BACKGROUND Epilepsy is a syndrome characterized by transient,rigid,paroxysmal,and repetitive central nervous system dysfunction.Prevention,control,and improvement of cognitive and behavioral dysfunction are of great s...BACKGROUND Epilepsy is a syndrome characterized by transient,rigid,paroxysmal,and repetitive central nervous system dysfunction.Prevention,control,and improvement of cognitive and behavioral dysfunction are of great significance for improving the patients’intellectual development and quality of life.Electroencephalograms(EEG)can predict an accelerated decline in cognitive function.AIM To determine the clinical and EEG characteristics and treatment results of benign epilepsy in spiking children.METHODS A total of 106 cases of benign epilepsy in children with myocardial spines treated at our hospital from January 2017 to January 2020 were selected.Differences in clinical data and EGG characteristics between treatment-effective/-ineffective patients were analyzed,and children’s intellectual development before and after treatment evaluated using the Gesell Development Diagnostic Scale.RESULTS EEG showed that the discharge proportion in the awake and sleep periods was 66.04%,and the peak/peak discharge was mainly single-sided,accounting for 81.13%,while the discharge generalization accounted for 31.13%.There was no significant difference in any of these variables between sexes and ages(P>0.05).The proportion of patients with early onset(<5 years old)and seizure frequency>3 times/half a year was 40.00%and 60.00%,respectively;the incidence rate and seizure frequency in the younger age group(<5 years old)were significantly higher than those in the treatment-effective group(P<0.05),while the discharge index was significantly lower than that in the treatment-effective group(P<0.05).The discharge index was negatively correlated with fine motor skill and language development(r=-0.274 and-0.247,respectively;P<0.05),but not with the rest(P>0.05).Logistic regression analysis showed that low age onset(<5 years old)and seizure frequency were the factors affecting ineffective-treatment of benign epilepsy in children(odds ratio=11.304 and 5.784,respectively;P<0.05).The discharge index of the responsive group after treatment was significantly lower than that of the unresponsive group(P<0.05).However,there was no significant difference between groups after treatment in gross and fine motor skills,adaptability,language,and personal social development(P>0.05).CONCLUSION The EEG of children with benign epilepsy due to spinal wave in central time zone has characteristic changes,and the therapeutic effect is influenced by age of onset and attack frequency.展开更多
Background:Recent studies have shown a possible coexistence of absence seizures with other forms of epilepsy.The purpose of this study was to ascertain the possible contemporary or subsequent presence of childhood abs...Background:Recent studies have shown a possible coexistence of absence seizures with other forms of epilepsy.The purpose of this study was to ascertain the possible contemporary or subsequent presence of childhood absence epilepsy (CAE) and benign epilepsy with centro-temporal spikes (BECTS) in pediatric epileptic patients.Data sources:A PubMed systematic search indexed for MEDLINE,PubMed and EMBASE was undertaken to identify studies in children including articles written between 1996 and 2015.Retrospective studies,meta-analysis and case reports were included.The list of references of all the relevant articles was also studied.The date of our last search was December 2015.Results:Review of the literature revealed 19 cases,8 females and 11 males,reporting a consecutive or contemporary coexistence of CAE and BECTS within the same patients.Patient's age ranged between 4 and 12 years.Three out of 19 patients presented concomitant features of both syndromes,whereas 16 patients experienced the two syndromes at different times.Conclusions:BECTS and CAE may be pathophysiologically related,and the two epileptic phenotypes may indicate a neurobiological continuum.Further studies are needed to elucidate a probable genetic or functional link between partial and primarily generalized electro-clinical patterns in idiopathic childhood epilepsies.展开更多
We read with great interest the recent review of benign epilepsy with centro-temporal spikes (BECTS) and child-hood absence epilepsy (CAE) by Verrotti et al. (1)BECTS and CAE are the most common epilepsy syndromes in ...We read with great interest the recent review of benign epilepsy with centro-temporal spikes (BECTS) and child-hood absence epilepsy (CAE) by Verrotti et al. (1)BECTS and CAE are the most common epilepsy syndromes in childhood and share certain clinical features: similar age at onset, overall good prognosis, and genetic predispo-sition. Several studies have reported the coexistence of the two syndromes, and recently, Verrotti et al. analyzed 19 cases reported to have clinical features of CAE and BECTS. Among the total 19 cases, three cases had fea-tures of both syndromes contemporarily;three cases expe-rienced absence seizures initially followed by BECTS;and the other 13 cases experienced BECTS at onset and had absence seizures later.展开更多
自限性癫痫伴中央颞区棘波(self-limited epilepsy with centrotemporal spikes,SLECTS)是最常见的儿童局灶性癫痫综合征,临床上多伴有一系列认知和行为缺陷。目前该病发病机制尚不明确,临床干预存在争议。随着神经影像学技术的不断进步...自限性癫痫伴中央颞区棘波(self-limited epilepsy with centrotemporal spikes,SLECTS)是最常见的儿童局灶性癫痫综合征,临床上多伴有一系列认知和行为缺陷。目前该病发病机制尚不明确,临床干预存在争议。随着神经影像学技术的不断进步和MRI新技术的广泛应用,SLECTS脑结构和功能改变及其与认知障碍的相关性成为当今的研究热点。同步脑电图-功能磁共振成像(electroencephalogram-functional MRI,EEG-fMRI)技术结合基因组学以及人工智能的跨学科模式将是未来SLECTS研究的大方向,有望进一步阐明SLECTS认知功能障碍发生的神经病理学机制,为早期诊断和个体化治疗提供更确切的临床依据。本文就SLECTS的MRI研究现状和潜在不足进行综述,旨在为该领域未来研究提供参考。展开更多
文摘BACKGROUND Epilepsy is a syndrome characterized by transient,rigid,paroxysmal,and repetitive central nervous system dysfunction.Prevention,control,and improvement of cognitive and behavioral dysfunction are of great significance for improving the patients’intellectual development and quality of life.Electroencephalograms(EEG)can predict an accelerated decline in cognitive function.AIM To determine the clinical and EEG characteristics and treatment results of benign epilepsy in spiking children.METHODS A total of 106 cases of benign epilepsy in children with myocardial spines treated at our hospital from January 2017 to January 2020 were selected.Differences in clinical data and EGG characteristics between treatment-effective/-ineffective patients were analyzed,and children’s intellectual development before and after treatment evaluated using the Gesell Development Diagnostic Scale.RESULTS EEG showed that the discharge proportion in the awake and sleep periods was 66.04%,and the peak/peak discharge was mainly single-sided,accounting for 81.13%,while the discharge generalization accounted for 31.13%.There was no significant difference in any of these variables between sexes and ages(P>0.05).The proportion of patients with early onset(<5 years old)and seizure frequency>3 times/half a year was 40.00%and 60.00%,respectively;the incidence rate and seizure frequency in the younger age group(<5 years old)were significantly higher than those in the treatment-effective group(P<0.05),while the discharge index was significantly lower than that in the treatment-effective group(P<0.05).The discharge index was negatively correlated with fine motor skill and language development(r=-0.274 and-0.247,respectively;P<0.05),but not with the rest(P>0.05).Logistic regression analysis showed that low age onset(<5 years old)and seizure frequency were the factors affecting ineffective-treatment of benign epilepsy in children(odds ratio=11.304 and 5.784,respectively;P<0.05).The discharge index of the responsive group after treatment was significantly lower than that of the unresponsive group(P<0.05).However,there was no significant difference between groups after treatment in gross and fine motor skills,adaptability,language,and personal social development(P>0.05).CONCLUSION The EEG of children with benign epilepsy due to spinal wave in central time zone has characteristic changes,and the therapeutic effect is influenced by age of onset and attack frequency.
文摘Background:Recent studies have shown a possible coexistence of absence seizures with other forms of epilepsy.The purpose of this study was to ascertain the possible contemporary or subsequent presence of childhood absence epilepsy (CAE) and benign epilepsy with centro-temporal spikes (BECTS) in pediatric epileptic patients.Data sources:A PubMed systematic search indexed for MEDLINE,PubMed and EMBASE was undertaken to identify studies in children including articles written between 1996 and 2015.Retrospective studies,meta-analysis and case reports were included.The list of references of all the relevant articles was also studied.The date of our last search was December 2015.Results:Review of the literature revealed 19 cases,8 females and 11 males,reporting a consecutive or contemporary coexistence of CAE and BECTS within the same patients.Patient's age ranged between 4 and 12 years.Three out of 19 patients presented concomitant features of both syndromes,whereas 16 patients experienced the two syndromes at different times.Conclusions:BECTS and CAE may be pathophysiologically related,and the two epileptic phenotypes may indicate a neurobiological continuum.Further studies are needed to elucidate a probable genetic or functional link between partial and primarily generalized electro-clinical patterns in idiopathic childhood epilepsies.
文摘We read with great interest the recent review of benign epilepsy with centro-temporal spikes (BECTS) and child-hood absence epilepsy (CAE) by Verrotti et al. (1)BECTS and CAE are the most common epilepsy syndromes in childhood and share certain clinical features: similar age at onset, overall good prognosis, and genetic predispo-sition. Several studies have reported the coexistence of the two syndromes, and recently, Verrotti et al. analyzed 19 cases reported to have clinical features of CAE and BECTS. Among the total 19 cases, three cases had fea-tures of both syndromes contemporarily;three cases expe-rienced absence seizures initially followed by BECTS;and the other 13 cases experienced BECTS at onset and had absence seizures later.
文摘目的伴中央颞区棘波儿童自限性癫痫(selflimited epilepsy with centrotemporal spikes,SeLECTS)是儿童最常见特发性局灶性癫痫,与静息状态大脑网络连接时空变化有关,本研究采用基于静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)的二值化度中心度(degree centrality,DC)和加权DC分析方法分析SeLECTS患者静息状态下大脑功能网络的改变,从而探讨SeLECTS潜在神经生物学机制。材料与方法对26例临床诊断为SeLECTS的患者(SeLECTS组)和26名健康自愿者(对照组)采集rs-fMRI图像。采用基于体素脑功能网络DC法处理数据,获取二值化的DC值和加权的DC值,比较2组内及组间上述参数的差异。结果SeLECTS组与对照组的组内二值化的DC值和加权的DC值空间分布均存在广泛的相似性。与对照组相比,SeLECTS组在双侧枕中回、距状回和右侧梭状回的二值化的DC值增加,而在右侧颞下回和左侧小脑、小脑脚、顶上小叶的二值化的DC值下降;SeLECTS组在双侧距状回、枕中回和右侧梭状回的加权的DC值增加,而在右侧颞下回和左侧顶下小叶、小脑、小脑脚以及楔前叶的加权的DC值下降。此外,相关分析发现距状回二值化的DC值和加权的DC值与病程呈正相关(r=0.712,r=0.700,P<0.001),而顶上小叶的二值化的DC值和加权的DC值与病程呈负相关(r=-0.680,r=-0.717,P<0.001)。结论本研究表明枢纽节点的选择性和特异性破坏,特别是高度连接的脑区配置异常的功能网络节点可能与SeLECTS的发病机制有关。
