Dynamic operating envelopes(DOEs),as key enablers to facilitate distributed energy resource(DER)integration,have attracted increasing attention in the past years.However,uncertainties,which may come from load forecast...Dynamic operating envelopes(DOEs),as key enablers to facilitate distributed energy resource(DER)integration,have attracted increasing attention in the past years.However,uncertainties,which may come from load forecasting errors or inaccurate network parameters,have been rarely discussed in DOE calculation,leading to compromised quality of the hosting capacity allocation strategy.This letter studies how to calculate DOEs that are immune to such uncertainties based on a linearised unbalanced three-phase optimal power flow(UTOPF)model.With uncertain parameters constrained by norm balls,formulations for calculating robust DOEs(RDOEs)are presented along with discussions on their tractability.Two cases,including a 2-bus illustrative network and a representative Australian network,are tested to demonstrate the effectiveness and efficiency of the proposed approach.展开更多
The optical potential ambiguity is a long-standing problem in the analysis of elastic scattering data.For a specific collid-ing system,ambiguous potential families can lead to different behaviors in the nearside and f...The optical potential ambiguity is a long-standing problem in the analysis of elastic scattering data.For a specific collid-ing system,ambiguous potential families can lead to different behaviors in the nearside and farside scattering components.By contrast,the envelope method can decompose the experimental data into two components with negative and positive deflection angles,respectively.Hence,a question arises as to whether the comparison between the calculated nearside(or farside)component and the derived positive-deflection-angle(or negative-deflection-angle)component can help analyze the potential ambiguity problem.In this study,we conducted a trial application of the envelope method to the potential ambiguity problem.The envelope method was improved by including uncertainties in the experimental data.The colliding systems of 16O+28Si at 215.2 MeV and 12C+12C at 1016 MeV were considered in the analyses.For each colliding system,the angular distribution experimental data were described nearly equally well by two potential sets,one of which is“surface transpar-ent”and the other is refractive.The calculated angular distributions were decomposed into nearside and farside scattering components.Using the improved envelope method,the experimental data were decomposed into the positive-deflection-angle and negative-deflection-angle components,which were then compared with the calculated nearside and farside components.The capability of the envelope method to analyze the potential ambiguities was also discussed.展开更多
The development of machine learning technology enables more robust real-time earthquake monitoring through automated implementations. However, the application of machine learning to earthquake location problems faces ...The development of machine learning technology enables more robust real-time earthquake monitoring through automated implementations. However, the application of machine learning to earthquake location problems faces challenges in regions with limited available training data. To address the issues of sparse event distribution and inaccurate ground truth in historical seismic datasets, we expand the training dataset by using a large number of synthetic envelopes that closely resemble real data and build an earthquake location model named ENVloc. We propose an envelope-based machine learning workflow for simultaneously determining earthquake location and origin time. The method eliminates the need for phase picking and avoids the accumulation of location errors resulting from inaccurate picking results. In practical application, ENVloc is applied to several data intercepted at different starting points. We take the starting point of the time window corresponding to the highest prediction probability value as the origin time and save the predicted result as the earthquake location. We apply ENVloc to observed data acquired in the southern Sichuan Basin, China, between September 2018 and March 2019. The results show that the average difference with the catalog in latitude, longitude, depth, and origin time is 0.02°,0.02°, 2 km, and 1.25 s, respectively. These suggest that our envelope-based method provides an efficient and robust way to locate earthquakes without phase picking, and can be used in earthquake monitoring in near-real time.展开更多
Substantially glazed facades are extensively used in contemporary high-rise buildings to achieve attractive architectural aesthetics.Inherent conflicts exist among architectural aesthetics,building energy consumption,...Substantially glazed facades are extensively used in contemporary high-rise buildings to achieve attractive architectural aesthetics.Inherent conflicts exist among architectural aesthetics,building energy consumption,and solar energy harvesting for glazed facades.In this study,we addressed these conflicts by introducing a new dynamic and vertical photovoltaic integrated building envelope(dvPVBE)that offers extraordinary flexibility with weather-responsive slat angles and blind positions,superior architectural aesthetics,and notable energy-saving potential.Three hierarchical control strategies were proposed for different scenarios of the dvPVBE:power generation priority(PGP),natural daylight priority(NDP),and energy-saving priority(ESP).Moreover,the PGP and ESP strategies were further analyzed in the simulation of a dvPVBE.An office room integrated with a dvPVBE was modeled using EnergyPlus.The influence of the dvPVBE in improving the building energy efficiency and corresponding optimal slat angles was investigated under the PGP and ESP control strategies.The results indicate that the application of dvPVBEs in Beijing can provide up to 131%of the annual energy demand of office rooms and significantly increase the annual net energy output by at least 226%compared with static photovoltaic(PV)blinds.The concept of this novel dvPVBE offers a viable approach by which the thermal load,daylight penetration,and energy generation can be effectively regulated.展开更多
BACKGROUND Occult hepatitis B infection(OBI)is characterized by the detection of hepatitis B virus(HBV)DNA in serum(usually HBV DNA<200 IU/mL)or the liver but negativity for hepatitis B surface antigen(HBsAg).The d...BACKGROUND Occult hepatitis B infection(OBI)is characterized by the detection of hepatitis B virus(HBV)DNA in serum(usually HBV DNA<200 IU/mL)or the liver but negativity for hepatitis B surface antigen(HBsAg).The diagnosis of OBI relies on the sensitivity of assays used in the detection of HBV DNA and HBsAg.HBsAg assays with inadequate sensitivity or inability to detect HBV S variants may lead to misdiagnosis of OBI in people with overt HBV infection.CASE SUMMARY We report a HBsAg-negative but hepatitis B envelope antigen-positive patient who had a significant HBV DNA level.The patient was initially diagnosed as having OBI.However,sequence analysis revealed a unique insertion of amino acid residues at positions 120-124 in the S protein,which affects the formation of a disulfide bond that is associated with the formation of a loop.It is well known that there is an overlap between the S protein and Pol protein.We found that this new insertion site occurred in polymerase/reverse transcriptase domain,indi-cating that this insertion might be involved in HBV pathogenicity.The patient was finally diagnosed with a false OBI.CONCLUSION An insertion of amino acid residues at positions 120-124 of the S protein affects the formation of immunodominant epitopes and results in negative HBsAg levels.展开更多
针对加工汽车碳纤维材料的钻头寿命短、加工质量差的问题,设计了一种新型钻头。通过DOE(design of experiment)试验方法,给出了钻头齿数、前角和后角等3个参数的全因子试验方案。利用MINITAB软件对试验数据进行回归分析,并利用响应优化...针对加工汽车碳纤维材料的钻头寿命短、加工质量差的问题,设计了一种新型钻头。通过DOE(design of experiment)试验方法,给出了钻头齿数、前角和后角等3个参数的全因子试验方案。利用MINITAB软件对试验数据进行回归分析,并利用响应优化获得最优设计参数。结果表明:齿数和后角对钻孔个数及钻头寿命影响不显著,前角对钻头寿命有显著影响,后角与前角的交互作用对钻头寿命也有显著影响。齿数、前角和后角对第一孔钻孔时间及钻孔速度有显著影响,齿数与后角的交互作用以及前角与后角的交互作用对钻孔速度有显著影响。通过试验测试验证优化后的最佳设计参数是有效合理的。展开更多
Pepper mild mottle virus(PMMoV)is a devastating viral pathogen of pepper(Capsicum annuum)but it is unclear whether and how peppers protect against PMMoV infection.The expression of the chloroplast outer membrane prote...Pepper mild mottle virus(PMMoV)is a devastating viral pathogen of pepper(Capsicum annuum)but it is unclear whether and how peppers protect against PMMoV infection.The expression of the chloroplast outer membrane protein 24(OMP24)of C.annuum was upregulated under PMMoV infection and it interacted with PMMoV coat protein(CP).Silencing of OMP24 in either C.annuum or Nicotiana benthamiana facilitated PMMoV infection,whereas overexpression of N.benthamiana OMP24 in transgenic plants inhibited PMMoV infection.Both C.annuum OMP24(CaOMP24)and N.benthamiana OMP24(NbOMP24)localized to the chloroplast and have a moderately hydrophobic transmembrane domain that is necessary for their localization.Overexpression of CaOMP24 induced stromules,perinuclear chloroplast clustering,and accumulation of reactive oxygen species(ROS),the typical defense responses of chloroplasts transferring the retrograde signaling to the nucleus to regulate resistance genes.The expression of PR1 and PR2 was also upregulated significantly in plants overexpressing OMP24.Self-interaction of OMP24 was demonstrated and was required for OMP24-mediated plant defense.Interaction with PMMoV CP interfered with the self-interaction of OMP24 and impaired OMP24-induced stromules,perinuclear chloroplast clustering and ROS accumulation.The results demonstrate the defense function of OMP24 in pepper during viral infection and suggest a possible mechanism by which PMMoV CP modulates the plant defense to facilitate viral infection.展开更多
The carrier-envelope phase(CEP)φ_(0)is one of the key parameters in the generation of isolated attosecond pulses.In particular,“cosine”pulses(φ_(0)=0)are best suited for generation of single attosecond pulses in a...The carrier-envelope phase(CEP)φ_(0)is one of the key parameters in the generation of isolated attosecond pulses.In particular,“cosine”pulses(φ_(0)=0)are best suited for generation of single attosecond pulses in atomic media.Such“cosine”pulses have the peak of the most intense cycle aligned with the peak of the pulse envelope,and therefore have the highest contrast between the peak intensity and the neighboring cycles.In this paper,the dynamics of single attosecond pulse generation from a relativistically oscillating plasma mirror is investigated.We use an elementary analytical model as well as particle-in-cell simulations to study few-cycle attosecond pulses.We find that the phase of the field driving the surface oscillations depends on the plasma density and preplasma scale length.This leads us to a counterintuitive conclusion:for the case of normal incidence and a sharp plasma-vacuum boundary,the CEP required for the generation of a single attosecond pulse phase is closer toφ_(0)=π/2(a“sine”pulse),with the exact value depending on the plasma parameters.展开更多
铁氧体隔离器作为一种大量应用于5G通讯基站的通讯元器件,其可靠性关系到基站整机运行的持续性与稳定性,而隔离器的衰减片存在的焊接空洞问题可能导致隔离器在再流焊过程中发生失效,严重时导致基站电路板烧毁,因此管控及降低衰减片焊接...铁氧体隔离器作为一种大量应用于5G通讯基站的通讯元器件,其可靠性关系到基站整机运行的持续性与稳定性,而隔离器的衰减片存在的焊接空洞问题可能导致隔离器在再流焊过程中发生失效,严重时导致基站电路板烧毁,因此管控及降低衰减片焊接空洞率十分重要。首先对铁氧体隔离器的衰减片焊接空洞产生的机理进行分析,并通过实验设计(Design of Experiment,DOE)对点锡过程中可能导致焊接空洞问题的因素进行了析因分析及点锡工艺的优化。实验结果表明,通过控制点锡轨迹及点锡速度,能显著减少焊接空洞,并明显提升该焊接过程的制程能力,大幅提升了分布参数隔离器的可靠度,降低了隔离器经历再流焊后失效的风险。展开更多
为了提高锆合金包壳管的冷轧质量,通过统计过程控制技术和工序能力分析研究了锆合金包壳管冷轧后的壁厚偏差问题,并基于试验设计(design of experiment, DOE)技术对皮格尔冷轧工艺进行了优化。包壳管冷轧质量分析和工艺优化试验的结果表...为了提高锆合金包壳管的冷轧质量,通过统计过程控制技术和工序能力分析研究了锆合金包壳管冷轧后的壁厚偏差问题,并基于试验设计(design of experiment, DOE)技术对皮格尔冷轧工艺进行了优化。包壳管冷轧质量分析和工艺优化试验的结果表明,轧制前管材的壁厚偏差和送进量对轧制后的管材壁厚偏差有显著影响;当轧制前管材壁厚偏差<0.3 mm、壁厚变形量为65%、送进量为1.0 mm/次时,轧制后的管材壁厚偏差最小;通过轧制工艺优化后,反映壁厚偏差离散性的极差平均值由0.036减小到0.018,极差波动也明显减小,轧制质量显著提高;当轧制管材壁厚变形量一定时,对轧制前壁厚偏差较大的管材,采用小送进量轧制,可减小轧制后管材的壁厚偏差,达到提高锆合金包壳管材质量的目的。展开更多
基金supported by the CSIRO Strategic Project on Network Optimisation&Decarbonisation(No.OD-107890).
文摘Dynamic operating envelopes(DOEs),as key enablers to facilitate distributed energy resource(DER)integration,have attracted increasing attention in the past years.However,uncertainties,which may come from load forecasting errors or inaccurate network parameters,have been rarely discussed in DOE calculation,leading to compromised quality of the hosting capacity allocation strategy.This letter studies how to calculate DOEs that are immune to such uncertainties based on a linearised unbalanced three-phase optimal power flow(UTOPF)model.With uncertain parameters constrained by norm balls,formulations for calculating robust DOEs(RDOEs)are presented along with discussions on their tractability.Two cases,including a 2-bus illustrative network and a representative Australian network,are tested to demonstrate the effectiveness and efficiency of the proposed approach.
基金This work was supported by the National Natural Science Foundation of China(Nos.12005047 and U1832105).
文摘The optical potential ambiguity is a long-standing problem in the analysis of elastic scattering data.For a specific collid-ing system,ambiguous potential families can lead to different behaviors in the nearside and farside scattering components.By contrast,the envelope method can decompose the experimental data into two components with negative and positive deflection angles,respectively.Hence,a question arises as to whether the comparison between the calculated nearside(or farside)component and the derived positive-deflection-angle(or negative-deflection-angle)component can help analyze the potential ambiguity problem.In this study,we conducted a trial application of the envelope method to the potential ambiguity problem.The envelope method was improved by including uncertainties in the experimental data.The colliding systems of 16O+28Si at 215.2 MeV and 12C+12C at 1016 MeV were considered in the analyses.For each colliding system,the angular distribution experimental data were described nearly equally well by two potential sets,one of which is“surface transpar-ent”and the other is refractive.The calculated angular distributions were decomposed into nearside and farside scattering components.Using the improved envelope method,the experimental data were decomposed into the positive-deflection-angle and negative-deflection-angle components,which were then compared with the calculated nearside and farside components.The capability of the envelope method to analyze the potential ambiguities was also discussed.
基金the financial support of the National Key R&D Program of China(2021YFC3000701)the China Seismic Experimental Site in Sichuan-Yunnan(CSES-SY)for providing data for this study.
文摘The development of machine learning technology enables more robust real-time earthquake monitoring through automated implementations. However, the application of machine learning to earthquake location problems faces challenges in regions with limited available training data. To address the issues of sparse event distribution and inaccurate ground truth in historical seismic datasets, we expand the training dataset by using a large number of synthetic envelopes that closely resemble real data and build an earthquake location model named ENVloc. We propose an envelope-based machine learning workflow for simultaneously determining earthquake location and origin time. The method eliminates the need for phase picking and avoids the accumulation of location errors resulting from inaccurate picking results. In practical application, ENVloc is applied to several data intercepted at different starting points. We take the starting point of the time window corresponding to the highest prediction probability value as the origin time and save the predicted result as the earthquake location. We apply ENVloc to observed data acquired in the southern Sichuan Basin, China, between September 2018 and March 2019. The results show that the average difference with the catalog in latitude, longitude, depth, and origin time is 0.02°,0.02°, 2 km, and 1.25 s, respectively. These suggest that our envelope-based method provides an efficient and robust way to locate earthquakes without phase picking, and can be used in earthquake monitoring in near-real time.
基金supported by the National Natural Science Foundation of China(52078269 and 52325801).
文摘Substantially glazed facades are extensively used in contemporary high-rise buildings to achieve attractive architectural aesthetics.Inherent conflicts exist among architectural aesthetics,building energy consumption,and solar energy harvesting for glazed facades.In this study,we addressed these conflicts by introducing a new dynamic and vertical photovoltaic integrated building envelope(dvPVBE)that offers extraordinary flexibility with weather-responsive slat angles and blind positions,superior architectural aesthetics,and notable energy-saving potential.Three hierarchical control strategies were proposed for different scenarios of the dvPVBE:power generation priority(PGP),natural daylight priority(NDP),and energy-saving priority(ESP).Moreover,the PGP and ESP strategies were further analyzed in the simulation of a dvPVBE.An office room integrated with a dvPVBE was modeled using EnergyPlus.The influence of the dvPVBE in improving the building energy efficiency and corresponding optimal slat angles was investigated under the PGP and ESP control strategies.The results indicate that the application of dvPVBEs in Beijing can provide up to 131%of the annual energy demand of office rooms and significantly increase the annual net energy output by at least 226%compared with static photovoltaic(PV)blinds.The concept of this novel dvPVBE offers a viable approach by which the thermal load,daylight penetration,and energy generation can be effectively regulated.
基金Supported by the Shanghai Municipal Commission of Health and Family Planning,No.PKJ2018-Y05.
文摘BACKGROUND Occult hepatitis B infection(OBI)is characterized by the detection of hepatitis B virus(HBV)DNA in serum(usually HBV DNA<200 IU/mL)or the liver but negativity for hepatitis B surface antigen(HBsAg).The diagnosis of OBI relies on the sensitivity of assays used in the detection of HBV DNA and HBsAg.HBsAg assays with inadequate sensitivity or inability to detect HBV S variants may lead to misdiagnosis of OBI in people with overt HBV infection.CASE SUMMARY We report a HBsAg-negative but hepatitis B envelope antigen-positive patient who had a significant HBV DNA level.The patient was initially diagnosed as having OBI.However,sequence analysis revealed a unique insertion of amino acid residues at positions 120-124 in the S protein,which affects the formation of a disulfide bond that is associated with the formation of a loop.It is well known that there is an overlap between the S protein and Pol protein.We found that this new insertion site occurred in polymerase/reverse transcriptase domain,indi-cating that this insertion might be involved in HBV pathogenicity.The patient was finally diagnosed with a false OBI.CONCLUSION An insertion of amino acid residues at positions 120-124 of the S protein affects the formation of immunodominant epitopes and results in negative HBsAg levels.
文摘针对加工汽车碳纤维材料的钻头寿命短、加工质量差的问题,设计了一种新型钻头。通过DOE(design of experiment)试验方法,给出了钻头齿数、前角和后角等3个参数的全因子试验方案。利用MINITAB软件对试验数据进行回归分析,并利用响应优化获得最优设计参数。结果表明:齿数和后角对钻孔个数及钻头寿命影响不显著,前角对钻头寿命有显著影响,后角与前角的交互作用对钻头寿命也有显著影响。齿数、前角和后角对第一孔钻孔时间及钻孔速度有显著影响,齿数与后角的交互作用以及前角与后角的交互作用对钻孔速度有显著影响。通过试验测试验证优化后的最佳设计参数是有效合理的。
基金This work was financially supported by National Key R&D Program of China(2022YFD1401200)China Agriculture Research System of MOF and MARA(CARS-24-C-04)+3 种基金National Natural Science Foundation of China(32270294)Ningbo Major Special Projects of the Plan‘Science and Technology Innovation 2025’(2021Z106)the Postdoctoral Science Foundation of Anhui Province,China(2021B558)K.C.Wong Magna Fund in Ningbo University.
文摘Pepper mild mottle virus(PMMoV)is a devastating viral pathogen of pepper(Capsicum annuum)but it is unclear whether and how peppers protect against PMMoV infection.The expression of the chloroplast outer membrane protein 24(OMP24)of C.annuum was upregulated under PMMoV infection and it interacted with PMMoV coat protein(CP).Silencing of OMP24 in either C.annuum or Nicotiana benthamiana facilitated PMMoV infection,whereas overexpression of N.benthamiana OMP24 in transgenic plants inhibited PMMoV infection.Both C.annuum OMP24(CaOMP24)and N.benthamiana OMP24(NbOMP24)localized to the chloroplast and have a moderately hydrophobic transmembrane domain that is necessary for their localization.Overexpression of CaOMP24 induced stromules,perinuclear chloroplast clustering,and accumulation of reactive oxygen species(ROS),the typical defense responses of chloroplasts transferring the retrograde signaling to the nucleus to regulate resistance genes.The expression of PR1 and PR2 was also upregulated significantly in plants overexpressing OMP24.Self-interaction of OMP24 was demonstrated and was required for OMP24-mediated plant defense.Interaction with PMMoV CP interfered with the self-interaction of OMP24 and impaired OMP24-induced stromules,perinuclear chloroplast clustering and ROS accumulation.The results demonstrate the defense function of OMP24 in pepper during viral infection and suggest a possible mechanism by which PMMoV CP modulates the plant defense to facilitate viral infection.
基金This work was supported by the Russian Science Foundation(Grant No.22-22-01031).
文摘The carrier-envelope phase(CEP)φ_(0)is one of the key parameters in the generation of isolated attosecond pulses.In particular,“cosine”pulses(φ_(0)=0)are best suited for generation of single attosecond pulses in atomic media.Such“cosine”pulses have the peak of the most intense cycle aligned with the peak of the pulse envelope,and therefore have the highest contrast between the peak intensity and the neighboring cycles.In this paper,the dynamics of single attosecond pulse generation from a relativistically oscillating plasma mirror is investigated.We use an elementary analytical model as well as particle-in-cell simulations to study few-cycle attosecond pulses.We find that the phase of the field driving the surface oscillations depends on the plasma density and preplasma scale length.This leads us to a counterintuitive conclusion:for the case of normal incidence and a sharp plasma-vacuum boundary,the CEP required for the generation of a single attosecond pulse phase is closer toφ_(0)=π/2(a“sine”pulse),with the exact value depending on the plasma parameters.
文摘铁氧体隔离器作为一种大量应用于5G通讯基站的通讯元器件,其可靠性关系到基站整机运行的持续性与稳定性,而隔离器的衰减片存在的焊接空洞问题可能导致隔离器在再流焊过程中发生失效,严重时导致基站电路板烧毁,因此管控及降低衰减片焊接空洞率十分重要。首先对铁氧体隔离器的衰减片焊接空洞产生的机理进行分析,并通过实验设计(Design of Experiment,DOE)对点锡过程中可能导致焊接空洞问题的因素进行了析因分析及点锡工艺的优化。实验结果表明,通过控制点锡轨迹及点锡速度,能显著减少焊接空洞,并明显提升该焊接过程的制程能力,大幅提升了分布参数隔离器的可靠度,降低了隔离器经历再流焊后失效的风险。