期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Current understandings of the pathogenesis of type 1 diabetes:Genetics to environment 被引量:3
1
作者 Adebola Matthew Giwa Rizwan Ahmed +5 位作者 Zahra Omidian Neha Majety Kagan Ege Karakus Sarah M Omer Thomas Donner Abdel Rahim A Hamad 《World Journal of Diabetes》 2020年第1期13-25,共13页
Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any age.It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancre... Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any age.It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancreas.Epidemiological studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2%-5%annually worldwide.The daily responsibility,clinical management,and vigilance required to maintain blood sugar levels within normal range and avoid acute complications(hypoglycemic episodes and diabetic ketoacidosis)and long term micro-and macro-vascular complications significantly affects quality of life and public health care costs.Given the expansive impact of T1D,research work has accelerated and T1D has been intensively investigated with the focus to better understand,manage and cure this condition.Many advances have been made in the past decades in this regard,but key questions remain as to why certain people develop T1D,but not others,with the glaring example of discordant disease incidence among monozygotic twins.In this review,we discuss the field’s current understanding of its pathophysiology and the role of genetics and environment on the development of T1D.We examine the potential implications of these findings with an emphasis on T1D inheritance patterns,twin studies,and disease prevention.Through a better understanding of this process,interventions can be developed to prevent or halt it at early stages. 展开更多
关键词 type 1 diabetes genetics type 1 diabetes epigenetics Role of genetics in type 1 diabetes Diabetes prevention type 1 diabetes environment type 1 diabetes twin studies type 1 diabetes concordance type 1 diabetes discordance
下载PDF
Atmospheric environmental capacity and urban atmospheric load in China's Mainland 被引量:8
2
作者 XU DaHai WANG Yu ZHU Rong 《Science China Earth Sciences》 SCIE EI CAS CSCD 2018年第1期33-46,共14页
Daily and annual average atmospheric environmental capacity coefficient(A-value) sequences for China's Mainland are calculated from hourly data recorded at 378 ground stations over 1975–2014. A-values at differen... Daily and annual average atmospheric environmental capacity coefficient(A-value) sequences for China's Mainland are calculated from hourly data recorded at 378 ground stations over 1975–2014. A-values at different recurrence intervals are calculated by fitting the sequences to Pearson type III distribution curves. Based on these A-values and source-sink balance(reference concentration 100 μg m^(-3)), atmospheric environmental capacities at the recurrence intervals are calculated for all of China's Mainland and each provincial administrative region. The climate average atmospheric environmental capacity reference value for the entire mainland is 2.169×10~7 t yr^(-1). An urban atmospheric load index is defined for analyses of the impact of population density on the urban atmospheric environment. Analyses suggest that this index is also useful for differentiating whether air quality changes are attributable to varying meteorological conditions or variations of artificial emission rate.Equations guiding the control of unorganized emission sources are derived for preventing air quality deterioration during urban expansion and population concentration. 展开更多
关键词 Atmospheric environmental capacity Pearson type III distribution Recurrence interval Urban atmospheric load index Emission rate density
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部