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Computational Identification of Active Enhancers in Model Organisms
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作者 Chengqi Wang Michael Q. Zhang Zhihua Zhang 《Genomics, Proteomics & Bioinformatics》 SCIE CAS CSCD 2013年第3期142-150,共9页
As a class of cis-regulatory elements, enhancers were first identified as the genomic regions that are able to markedly increase the transcription of genes nearly 30 years ago. Enhancers can regulate gene expression i... As a class of cis-regulatory elements, enhancers were first identified as the genomic regions that are able to markedly increase the transcription of genes nearly 30 years ago. Enhancers can regulate gene expression in a cell-type specific and developmental stage specific manner. Although experimental technologies have been developed to identify enhancers genome-wide, the design principle of the regulatory elements and the way they rewire the transcriptional regulatory network tempo-spatially are far from clear. At present, developing predictive methods for enhanc- ers, particularly for the cell-type specific activity of enhancers, is central to computational biology. In this review, we survey the current computational approaches for active enhancer prediction and discuss future directions. 展开更多
关键词 enhancer identification Active enhancer recognition Histone modification mark Transcription factor
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