To make clear the precise hemodynamic mechanism underlying the anti-atherogenesis benefit of enhanced external couterpulsation(EECP) treatment, and to investigate the proper role of some important hemodynamic factors ...To make clear the precise hemodynamic mechanism underlying the anti-atherogenesis benefit of enhanced external couterpulsation(EECP) treatment, and to investigate the proper role of some important hemodynamic factors during the atherosclerotic progress, a comprehensive study combining long-term animal experiment and numerical solving was conducted in this paper. An experimentally induced hypercholesterolemic porcine model was developed and the chronic EECP intervention was subjected. Basic hemodynamic measurement was performed in vivo, as well as the arterial endothelial samples were extracted for physiological examination. Meanwhile, a numerical model was introduced to solve the complex hemodynamic factors such as WSS and OSI. The results show that EECP treatment resulted in significant increase of the instant levels of arterial WSS, blood pressure, and OSI. During EECP treatment, the instant OSI level of the common carotid arteries over cardiac cycles raised to a mean value of 8.58 ×10-2±2.13 ×10-2. Meanwhile, the chronic intervention of EECP treatment significantly reduced the atherosclerotic lesions in abdominal aortas and the endothelial cellular adherence. The present study suggests that the unique blood flow pattern induced by EECP treatment and the augmentation of WSS level in cardiac cycles may be the most important hemodynamic mechanism that contribute to its anti-atherogenesis effect. And as one of the indices that cause great concern in current hemodynamic study, OSI may not play a key role during the initiation of atherosclerosis.展开更多
Objective To explore the effects of enhanced external counterpulsation(EECP)on the serum level of C-reactive protein and endothelin-1 in patients with cerebral ischemic stroke,to provide clinical evidence for the trea...Objective To explore the effects of enhanced external counterpulsation(EECP)on the serum level of C-reactive protein and endothelin-1 in patients with cerebral ischemic stroke,to provide clinical evidence for the treatment and secondary prevention of patients with serebral ischemic stroke.Methods Total 187 patients with ischemic stroke and enrolled measure the serum level展开更多
随着基于数字影像和通信(digital i maging and communications in medicine,DICOM)标准的体外反搏局域网系统和基于可扩展标记语言(extensible markuplanguage,XML)的远程体外反搏信息系统的建立和完善,体外反搏医学信息正逐步实现数...随着基于数字影像和通信(digital i maging and communications in medicine,DICOM)标准的体外反搏局域网系统和基于可扩展标记语言(extensible markuplanguage,XML)的远程体外反搏信息系统的建立和完善,体外反搏医学信息正逐步实现数字化的管理和共享。为了节省存储空间和提高传输效率,需要对长时间采集的反搏数据压缩并标准化存储。本文针对具有双通道采集、信号相关性强等特点的增强型体外反搏(enhanced external counterpulsation,EECP)数据设计了改进的模板匹配和快速折线距离阈值拟合(linear approxi mation distance threshol-ding,LADT)变换相结合的压缩算法,并结合DICOM标准定义了压缩波形的私有传输语法,通过调用波形写入模块将压缩数据存储为DICOM格式文件。经过实验和调试,在本EECP实验室中成功实现了EECP采集数据的压缩、解压以及在EECP工作站之间的正确传输和显示。展开更多
基金Key Clinical Project from the Ministry of Healthgrant number:25400+1 种基金National Natural Science Foundation of Chinagrant number:81170272
文摘To make clear the precise hemodynamic mechanism underlying the anti-atherogenesis benefit of enhanced external couterpulsation(EECP) treatment, and to investigate the proper role of some important hemodynamic factors during the atherosclerotic progress, a comprehensive study combining long-term animal experiment and numerical solving was conducted in this paper. An experimentally induced hypercholesterolemic porcine model was developed and the chronic EECP intervention was subjected. Basic hemodynamic measurement was performed in vivo, as well as the arterial endothelial samples were extracted for physiological examination. Meanwhile, a numerical model was introduced to solve the complex hemodynamic factors such as WSS and OSI. The results show that EECP treatment resulted in significant increase of the instant levels of arterial WSS, blood pressure, and OSI. During EECP treatment, the instant OSI level of the common carotid arteries over cardiac cycles raised to a mean value of 8.58 ×10-2±2.13 ×10-2. Meanwhile, the chronic intervention of EECP treatment significantly reduced the atherosclerotic lesions in abdominal aortas and the endothelial cellular adherence. The present study suggests that the unique blood flow pattern induced by EECP treatment and the augmentation of WSS level in cardiac cycles may be the most important hemodynamic mechanism that contribute to its anti-atherogenesis effect. And as one of the indices that cause great concern in current hemodynamic study, OSI may not play a key role during the initiation of atherosclerosis.
文摘Objective To explore the effects of enhanced external counterpulsation(EECP)on the serum level of C-reactive protein and endothelin-1 in patients with cerebral ischemic stroke,to provide clinical evidence for the treatment and secondary prevention of patients with serebral ischemic stroke.Methods Total 187 patients with ischemic stroke and enrolled measure the serum level
文摘随着基于数字影像和通信(digital i maging and communications in medicine,DICOM)标准的体外反搏局域网系统和基于可扩展标记语言(extensible markuplanguage,XML)的远程体外反搏信息系统的建立和完善,体外反搏医学信息正逐步实现数字化的管理和共享。为了节省存储空间和提高传输效率,需要对长时间采集的反搏数据压缩并标准化存储。本文针对具有双通道采集、信号相关性强等特点的增强型体外反搏(enhanced external counterpulsation,EECP)数据设计了改进的模板匹配和快速折线距离阈值拟合(linear approxi mation distance threshol-ding,LADT)变换相结合的压缩算法,并结合DICOM标准定义了压缩波形的私有传输语法,通过调用波形写入模块将压缩数据存储为DICOM格式文件。经过实验和调试,在本EECP实验室中成功实现了EECP采集数据的压缩、解压以及在EECP工作站之间的正确传输和显示。
