilitation on neurofunctional outcome after surgery in chil- dren with spinal tumors, this study reviewed the medical charts and radiographic records of 70 pediatric patients (1... To investigate the effect of early rehabilitation on neurofunctional outcome after surgery in chil- dren with spinal tumors, this study reviewed the medical charts and radiographic records of 70 pediatric patients (1-17 years old) who received spinal tumor surgical removal. The peddiatric patients received rahabilitation treatment at 4 (range, 2-7) days after surgery for 10 (range, 7-23) days. Results from the Modified McCormick Scale, Functional Independence Measure for Chil- dren, American Spinal Injury Association Impairment Scale and Karnofsky Performance Status Scale demonstrated that the sensory function, motor function and activity of daily living of pedi- atric children who received early rehabilitation were significantly improved. Results also showed that tumor setting and level localization as well as patients's clinical symptoms have no influences on neurofunctional outcomes. 展开更多
关键词 nerve regeneration spinal cord injury spinal cord tumor CHILDREN rehabilitation func-tion SENSE motor retrospective analysis neural regeneration
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Generalized Gr?tzsch ring function and generalized elliptic integrals 被引量:1
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作者 MA Xiao-yan QIU Song-liang TU Guo-yan 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2016年第4期458-468,共11页
Abstract. In this paper, we study the quotient of hypergeometric functions μα (r) in the theory of Ramanujan's generalized modular equation for α ∈(0, 1/2]. Several new inequalities are given for this and rela... Abstract. In this paper, we study the quotient of hypergeometric functions μα (r) in the theory of Ramanujan's generalized modular equation for α ∈(0, 1/2]. Several new inequalities are given for this and related functions. Our main results complement and generalize some known results in the literature. 展开更多
关键词 Gaussian hypergeometric function generalized GrStzsch ring function generalized elliptic func-tion.
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Standard Gibbs Free Energy of Formation of Zirconium Oxysulphides
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作者 隋智通 肖兴义 +1 位作者 黄克勤 王常珍 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 1991年第1期65-67,共3页
1.IntroductionThe chemistry of rare earthoxysulphides is well known [1-5] and theyhave extensive technological applications,but the d-transition metal oxysulphides wasnot known until recently [6-9].Therefore,itis nece... 1.IntroductionThe chemistry of rare earthoxysulphides is well known [1-5] and theyhave extensive technological applications,but the d-transition metal oxysulphides wasnot known until recently [6-9].Therefore,itis necessary to study the thermodynamicproperties of these compounds. 展开更多
关键词 standard free energy of forma tion Zr oxysulphide
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Interaction Energy Prediction of Organic Molecules using Deep Tensor Neural Network
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作者 Yuan Qi Hong Ren +6 位作者 Hong Li Ding-lin Zhang Hong-qiang Cui Jun-ben Weng Guo-hui Li Gui-yan Wang Yan Li 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2021年第1期112-124,I0012,共14页
The interaction energy of two molecules system plays a critical role in analyzing the interacting effect in molecular dynamic simulation.Since the limitation of quantum mechanics calculating resources,the interaction ... The interaction energy of two molecules system plays a critical role in analyzing the interacting effect in molecular dynamic simulation.Since the limitation of quantum mechanics calculating resources,the interaction energy based on quantum mechanics can not be merged into molecular dynamic simulation for a long time scale.A deep learning framework,deep tensor neural network,is applied to predict the interaction energy of three organic related systems within the quantum mechanics level of accuracy.The geometric structure and atomic types of molecular conformation,as the data descriptors,are applied as the network inputs to predict the interaction energy in the system.The neural network is trained with the hierarchically generated conformations data set.The complex tensor hidden layers are simplified and trained in the optimization process.The predicted results of different molecular sys tems indica te that deep t ensor neural net work is capable to predic t the interaction energy with 1 kcal/mol of the mean absolute error in a relatively short time.The prediction highly improves the efficiency of interaction energy calculation.The whole proposed framework provides new insights to introducing deep learning technology into the interaction energy calculation. 展开更多
关键词 Deep tensor neural net work Interac tion energy Organic molecules
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Study on Ecological Compensation Policy among the Micro Subjects on Water Energy Resources Development 被引量:2
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作者 Shihua LI Deshan TANG 《Journal of Water Resource and Protection》 2009年第1期10-15,共6页
The subjects of ecological compensation involve the nation, society, development enterprises of wa-ter-energy resources, as well as the location of resource itself. This paper systematically studies on how to make “w... The subjects of ecological compensation involve the nation, society, development enterprises of wa-ter-energy resources, as well as the location of resource itself. This paper systematically studies on how to make “water energy sources market compensation policy”, “the economic compensation policy for relevant interest subjects” and “the ecological compensation policy of basin ecological water.” So, it is necessary to exert the complementary function between market compensation and government compensation by the means of economic compensation and to establish the ecological compensation policy of basin ecological water, which is beneficial to coordinating the stakeholders’ interests of cross-region or inter-basin. And it is important and significant to establish constantly perfected ecological compensation policy among the micro subjects on water energy resources development, so as to coordinate interest relationships among various subjects and finally reach the aim of sustainable use of water energy resources and environmental protection as possible. 展开更多
关键词 ECOLOGICAL COMPENSAtion POLICY WATER energy Resources Development MICRO SUBJECTS Re-source COMPENSAtion Economic COMPENSAtion Regional ECOLOGICAL WATER Market Compensa-tion Government COMPENSAtion
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Saving Energy for Wireless Transmission:An Important Revelation from Shannon Formula
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作者 ZHU Jinkang ZHAO Ming 《ZTE Communications》 2021年第1期2-10,共9页
The reduction of power consumption is important for wireless communications and networks.To develop the energy-saving technologies for future wireless transmissions and networks,this paper presents two basic study poi... The reduction of power consumption is important for wireless communications and networks.To develop the energy-saving technologies for future wireless transmissions and networks,this paper presents two basic study points:1)The multiple events are merged into a single event;2)the high-order mode is changed to the low-order mode.For this rea⁃son,we seek that multiple events in wireless transmission links are fused into a single event from Shannon formulas.We also analyze the relationship between the information modula⁃tion and the error correction,and give a fusion structure of error-corrected modulation.The energy-saving performance of the error-corrected modulation method is further analyzed through comparison with the traditional methods of modulation plus error correction.The re⁃sults of numerical analysis demonstrate the wireless energy saving methods for wireless sys⁃tems based on Shannon formulas are the achievable efficient schemes. 展开更多
关键词 wireless saving energy extension of Shannon formula error-corrected modula⁃tion energy-saving performance
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Command functions of open loop galvanometer scanners with optimized duty cycles
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作者 V.F.Duma 《Theoretical & Applied Mechanics Letters》 CAS 2012年第4期34-39,共6页
The paper approaches the problem of the command functions of galvanometer-based scanners (GS) that are necessary to produce the linear plus parabolic scanning function of the GS, which we have proved previously to p... The paper approaches the problem of the command functions of galvanometer-based scanners (GS) that are necessary to produce the linear plus parabolic scanning function of the GS, which we have proved previously to produce the highest possible duty cycle (i.e., time efficiency) of the device. We have completed this theoretical aspect (which contradicted what has been stated previously in the literature, where it has been considered that the linear plus sinusoidal scanning function was the best) with the experimental study of the most used scanning functions of the GSs (sawtooth, sinusoidal and triangular), with applications in biomedical imaging, in particular in optical coherence tomography, demonstrating that the triangular function is always the best one to be applied, from both an optical and a mechanical point of view. In the present study the input voltage/command function which should be applied to the GS to produce the desired triangular scanning function (with controlled non-linearity for the fastest possible stop-and-turn portions) was determined analytically, in relationship with the active torque that drives the device. This command function is analyzed with regard to the specific, respectively required parameters of the GS: natural frequency and damping factor, respectively scan speed and amplitude. The modeling in an open loop control structure of the GS is finally discussed as a trade-off between using the highest possible duty cycle and minimizing the maximum peaks of the input voltage. 展开更多
关键词 scanners galvanometer scanner optomechatronics scanning functions command func-tions duty cycle driving torque
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A new detection method in studying penetration depth of low-energy heavy ions in botanic samples
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作者 LIU Feng, WANG Yu-Gang, XUE Jian-Ming, WANG Si-Xue ZHAO Wei-Jiang (Ion Beam Group, Institute of Heavy Ion Physics, Peking University, Beijing 100871) 《Nuclear Science and Techniques》 SCIE CAS CSCD 2001年第3期169-176,共8页
A new detection method has been applied to study the penetration depth of low-energy heavy ions in botanic samples. Highly oriented pyrolytic graphite (HOPG) pieces were placed behind the target samples with certain t... A new detection method has been applied to study the penetration depth of low-energy heavy ions in botanic samples. Highly oriented pyrolytic graphite (HOPG) pieces were placed behind the target samples with certain thickness to receive energetic penetrated ions during the irradiation. After irradiation, statistic number density of protrusion-like damage induced by energetic penetrated ions can be ob- tained through scanning tunneling microscope (STM) observation on the surfaces of HOPG. The results of test indicate that the detection limit can be as low as 1.0×109 protrusions/cm2. With the method, the penetration depth of at least 60μm can be detected in kidney bean slices irradiated by N+ ions with dose of 0.3-3×1017ions/cm2. 展开更多
关键词 低能重离子 植物样品 贯穿深度 探测法
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Beneficial Effects of Delayed Opening the Infarct - related Artery on Late Phase Left Ventricular Function in Acute Anterior Myocardial Infarction
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作者 马礼坤 余华 +5 位作者 黄向阳 褚俊 冯克福 丁晓梅 严激 顾统元 《South China Journal of Cardiology》 CAS 2004年第2期71-74,79,共5页
Objectives To assess the effect of delayed opening the infarct - related artery (IRA) by percutanous coronary intervention (PCI) on the late phase left ventricular function after acute ante- rior myocardial infarction... Objectives To assess the effect of delayed opening the infarct - related artery (IRA) by percutanous coronary intervention (PCI) on the late phase left ventricular function after acute ante- rior myocardial infarction. Methods 64 patients with initial Q - wave anterior myocardial infarction and the infarct - related arteries were total occluded conformed by angiogram at 2 to 14 days after onset were divided into successful PCI group and control group ( not re- ceiving PCI or the IRA not re - opened). 2 - DE was performed at early phase ( about 3 weeks) , 2 and 6 months after onset of AMI respectively to detect the left ventricular function and left ventricular wall motion ab- normality (VWMA). The total congestive heart failure events were recorded during 6 months follow-up. Re- sults VWMA scores, left ventricular ejection frac- tion (LVEF) , left ventricular end - diastolic and end - systolic volume indices ( LVEDVI and LVDSVI) were similar in 2 groups at early phase and 2 months. There were no differences between early phase and 2 months in each group too. VWMA scores and LVEF did not changed at 6 months in each group compared with the early phase and 2 months ( P > 0. 05 ). But LVEDVI and LVESVI were significantly smaller in the successful PCI group than in the control group (P < 0.01, P < 0. 05). The congestive heart failure events were taken place in 19% of patients in control group com- pared with 2% in successful PCI group ( P > 0. 05 ). Conclusions Although the infarct size does not changed, delayed opening the IRA has beneficial effect to the late phase left ventricular dilatation after acuteanterior myocardial infarction. 展开更多
关键词 Acute myocardial infarction Per- cutanous coronary intervention Left ventricular func- tion
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算力-热力灵活性协同的数据中心能量管理方法
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作者 王天琪 于浩 +3 位作者 赵金利 宋关羽 习伟 李鹏 《高电压技术》 EI CAS CSCD 北大核心 2024年第9期4069-4079,I0022,I0023,共13页
随着数字经济产业快速发展,数据中心成为电能消耗的重要部分。多样化的数据处理需求、大量的计算用电及制冷用电,在带来高能耗问题的同时也为数据中心的运行调度提供了灵活性。因此,协同考虑计算灵活性和热灵活性,制定数据中心优化运行... 随着数字经济产业快速发展,数据中心成为电能消耗的重要部分。多样化的数据处理需求、大量的计算用电及制冷用电,在带来高能耗问题的同时也为数据中心的运行调度提供了灵活性。因此,协同考虑计算灵活性和热灵活性,制定数据中心优化运行策略,可有效提高能源利用效率,提升数据中心运行经济性。该文提出一种考虑算力-热力灵活性协同的数据中心能量管理方法。首先,考虑数据负载灵活调度、冷却系统温度变化以及冷热通道热惯性等精细化要素,实现了信息技术设备和冷却设备的协同建模。其次,进行模型的线性化转换,降低了求解难度。在此基础上,实现了基于灵活性协同的数据中心能量管理,从而降低数据中心运行能耗及成本。最后通过算例验证了所提方法的有效性。 展开更多
关键词 数据中心 数据负载调度 热灵活性 精细化建模 能量管理 经济运行
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基于能量均衡的非均匀分簇调度算法
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作者 崔颖 李巧珏 +1 位作者 高山 陈立伟 《哈尔滨工程大学学报》 EI CAS CSCD 北大核心 2024年第9期1834-1839,共6页
针对无线传感器网络节点能量有限且不可充电的问题,本文提出基于能量均衡的非均匀分簇调度算法(EBNC_CHES)延长网络寿命。EBNC_CHES在麻雀搜索算法的基础上,引入时间竞争机制减少冗余信息获取和能耗传递的同时,采取K-means非均匀分簇均... 针对无线传感器网络节点能量有限且不可充电的问题,本文提出基于能量均衡的非均匀分簇调度算法(EBNC_CHES)延长网络寿命。EBNC_CHES在麻雀搜索算法的基础上,引入时间竞争机制减少冗余信息获取和能耗传递的同时,采取K-means非均匀分簇均衡簇间网络能量消耗,引入改进的麻雀搜索在簇头选举中均衡簇内能耗。仿真结果表明:该算法与LEACH、EECHS_ISSADE和EESSTBRP相比,冗余信息降低了81%、80%、55%,能耗利用率提高了133%、50%、11.4%,寿命延长了52.8%、43.5%、12.2%。此算法能减少冗余信息,降低网络能耗、延长网络寿命。 展开更多
关键词 麻雀搜索算法 时间竞争调度 K-MEANS算法 网络能耗 非均匀分簇 层次分析法 簇头选举 能量均衡
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改进非洲秃鹫算法的汽车充电站选址方法
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作者 范德会 马春龙 《计算机仿真》 2024年第9期424-428,共5页
充电站选址需要综合考虑多个因素,如充电需求密度、车流密度、车速等,这些因素之间存在复杂的相互关系和约束条件,如何将它们综合考虑是一个难点。为了获取用户满意度较高的选址方案,提出一种考虑交通拥堵的新能源汽车充电站选址优化方... 充电站选址需要综合考虑多个因素,如充电需求密度、车流密度、车速等,这些因素之间存在复杂的相互关系和约束条件,如何将它们综合考虑是一个难点。为了获取用户满意度较高的选址方案,提出一种考虑交通拥堵的新能源汽车充电站选址优化方法。考虑交通拥堵指数对新能源汽车用户出行和充电站选取的影响,以运营商投资成本最小和用户满意度最大为目标,建立新能源汽车充电站选址优化模型。利用改进非洲秃鹫优化算法对模型求解,确定新能源汽车充电站选址最优解决方案。仿真实验结果表明,所提方法可以有效提升用户满意度,减少网损率和路径长度,获取更加贴合实际需求的新能源汽车充电站选址方案。 展开更多
关键词 交通拥堵 新能源汽车 充电站选址 改进非洲秃鹫优化算法
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高精度经颅直流电刺激联合悬吊运动训练对脑卒中患者下肢运动功能的影响 被引量:1
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作者 张海泉 胡川 +2 位作者 黄磊 路伟 王欣 《康复学报》 CSCD 2024年第2期110-116,共7页
目的 观察高精度经颅直流电刺激(HD-tDCS)联合悬吊运动训练对脑卒中患者下肢运动功能的影响。方法 选择2022年1月-2023年2月在山东大学附属山东省立第三医院康复医学部住院治疗的脑卒中患者120例,按照随机数字表法分为对照组、HD-tDCS... 目的 观察高精度经颅直流电刺激(HD-tDCS)联合悬吊运动训练对脑卒中患者下肢运动功能的影响。方法 选择2022年1月-2023年2月在山东大学附属山东省立第三医院康复医学部住院治疗的脑卒中患者120例,按照随机数字表法分为对照组、HD-tDCS组、悬吊组和联合治疗组,每组30例。治疗过程中有4例因中途出院无法继续接受治疗而脱落,其中对照组3例,HD-tDCS组1例,最终对照组、HD-tDCS组、悬吊组和联合治疗组分别纳入27、29、30、30例。对照组接受运动疗法和神经肌肉电刺激等常规康复治疗,25 min/d,1次/d,5 d/周,持续治疗8周;HD-tDCS组在对照组基础上接受HD-tDCS治疗,主要刺激电极置于偏瘫侧脑初级运动皮层M1区(C3/C4),4个接受极分别置于M1区四周约3.5 cm处的C1/C2、C5/C6、FC3/FC4、CP3/CP4区,电流恒定强度2 mA,电流起伏时间30 s,20 min/次,1次/d,5 d/周,持续治疗8周;悬吊组在对照组基础上接受偏瘫侧下肢分离组合运动、动态闭链稳定运动、骨盆摆动和放松运动等悬吊运动训练,25 min/次,1次/d,5 d/周,持续治疗8周;联合治疗组在对照组基础上接受HD-tDCS联合悬吊运动训练。分别于治疗前和治疗4、8周后,采用Fugl-Meyer运动功能量表下肢部分(FMA-LE)评定患者下肢运动功能;采用Berg平衡量表(BBS)评定患者平衡功能;采用功能性步行能力量表(FAC)评定患者功能性步行能力;采用视频步态分析系统评定患者步态时空参数(步频、步速、步长和步行周期)。结果 与治疗前比较,4组治疗4、8周后FMA-LE评分、BBS评分、FAC等级及步态时空参数(步频、步速、步长和步行周期)均明显提高,差异具有统计学意义(P<0.05)。与对照组、HD-tDCS组、悬吊组同一时间点比较,联合治疗组治疗4、8周后FMA-LE、BBS评分均明显更高,治疗8周后FAC等级及步态时空参数(步频、步速、步长及步行周期)均明显更高,差异具有统计学意义(P<0.05)。结论 HD-tDCS联合悬吊运动训练可有效提高脑卒中患者下肢运动功能、平衡能力和步行能力,值得临床推广应用。 展开更多
关键词 脑卒中 高精度经颅直流电刺激 悬吊运动训练 下肢运动功能 平衡功能 步行能力
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参芎葡萄糖注射液联合达格列净对早期2型糖尿病肾病患者肾功能、尿蛋白的影响 被引量:1
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作者 常丽 郭东亮 刘继红 《分子诊断与治疗杂志》 2024年第5期864-867,876,共5页
目的 探讨参芎葡萄糖注射液联合达格列净对早期2型糖尿病(T2DM)肾病患者肾功能、尿蛋白的影响。方法 选取2021年1月至2023年1月临泉县人民医院收治的早期T2DM肾病患者100例为研究对象,根据治疗方法分为研究组(参芎葡萄糖注射液联合达格... 目的 探讨参芎葡萄糖注射液联合达格列净对早期2型糖尿病(T2DM)肾病患者肾功能、尿蛋白的影响。方法 选取2021年1月至2023年1月临泉县人民医院收治的早期T2DM肾病患者100例为研究对象,根据治疗方法分为研究组(参芎葡萄糖注射液联合达格列净治疗,n=57)和对照组(达格列净治疗,n=43)。比较两组肾功能、尿蛋白、临床疗效及不良反应。结果 治疗后研究组尿素氮(BUN)、血肌酐(Scr)低于对照组,差异有统计学意义(t=3.376、3.010,P<0.05);治疗后研究组内生肌酐清除率(Ccr)、肾小球滤过率(eGFR)高于对照组,差异有统计学意义(t=2.377、2.802,P<0.05)。治疗后研究组尿微量白蛋白(UALB)、尿微量白蛋白与肌酐比值(UACR)水平低于对照组,差异有统计学意义(t=6.728、4.994,P<0.05)。研究组治疗总有效率高于对照组,差异有统计学意义(χ^(2)=5.697,P<0.05)。两组不良反应发生率比较差异无统计学意义(χ^(2)=0.018,P>0.05)。结论 参芎葡萄糖注射液联合达格列净可以更好地改善早期T2DM肾病患者肾功能,减少尿蛋白,具有良好的治疗效果。 展开更多
关键词 参芎葡萄糖注射液 达格列净 2型糖尿病肾病 肾功能 尿蛋白
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瞬时受体电位信号通路在肝细胞癌中的表达及生物学功能
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作者 吴智鹏 张钰琴 +2 位作者 王明刚 张荣臻 毛德文 《实用医学杂志》 CAS 北大核心 2024年第6期743-747,共5页
近年来,在全球范围内肝细胞癌(hepatocellular carcinoma, HCC)的发病率和病死率不断攀升,针对HCC的治疗策略仍然不足,凸显了探讨HCC发病和进展机制的重要性。瞬时受体电位(transient receptor potential, TRP)通路是重要的非选择性阳... 近年来,在全球范围内肝细胞癌(hepatocellular carcinoma, HCC)的发病率和病死率不断攀升,针对HCC的治疗策略仍然不足,凸显了探讨HCC发病和进展机制的重要性。瞬时受体电位(transient receptor potential, TRP)通路是重要的非选择性阳离子通路,与炎性反应、感觉传导等方面密切相关。目前,多项研究表明,TRP通路也参与了HCC的发生和发展,诱导HCC的侵袭和迁移。然而,TRP通路在HCC中的整体潜在机制和可能的信号转导通路仍不清楚。因此,本文讨论了TRP通路在HCC中的异常表达,并就TRP通路参与肝脏慢性炎症-纤维化进展、HCC细胞增殖、迁移、凋亡以及HCC干细胞生成等HCC形成与进展的关键生物事件进行综述,展望其在HCC治疗中的应用前景。旨在更好地理解TRP通路在HCC中的意义,有助于发现新的治疗靶点和有效的药物,并为未来临床治疗开拓新局面。 展开更多
关键词 瞬时受体电位信号通路 肝细胞癌 表达特征 生物学功能
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板栗外生菌根诱导基因CmNRT3的表达及功能研究
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作者 任艳艳 李子平 +6 位作者 何玉吉 张昊琳 王韵清 张卿 肖婷婷 李虎臣 曹庆芹 《果树学报》 CAS CSCD 北大核心 2024年第10期2014-2024,共11页
【目的】外生菌根是板栗获取土壤氮素的重要途径,但目前外生菌根对提高板栗氮素吸收和利用的分子机制尚不明确。探明板栗外生菌根诱导上调的硝酸盐转运蛋白基因CmNRT3的序列特征、表达模式及相关功能,将为外生菌根促氮吸收提供理论依据... 【目的】外生菌根是板栗获取土壤氮素的重要途径,但目前外生菌根对提高板栗氮素吸收和利用的分子机制尚不明确。探明板栗外生菌根诱导上调的硝酸盐转运蛋白基因CmNRT3的序列特征、表达模式及相关功能,将为外生菌根促氮吸收提供理论依据。【方法】通过转录组数据分析、荧光定量PCR、瞬时转化体系及酵母互补等方法研究CmNRT3基因的表达特征和生理功能。【结果】CmNRT3基因在板栗外生菌根中显著上调表达。在未接种板栗及苜蓿转基因根系的表皮细胞中检测到CmNRT3启动子驱动的GUS信号,而在苜蓿的丛枝菌根中,GUS信号主要存在于含有丛枝的皮层细胞中。亚细胞定位结果显示CmNRT3定位于细胞膜及苜蓿含有丛枝的细胞膜上。酵母互补试验表明,CmNRT3转运蛋白不能互补硝酸盐转运缺陷型酵母的功能。【结论】CmNRT3受外生菌根诱导表达,定位于细胞膜上。CmNRT3启动子驱动的GUS信号在含丛枝的苜蓿根系皮层细胞中强烈表达,但不具备硝酸盐吸收或转运功能。该研究为进一步揭示板栗外生菌根促氮吸收提供了理论基础。 展开更多
关键词 板栗 外生菌根 CmNRT3 硝酸盐吸收转运 基因功能
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基于多层级条件风险价值的高渗透可再生能源电力系统低碳运行联合优化 被引量:1
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作者 沈佳程 李梦诗 +1 位作者 季天瑶 林镇佳 《电网与清洁能源》 CSCD 北大核心 2024年第2期37-46,共10页
在双碳目标下,风电渗透率增加给新型电力系统的安稳运行带来挑战,而条件风险价值法(Conditional Value-at-Risk,CVaR)可对风电的随机风险进行分类量化评估,以用于系统调度运行。根据CVaR提出了改进的多层级条件风险价值法(Multi-layer C... 在双碳目标下,风电渗透率增加给新型电力系统的安稳运行带来挑战,而条件风险价值法(Conditional Value-at-Risk,CVaR)可对风电的随机风险进行分类量化评估,以用于系统调度运行。根据CVaR提出了改进的多层级条件风险价值法(Multi-layer Conditional Value-at-Risk,MCVaR),并建立了基于MCVaR的高渗透可再生能源电力系统低碳运行联合优化模型。仿真算例结果表明,MCVaR相较于CVaR能够显著降低系统的弃风与切负荷量,同时系统的极端损失下降了49.45%。所提方法能够在满足系统可控风险约束的前提下,实现运行经济效益与低碳环保收益的综合最优化。 展开更多
关键词 条件风险价值 低碳运行 可再生能源 备用优化
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