We investigated the effect of the 2-mercaptobenzothiazole concentration on the sour-corrosion behavior of API X60 pipeline steel in an environment containing H_(2)S at 25°C and in the presence of 0,2.5,5.0,7.5,an...We investigated the effect of the 2-mercaptobenzothiazole concentration on the sour-corrosion behavior of API X60 pipeline steel in an environment containing H_(2)S at 25°C and in the presence of 0,2.5,5.0,7.5,and 10.0 g/L of 2-mercaptobenzothiazole inhibitor.To examine this behavior,we conducted open-circuit potential(OCP),potentiodynamic polarization,and electrochemical impedance spectroscopy(EIS)tests.Energy dispersive spectroscopy and scanning electron microscopy were also used to analyze the corrosion products.The results of the OCP and potentiodynamic polarization tests revealed that 2-mercaptobenzothiazole reduces the speed of both the anodic and cathodic reactions.An assessment of the Gibbs free energy of the inhibitor(△G_(ads)^(■))indicated that its value was less than-20 kJ·mol^(-1)and greater than-40 k J·mol^(-1).Therefore,the adsorption of 2-mercaptobenzothiazole onto the surface of the API X60 pipeline steel occurs both physically and chemically,the latter of which is particularly intentional.In addition,as the△G_(ads)^(■)dsvalue was negative,we could conclude that the adsorption of 2-mercaptobenzothiazole onto the surface of the pipeline steel occurs spontaneously.The EIS results indicate that with the increase in the 2-mercaptobenzothiazole inhibitor concentration,the corrosion resistance of API X60 steel increases.An analysis of the corrosion products revealed that iron sulfide compounds form on the surface.In summary,the results showed that an increase in the inhibitor concentration results in a decrease in the corrosion rate and an increase in inhibitory efficiency.Additionally,we found that the 2-mercaptobenzothiazole adsorption process on the API X60 steel surfaces in an H2 S-containing environment follows the Langmuir adsorption isotherm and occurs spontaneously.展开更多
Objective： To explore the pharmacologic effects of Chinese medicine Bushen Huayu Jiedu Compound Recipe （补肾化瘀解毒复方,BSHYJDR） in drug-resistance cells of lung cancer. Methods： Human lung adenocarcinoma A549/DD...Objective： To explore the pharmacologic effects of Chinese medicine Bushen Huayu Jiedu Compound Recipe （补肾化瘀解毒复方,BSHYJDR） in drug-resistance cells of lung cancer. Methods： Human lung adenocarcinoma A549/DDP cell strain was selected, serum pharmacology and flow cytometer （FCM） method were adopted, $180 tumor-bearing mice and normal mice were given, through gastrogavage, different doses of a decocted concentration of BSHYJDR. Serum from the abdominal aorta was taken to observe the effect of drug-serum on cisplatin （DDP） concentration, free Ca^2＋ concentration and the expression of lung drug-resistance protein LRP-56 in A549/DDP cells. Results： Compared with the drug-resistance group, the intracellular DDP concentration in the group taking a high dose and the normal group of Chinese medicine showed significant difference （P〈0.05）, while no significant difference was found in the low-dose group （P〉0.05）. Compared with the drug-resistance group, the Ca^2＋ concentration in cells and the expression of LRP in lung cancer drug-resistance cells A549/DDP of the high-dose group, the low-dose group and the normal group of Chinese medicine were significantly different （all P〈0.01）, the LRP expression of the normal group was obviously higher than that of the drug-resistance group （P〈0.05）. Cenclusien： It was indicated that serum containing Chinese medicine BSHYJDR in the tumor-bearing mice and the normal mice had certainly different, tumor-bearing mice serum containing could improve drug concentration in lung cancer drug-resistance cells, prevent the inflow and release of Ca^2＋, and inhibit the expression of the drug-resistance gene in the lung cancer drug-resistance cells, which might be the mechanism of BSHYJDR in enhancing the efficacy in reversing and inhibiting tumor.展开更多
High-performance computing(HPC)systems are about to reach a new height:exascale.Application deployment is becoming an increasingly prominent problem.Container technology solves the problems of encapsulation and migrat...High-performance computing(HPC)systems are about to reach a new height:exascale.Application deployment is becoming an increasingly prominent problem.Container technology solves the problems of encapsulation and migration of applications and their execution environment.However,the container image is too large,and deploying the image to a large number of compute nodes is time-consuming.Although the peer-to-peer(P2P)approach brings higher transmission efficiency,it introduces larger network load.All of these issues lead to high startup latency of the application.To solve these problems,we propose the topology-aware execution environment service(TEES)for fast and agile application deployment on HPC systems.TEES creates a more lightweight execution environment for users,and uses a more efficient topology-aware P2P approach to reduce deployment time.Combined with a split-step transport and launch-in-advance mechanism,TEES reduces application startup latency.In the Tianhe HPC system,TEES realizes the deployment and startup of a typical application on 17560 compute nodes within 3 s.Compared to container-based application deployment,the speed is increased by 12-fold,and the network load is reduced by 85%.展开更多
文摘We investigated the effect of the 2-mercaptobenzothiazole concentration on the sour-corrosion behavior of API X60 pipeline steel in an environment containing H_(2)S at 25°C and in the presence of 0,2.5,5.0,7.5,and 10.0 g/L of 2-mercaptobenzothiazole inhibitor.To examine this behavior,we conducted open-circuit potential(OCP),potentiodynamic polarization,and electrochemical impedance spectroscopy(EIS)tests.Energy dispersive spectroscopy and scanning electron microscopy were also used to analyze the corrosion products.The results of the OCP and potentiodynamic polarization tests revealed that 2-mercaptobenzothiazole reduces the speed of both the anodic and cathodic reactions.An assessment of the Gibbs free energy of the inhibitor(△G_(ads)^(■))indicated that its value was less than-20 kJ·mol^(-1)and greater than-40 k J·mol^(-1).Therefore,the adsorption of 2-mercaptobenzothiazole onto the surface of the API X60 pipeline steel occurs both physically and chemically,the latter of which is particularly intentional.In addition,as the△G_(ads)^(■)dsvalue was negative,we could conclude that the adsorption of 2-mercaptobenzothiazole onto the surface of the pipeline steel occurs spontaneously.The EIS results indicate that with the increase in the 2-mercaptobenzothiazole inhibitor concentration,the corrosion resistance of API X60 steel increases.An analysis of the corrosion products revealed that iron sulfide compounds form on the surface.In summary,the results showed that an increase in the inhibitor concentration results in a decrease in the corrosion rate and an increase in inhibitory efficiency.Additionally,we found that the 2-mercaptobenzothiazole adsorption process on the API X60 steel surfaces in an H2 S-containing environment follows the Langmuir adsorption isotherm and occurs spontaneously.
基金Supported by Post-Doctoral Foundation of China,(2001)5,Guangdong Province Technology Project(No.73062)
文摘Objective： To explore the pharmacologic effects of Chinese medicine Bushen Huayu Jiedu Compound Recipe （补肾化瘀解毒复方,BSHYJDR） in drug-resistance cells of lung cancer. Methods： Human lung adenocarcinoma A549/DDP cell strain was selected, serum pharmacology and flow cytometer （FCM） method were adopted, $180 tumor-bearing mice and normal mice were given, through gastrogavage, different doses of a decocted concentration of BSHYJDR. Serum from the abdominal aorta was taken to observe the effect of drug-serum on cisplatin （DDP） concentration, free Ca^2＋ concentration and the expression of lung drug-resistance protein LRP-56 in A549/DDP cells. Results： Compared with the drug-resistance group, the intracellular DDP concentration in the group taking a high dose and the normal group of Chinese medicine showed significant difference （P〈0.05）, while no significant difference was found in the low-dose group （P〉0.05）. Compared with the drug-resistance group, the Ca^2＋ concentration in cells and the expression of LRP in lung cancer drug-resistance cells A549/DDP of the high-dose group, the low-dose group and the normal group of Chinese medicine were significantly different （all P〈0.01）, the LRP expression of the normal group was obviously higher than that of the drug-resistance group （P〈0.05）. Cenclusien： It was indicated that serum containing Chinese medicine BSHYJDR in the tumor-bearing mice and the normal mice had certainly different, tumor-bearing mice serum containing could improve drug concentration in lung cancer drug-resistance cells, prevent the inflow and release of Ca^2＋, and inhibit the expression of the drug-resistance gene in the lung cancer drug-resistance cells, which might be the mechanism of BSHYJDR in enhancing the efficacy in reversing and inhibiting tumor.
基金Project supported by the National Natural Science Foundation of China(No.61902405)the Tianhe Supercomputer Project of China(No.2018YFB0204301)+1 种基金the PDL Research Fund of China(No.6142110190404)the National High-Level Personnel for Defense Technology Program,China(No.2017-JCJQ-ZQ-013)。
文摘High-performance computing(HPC)systems are about to reach a new height:exascale.Application deployment is becoming an increasingly prominent problem.Container technology solves the problems of encapsulation and migration of applications and their execution environment.However,the container image is too large,and deploying the image to a large number of compute nodes is time-consuming.Although the peer-to-peer(P2P)approach brings higher transmission efficiency,it introduces larger network load.All of these issues lead to high startup latency of the application.To solve these problems,we propose the topology-aware execution environment service(TEES)for fast and agile application deployment on HPC systems.TEES creates a more lightweight execution environment for users,and uses a more efficient topology-aware P2P approach to reduce deployment time.Combined with a split-step transport and launch-in-advance mechanism,TEES reduces application startup latency.In the Tianhe HPC system,TEES realizes the deployment and startup of a typical application on 17560 compute nodes within 3 s.Compared to container-based application deployment,the speed is increased by 12-fold,and the network load is reduced by 85%.
