Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and disease.To enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid culture.This involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid system.This cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology testing.As a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental toxins.Brain organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature differentiation.Cadmium exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic locations.The convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

Illustrating the multi-stakeholder perceptions of environmental pollution based on big data:Lessons from China

The relationship between stakeholders and the environment influences sustainable development and human wellbeing.To illustrate the multi-stakeholder perceptions of environmental pollution in China,we interpreted a feedback loop in the perception-behavior-environment nexus from the perspective of the coupled human-environment system,measured the differences of environmental perceptions among five stakeholders(the public,government,media,companies,and scientists)and regions(including 31 provinces,autonomous regions,and municipalities in China,with exceptions of Taiwan of China,Hong Kong of China,and Macao of China due to a lack of data)using big data,and made a comparison between the perceptions and the actual pollution situation.The results showed that the five stakeholders exhibited similar perceptions of environmental pollution at the national scale,with air pollution being of most concern,followed by water pollution and soil pollution.There were significant spatial differences in environmental perceptions.All stakeholders in the developed regions in eastern China paid relatively high attention to environmental issues,while those in the northwestern regions paid much less attention.There existed a mutual influence and interaction among the different stakeholders.More attention should be paid to air pollution in Xinjiang Uygur Autonomous Region and Ningxia Hui Autonomous Region,water pollution in Hainan Province,Inner Mongolia Autonomous Region,Heilongjiang Province,and Jilin Province,and soil pollution in Hainan Province,Fujian Province,and Jilin Province.This paper provides a research paradigm on multi-stakeholder environmental perceptions based on big data,and the results provide a background reference for regional environmental governance.

Spatial Design Strategies for Community Parks Based on Environmental Perception

By applying environmental perception theories, spatial configurations of community parks were analyzed, and spatial design strategies meeting perceptual psychology of users were proposed to integrate the community park environment into daily life of local residents, and create a harmonious and vital living environment.

Environmental risk and risk perception management in public health

When evaluating environmental risk and its perception, psychosocial and psychosomatic factors may be of fundamental importance for public health programming and the promotion of quality of life. This is the case in particular where knowledge of the true health consequences of environmental exposure to given risk factors are incomplete or its action is within the range of values where we do not anticipate the measurable biological effect. This applies not only in the case of the indoor environment related complaints but also to that of non-ionizing electromagnetic radiation and electroionic microclimate, among many others. A serious consequence found in the syndrome of mass hysteria is the fact that due to differently motivated information and disinformation, part of the population can suffer from psychosomatic symptoms and deterioration quality of life for those affected.

Posting of Graphical Bills: An Analytical Perception of Environmental Pollutions in Nigerian Cities

More than ever before, environmental preservation has been a critical issue for the survival of the world’s habitat. An attempt to explore global trends in environmental monitoring using numerous ways based on different techniques is an exercise in the right direction. This is expedient, given the recent overwhelming growing rate of environmental pollution of advertisement graphical bills worldwide. Posting of advertisement graphical bills constitutes one of the biggest threats to man and his environment as it now appears and as we live in an age of growing sensitivity to environmental cleanliness. Pollution of the Nigerian cities through advertisement bills assumes the general term of outdoor advertising ranging from hand-printed signs, posters, painted bulletins and spectaculars. However this paper discusses the trends of posting graphic advertisement bills in Nigerian cities. Its impact on aesthetics, as well as the pollution problems associated with the urban development. The study areas are Abuja, Akure, Ibadan and Lagos. In order to ensure that each unit of the population is represented, random sampling technique was used to get the necessary information from the samples. The findings emphasize the importance of strict control and market regulations in posting of advertisement bill in built environment and eradication of pollution of the environment.

Intelligent Recognition Using Ultralight Multifunctional Nano‑Layered Carbon Aerogel Sensors with Human‑Like Tactile Perception

Humans can perceive our complex world through multi-sensory fusion.Under limited visual conditions,people can sense a variety of tactile signals to identify objects accurately and rapidly.However,replicating this unique capability in robots remains a significant challenge.Here,we present a new form of ultralight multifunctional tactile nano-layered carbon aerogel sensor that provides pressure,temperature,material recognition and 3D location capabilities,which is combined with multimodal supervised learning algorithms for object recognition.The sensor exhibits human-like pressure(0.04–100 kPa)and temperature(21.5–66.2℃)detection,millisecond response times(11 ms),a pressure sensitivity of 92.22 kPa^(−1)and triboelectric durability of over 6000 cycles.The devised algorithm has universality and can accommodate a range of application scenarios.The tactile system can identify common foods in a kitchen scene with 94.63%accuracy and explore the topographic and geomorphic features of a Mars scene with 100%accuracy.This sensing approach empowers robots with versatile tactile perception to advance future society toward heightened sensing,recognition and intelligence.

Hospital Stakeholders’ Perception on Environmental Effects Related to Biomedical Waste in Togo’s University Hospitals (UHC) in 2021

Introduction: Given its effects, hospital waste is an environmental concern and a threat to health personnel, users of health services and neighboring populations. Our objective was to assess the perception of health care stakeholders on the environmental effects related to biomedical waste produced in Teaching Hospitals (CHU) in Togo in 2021. Methods: This was a cross-sectional study held from June 24 to August 28, 2021. It targeted three university hospitals, 340 health care providers and services selected by a probabilistic method with a simple random technique in 25 services, 72 directors, deputy directors, supervisors and heads of services, 27 collection and incineration agents selected by a non-probabilistic method with a reasoned choice technique, 44 patients and attendants and 36 householders of neighboring residents selected by a non-probabilistic method with an accidental choice technique. Variables such as the spreading of disease vectors, soil, air and water contamination, the presence of unpleasant odors and unsightly living conditions were assessed. Results: According to the respondents, biomedical waste causes the proliferation of vectors (55.3%), an unsightly environment inside the hospital (47.1%), and unpleasant odors (61.2%). Incineration operations disturb hospital residents (52.8%), according to the householders of the residents. During observation, we note deposits of waste that have not been destroyed and wastewater flowing in some places. Conclusion: Biomedical waste in Togo’s university hospitals generates environmental effects and therefore potentially high risks for human health. Improving their management should be a concern for all hospital actors.

Defining a mountain landscape characterized by grazing using actor perception, governmental strategy, and environmental monitoring data

In multi-functional mountainous landscapes worldwide,conservation of natural values is a major task.Here,pro-active policies can be a way forward.National Environmental Quality Objectives(EQO)to solve environmental problems for future generations,however,often wrestle with being too visionary and lacking specificity,which complicates their implementation.The EQO“A Magnificent Mountain Landscape”that has been adopted by the Swedish Parliament in 1999 to preserve the pristine mountain environment in Sweden,experiences all these flaws.To aid its implementation,we studied the conditions and processes needed to define,to evaluate,and to preserve its goals across the Swedish mountain chain,using one of its milestone targets(a landscape characterized by grazing)as a study system.Applying qualitative and quantitative methods,we analyzed three types of data:1)referral responses to the governmental strategy document,2)interviews with relevant actors,and 3)environmental monitoring data(reindeer position data).Nationally,our results suggest a need for geographical differentiation to match regional/local conditions.Regionally,difference in both perception and definition of the milestone target among the actors hinders the formulation,monitoring,and evaluation of a common goal.Next to a culture-nature divide,we found that a“within as a user”and“from the outside as an observer”perspective influenced suggested definitions.Moreover,we found a need for better defining whether the goal is maintaining current conditions or restoring previous ones.Our result supports the use of animal position data as a decision support tool to monitor and to aid evaluation of the target.Given the number of actors involved and conflicts of interests present,we suggest the application of a structured decision process to accomplish agreements on a common goal.Here,environmental monitoring data can aid a“landscape assessment step”as a natural part in the decision process to target landscape management actions resourcefully and effectively.

The impact of demographic dynamics on food consumption and its environmental outcomes:Evidence from China

With increasing population and changing demographics,food consumption has experienced a significant transition in quantity and quality.However,a dearth of knowledge remains regarding its environmental impacts and how it responds to demographic dynamics,particularly in emerging economies like China.Using the two-stage Quadratic Almost Demand System(QUAIDS)model,this study empirically examines the impact of demographic dynamics on food consumption and its environmental outcomes based on the provincial data from 2000 to 2020 in China.Under various scenarios,according to changes in demographics,we extend our analysis to project the long-term trend of food consumption and its environmental impacts,including greenhouse gas(GHG)emissions,water footprint(WF),and land appropriation(LA).The results reveal that an increase in the proportion of senior people significantly decreases the consumption of grain and livestock meat and increases the consumption of poultry,egg,and aquatic products,particularly for urban residents.Moreover,an increase in the proportion of males in the population leads to higher consumption of poultry and aquatic products.Correspondingly,in the current scenario of an increased aging population and sex ratio,it is anticipated that GHG emissions,WF,and LA are likely to decrease by 1.37,2.52,and 3.56%,respectively.More importantly,in the scenario adhering to the standards of nutritional intake according to the Dietary Guidelines for Chinese Residents in 2022,GHG emissions,WF,and LA in urban areas would increase by 12.78,20.94,and 18.32%,respectively.Our findings suggest that changing demographics should be considered when designing policies to mitigate the diet-environment-health trilemma and achieve sustainable food consumption.

Edge enhanced depth perception with binocular meta-lens

The increasing popularity of the metaverse has led to a growing interest and market size in spatial computing from both academia and industry.Developing portable and accurate imaging and depth sensing systems is crucial for advancing next-generation virtual reality devices.This work demonstrates an intelligent,lightweight,and compact edge-enhanced depth perception system that utilizes a binocular meta-lens for spatial computing.The miniaturized system comprises a binocular meta-lens,a 532 nm filter,and a CMOS sensor.For disparity computation,we propose a stereo-matching neural network with a novel H-Module.The H-Module incorporates an attention mechanism into the Siamese network.The symmetric architecture,with cross-pixel interaction and cross-view interaction,enables a more comprehensive analysis of contextual information in stereo images.Based on spatial intensity discontinuity,the edge enhancement eliminates illposed regions in the image where ambiguous depth predictions may occur due to a lack of texture.With the assistance of deep learning,our edge-enhanced system provides prompt responses in less than 0.15 seconds.This edge-enhanced depth perception meta-lens imaging system will significantly contribute to accurate 3D scene modeling,machine vision,autonomous driving,and robotics development.

Optoelectronic Synapses Based on MXene/Violet Phosphorus van der Waals Heterojunctions for Visual‑Olfactory Crossmodal Perception

The crossmodal interaction of different senses,which is an important basis for learning and memory in the human brain,is highly desired to be mimicked at the device level for developing neuromorphic crossmodal perception,but related researches are scarce.Here,we demonstrate an optoelectronic synapse for vision-olfactory crossmodal perception based on MXene/violet phosphorus(VP)van der Waals heterojunctions.Benefiting from the efficient separation and transport of photogenerated carriers facilitated by conductive MXene,the photoelectric responsivity of VP is dramatically enhanced by 7 orders of magnitude,reaching up to 7.7 A W^(−1).Excited by ultraviolet light,multiple synaptic functions,including excitatory postsynaptic currents,pairedpulse facilitation,short/long-term plasticity and“learning-experience”behavior,were demonstrated with a low power consumption.Furthermore,the proposed optoelectronic synapse exhibits distinct synaptic behaviors in different gas environments,enabling it to simulate the interaction of visual and olfactory information for crossmodal perception.This work demonstrates the great potential of VP in optoelectronics and provides a promising platform for applications such as virtual reality and neurorobotics.

The Impact of Central Environmental Inspections on the Perception of Respect for Human Rights and Its Empirical Analysis

To develop China’s human rights cause with a people-centered approach,we should pay close attention to the concrete experiences of the general public regarding the protection of human rights.Deepening the research on the perception of respect for human rights can contribute to a more comprehensive understanding of the practical achievements of the hu man rights cause.Public environmental rights,as a new type of human rights,have become an important aspect of the development of the human rights cause in the new era.The central envi ronmental inspection,as an authoritative and interventionist vertical governance mechanism,promotes the implementation of environmental policies by local Party committees and govern ments and strengthens environmental information disclosure and public participation in environ mental matters.As a result,it contributes to the realization of public environmental rights and stimulates public perception of respect for human rights.Among them,the“look-back inspec tion is an important component of the central environmental inspection,and its implemen tation consolidates and enhances the previous inspection work.An empirical analysis based on the World Values Survey’s data for China indicates that residents in the provinces that have underg one“look-back inspections are more inclined to believe that human rights are adequately re spected compared to residents in the provinces that have not underwent such inspections.It suggests that the advancement and improvement of the central environmental inspection system promote improvements in ecological environment quality and contribute to enhancing the public percep tion of respect for human rights.

Perception of dental appearance and aesthetic analysis among patients,laypersons and dentists

BACKGROUND Current concepts of beauty are increasingly subjective,influenced by the viewpoints of others.The aim of the study was to evaluate divergences in the perception of dental appearance and smile esthetics among patients,laypersons and dental practitioners.The study goals were to evaluate the influence of age,sex,education and dental specialty on the participants’judgment and to identify the values of different esthetic criteria.Patients sample included 50 patients who responded to a dental appearance questionnaire(DAQ).Two frontal photographs were taken,one during a smile and one with retracted lips.Laypersons and dentists were asked to evaluate both photographs using a Linear Scale from(0-10),where 0 represent(absolutely unaesthetic)and 10 represent(absolutely aesthetic).One-way analysis of variance(ANOVA)and t-test analysis were measured for each group.Most patients in the sample expressed satisfaction with most aspects of their smiles and dental appearance.Among laypersons(including 488 participants),47 pictures“with lips”out of 50 had higher mean aesthetic scores compared to pictures“without lips”.Among the dentist sample,90 dentists’perception towards the esthetic smile and dental appearance for photos“with lips”and“without lips”were the same for 23 out of 50 patients.Perception of smile aesthetics differed between patients,laypersons and dentists.Several factors can contribute to shape the perception of smile aesthetic.AIM To compare the perception of dental aesthetic among patients,laypersons,and professional dentists,to evaluate the impact of age,sex,educational background,and income on the judgments made by laypersons,to assess the variations in experience,specialty,age,and sex on professional dentists’judgment,and to evaluate the role of lips,skin shade and tooth shade in different participants’judgments.METHODS Patients sample included 50 patients who responded to DAQ.Two frontal photographs were taken:one during a smile and one with retracted lips.Laypersons and dentists were asked to evaluate both photographs using a Linear Scale from(0-10),where 0 represent(absolutely unaesthetic)and 10 represent(absolutely aesthetic).One-way ANOVA and t-test analysis were measured for each group.RESULTS Most patients in the sample expressed satisfaction with most aspects of their smiles and dental appearance.Among laypersons(including 488 participants),47 pictures“with lips”out of 50 had higher mean aesthetic scores compared to pictures“without lips”.Whereas among the dentist sample,90 dentists’perception towards the esthetic smile and dental appearance for photos“with lips”and“without lips”were the same for 23 out of 50 patients.Perception of smile aesthetics differed between patients,laypersons and dentists.CONCLUSION Several factors can contribute to shape the perception of smile aesthetic.

Compositional and Hollow Engineering of Silicon Carbide/Carbon Microspheres as High-Performance Microwave Absorbing Materials with Good Environmental Tolerance

Microwave absorbing materials(MAMs)characterized by high absorption efficiency and good environmental tolerance are highly desirable in practical applications.Both silicon carbide and carbon are considered as stable MAMs under some rigorous conditions,while their composites still fail to produce satisfactory microwave absorption performance regardless of the improvements as compared with the individuals.Herein,we have successfully implemented compositional and structural engineering to fabricate hollow Si C/C microspheres with controllable composition.The simultaneous modulation on dielectric properties and impedance matching can be easily achieved as the change in the composition of these composites.The formation of hollow structure not only favors lightweight feature,but also generates considerable contribution to microwave attenuation capacity.With the synergistic effect of composition and structure,the optimized SiC/C composite exhibits excellent performance,whose the strongest reflection loss intensity and broadest effective absorption reach-60.8 dB and 5.1 GHz,respectively,and its microwave absorption properties are actually superior to those of most SiC/C composites in previous studies.In addition,the stability tests of microwave absorption capacity after exposure to harsh conditions and Radar Cross Section simulation data demonstrate that hollow SiC/C microspheres from compositional and structural optimization have a bright prospect in practical applications.

Family physicians’ perception on environmental influences in promoting physical activity in their obese patients

Although many obese patients do not engage in adequate physical activity (PA), little is known about whether physicians discuss environmental barriers in promoting PA. We conducted this study to describe physicians’ views about discussing environmental barriers in promoting PA with obese patients and determine whether counseling varies by years of practice. We conducted an online survey of family physicians practicing in 17 clinics in Central Texas. We performed descriptive analysis on barriers to PA, counseling on meeting PA recommendation, and written prescription for exercise and bivariate analysis by years of practice. Statistical significance was set at p < 0.05. Of 96 physicians invited, 57 (59.4%) completed the survey. Majority reported their obese patients brought up the environment as a barrier to walking (89.3%) or PA (91.2%). Majority (80.7%) also reported asking about environmental barriers to walking, with 84.2% giving specific examples to overcome these barriers. While 96.5% reported advising their obese patients about meeting the PA recommendation, only 26.3% reported giving them a written prescription for exercise. These did not vary significantly by years of practice. Physicians felt having more time with their patients and knowing specific strategies to overcome environmental barriers, safe places in patients’ neighborhoods, and what environmental factors influence PA may help discuss environmental issues with their obese patients. Physicians want and counsel their obese patients to be physically active, but do not generally give prescriptions for exercise irrespective of years of practice. They also want tools to enhance their abilities to better assist these patients.

Correlation linking illness perception,negative emotions,and the post-operative recovery effect in patients with perianal disease

BACKGROUND Improvements in the standard of living have led to increased attention to perianal disease.Although surgical treatments are effective,the outcomes of postoperative recovery(POR)are influenced by various factors,including individual differences among patients,the characteristics of the disease itself,and the psychological state of the patient.Understanding these factors can help healthcare providers develop more personalized and effective post-operative care plans for patients with perianal disease.AIM To investigate the effect of illness perception(IP)and negative emotions on POR outcomes in patients with perianal disease.METHODS A total of 146 patients with perianal disease admitted to the First People's Hospital of Changde City from March to December 2023 were recruited.We employed a general information questionnaire,the Brief Illness Perception Questionnaire(B-IPQ),and the Hospital Anxiety and Depression Scale(HADS).We used the 15-item Quality of Recovery Score(QoR-15)to measure patients’recovery effects.Finally,we conducted Pearson’s correlation analysis to examine the relationship between pre-operative IP and anxiety and depression levels with POR quality.RESULTS Fifty-three(36.3%)had poor knowledge of their disease.Thirty(20.5%)were suspected of having anxiety and 99(67.8%)exhibited symptoms.Forty(27.4%)were suspected of having depression and 102(69.9%)displayed symptoms.The B-IPQ,HADS-A,HADS-D,and QoR-15 scores were 46.82±9.97,12.99±3.60,12.58±3.36,and 96.77±9.85,respectively.There was a negative correlation between pre-operative IP,anxiety,and depression with POR quality.The influence of age and disease course on post-operative rehabilitation effect are both negative.The impact of B-IPQ,HADS-A,and HADS-D on POR was negative.Collectively,these variables accounted for 72.6%of the variance in POR.CONCLUSION The quality of POR in patients with perianal disease is medium and is related to age,disease course,IP,anxiety,and depression.

Willingness to pay for environmental protection in China:Air pollution,perception,and government involvement

The deteriorating environment has become an urgent global problem.As developing country,China is no exception.Demand for clean air is increasing in response to health and social problems.We use China's micro household survey data to explore individual residents'willingness to pay for environmental protection(WTP).Results show that air pollution improves WTP.A 100​μg/m^(³)increase in PM_(2.5)leads to approximately 84.1%WTP on a given day,but local residents are habituated to local pollution.We further study air pollution affects individual perceptions.We discuss the belief that local governments take pollution seriously can promote WTP.In addition,respondents who own smartphones,demonstrate environmental awareness,are happier,and enjoy higher household assets and income are willing to pay more.

Environmental Education, Environmental Ethics, and Environmental Perceptions of Food Establishment Employees in a Philippine University

The waste management challenge in university campuses includes food and food packaging materials. Being foremost affected by the food-related waste stream, 92 employees from food establishments located inside the University of the Philippines were provided expert-validated survey questionnaire to identify their perception on environment and pollution as well as describe their awareness on environmental education and environmental ethics concepts. Thirty-nine （42.4%） related the concept of environment mainly to trees, plants, animals, and the physical environment such as rivers. Only twenty-six （28.3%） expressed an attitude of concern on the current state of the environment. Six （6.5%） conveyed negative human behavior as the reason why the environment is in a dismal state and the same percentage （6.5%） showed concern for the environment mainly because humans benefit from it. Fifteen （16.3%） opted not to share their opinion. For perception on pollution, thirty-six （39.1%） linked the concept to the presence of land, air, or water pollution and twenty-three （25%） associated the pollution to negative effects on human health and on the environment. Twelve （13%） mentioned concern over the presence of pollution and twenty-one （22.8%） did not share their opinion on pollution. Awareness on environmental ethics concepts was identified using 15-item Likert Scale Questionnaire. Areas in environmental concepts where participants most strongly agreed include ＂value of life,＂ diversity and intrinsic value, cooperation, common good, and social responsibility. Results of this survey will be integrated into the discourse on the proposed policy of the University of the Philippines to segregate waste at-source. The said policy seeks to ensure that： （1） only food waste from concessionaires will be deposited directly to the compost site; （2） recyclables are to be sold; and （3） only residuals such as non-biodegradables and non-recyclables are to be sent to the dumpsite.

Research on the Relationship Between Environmental and Economic Coupling Systems in Bohai Bay Area Based on a Vector Autoregression(VAR)Model

This study analyzed the impact of land-based contaminants and tertiary industrial structure on economic development in the selected Bohai Bay area,China.Based on panel data spanning 2011-2020,a vector autoregressive(VAR)model is used to analyze and forecast the short-run and long-run relationships between three industrial structures,pollutant discharge,and economic development.The results showed that the environmental index had a long-term cointegration relationship with the industrial structure economic index.Per capital chemical oxygen demand(PCOD)and per capita ammonia nitrogen(PNH_(3)N)had a positive impact on delta per capita GDP(dPGDP),while per capita solid waste(PSW),the secondary industry rate(SIR)and delta tertiary industry(dTIR)had a negative impact on dPGDP.The VAR model under this coupling system had stability and credibility.The impulse response results showed that the short-term effect of the coupling system on dPGDP was basically consistent with the Granger causality test results.In addition,variance decomposition was used in this study to predict the long-term impact of the coupling system in the next ten periods(i.e.,ten years).It was found that dTIR had a great impact on dPGDP,with a contribution rate as high as 74.35%in the tenth period,followed by the contribution rate of PCOD up to 3.94%,while the long-term contribution rates of PSW,SIR and PNH3N were all less than 1%.The results show that the government should support the development of the tertiary industry to maintain the vitality of economic development and prevent environmental deterioration.

Interplay between microglia and environmental risk factors in Alzheimer's disease

Alzheimer s disease,among the most common neurodegenerative disorders,is chara cterized by progressive cognitive impairment.At present,the Alzheimer’s disease main risk remains genetic ris ks,but major environmental fa ctors are increasingly shown to impact Alzheimer’s disease development and progression.Microglia,the most important brain immune cells,play a central role in Alzheimer’s disease pathogenesis and are considered environmental and lifestyle"sensors."Factors like environmental pollution and modern lifestyles(e.g.,chronic stress,poor dietary habits,sleep,and circadian rhythm disorde rs)can cause neuroinflammato ry responses that lead to cognitive impairment via microglial functioning and phenotypic regulation.However,the specific mechanisms underlying interactions among these facto rs and microglia in Alzheimer’s disease are unclear.Herein,we:discuss the biological effects of air pollution,chronic stress,gut micro biota,sleep patterns,physical exercise,cigarette smoking,and caffeine consumption on microglia;consider how unhealthy lifestyle factors influence individual susceptibility to Alzheimer’s disease;and present the neuroprotective effects of a healthy lifestyle.Toward intervening and controlling these environmental risk fa ctors at an early Alzheimer’s disease stage,understanding the role of microglia in Alzheimer’s disease development,and to rgeting strategies to to rget microglia,co uld be essential to future Alzheimer’s disease treatments.