Dynamic Interaction Analysis of Coupled Axial-Torsional-Lateral Mechanical Vibrations in Rotary Drilling Systems

Maintaining the integrity and longevity of structures is essential in many industries,such as aerospace,nuclear,and petroleum.To achieve the cost-effectiveness of large-scale systems in petroleum drilling,a strong emphasis on structural durability and monitoring is required.This study focuses on the mechanical vibrations that occur in rotary drilling systems,which have a substantial impact on the structural integrity of drilling equipment.The study specifically investigates axial,torsional,and lateral vibrations,which might lead to negative consequences such as bit-bounce,chaotic whirling,and high-frequency stick-slip.These events not only hinder the efficiency of drilling but also lead to exhaustion and harm to the system’s components since they are difficult to be detected and controlled in real time.The study investigates the dynamic interactions of these vibrations,specifically in their high-frequency modes,usingfield data obtained from measurement while drilling.Thefindings have demonstrated the effect of strong coupling between the high-frequency modes of these vibrations on drilling sys-tem performance.The obtained results highlight the importance of considering the interconnected impacts of these vibrations when designing and implementing robust control systems.Therefore,integrating these compo-nents can increase the durability of drill bits and drill strings,as well as improve the ability to monitor and detect damage.Moreover,by exploiting thesefindings,the assessment of structural resilience in rotary drilling systems can be enhanced.Furthermore,the study demonstrates the capacity of structural health monitoring to improve the quality,dependability,and efficiency of rotary drilling systems in the petroleum industry.

Research status and prospects of the fractal analysis of metal material surfaces and interfaces

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine properties.Fractal analysis has been used to characterize the shapes of metal materials at various scales and dimensions.Conventional methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and interfaces.However,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal materials.From the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear surfaces.The relationship between the fractal dimensions and properties of metal material surfaces and interfaces is summarized.Starting from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be developed.It is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

Antioxidant and lipoxygenase inhibitory properties of a novel flavonoid from Pistacia chinensis Bunge and its molecular docking analysis

Background:Pistacia chinensis Bunge has been traditionally used to manage various conditions,including asthma,pain,inflammation,hepatoprotection,and diabetes.The study was conducted to investigate the antioxidant and anti-lipoxygenase(LOX)properties of the isolated compound 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one from Pistacia chinensis.Methods:LOX assay and antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl(DPPH)assay were performed.Molecular docking studies were conducted using a molecular operating environment.Results:The LOX assay revealed significant inhibitory effects at 0.2µM concentration,with an IC50 value of 37.80µM.The antioxidant effect demonstrated dose-dependency across 5 to 100µg/mL concentrations,reaching 93.09%at 100µg/mL,comparable to ascorbic acid’s 95.43%effect.Molecular docking studies highlighted strong interactions with the lipoxygenase enzyme,presenting an excellent docking score of-10.98 kcal/mol.Conclusion:These findings provide valuable insights into Pistacia chinensis’chemical components and biological effects,reinforcing its traditional medicinal applications.

Prenatal ultrasonography and genetic analysis of fetal cleidocranial dysplasia:A case report

BACKGROUND Cleidocranial dysplasia(CCD)is an infrequent clinical condition with an autosomal dominant inheritance pattern.It is characterized by abnormal clavicles,patent sutures and fontanelles,supernumerary teeth,and short stature.Approximately 60%-70%of patients with CCD have mutations in the RUNX family transcription factor 2 gene.However,prenatal diagnosis of CCD is difficult when the family history is unknown.CASE SUMMARY We report a rare case of fetal CCD with an unknown family history,confirmed by prenatal ultrasonography and genetic testing at a gestational age of 16 weeks.The genetic reports indicated that the fetus carried pathogenic mutations in the RUNX family transcription factor 2 gene(c.674G>A).After careful consideration,the pregnant woman and her family decided to continue the pregnancy.CONCLUSION Definitive prenatal diagnosis of CCD should include family history,ultrasound diagnosis,and genetic analysis,especially if family history is unknown.

Retrospective analysis of pathological types and imaging features in pancreatic cancer: A comprehensive study

BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late diagnosis.Understanding the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment planning.AIM To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging features.METHODS We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our institution.Pathological types were determined by histopathological examination of the surgical spe-cimens or biopsy samples.The imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic ultrasound.Statistical analyses were performed to identify significant associations between pathological types and specific imaging characteristics.RESULTS There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare types.Distinct imaging features were identified in each pathological type.Pancreatic ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural nodules.Neuroendocrine tumors often appear as hypervascular lesions in contrast-enhanced imaging.Statistical analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging features.These findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.

Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions

BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood swings.Effective drug treatment modalities are crucial for managing BD.AIM To analyze the current status and future trends of global research on BD drug treatment over the last decade.METHODS The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were extracted.Data visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration networks.The University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this field.The Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited paper.CONCLUSION This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future directions.The study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.

Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma:A case report

BACKGROUND Gallbladder neuroendocrine carcinoma(NEC)represents a subtype of gallbladder malignancies characterized by a low incidence,aggressive nature,and poor prognosis.Despite its clinical severity,the genetic alterations,mechanisms,and signaling pathways underlying gallbladder NEC remain unclear.CASE SUMMARY This case study presents a rare instance of primary gallbladder NEC in a 73-year-old female patient,who underwent a radical cholecystectomy with hepatic hilar lymphadenectomy and resection of liver segments IV-B and V.Targeted gene sequencing and bioinformatics analysis tools,including STRING,GeneMANIA,Metascape,TRRUST,Sangerbox,cBioPortal and GSCA,were used to analyze the biological functions and features of mutated genes in gallbladder NEC.Twelve mutations(APC,ARID2,IFNA6,KEAP1,RB1,SMAD4,TP53,BTK,GATA1,GNAS,and PRDM3)were identified,and the tumor mutation burden was determined to be 9.52 muts/Mb via targeted gene sequencing.A protein-protein interaction network showed significant interactions among the twelve mutated genes.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were used to assess mutation functions and pathways.The results revealed 40 tumor-related pathways.A key regulatory factor for gallbladder NEC-related genes was identified,and its biological functions and features were compared with those of gallbladder carcinoma.CONCLUSION Gallbladder NEC requires standardized treatment.Comparisons with other gallbladder carcinomas revealed clinical phenotypes,molecular alterations,functional characteristics,and enriched pathways.

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target organs.This has led to restrictions on current therapeutic approaches.In this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target organs.After peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal cord.The nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury site.Corresponding damage to target organs can occur,including skeletal muscle atrophy and sensory receptor disruption.We then provide a brief review of the research advances in therapeutic approaches to peripheral nerve injury.The main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical exercise.However,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ pathway.Therefore,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

Separation of closely spaced modes by combining complex envelope displacement analysis with method of generating intrinsic mode functions through filtering algorithm based on wavelet packet decomposition

One of the important issues in the system identification and the spectrum analysis is the frequency resolution, i.e., the capability of distinguishing between two or more closely spaced frequency components. In the modal identification by the empirical mode decomposition （EMD） method, because of the separating capability of the method, it is still a challenge to consistently and reliably identify the parameters of structures of which modes are not well separated. A new method is introduced to generate the intrin- sic mode functions （IMFs） through the filtering algorithm based on the wavelet packet decomposition （GIFWPD）. In this paper, it is demonstrated that the CIFWPD method alone has a good capability of separating close modes, even under the severe condition beyond the critical frequency ratio limit which makes it impossible to separate two closely spaced harmonics by the EMD method. However, the GIFWPD-only based method is impelled to use a very fine sampling frequency with consequent prohibitive computational costs. Therefore, in order to decrease the computational load by reducing the amount of samples and improve the effectiveness of separation by increasing the frequency ratio, the present paper uses a combination of the complex envelope displacement analysis （CEDA） and the GIFWPD method. For the validation, two examples from the previous works are taken to show the results obtained by the GIFWPD-only based method and by combining the CEDA with the GIFWPD method.

A Fault Diagnosis Approach for Broken Rotor Bars Based on EMD and Envelope Analysis

Empirical Mode Decomposition (EMD) used to deal with non-linear and non-stable signals,is a time-frequency analytical method that has been developed recently. In this paper the EMD method is used to filter the noise from the stator current signal that arises when rotor bars break. Then a Hilbert Transform is used to extract the envelope from the filtered signal. With the EMD method again,the frequency band containing the fault characteris-tic-frequency components,2sf,can be extracted from the signal's envelope. The last step is to use a Fast Fourier Trans-form (FFT) method to extract the fault characteristic frequency. This frequency can be detected in actual data from a faulty motor,as shown by example. Compared to the Extend Park Vector method this method is proved to be more sen-sitive under light motor load.

Fractional Envelope Analysis for Rolling Element Bearing Weak Fault Feature Extraction

The bearing weak fault feature extraction is crucial to mechanical fault diagnosis and machine condition monitoring. Envelope analysis based on Hilbert transform has been widely used in bearing fault feature extraction. A generalization of the Hilbert transform, the fractional Hilbert transform is defined in the frequency domain, it is based upon the modification of spatial filter with a fractional parameter, and it can be used to construct a new kind of fractional analytic signal. By performing spectrum analysis on the fractional envelope signal, the fractional envelope spectrum can be obtained. When weak faults occur in a bearing, some of the characteristic frequencies will clearly appear in the fractional envelope spectrum. These characteristic frequencies can be used for bearing weak fault feature extraction. The effectiveness of the proposed method is verified through simulation signal and experiment data. © 2017 Chinese Association of Automation.

Constant envelope FrFT OFDM: spectral and energy efficiency analysis

Constant envelope with a fractional Fourier transformorthogonal frequency division multiplexing(CE-FrFT-OFDM)is a special case of a constant envelope OFDM(CE-OFDM),both being energy efficient wireless communication techniques with a 0 dB peak to average power ratio(PAPR).However,with the proper selection of fractional order,the first technique has a high bit error rate(BER)performance in the frequency-time selective channels.This paper performs further analysis of CE-FrFT-OFDM by examining its spectral efficiency(SE)and energy efficiency(EE)and compare to the famous OFDM and FrFT-OFDM techniques.Analytical and comprehensive simulations conducted show that,the CE-FrFT-OFDM has five times the EE of OFDM and FrFT-OFDM systems with a slightly less SE.Increasing CE-FrFT-OFDM’s transmission power by increasing its amplitude to 1.7 increases its SE to match that of the OFDM and FrFT-OFDM systems while slightly reducing its EE by 20%to be four times that of OFDM and FrFTOFDM systems.OFDM and FrFT-OFDM’s amplitude fluctuations cause rapid changing output back-off(OBO)power requirements and further reduce power amplifier(PA)efficiency while CE-FrFTOFDM stable operational linear range makes it a better candidate and outperforms the other techniques when their OBO exceeds 1.7.Higher EE and low BER in time-frequency selective channel are attracting features for CE-FrFT-OFDM deployment in mobile devices.

Rolling Element Bearing Diagnostics by Combination of Envelope Analysis and Wavelet Transform

Rolling element-bearing diagnostics has been studied over the last thirty years, and envelope analysis is widely recognized as being the best approach for detection and diagnosis of rolling element bearing incipient failure. But one of the on-going difficulties with envelope technique is to determine the best frequency band to envelop. Here, wavelet transform technique is introduced into envelope analysis to solve the problem by capturing bearing defects-sensory scales (i.e. frequency bands). A modulated Gaussian function is chosen to be the analytical wavelet because it coincides well with bearing defect-induced vibration signal patterns. Vibration signals measured from railway bearing tests were studied by the proposed method. Cases of bearings with single and multiple defects on inner and outer race under different testing conditions are presented. Experimental results showed that the proposed method allowed a more accurate local description and separation of transient signal part, which were caused by impacts between defects and the mating surfaces in the bearing. The combination method provides an effective signal detection technique for rolling element-bearing diagnostics.

Influence of Kinematic Analysis Parameters of Drag Anchor Trajectory Prediction Using Yield Envelope Method

Drag anchor is widely applied in offshore engineering for offshore mooring systems.The prediction of the invisible trajectory during its drag-in installation is challenging for anchor design in determining the anchor final position for ensuring sufficient holding capacity.The yield envelope method based on deep anchor failure for kinematic analysis was proposed as a promising trajectory prediction method for drag anchor.However,there is a lack of analysis on the effects of the parameters applied in the kinematic analysis.The current work studies the effects of the yield envelope parameters,anchor line bearing capacity factor and the anchor/soil interface friction.It is found that the accuracy of the yield envelope parameters has large impact on the prediction results based on deep yield envelopes.Analyses of cases with smooth fluke predict deeper embedment depth than that from analyses of cases with rough fluke.The decrease of the capacity factor results in the increase of the anchor embedment depth,the anchor line load,the anchor chain angle and the stable value of the normalized horizontal load component for the same drag length,while the stable value of the normalized vertical load component decreases when the capacity factor decreases.This illustrates the importance in applying reasonable parameters and improving the method for more reliable prediction of the anchor trajectory.

THREE-DIMENSIONAL SLOPE STABILITY ANALYSIS BASED ON NONLINEAR FAILURE ENVELOPE

The effects of nonlinearity of strength envelopes on 3D slope stability analysis are investigated.A power relation for the nonlinear envelope is employed to derive the 3D factor of safety equations of an extended Spencer method hich satisfies boty force equilibrium and moment equilibrium.Then,a search procedure is presented based on dynamic programming to determine the 3D critical slip surface for a general slope,Linear and nonlinear strength envelopes used for slope stability computations are obtained by fitting curves to the 103 strength data of consolidated-undrained(CU)triaxial compression tests for compacted Israeli clay.Results of a typical 3D problem show that a linear approximation of the nonlinear strength envelope may lead to a significant overestimation of calculated safety factors.

Screening biomarkers for spinal cord injury using weighted gene co-expression network analysis and machine learning

Immune changes and inflammatory responses have been identified as central events in the pathological process of spinal co rd injury.They can greatly affect nerve regeneration and functional recovery.However,there is still limited understanding of the peripheral immune inflammato ry response in spinal cord inju ry.In this study.we obtained microRNA expression profiles from the peripheral blood of patients with spinal co rd injury using high-throughput sequencing.We also obtained the mRNA expression profile of spinal cord injury patients from the Gene Expression Omnibus(GEO)database(GSE151371).We identified 54 differentially expressed microRNAs and 1656 diffe rentially expressed genes using bioinformatics approaches.Functional enrichment analysis revealed that various common immune and inflammation-related signaling pathways,such as neutrophil extracellular trap formation pathway,T cell receptor signaling pathway,and nuclear factor-κB signal pathway,we re abnormally activated or inhibited in spinal cord inju ry patient samples.We applied an integrated strategy that combines weighted gene co-expression network analysis,LASSO logistic regression,and SVM-RFE algorithm and identified three biomarke rs associated with spinal cord injury:ANO10,BST1,and ZFP36L2.We verified the expression levels and diagnostic perfo rmance of these three genes in the original training dataset and clinical samples through the receiver operating characteristic curve.Quantitative polymerase chain reaction results showed that ANO20 and BST1 mRNA levels were increased and ZFP36L2 mRNA was decreased in the peripheral blood of spinal cord injury patients.We also constructed a small RNA-mRNA interaction network using Cytoscape.Additionally,we evaluated the proportion of 22 types of immune cells in the peripheral blood of spinal co rd injury patients using the CIBERSORT tool.The proportions of naive B cells,plasma cells,monocytes,and neutrophils were increased while the proportions of memory B cells,CD8^(+)T cells,resting natural killer cells,resting dendritic cells,and eosinophils were markedly decreased in spinal cord injury patients increased compared with healthy subjects,and ANO10,BST1 and ZFP26L2we re closely related to the proportion of certain immune cell types.The findings from this study provide new directions for the development of treatment strategies related to immune inflammation in spinal co rd inju ry and suggest that ANO10,BST2,and ZFP36L2 are potential biomarkers for spinal cord injury.The study was registe red in the Chinese Clinical Trial Registry(registration No.ChiCTR2200066985,December 12,2022).

Social-ecological perspective on the suicidal behaviour factors of early adolescents in China:a network analysis

Background In early adolescence,youth are highly prone to suicidal behaviours.Identifying modifiable risk factors during this critical phase is a priority to inform effective suicide prevention strategies.Aims To explore the risk and protective factors of suicidal behaviours(ie,suicidal ideation,plans and attempts)in early adolescence in China using a social-ecological perspective.Methods Using data from the cross-sectional project‘Healthy and Risky Behaviours Among Middle School Students in Anhui Province,China',stratified random cluster sampling was used to select 5724 middle school students who had completed self-report questionnaires in November 2020.Network analysis was employed to examine the correlates of suicidal ideation,plans and attempts at four levels,namely individual(sex,academic performance,serious physical llness/disability,history of self-harm,depression,impulsivity,sleep problems,resilience),family(family economic status,relationship with mother,relationship with father,family violence,childhood abuse,parental mental illness),school(relationship with teachers,relationship with classmates,school-bullying victimisation and perpetration)and social(social support,satisfaction with society).Results In total,37.9%,19.0%and 5.5%of the students reported suicidal ideation,plans and attempts in the past 6 months,respectively.The estimated network revealed that suicidal ideation,plans and attempts were collectively associated with a history of self-harm,sleep problems,childhood abuse,school bullying and victimisation.Centrality analysis indicated that the most influential nodes in the network were history of self-harm and childhood abuse.Notably,the network also showed unique correlates of suicidal ideation(sex,weight=0.60;impulsivity,weight=0.24;family violence,weight=0.17;relationship with teachers,weight=-0.03;school-bullying perpetration,weight=0.22),suicidal plans(social support,weight=-0.15)and suicidal attempts(relationship with mother,weight=-0.10;parental mental llness,weight=0.61).Conclusions This study identified the correlates of suicidal ideation,plans and attempts,and provided practical implications for suicide prevention for young adolescents in China.Firstly,this study highlighted the importance of joint interventions across multiple departments.Secondly,the common risk factors of suicidal ideation,plans and attempts were elucidated.Thirdly,this study proposed target interventions to address the unique influencing factors of suicidal ideation,plans and attempts.

IGIgram:An Improved Gini Index-Based Envelope Analysis for Rolling Bearing Fault Diagnosis

The transient impulse features caused by rolling bearing faults are often present in the resonance frequency band which is closely related to the dynamic characteristics of the machine structure.Informative frequency band identification is a crucial prerequisite for envelope analysis and thereby accurate fault diagnosis of rolling bearings.In this paper,based on the ratio of quasi-arithmetic means and Gini index,improved Gini indices(IGIs)are proposed to quantify the transient impulse features of a signal,and their effectiveness and advantages in sparse quantification are confirmed by simulation analysis and comparisons with traditional sparsity measures.Furthermore,an IGI-based envelope analysis method named IGIgram is developed for fault diagnosis of rolling bearings.In the new method,an IGI-based indicator is constructed to evaluate the impulsiveness and cyclostationarity of the narrow-band filtered signal simultaneously,and then a frequency band with abundant fault information is adaptively determined for extracting bearing fault features.The performance of the IGIgram method is verified on the simulation signal and railway bearing experimental signals and compared with typical sparsity measures-based envelope analysis methods and log-cycligram.The results demonstrate that the proposed IGIs are efficient in quantifying bearing fault-induced transient features and the IGIgram method with appropriate power exponent can effectively achieve the diagnostics of different axle-box bearing faults.

Advances in microfluidic-based DNA methylation analysis

DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various diseases.Progress in analytical methods can greatly increase the relevance of DNA methylation studies to both clinical medicine and scientific research.Microflu-idic chips are excellent carriers for molecular analysis,and their use can provide improvements from multiple aspects.On-chip molecular analysis has received extensive attention owing to its advantages of portability,high throughput,low cost,and high efficiency.In recent years,the use of novel microfluidic chips for DNA methylation analysis has been widely reported and has shown obvious superiority to conventional methods.In this review,wefirst focus on DNA methylation and its applications.Then,we discuss advanced microfluidic-based methods for DNA methylation analysis and describe the great progress that has been made in recent years.Finally,we summarize the advantages that microfluidic technology brings to DNA methylation analysis and describe several challenges and perspectives for on-chip DNA methylation analysis.This review should help researchers improve their understanding and make progress in developing microfluidic-based methods for DNA methylation analysis.