Twenty one health hybrid dogs weighted （7±3.2） kg were intramuscularly injected with tetracyclinum in a dose of 10 mg/kg body weight for continuous 5 days while the blood eperythrozoon test showing negative rea...Twenty one health hybrid dogs weighted （7±3.2） kg were intramuscularly injected with tetracyclinum in a dose of 10 mg/kg body weight for continuous 5 days while the blood eperythrozoon test showing negative reaction and divided randomly into three groups. The treating methods were respectively GroupⅠ, lienectomy, Group Ⅱ, both lienectomy and injection of immunosuppressor and Group Ⅲ, control. All dogs were intraperitoneal injected with 4ml anticoagulative blood from dog with eperythrozoonosis (the erythrozoon infection rate was 94 %, erythrocyte was 3.8×106/mm3). The result shown the eperythrozoon infection rate in GroupⅠ and Ⅱ were respectively 1.5 % and 2.1 % on the first day after administration. On the sixth day, the infection rate of GroupⅠ, Ⅱ and Ⅲ were 81.3 %, 86.5 % and 75.2 % respectively. The hematological changes in GroupⅠ and Ⅱ included both decrease in packed cell volume （HCT PCV）, hemoglobin, total erythrocyte, acidocyte number and lymphocyte, and rise in total leukocyte, neutrocyte and monocyte. Five dogs in GroupⅠ and seven dogs in Group Ⅱ showed apparent symptoms of anaemia, icterus, high fever, anorexia, diarrhea and emesis,etc. The morbidity in GroupⅠ and Ⅱ were respectively 71 % and 100 %, and two dogs in Group Ⅱdied. The changes in clinical symptoms, the hemogram and the physiological indexes in GroupⅠ and Ⅱ were the same as those in natural eperythrozoonosis.展开更多
The comparison of the efficacy of arteanninum, allicinum, tetracyclinum, neoarsphenamine, penicillinum G, streplomycini sulfate, sulfadiazinum in dogs infected eperythrozoosis was studied. The result showed that the a...The comparison of the efficacy of arteanninum, allicinum, tetracyclinum, neoarsphenamine, penicillinum G, streplomycini sulfate, sulfadiazinum in dogs infected eperythrozoosis was studied. The result showed that the arteanninum, allicinum, tetracyclinum, and neoarsphenamine had obviously therapeutic effect in inhibiting and sterilizing eperythrozoon, while penicillinum G, streplomycini sulfas, sulfadiazinum did not. The curative rate of arteanninum, allicinum, tetracyclinum and neoarsphenamine were 100%, 90%, 80%, 80% respectively. The success of applying arteanninum and allicinum in the treatment of eperythrozoonos has provided a novel feasible way and a theoretical probability for exploring the precious legacy of traditional Chinese medicine and pharmacology. It is the new treating method avoiding toxicosis or side effect of tetracylinum and neparshenamine, and treating human eperythrozoonosis.展开更多
基金Item supported by Shanghai scientific andtechnological commission
文摘Twenty one health hybrid dogs weighted （7±3.2） kg were intramuscularly injected with tetracyclinum in a dose of 10 mg/kg body weight for continuous 5 days while the blood eperythrozoon test showing negative reaction and divided randomly into three groups. The treating methods were respectively GroupⅠ, lienectomy, Group Ⅱ, both lienectomy and injection of immunosuppressor and Group Ⅲ, control. All dogs were intraperitoneal injected with 4ml anticoagulative blood from dog with eperythrozoonosis (the erythrozoon infection rate was 94 %, erythrocyte was 3.8×106/mm3). The result shown the eperythrozoon infection rate in GroupⅠ and Ⅱ were respectively 1.5 % and 2.1 % on the first day after administration. On the sixth day, the infection rate of GroupⅠ, Ⅱ and Ⅲ were 81.3 %, 86.5 % and 75.2 % respectively. The hematological changes in GroupⅠ and Ⅱ included both decrease in packed cell volume （HCT PCV）, hemoglobin, total erythrocyte, acidocyte number and lymphocyte, and rise in total leukocyte, neutrocyte and monocyte. Five dogs in GroupⅠ and seven dogs in Group Ⅱ showed apparent symptoms of anaemia, icterus, high fever, anorexia, diarrhea and emesis,etc. The morbidity in GroupⅠ and Ⅱ were respectively 71 % and 100 %, and two dogs in Group Ⅱdied. The changes in clinical symptoms, the hemogram and the physiological indexes in GroupⅠ and Ⅱ were the same as those in natural eperythrozoonosis.
基金Item supported by science and technologycommission of Shanghai
文摘The comparison of the efficacy of arteanninum, allicinum, tetracyclinum, neoarsphenamine, penicillinum G, streplomycini sulfate, sulfadiazinum in dogs infected eperythrozoosis was studied. The result showed that the arteanninum, allicinum, tetracyclinum, and neoarsphenamine had obviously therapeutic effect in inhibiting and sterilizing eperythrozoon, while penicillinum G, streplomycini sulfas, sulfadiazinum did not. The curative rate of arteanninum, allicinum, tetracyclinum and neoarsphenamine were 100%, 90%, 80%, 80% respectively. The success of applying arteanninum and allicinum in the treatment of eperythrozoonos has provided a novel feasible way and a theoretical probability for exploring the precious legacy of traditional Chinese medicine and pharmacology. It is the new treating method avoiding toxicosis or side effect of tetracylinum and neparshenamine, and treating human eperythrozoonosis.
