基于Transformer和CNN特征融合的非接触式心率检测算法

心率失调是心血管疾病的常见危险因素,如何及时地对心率失调作出预警,成为了研究的热点。传统的心率检测是接触式的,检测十分不便。远程光电容积脉搏波描记法(Remote photoplethysmography,rPPG)的提出旨在实现无须接触的测量,在许多场景中具有巨大的应用价值。然而,非接触式的测量方法容易受到环境和受试者运动的影响。针对这些问题,本文提出了基于Transformer全局表达和CNN局部特征融合的非接触式心率检测模型(TC-Net)。本文搭建了一个并联的Transformer网络和CNN网络的TC-Net模型。本模型包括两个分支,CNN分支用于提取rPPG信号的局部区域特征,Transformer用于提取rPPG信号的全局表达。由于全局表达特征和局部特征两者特征长度不一,本文提出了特征交互模块,该模块通过卷积层和上下采样模块以对齐两个分支的特征长度。随后,TC-Net通过特征交互模块将局部特征和全局表达进行融合得到最终用于检测的特征向量。最后,在远程心率测量评估中最广泛使用基准之一MAHNOB-HCI数据集上进行对比验证,模型在误差偏差(MAE)、均方根误差(RMSE)和平均绝对百分比误差(MAPE)等三个指标上都达到了最佳水平。因此,本文提出的非接触式心率检测模型TC-Net基于Transformer全局表达和CNN局部特征融合,具有较高的准确性和鲁棒性。此外,TC-Net仅由简单的几层卷积层和注意力层搭建而成,模型复杂度低,便于后续投入实际应用。

一种基于Swin Transformer神经网络的低截获概率雷达信号调制类型的识别方法

本文针对低截获概率(Low Probability of Intercept,LPI)雷达信号调制类型的识别问题提出了一种基于Swin Transformer神经网络的识别方法.该方法首先用平滑伪Wigner-Ville分布对信号进行时频变换,将一维时域信号转换为二维时频图像,然后使用Swin Transformer神经网络对时频图像进行特征提取和调制类型识别.仿真结果显示该方法具有较强的抗噪声能力,在低信噪比条件下识别准确率高,且具有较强的小样本适应能力.

Behavior characteristics and market operation problems of existing building energy-saving renovation market

The long-term and effective implementation of the existing building energy efficiency renovation depends on the development of the existing building energy efficiency renovation market.The key to the development of the existing building energy efficiency renovation market is the joint role of the market players.Starting with the analysis of the externalities and information asymmetry of the existing building energy efficiency renovation market,this paper analyzes the behavioral characteristics and influencing factors of the existing building energy efficiency renovation market entities(central government,local government,owners,energy conservation service enterprises,third-party evaluation institutions,and other market entities),and reveals the problems of the existing building energy efficiency renovation market,such as the absence of government,the lack of main power,and the lack of financing channels,Thus,it lays a platform foundation for the research on the behavior strategy and security system of the existing building energy-s aving renovation market.

Dihydroergotamine ameliorates liver fibrosis by targeting transforming growth factor β type Ⅱ receptor

BACKGROUND The transforming growth factor β(TGFβ) signaling pathway plays a crucial role in the development of liver fibrosis by activating TGFβ type Ⅱ receptor(TGFβR2), followed by the recruitment of TGFβR1 finally triggering downstream signaling pathway.AIM To find drugs targeting TGFβR2 that inhibit TGFβR1/TGFβR2 complex formation, theoretically inhibit TGFβ signaling pathway, and thereby ameliorate liver fibrosis.METHODS Food and Drug Administration-approved drugs were screened for binding affinity with TGFβR2 by virtual molecular docking. We identified 6 candidates and further explored their potential by Cell Counting Kit-8(CCK-8) cell cytotoxic experiment to validate toxicity and titrated the best cellular working concentrations. Next, we further demonstrated the detailed molecular working mechanisms using mutagenesis analysis. Finally, we used a mouse model to investigate its potential anti-liver fibrosis effect.RESULTS We identified 6 drug candidates. Among these 6 drugs, dihydroergotamine(DHE) shows great ability in reducing fibrotic gene expressions such as collagen, p-SMAD3, and α-SMA in TGFβ induced cellular model of liver fibrosis in LX-2 cells. Furthermore, we demonstrated that DHE binds to TGFβR2. Moreover, mutation of Leu27, Phe30, Thr51, Ser52, Ile53, and Glu55 of TGFβR2 disrupted the binding of TGFβR2 with DHE. In addition, DHE significantly improved liver fibrosis, as evidenced by Masson’s trichrome staining of liver sections. This is further supported by the width and the velocity of the portal vein, and serum markers of liver function. In line with those observations, DHE also decreased macrophages infiltration and extracellular matrix deposition in the liver.CONCLUSION DHE alleviates liver fibrosis by binding to TGFβR2 thereby suppressing TGFβ signaling pathway. We show here that as far as drug repurposing, DHE has great potential to treat liver fibrosis.

Organic matter transformation ratio, hydrocarbon expulsion efficiency and shale oil enrichment type in Chang 7_(3) shale of Upper Triassic Yanchang Formation in Ordos Basin, NW China

The major enrichment type of shale oil in the Chang 7_(3) shale of Upper Triassic Yanchang Formation in the Ordos Basin is unknown.This paper analyzes the organic matter transformation ratio,hydrocarbon expulsion efficiency and roof/floor sealing conditions of the Chang 7_(3) shale,and evaluates the major enrichment type of shale oil in this interval.The average organic matter transformation ratio of the Chang 7_(3) shale is about 45%;in other words,more than 50%of the organic matters have not transformed to hydrocarbons,and the lower the maturity,the greater the proportion of untransformed organic matters.The cumulative hydrocarbon expulsion efficiency of the transformed hydrocarbon is 27.5% on average,and the total proportion of untransformed organic matters plus retained hydrocarbons is greater than 70%.The relative hydrocarbon expulsion efficiency of the Chang 7_(3) shale is 60%on average,that is,about 40% of hydrocarbons retain in the shale.The Chang 7_(3) shale corresponds to Chang 7_(1+2) and Chang 8 sandstones as the roof and floor,respectively,and is further overlaid by Chang 6 shale,where extensive low porosity and low permeability–tight oil reservoirs have formed in the parts with relatively good porosity and permeability.Moreover,the Chang 7_(3) shale is tested to be in a negative pressure system(the pressure coefficient of 0.80–0.85).Therefore,the roof/floor sealing conditions of the Chang 7_(3) shale are poor.The retained hydrocarbons appear mostly in absorbed status,with low mobility.It is concluded that the medium–high mature shale oil is not the major enrichment type of shale oil in the Chang 7_(3) shale,but there may be enrichment opportunity for shale oil with good mobility in the areas where the sealing conditions are good without faults and fractures and oil reservoirs are formed off Chang 7_(1+2),Chang 6 and Chang 8.Furthermore,low–medium mature shale oil is believed to have great potential and is the major enrichment type of shale oil in the Chang 7_(3) shale.It is recommended to prepare relevant in-situ conversion technologies by pilot test and figure out the resource availability and distribution.

Optimization and implementation strategy of ESCO driving force in the development of energy-saving transformation market of existing buildings

The development of the existing building energy-saving transformation market is inseparable from the internal driving force of ESCO.Giving full play to the driving role of ESCO scientifically is the internal requirement to promote the healthy and orderly operation of the existing building energy-saving transformation market.This paper summarizes the practical experience of developing ESCO driving force operation in foreign existing building energy-saving transformation market,analyzes the bottleneck of developing ESCO driving force operation in China’s existing building energy-saving transformation market,and puts forward useful practical enlightenment based on the comparison between home and abroad;According to the optimization principle of ESCO driving force operation in the development of existing building energy-saving transformation market,the optimization design framework of ESCO driving force is proposed,and the implementation strategy of ESCO driving force optimization in the development of existing building energy-saving transformation market is planned.In order to optimize and improve the effectiveness of the operation and development of the energy-saving transformation market of existing buildings with the internal driving force of ESCO.

Advances in the Mechanisms of Hemorrhagic Transformation and Therapeutic Agents after Intravenous Thrombolysis in Ischemic Stroke

Ischemic stroke is an important disease leading to death and disability for all human beings, and the key to its treatment lies in the early opening of obstructed vessels and restoration of perfusion to the local infarcted area. Intravenous thrombolysis with tissue plasminogen activator (tPA) is one of the effective therapies to achieve revascularization, but it faces strict indications with a narrow therapeutic time window, and significantly increases the incidence of hemorrhagic transformation, HT, after reperfusion of the infarcted foci, which greatly reduces the incidence of patients with ischemic stroke. which significantly increases the incidence of hemorrhagic transformation (HT) after reperfusion of the infarcted focus, greatly reducing patient utilization and clinical benefit. Since the mechanism of HT has not been fully elucidated, and the related molecular mechanisms are complex and interactive, there is no specific and effective therapy to avoid the occurrence of HT. In this article, we focus on the research progress on the mechanism of HT after tPA intravenous thrombolysis in ischemic stroke patients from the aspects of vascular integrity disruption, oxidative stress, and neuroinflammatory response and the corresponding therapeutic strategies, in order to improve the safety and prognosis of tPA intravenous thrombolysis in the clinic.

Study on the Effect of Multi-Type Current Transformers Hybrid Operation on Differential Protection of the Bus Based on Dynamic Simulation

This paper analyzes characteristics of multi type current transformers hybrid operation for each branch of the bus and their effects on differential protection of the bus. By theoretically analyzing transmission characteristics of multi type current transformers and their influence factors, we study the dynamic model testing method of multi type current transformers for the bus, and design 3 kinds of testing schemes by making the equivalent model based on the field of P-level current transformer, TPY-level current transformer and electronic current transformer, and build the hybrid operation testing platform of multi type current transformers. Finally, we compare and analyze the transmission characteristics difference of multi type current transformers on the same branch and the characteristics difference of hybrid operation in two successive external faults, analyze the cause behind the differences, and put forward the corresponding improvement measures.

Interference of Y-27632 on the signal transduction of transforming growth factor beta type 1 in ocular Tenon capsule fibroblasts

AIM: To investigate the interfering effect of Y-27632, a ROCK-I selective inhibitor, on the signal transduction pathway of transforming growth factor-beta 1 (TGF-beta 1) in ocular Tenon capsule fibroblasts (OTFS) in vitro. METHODS: After OTFS from passages 4 to 6 47 vitro were induced by TGF-beta 1 and then treated by Y-27632, the changes of the OTFS cell cycles were analyzed via flow cytometry, and the proteins expression of the alpha -smooth muscular actin (alpha -SMA), connective tissue growth factor (CTGF), collagen I were calculated by Western blot. After OTFS treated by the different concentrations of Y-27632, the expression levels of the alpha -SMA, CTGF and collagen I mRNA were assayed by RT-PCR. RESULTS: Y-27632 had no markedly effect on the OTFS cell cycles. After treated by TGF-beta 1, OTFS in G1 period significantly increased. The cell cycles distribution by both TGF-beta 1 and Y-27632 had no remarkable difference from that in control group. Y-27632 significantly inhibited the proteins expressions of both alpha -SMA and CTGF, while to some extent inhibited that of collagen I. TGF-beta 1 significantly promoted the proteins expressions of alpha -SMA, CTGF and collagen I. After OTFS treated by both TGF-beta 1 and Y-27632, of alpha -SMA, the protein expression was similar with that in control group (P=0.066>0.05), but the protein expression of CTGF or collagen I, respectively, was significantly different from that in control group (P=0.000<0.01). The differences of expressions of the alpha -SMA, CTGF and collagen I mRNA in 30, 150, 750 mu mol/L Y-27632 group were statistically significant, compared with those in control group, respectively (alpha -SMA, P=0.002, 0.000, 0.000; CTGF, P=0.014, 0.002, 0.001; collagen I,P=0.003, 0.002, 0.000). CONCLUSION: Blocking the Rho/ROCK signaling pathway by using of Y-27632 could inhibit the cellular proliferation and the expression of both CTGF and alpha -SMA whatever OTFS induced by TGF-beta 1 or not. Y-27632 suppressed the expression of collagen I mRNA without induction.

基于Transformer神经网络的滚动轴承故障类型识别

工程应用中的滚动轴承故障类型识别要求同时具有较高的识别准确度和时间效率,基于上述需求提出基于Transformer神经网络的滚动轴承故障类型识别方法。所提方法结合小波包变换时频域能量特征和快速傅里叶变换频域特征生成满足Transformer神经网络的输入样本矩阵,解决Transformer神经网络的输入问题。同时,提出应用于滚动轴承故障类型识别的归一化位置编码方法,解决Transformer神经网络在滚动轴承故障分析领域的位置编码问题。在此基础上,提出Transformer神经网络双向输入样本矩阵处理机制和算法训练过程中错误样本权重增强机制,提升所提方法的鲁棒性。使用KAt数据中心的滚动轴承数据集验证所提方法的识别性能,与现有常用深度学习方法相比,所提方法在时间效率和准确度性能上均有一定的优势,其中,准确度能够提升11%以上,单个样本的平均处理时间小于1 ms。

Studies on the Photosynthetic Characteristics andAssimilate's Accumulation and Transformation inHeavy Panicle Type of Rice

Using 18 indica rice varieties with different panicle weight, the photosynthetic characteristics and assimilate's accumulation and transformation in heavy panicle type of rice(HPT)were studied. The results showed that the net photosynthetic rate of the flag leaf in HPT after heading was obviously higher than that in medium panicle type(MPT)and light panicle type(LPT). The reason for the high net photosynthetic rate in HPT was the increase of Rubisco activities and chlorophyll content, and keeping high assimilate ability to CO2 under high and low light intensity, high temperature and low CO2 content, and light midday depression and wide adaptability to environmental conditions. The high net photosynthetic rate of HPT might be also the results of its excellent stomatal characteristics and higher total quantity of stomatal opening degrees(stomatal density X stomatal opening degrees). There was a large amount of dry matter production after heading and obvious high assimilate's transformation to panicle in HPT.

THE INTEGRAL TYPE GAUGE TRANSFORMATION AND THE ADDITIONAL SYMMETRY FOR THE CONSTRAINED KP HIERARCHY

In this paper, the compatibility between the integral type gauge transformation and the additional symmetry of the constrained KP hierarchy is given. And the string-equation constraint in matrix models is also derived.

Comparison of the Length of Stay and Medical Expenditures among Japanese Hospitals for Type 2 Diabetes Treatments: The Box-Cox Transformation Model under Heteroscedasticity

In this paper, we analyzed length of stay (LOS) in hospitals and medical expenditures for type 2 diabetes patients. LOS was analyzed by the power Box-Cox transformation model when variances differed among hospitals. We proposed a new test and consistent estimator. We rejected the ho-moscedasticity of variances among hospitals, and then analyzed the LOS of 12,666 type 2 diabetes patients hospitalized for regular medical treatments collected from 60 general hospitals in Japan. The variables found to affect LOS were age, number of comorbidities and complications, introduced by another hospital, one-week hospitalization, 2010 revision, specific-hospitalization-period (SHP), and principal diseases E11.5, E11.6 and E11.7. There were surprisingly large differences in ALOS among hospitals even after eliminating the influence of characteristics and conditions of patients. We then analyzed daily medical expenditure (DME) by the ordinary least squares methods. The variables that affected DME were LOS, number of comorbidities and complications, acute hospitalization, hospital’s own outpatient, season, introduced by another hospital, one-week hospitalization, 2010 revision, SHP, time trend, and principal diseases E11.2, E11.4 and E117. The DME did not decrease after the SHP. After eliminating the influences of characteristics and conditions of patients, the differences among hospitals were relatively small, 12% of the overall average. LOS is the main determinant of medical expenditures, and new incentives to reduce LOS are needed to control Japanese medical expenditures. Since at least 99% of patients require medical care after leaving the hospital, systems that take proper care of patients for long periods of time after hospitalization are absolutely necessary for efficient treatment of diabetes.

Assessing effectiveness of existing building energy-saving reconstruction policy adapted to market development

The market development and policy matching of existing building energy-saving retrofits determine the effectiveness of policies in promoting the operation of existing building energy-saving retrofit market.Based on the perspective of market development to evaluate the effectiveness of existing building energy-saving transformation policy,it is necessary to clarify the basic connotation of the effectiveness of existing building energy-saving transformation policy,systematically analyze the evaluation content,construct a multi-level evaluation index system,and select scientific and effective quantitative evaluation methods to implement a strict evaluation process.

基于“Four-hot”编码和Transformer-LSTM模型的船型识别方法

为克服依靠图像数据进行识别的局限,使用航迹数据和深度学习方法是当前船型识别的热门方案。针对船型识别任务中常用的长短时记忆(Long Short Term Memory,LSTM)网络对航迹数据特征提取的性能饱和问题,提出了一种基于“Four-hot”编码和Transformer-LSTM神经网络模型的船型识别方法。首先将航迹数据编码为“Four-hot”向量形式;然后构建由Transformer编码模块和LSTM网络级联的Transformer-LSTM神经网络模型,用LSTM网络对Transformer输出的高层表示进行二次学习。在船舶自动识别系统(Automatic Identification System,AIS)数据集上的实验结果显示,所提出的方法在测试集上的加权平均F1分数(Weighted Average F1,WAF1)比未编码航迹数据经5类实验模型直接训练和测试得到的值高3.09百分点以上。

On <i>q</i>-Analogues of Laplace Type Integral Transforms of <i>q</i>²-Bessel Functions

The present paper deals with the evaluation of the q-Analogues of Laplece transforms of a product of basic analogues of q2-special functions. We apply these transforms to three families of q-Bessel functions. Several special cases have been deducted.

The Dual Functionals for the Generalized Ball Basis of Wang-Said Type and Basis Transformation Formulas

The generalized Ball curves of Wang-Said type with a position parameter L not only unify the Wang-Ball curves and the Said-Ball curves, but also include several useful intermediate curves. This paper presents the dual functionals for the generalized Ball basis of Wang-Said type. The relevant basis transformation formulae are also worked out.

Inhibition of Ubiquitin-specific Protease 4 Attenuates Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via Transforming Growth Factor Beta Receptor Type Ⅰ

Objective Ubiquitin-specific protease 4(USP4)facilitates the development of transforming growth factor-beta 1(TGF-β1)-induced epithelial-mesenchymal transition(EMT)in various cancer cells.Moreover,EMT of renal tubular epithelial cells(RTECs)is required for the progression of renal interstitial fibrosis.However,the role of USP4 in EMT of RTECs remains unknown.The present study aimed to explore the effect of USP4 on the EMT of RTECs as well as the involved mechanism.Methods In established unilateral ureteral obstruction(UUO)rats and NRK-52E cells,immunohistochemistry and Western blot assays were performed.Results USP4 expression was increased significantly with obstruction time.In NRK-52E cells stimulated by TGF-β1,USP4 expression was increased in a time-dependent manner.In addition,USP4 silencing with specific siRNA indicated that USP4 protein was suppressed effectively.Meanwhile,USP4 siRNA treatment restored E-cadherin and weakened alpha smooth muscle actin(α-SMA)expression,indicating that USP4 may promote EMT.After treatment with USP4 siRNA and TGF-β1 for 24 h,the expression of TGF-β1 receptor type I(TβRI)was decreased.Conclusion USP4 promotes the EMT of RTECs through upregulating TβRI,thereby facilitating renal interstitial fibrosis.These findings may provide a potential target of USP4 in the treatment of renal fibrosis.

Solution of Modified Equations of Emden-Type by Differential Transform Method

In this paper the Modified Equations of Emden type (MEE), χ+αχχ+βχ 3 is solved numerically by the differential transform method. This technique doesn’t require any discretization, linearization or small perturbations and therefore it reduces significantly the numerical computation. The current results of this paper are in excellent agreement with those provided by Chandrasekar et al. [1] and thereby illustrate the reliability and the performance of the differential transform method. We have also compared the results with the classical Runge-Kutta 4 (RK4) Method.