In this study,we proposed a method to measure the epidermal thickness(ET)of skin based on deep convolutional neural network,which was used to determine the boundaries of skin surface and the ridge portion in dermal-ep...In this study,we proposed a method to measure the epidermal thickness(ET)of skin based on deep convolutional neural network,which was used to determine the boundaries of skin surface and the ridge portion in dermal-epidermis junction(DE J)in cross-section optical coherence tomography(OCT)images of fingertip skin.The ET was calculated based on the row difference between the surface and the ridge top,which is determined by search the local maxima of boundary of the ridge portion.The results demonstrated that the region of ridge portion in DEJ was well determined and the ET measurement in this work can reduce the effect of the papillae valley in DEJ by 9.85%.It can be used for quantitative characterization of skin to differentiate the skin diseases.展开更多
Optical coherence tomography(OCT)enables in vivo imaging of port wine stains(PWS)lesions.The knowledge of vascular struct ure and epidermal thickness(ET)of PWS may aid the objectivediagnosis and optimal treatment.To o...Optical coherence tomography(OCT)enables in vivo imaging of port wine stains(PWS)lesions.The knowledge of vascular struct ure and epidermal thickness(ET)of PWS may aid the objectivediagnosis and optimal treatment.To obtain the structural parameters more rapidly and avoiduser intervention,an automated algorithm of energy map is introduced based on intensity andedge information to extract the skin surface using dynamic programming method.Subsequently,an averaged A-scan analysis is performed to obtain the mean ET and the relative intensity ofdermis indicating the corresponding vascular density.This approach is currently successfullyapplied in clinical diagnosis and shows promising guidance and assessment of PDT treatment.展开更多
Objective:The clinical effectiveness of blood-heat psoriasis treated by Qingre Liangxue decoction and ultrasound imaging changes of lesions was observed.Methods:Patients with blood-heat psoriasis were selected and ran...Objective:The clinical effectiveness of blood-heat psoriasis treated by Qingre Liangxue decoction and ultrasound imaging changes of lesions was observed.Methods:Patients with blood-heat psoriasis were selected and randomly grouped into two groups:the treatment group taking the Qingre Liangxue decoction orally,the control group taking the Compound Glycyrrhizin Tablets orally,both groups applying topical emollient lotion for a 12-week treatment period.Ultrasound images of target lesions and healthy skin were collected at different treatment times.Results:The epidermal thickness thought,the dermal density incremented as well as the subepidermal low-echogenic band(SLEB)width narrowed in both groups during the treatment.Conclusion:Qingre Liangxue decoction has signified efficiency in the treatment of blood-heat psoriasis,and high-frequency ultrasound has the advantages of non-invasive,timely and objective in the evolution.展开更多
基金This work has been supported by the National Natural Science Foundation of China(Nos.61875038 and 81901787)Fujian Provincial National Science Foundation(No.2019J01268)the Fund for High-level Talents of Xiamen University of Technology(No.YKJ19010R).
文摘In this study,we proposed a method to measure the epidermal thickness(ET)of skin based on deep convolutional neural network,which was used to determine the boundaries of skin surface and the ridge portion in dermal-epidermis junction(DE J)in cross-section optical coherence tomography(OCT)images of fingertip skin.The ET was calculated based on the row difference between the surface and the ridge top,which is determined by search the local maxima of boundary of the ridge portion.The results demonstrated that the region of ridge portion in DEJ was well determined and the ET measurement in this work can reduce the effect of the papillae valley in DEJ by 9.85%.It can be used for quantitative characterization of skin to differentiate the skin diseases.
基金supported in part by the National Natural Science Foundation of China under Grant 61227807by the Ministry of Science and Technology of China under contracts 2006AA02Z472,001CB510307 and 2009CB929400+1 种基金by the Ministryof Education of China Grant 20130002110079 for Doctoral Programby the Tsinghua Initiative Scientific Research Program Grant 2013THZ02-3.
文摘Optical coherence tomography(OCT)enables in vivo imaging of port wine stains(PWS)lesions.The knowledge of vascular struct ure and epidermal thickness(ET)of PWS may aid the objectivediagnosis and optimal treatment.To obtain the structural parameters more rapidly and avoiduser intervention,an automated algorithm of energy map is introduced based on intensity andedge information to extract the skin surface using dynamic programming method.Subsequently,an averaged A-scan analysis is performed to obtain the mean ET and the relative intensity ofdermis indicating the corresponding vascular density.This approach is currently successfullyapplied in clinical diagnosis and shows promising guidance and assessment of PDT treatment.
基金Ma Lili Famous Veteran Teran Doctors of TCM Inheritance Studio(No.GZS2021019)Zhejiang Provincial Key Laboratory of Integrated Dermatology(No.2A11829).Abbreviations。
文摘Objective:The clinical effectiveness of blood-heat psoriasis treated by Qingre Liangxue decoction and ultrasound imaging changes of lesions was observed.Methods:Patients with blood-heat psoriasis were selected and randomly grouped into two groups:the treatment group taking the Qingre Liangxue decoction orally,the control group taking the Compound Glycyrrhizin Tablets orally,both groups applying topical emollient lotion for a 12-week treatment period.Ultrasound images of target lesions and healthy skin were collected at different treatment times.Results:The epidermal thickness thought,the dermal density incremented as well as the subepidermal low-echogenic band(SLEB)width narrowed in both groups during the treatment.Conclusion:Qingre Liangxue decoction has signified efficiency in the treatment of blood-heat psoriasis,and high-frequency ultrasound has the advantages of non-invasive,timely and objective in the evolution.
